High density lipoprotein cholesterol and alcohol consumption: are they related? Article Swipe
MR Santos
,
Andreia Pereira
,
JA Sousa
,
Fernando Mendonça
,
JP Monteiro
,
M Temtem
,
A C Sousa
,
Mariana Rodrigues
,
E Henriques
,
I Ornelas
,
A Drumond
,
MI Mendonca
,
Roberto Palma dos Reis
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1093/ehjacc/zuab020.216
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1093/ehjacc/zuab020.216
Funding Acknowledgements Type of funding sources: None. OnBehalf GENEMACOR Introduction High density lipoprotein cholesterol (HDL-C) is known to be inversely related to coronary artery disease (CAD). Previous observational studies have consistently reported that individuals with moderate alcohol consumption have a lower risk of cardiovascular disease compared with that of nondrinkers and heavy drinkers. The beneficial effects of moderate drinking appear to be mediated in large part by alcohol-induced increases in HDL-C concentrations. Objective To evaluate if a moderate alcohol consumption (30-50g a day) is associated with higher levels of HDL-C in coronary patients. Materials and methods 1676 patients selected from GENEMACOR study population, with at least one > 75% coronary stenosis by angiography (median age 53.3 ± 7.9 years, 78.6% male, median HDL 43.0 ± 11.1 mg/dL). Population was divided according to the HDL level quartiles (1st quartile HDL < 35.3 mg/dL; 2nd quartile HDL 35.3 – 42 mg/dL; 3rd quartile HDL 42 – 49 mg/dL; 4th quartile HDL > 49 mg/dL). Population of the 1st and 4th quartiles (825 patients, median age of 53.3 ± 8.0 years and 78.7% male) were adjudicated and prospectively followed-up by 5.0 ± 4.2 years. X2 and T student tests were used to analyze the demographic, laboratorial, angiographic and anthropometric characteristics of the population. Results 420 (50.9%) patients were included in the 1st quartile group (median age 53.2 ± 7.9 years, 85.7% men) and 405 (49.1%) patients were included in the 4th quartile group (median age 53.4 ± 8.0 years, 71.4% men). The mean HDL level was higher in the population with moderate alcohol consumption (mean HDL 43.7 ± 15mg/dL in patients with alcohol consumption <30g/day, mean HDL 48.8 ± 16mg/dL in patients with moderate alcohol consumption and mean HDL 41.6 ± 15mg/dL in patients with alcohol consumption >50g/day). From 104 (median age 51.9 ± 7.9 years, 96.2% male) patients with a moderate alcohol consumption, 62.5% vs 37.5% were in 4th HDL quartile, p 0.01. Conclusion We conclude that in our population, a moderate alcohol consumption is associated with higher levels of HDL-C. However, even if there is a causal association between alcohol consumption and higher HDL cholesterol levels, it is suggested that efforts to reduce coronary heart disease risks concentrate on the control of another risk factors.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1093/ehjacc/zuab020.216
- https://academic.oup.com/ehjacc/article-pdf/10/Supplement_1/zuab020.216/37407659/zuab020.216.pdf
- OA Status
- bronze
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3157093840
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3157093840Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1093/ehjacc/zuab020.216Digital Object Identifier
- Title
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High density lipoprotein cholesterol and alcohol consumption: are they related?Work title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
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2021-04-01Full publication date if available
- Authors
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MR Santos, Andreia Pereira, JA Sousa, Fernando Mendonça, JP Monteiro, M Temtem, A C Sousa, Mariana Rodrigues, E Henriques, I Ornelas, A Drumond, MI Mendonca, Roberto Palma dos ReisList of authors in order
- Landing page
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https://doi.org/10.1093/ehjacc/zuab020.216Publisher landing page
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https://academic.oup.com/ehjacc/article-pdf/10/Supplement_1/zuab020.216/37407659/zuab020.216.pdfDirect link to full text PDF
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YesWhether a free full text is available
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bronzeOpen access status per OpenAlex
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https://academic.oup.com/ehjacc/article-pdf/10/Supplement_1/zuab020.216/37407659/zuab020.216.pdfDirect OA link when available
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Quartile, Medicine, Internal medicine, Population, Anthropometry, Coronary artery disease, Alcohol consumption, Cholesterol, High-density lipoprotein, Alcohol, Cardiology, Environmental health, Confidence interval, Biology, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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