Heterogeneity of SOS response expression in clinical isolates of Escherichia coli influences adaptation to antimicrobial stress Article Swipe
Sara Díaz-Díaz
,
Andrea García-Montaner
,
Roberta Vanni
,
Marina Murillo-Torres
,
Esther Recacha
,
Marina R. Pulido
,
María Romero-Muñoz
,
Fernando Docobo-Pérez
,
Álvaro Pascual
,
Josè Manuel Rodriguez-Martínez
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.drup.2024.101087
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.drup.2024.101087
In recent years, new evidence has shown that the SOS response plays an important role in the response to antimicrobials, with involvement in the generation of clinical resistance. Here we evaluate the impact of heterogeneous expression of the SOS response in clinical isolates of Escherichia coli on response to the fluoroquinolone, ciprofloxacin. In silico analysis of whole genome sequencing data showed remarkable sequence conservation of the SOS response regulators, RecA and LexA. Despite the genetic homogeneity, our results revealed a marked differential heterogeneity in SOS response activation, both at population and single-cell level, among clinical isolates of E. coli in the presence of subinhibitory concentrations of ciprofloxacin. Four main stages of SOS response activation were identified and correlated with cell filamentation. Interestingly, there was a correlation between clinical isolates with higher expression of the SOS response and further progression to resistance. This heterogeneity in response to DNA damage repair (mediated by the SOS response) and induced by antimicrobial agents could be a new factor with implications for bacterial evolution and survival contributing to the generation of antimicrobial resistance.
Related Topics
Concepts
SOS response
Repressor lexA
Biology
Escherichia coli
Microbiology
Antibiotic resistance
Population
Antimicrobial
Stringent response
Genetics
Gene expression
Gene
Antibiotics
Medicine
Environmental health
Repressor
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.drup.2024.101087
- OA Status
- hybrid
- Cited By
- 4
- References
- 43
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4395013814
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4395013814Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1016/j.drup.2024.101087Digital Object Identifier
- Title
-
Heterogeneity of SOS response expression in clinical isolates of Escherichia coli influences adaptation to antimicrobial stressWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-04-23Full publication date if available
- Authors
-
Sara Díaz-Díaz, Andrea García-Montaner, Roberta Vanni, Marina Murillo-Torres, Esther Recacha, Marina R. Pulido, María Romero-Muñoz, Fernando Docobo-Pérez, Álvaro Pascual, Josè Manuel Rodriguez-MartínezList of authors in order
- Landing page
-
https://doi.org/10.1016/j.drup.2024.101087Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
hybridOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1016/j.drup.2024.101087Direct OA link when available
- Concepts
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SOS response, Repressor lexA, Biology, Escherichia coli, Microbiology, Antibiotic resistance, Population, Antimicrobial, Stringent response, Genetics, Gene expression, Gene, Antibiotics, Medicine, Environmental health, RepressorTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 3, 2024: 1Per-year citation counts (last 5 years)
- References (count)
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43Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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