High cut-off dialysis mitigates pro-calcific effects of plasma on vascular progenitor cells Article Swipe
Theres Schaub
,
Daniel Janke
,
Daniel Zickler
,
Claudia Lange
,
Matthias Girndt
,
Ralf Schindler
,
Duska Dragun
,
B. Hegner
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-020-80016-7
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-020-80016-7
Mortality of patients with end-stage renal disease tremendously exceeds that of the general population due to excess cardiovascular morbidity. Large middle-sized molecules (LMM) including pro-inflammatory cytokines are major drivers of uremic cardiovascular toxicity and cannot be removed sufficiently by conventional high-flux (HFL) hemodialysis. We tested the ability of plasma from 19 hemodialysis patients participating in a trial comparing HFL with high cut-off (HCO) membranes facilitating removal of LMM to induce calcification in mesenchymal stromal cells (MSC) functioning as vascular progenitors. HCO dialysis favorably changed plasma composition resulting in reduced pro-calcific activity. LMM were removed more effectively by HCO dialysis including FGF23, a typical LMM we found to promote osteoblastic differentiation of MSC. Protein-bound uremic retention solutes with known cardiovascular toxicity but not LMM inhibited proliferation of MSC without direct toxicity in screening experiments. We could not attribute the effect of HCO dialysis on MSC calcification to distinct mediators. However, we found evidence of sustained reduced inflammation that might parallel other anti-calcifying mechanisms such as altered generation of extracellular vesicles. Our findings imply protection of MSC from dysfunctional differentiation by novel dialysis techniques targeted at removal of LMM. HCO dialysis might preserve their physiologic role in vascular regeneration and improve outcomes in dialysis patients.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-020-80016-7
- https://www.nature.com/articles/s41598-020-80016-7.pdf
- OA Status
- gold
- Cited By
- 2
- References
- 60
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3119389186
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3119389186Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41598-020-80016-7Digital Object Identifier
- Title
-
High cut-off dialysis mitigates pro-calcific effects of plasma on vascular progenitor cellsWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-01-13Full publication date if available
- Authors
-
Theres Schaub, Daniel Janke, Daniel Zickler, Claudia Lange, Matthias Girndt, Ralf Schindler, Duska Dragun, B. HegnerList of authors in order
- Landing page
-
https://doi.org/10.1038/s41598-020-80016-7Publisher landing page
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https://www.nature.com/articles/s41598-020-80016-7.pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.nature.com/articles/s41598-020-80016-7.pdfDirect OA link when available
- Concepts
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Progenitor cell, Dialysis, Progenitor, Internal medicine, Medicine, Chemistry, Cell biology, Biology, Stem cellTop concepts (fields/topics) attached by OpenAlex
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-
2Total citation count in OpenAlex
- Citations by year (recent)
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2023: 2Per-year citation counts (last 5 years)
- References (count)
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60Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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