Journal of Neurosurgery Pediatrics • Vol 26 • No 2
High-dose MTX110 (soluble panobinostat) safely administered into the fourth ventricle in a nonhuman primate model
May 2020 • David I. Sandberg, Natasha Kharas, Bangning Yu, Christopher F. Janssen, Amanda Trimble, Leomar Y. Ballester, Rajan Patel, Afroz S. Mohammad, William …
OBJECTIVE Chemotherapy infusions directly into the fourth ventricle may play a role in treating malignant fourth-ventricular tumors. This study tested the safety and pharmacokinetics of short-term and long-term administration of MTX110 (soluble panobinostat; Midatech Pharma) into the fourth ventricle of nonhuman primates. METHODS Four rhesus macaque monkeys underwent posterior fossa craniectomy and catheter insertion into the fourth ventricle. In group I (n = 2), catheters were externalized and lumbar drain cathet…