High dose oral rifampicin to improve survival from adult tuberculous meningitis: A randomised placebo-controlled double-blinded phase III trial (the HARVEST study) Article Swipe
Suzaan Marais
,
Fiona V Cresswell
,
Raph L Hamers
,
Lindsey H. M. te Brake
,
Ahmad Rizal Ganiem
,
Darma Imran
,
Ananta Bangdiwala
,
Emily Martyn
,
John Kasibante
,
Enock Kagimu
,
Abdu K Musubire
,
Kartika Maharani
,
Riwanti Estiasari
,
Ardiana Kusumaningrum
,
Nadytia Kusumadjayanti
,
Vycke Yunivita
,
Kogieleum Naidoo
,
Richard Lessells
,
Mahomed‐Yunus S. Moosa
,
Elin M. Svensson
,
Katherine Huppler Hullsiek
,
Rob E. Aarnoutse
,
David R. Boulware
,
Reinout van Crevel
,
Rovina Ruslami
,
David B. Meya
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.12688/wellcomeopenres.15565.2
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.12688/wellcomeopenres.15565.2
Background: Tuberculous meningitis (TBM), the most severe form of tuberculosis (TB), results in death or neurological disability in >50%, despite World Health Organisation recommended therapy. Current TBM regimen dosages are based on data from pulmonary TB alone. Evidence from recent phase II pharmacokinetic studies suggests that high dose rifampicin (R) administered intravenously or orally enhances central nervous system penetration and may reduce TBM associated mortality. We hypothesize that, among persons with TBM, high dose oral rifampicin (35 mg/kg) for 8 weeks will improve survival compared to standard of care (10 mg/kg), without excess adverse events. Protocol: We will perform a parallel group, randomised, placebo-controlled, double blind, phase III multicentre clinical trial comparing high dose oral rifampicin to standard of care. The trial will be conducted across five clinical sites in Uganda, South Africa and Indonesia. Participants are HIV-positive or negative adults with clinically suspected TBM, who will be randomised (1:1) to one of two arms: 35 mg/kg oral rifampicin daily for 8 weeks (in combination with standard dose isoniazid [H], pyrazinamide [Z] and ethambutol [E]) or standard of care (oral HRZE, containing 10 mg/kg/day rifampicin). The primary end-point is 6-month survival. Secondary end points are: i) 12-month survival ii) functional and neurocognitive outcomes and iii) safety and tolerability. Tertiary outcomes are: i) pharmacokinetic outcomes and ii) cost-effectiveness of the intervention. We will enrol 500 participants over 2.5 years, with follow-up continuing until 12 months post-enrolment. Discussion: Our best TBM treatment still results in unacceptably high mortality and morbidity. Strong evidence supports the increased cerebrospinal fluid penetration of high dose rifampicin, however conclusive evidence regarding survival benefit is lacking. This study will answer the important question of whether high dose oral rifampicin conveys a survival benefit in TBM in HIV-positive and -negative individuals from Africa and Asia. Trial registration: ISRCTN15668391 (17/06/2019)
Related Topics
Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.12688/wellcomeopenres.15565.2
- https://wellcomeopenresearch.org/articles/4-190/v2/pdf
- OA Status
- gold
- Cited By
- 20
- References
- 44
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2990966794
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2990966794Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.12688/wellcomeopenres.15565.2Digital Object Identifier
- Title
-
High dose oral rifampicin to improve survival from adult tuberculous meningitis: A randomised placebo-controlled double-blinded phase III trial (the HARVEST study)Work title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-08-25Full publication date if available
- Authors
-
Suzaan Marais, Fiona V Cresswell, Raph L Hamers, Lindsey H. M. te Brake, Ahmad Rizal Ganiem, Darma Imran, Ananta Bangdiwala, Emily Martyn, John Kasibante, Enock Kagimu, Abdu K Musubire, Kartika Maharani, Riwanti Estiasari, Ardiana Kusumaningrum, Nadytia Kusumadjayanti, Vycke Yunivita, Kogieleum Naidoo, Richard Lessells, Mahomed‐Yunus S. Moosa, Elin M. Svensson, Katherine Huppler Hullsiek, Rob E. Aarnoutse, David R. Boulware, Reinout van Crevel, Rovina Ruslami, David B. MeyaList of authors in order
- Landing page
-
https://doi.org/10.12688/wellcomeopenres.15565.2Publisher landing page
- PDF URL
-
https://wellcomeopenresearch.org/articles/4-190/v2/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://wellcomeopenresearch.org/articles/4-190/v2/pdfDirect OA link when available
- Concepts
-
Medicine, Rifampicin, Pyrazinamide, Tolerability, Placebo, Regimen, Ethambutol, Tuberculosis, Adverse effect, Clinical endpoint, Internal medicine, Randomized controlled trial, Pathology, Alternative medicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
20Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 5, 2024: 2, 2023: 5, 2022: 4, 2021: 3Per-year citation counts (last 5 years)
- References (count)
-
44Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W2990966794 |
|---|---|
| doi | https://doi.org/10.12688/wellcomeopenres.15565.2 |
| ids.doi | https://doi.org/10.12688/wellcomeopenres.15565.2 |
| ids.mag | 2990966794 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/33083560 |
| ids.openalex | https://openalex.org/W2990966794 |
| fwci | 2.95499562 |
| type | preprint |
| title | High dose oral rifampicin to improve survival from adult tuberculous meningitis: A randomised placebo-controlled double-blinded phase III trial (the HARVEST study) |
| awards[0].id | https://openalex.org/G3646105629 |
| awards[0].funder_id | https://openalex.org/F4320319990 |
| awards[0].display_name | |
| awards[0].funder_award_id | MR/S004963/1 |
| awards[0].funder_display_name | National Institute for Health and Care Research |
| awards[1].id | https://openalex.org/G8666320532 |
| awards[1].funder_id | https://openalex.org/F4320321637 |
| awards[1].display_name | |
| awards[1].funder_award_id | MR/S004963/1 |
| awards[1].funder_display_name | Department for International Development |
| awards[2].id | https://openalex.org/G1464996059 |
| awards[2].funder_id | https://openalex.org/F4320307874 |
| awards[2].display_name | |
| awards[2].funder_award_id | 210772 |
| awards[2].funder_display_name | Wellcome |
| awards[3].id | https://openalex.org/G2712873472 |
| awards[3].funder_id | https://openalex.org/F4320307874 |
| awards[3].display_name | |
| awards[3].funder_award_id | MR/S004963/1 |
| awards[3].funder_display_name | Wellcome |
| awards[4].id | https://openalex.org/G1496757388 |
| awards[4].funder_id | https://openalex.org/F4320334626 |
| awards[4].display_name | |
| awards[4].funder_award_id | MR/S004963/1 |
| awards[4].funder_display_name | Medical Research Council |
| biblio.issue | |
| biblio.volume | 4 |
| biblio.last_page | 190 |
| biblio.first_page | 190 |
| grants[0].funder | https://openalex.org/F4320307874 |
| grants[0].award_id | 210772 |
| grants[0].funder_display_name | Wellcome |
| grants[1].funder | https://openalex.org/F4320307874 |
| grants[1].award_id | MR/S004963/1 |
| grants[1].funder_display_name | Wellcome |
| grants[2].funder | https://openalex.org/F4320319990 |
| grants[2].award_id | MR/S004963/1 |
| grants[2].funder_display_name | National Institute for Health and Care Research |
| grants[3].funder | https://openalex.org/F4320321637 |
| grants[3].award_id | MR/S004963/1 |
| grants[3].funder_display_name | Department for International Development |
| grants[4].funder | https://openalex.org/F4320334626 |
| grants[4].award_id | MR/S004963/1 |
| grants[4].funder_display_name | Medical Research Council |
| topics[0].id | https://openalex.org/T11381 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2746 |
| topics[0].subfield.display_name | Surgery |
| topics[0].display_name | Infectious Diseases and Tuberculosis |
| topics[1].id | https://openalex.org/T10038 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9987999796867371 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2725 |
| topics[1].subfield.display_name | Infectious Diseases |
| topics[1].display_name | Tuberculosis Research and Epidemiology |
| topics[2].id | https://openalex.org/T12369 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.996399998664856 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2713 |
| topics[2].subfield.display_name | Epidemiology |
| topics[2].display_name | Pneumocystis jirovecii pneumonia detection and treatment |
| funders[0].id | https://openalex.org/F4320307874 |
| funders[0].ror | https://ror.org/029chgv08 |
| funders[0].display_name | Wellcome |
| funders[1].id | https://openalex.org/F4320319990 |
| funders[1].ror | https://ror.org/0187kwz08 |
| funders[1].display_name | National Institute for Health and Care Research |
| funders[2].id | https://openalex.org/F4320321637 |
| funders[2].ror | https://ror.org/05rf29967 |
| funders[2].display_name | Department for International Development |
| funders[3].id | https://openalex.org/F4320334626 |
| funders[3].ror | https://ror.org/03x94j517 |
| funders[3].display_name | Medical Research Council |
| is_xpac | False |
| apc_list.value | 920 |
| apc_list.currency | GBP |
| apc_list.value_usd | 1128 |
| apc_paid.value | 920 |
| apc_paid.currency | GBP |
| apc_paid.value_usd | 1128 |
| concepts[0].id | https://openalex.org/C71924100 |
| concepts[0].level | 0 |
| concepts[0].score | 0.8210552930831909 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[0].display_name | Medicine |
| concepts[1].id | https://openalex.org/C2778607973 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6671038269996643 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q422652 |
| concepts[1].display_name | Rifampicin |
| concepts[2].id | https://openalex.org/C2780459521 |
| concepts[2].level | 4 |
| concepts[2].score | 0.6377698183059692 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q417571 |
| concepts[2].display_name | Pyrazinamide |
| concepts[3].id | https://openalex.org/C2778375690 |
| concepts[3].level | 3 |
| concepts[3].score | 0.6032123565673828 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q7814214 |
| concepts[3].display_name | Tolerability |
| concepts[4].id | https://openalex.org/C27081682 |
| concepts[4].level | 3 |
| concepts[4].score | 0.5083665251731873 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q269829 |
| concepts[4].display_name | Placebo |
| concepts[5].id | https://openalex.org/C2781413609 |
| concepts[5].level | 2 |
| concepts[5].score | 0.4878980815410614 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7308373 |
| concepts[5].display_name | Regimen |
| concepts[6].id | https://openalex.org/C2776228421 |
| concepts[6].level | 4 |
| concepts[6].score | 0.45499521493911743 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q412318 |
| concepts[6].display_name | Ethambutol |
| concepts[7].id | https://openalex.org/C2781069245 |
| concepts[7].level | 2 |
| concepts[7].score | 0.4435100555419922 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q12204 |
| concepts[7].display_name | Tuberculosis |
| concepts[8].id | https://openalex.org/C197934379 |
| concepts[8].level | 2 |
| concepts[8].score | 0.4410414397716522 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q2047938 |
| concepts[8].display_name | Adverse effect |
| concepts[9].id | https://openalex.org/C203092338 |
| concepts[9].level | 3 |
| concepts[9].score | 0.43259912729263306 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q1340863 |
| concepts[9].display_name | Clinical endpoint |
| concepts[10].id | https://openalex.org/C126322002 |
| concepts[10].level | 1 |
| concepts[10].score | 0.4254215359687805 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[10].display_name | Internal medicine |
| concepts[11].id | https://openalex.org/C168563851 |
| concepts[11].level | 2 |
| concepts[11].score | 0.3711760640144348 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q1436668 |
| concepts[11].display_name | Randomized controlled trial |
| concepts[12].id | https://openalex.org/C142724271 |
| concepts[12].level | 1 |
| concepts[12].score | 0.07621589303016663 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[12].display_name | Pathology |
| concepts[13].id | https://openalex.org/C204787440 |
| concepts[13].level | 2 |
| concepts[13].score | 0.0 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q188504 |
| concepts[13].display_name | Alternative medicine |
| keywords[0].id | https://openalex.org/keywords/medicine |
| keywords[0].score | 0.8210552930831909 |
| keywords[0].display_name | Medicine |
| keywords[1].id | https://openalex.org/keywords/rifampicin |
| keywords[1].score | 0.6671038269996643 |
| keywords[1].display_name | Rifampicin |
| keywords[2].id | https://openalex.org/keywords/pyrazinamide |
| keywords[2].score | 0.6377698183059692 |
| keywords[2].display_name | Pyrazinamide |
| keywords[3].id | https://openalex.org/keywords/tolerability |
| keywords[3].score | 0.6032123565673828 |
| keywords[3].display_name | Tolerability |
| keywords[4].id | https://openalex.org/keywords/placebo |
| keywords[4].score | 0.5083665251731873 |
| keywords[4].display_name | Placebo |
| keywords[5].id | https://openalex.org/keywords/regimen |
| keywords[5].score | 0.4878980815410614 |
| keywords[5].display_name | Regimen |
| keywords[6].id | https://openalex.org/keywords/ethambutol |
| keywords[6].score | 0.45499521493911743 |
| keywords[6].display_name | Ethambutol |
| keywords[7].id | https://openalex.org/keywords/tuberculosis |
| keywords[7].score | 0.4435100555419922 |
| keywords[7].display_name | Tuberculosis |
| keywords[8].id | https://openalex.org/keywords/adverse-effect |
| keywords[8].score | 0.4410414397716522 |
| keywords[8].display_name | Adverse effect |
| keywords[9].id | https://openalex.org/keywords/clinical-endpoint |
| keywords[9].score | 0.43259912729263306 |
| keywords[9].display_name | Clinical endpoint |
| keywords[10].id | https://openalex.org/keywords/internal-medicine |
| keywords[10].score | 0.4254215359687805 |
| keywords[10].display_name | Internal medicine |
| keywords[11].id | https://openalex.org/keywords/randomized-controlled-trial |
| keywords[11].score | 0.3711760640144348 |
| keywords[11].display_name | Randomized controlled trial |
| keywords[12].id | https://openalex.org/keywords/pathology |
| keywords[12].score | 0.07621589303016663 |
| keywords[12].display_name | Pathology |
| language | en |
| locations[0].id | doi:10.12688/wellcomeopenres.15565.2 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4210218052 |
| locations[0].source.issn | 2398-502X |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 2398-502X |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Wellcome Open Research |
| locations[0].source.host_organization | https://openalex.org/P4310311838 |
| locations[0].source.host_organization_name | Wellcome |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310311838 |
| locations[0].source.host_organization_lineage_names | Wellcome |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://wellcomeopenresearch.org/articles/4-190/v2/pdf |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Wellcome Open Research |
| locations[0].landing_page_url | https://doi.org/10.12688/wellcomeopenres.15565.2 |
| locations[1].id | pmid:33083560 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Wellcome open research |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/33083560 |
| locations[2].id | pmh:oai:researchonline.lshtm.ac.uk:4660179 |
| locations[2].is_oa | False |
| locations[2].source.id | https://openalex.org/S4306402527 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | LSHTM Research Online (London School of Hygiene and Tropical Medicine) |
| locations[2].source.host_organization | https://openalex.org/I4210089966 |
| locations[2].source.host_organization_name | London School of Hygiene & Tropical Medicine |
| locations[2].source.host_organization_lineage | https://openalex.org/I4210089966 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | acceptedVersion |
| locations[2].raw_type | Article |
| locations[2].license_id | |
| locations[2].is_accepted | True |
| locations[2].is_published | False |
| locations[2].raw_source_name | |
| locations[2].landing_page_url | |
| locations[3].id | pmh:oai:researchonline.lshtm.ac.uk:4662889 |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306402527 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | LSHTM Research Online (London School of Hygiene and Tropical Medicine) |
| locations[3].source.host_organization | https://openalex.org/I4210089966 |
| locations[3].source.host_organization_name | London School of Hygiene & Tropical Medicine |
| locations[3].source.host_organization_lineage | https://openalex.org/I4210089966 |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | acceptedVersion |
| locations[3].raw_type | Article |
| locations[3].license_id | |
| locations[3].is_accepted | True |
| locations[3].is_published | False |
| locations[3].raw_source_name | |
| locations[3].landing_page_url | https://researchonline.lshtm.ac.uk/view/creators/icrufcre.html>; |
| locations[4].id | pmh:ru:oai:repository.ubn.ru.nl:2066/229101 |
| locations[4].is_oa | True |
| locations[4].source.id | https://openalex.org/S4306401843 |
| locations[4].source.issn | |
| locations[4].source.type | repository |
| locations[4].source.is_oa | False |
| locations[4].source.issn_l | |
| locations[4].source.is_core | False |
| locations[4].source.is_in_doaj | False |
| locations[4].source.display_name | Data Archiving and Networked Services (DANS) |
| locations[4].source.host_organization | https://openalex.org/I1322597698 |
| locations[4].source.host_organization_name | Royal Netherlands Academy of Arts and Sciences |
| locations[4].source.host_organization_lineage | https://openalex.org/I1322597698 |
| locations[4].license | other-oa |
| locations[4].pdf_url | |
| locations[4].version | submittedVersion |
| locations[4].raw_type | info:eu-repo/semantics/article |
| locations[4].license_id | https://openalex.org/licenses/other-oa |
| locations[4].is_accepted | False |
| locations[4].is_published | False |
| locations[4].raw_source_name | Wellcome Open Research, 4 |
| locations[4].landing_page_url | http://hdl.handle.net/2066/229101 |
| locations[5].id | pmh:oai:repository.ubn.ru.nl:2066/229101 |
| locations[5].is_oa | False |
| locations[5].source.id | https://openalex.org/S4306401067 |
| locations[5].source.issn | |
| locations[5].source.type | repository |
| locations[5].source.is_oa | False |
| locations[5].source.issn_l | |
| locations[5].source.is_core | False |
| locations[5].source.is_in_doaj | False |
| locations[5].source.display_name | Radboud Repository (Radboud University) |
| locations[5].source.host_organization | https://openalex.org/I145872427 |
| locations[5].source.host_organization_name | Radboud University Nijmegen |
| locations[5].source.host_organization_lineage | https://openalex.org/I145872427 |
| locations[5].license | |
| locations[5].pdf_url | |
| locations[5].version | submittedVersion |
| locations[5].raw_type | Article / Letter to editor |
| locations[5].license_id | |
| locations[5].is_accepted | False |
| locations[5].is_published | False |
| locations[5].raw_source_name | |
| locations[5].landing_page_url | https://hdl.handle.net/2066/229101 |
| locations[6].id | pmh:oai:doaj.org/article:d06cf107e8164549a460f56a6aa07fa4 |
| locations[6].is_oa | True |
| locations[6].source.id | https://openalex.org/S4306401280 |
| locations[6].source.issn | |
| locations[6].source.type | repository |
| locations[6].source.is_oa | False |
| locations[6].source.issn_l | |
| locations[6].source.is_core | False |
| locations[6].source.is_in_doaj | False |
| locations[6].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[6].source.host_organization | |
| locations[6].source.host_organization_name | |
| locations[6].license | cc-by-sa |
| locations[6].pdf_url | |
| locations[6].version | submittedVersion |
| locations[6].raw_type | article |
| locations[6].license_id | https://openalex.org/licenses/cc-by-sa |
| locations[6].is_accepted | False |
| locations[6].is_published | False |
| locations[6].raw_source_name | Wellcome Open Research, Vol 4 (2020) |
| locations[6].landing_page_url | https://doaj.org/article/d06cf107e8164549a460f56a6aa07fa4 |
| locations[7].id | pmh:oai:pubmedcentral.nih.gov:7542255 |
| locations[7].is_oa | True |
| locations[7].source.id | https://openalex.org/S2764455111 |
| locations[7].source.issn | |
| locations[7].source.type | repository |
| locations[7].source.is_oa | False |
| locations[7].source.issn_l | |
| locations[7].source.is_core | False |
| locations[7].source.is_in_doaj | False |
| locations[7].source.display_name | PubMed Central |
| locations[7].source.host_organization | https://openalex.org/I1299303238 |
| locations[7].source.host_organization_name | National Institutes of Health |
| locations[7].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[7].license | cc-by |
| locations[7].pdf_url | |
| locations[7].version | submittedVersion |
| locations[7].raw_type | Text |
| locations[7].license_id | https://openalex.org/licenses/cc-by |
| locations[7].is_accepted | False |
| locations[7].is_published | False |
| locations[7].raw_source_name | Wellcome Open Res |
| locations[7].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/7542255 |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5084914479 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-8050-9610 |
| authorships[0].author.display_name | Suzaan Marais |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Neurology, Inkosi Albert Luthuli Central Hospital, Durban, 4091, South Africa |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Suzaan Marais |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Neurology, Inkosi Albert Luthuli Central Hospital, Durban, 4091, South Africa |
| authorships[1].author.id | https://openalex.org/A5070324473 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-5070-532X |
| authorships[1].author.display_name | Fiona V Cresswell |
| authorships[1].countries | GB, UG |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I91369620 |
| authorships[1].affiliations[0].raw_affiliation_string | MRC-UVRI, London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I2800872281, https://openalex.org/I4210116188 |
| authorships[1].affiliations[1].raw_affiliation_string | Infectious Diseases Institute, Mulago College of Health Sciences, Kampala, PO Box 22418, Uganda |
| authorships[1].affiliations[2].institution_ids | https://openalex.org/I4210089966 |
| authorships[1].affiliations[2].raw_affiliation_string | Clinical Research Department, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK |
| authorships[1].institutions[0].id | https://openalex.org/I4210089966 |
| authorships[1].institutions[0].ror | https://ror.org/00a0jsq62 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I124357947, https://openalex.org/I4210089966 |
| authorships[1].institutions[0].country_code | GB |
| authorships[1].institutions[0].display_name | London School of Hygiene & Tropical Medicine |
| authorships[1].institutions[1].id | https://openalex.org/I4210116188 |
| authorships[1].institutions[1].ror | https://ror.org/02caa0269 |
| authorships[1].institutions[1].type | nonprofit |
| authorships[1].institutions[1].lineage | https://openalex.org/I4210116188 |
| authorships[1].institutions[1].country_code | UG |
| authorships[1].institutions[1].display_name | Infectious Diseases Institute |
| authorships[1].institutions[2].id | https://openalex.org/I2800872281 |
| authorships[1].institutions[2].ror | https://ror.org/02rhp5f96 |
| authorships[1].institutions[2].type | healthcare |
| authorships[1].institutions[2].lineage | https://openalex.org/I2800872281 |
| authorships[1].institutions[2].country_code | UG |
| authorships[1].institutions[2].display_name | Mulago Hospital |
| authorships[1].institutions[3].id | https://openalex.org/I91369620 |
| authorships[1].institutions[3].ror | https://ror.org/04509n826 |
| authorships[1].institutions[3].type | facility |
| authorships[1].institutions[3].lineage | https://openalex.org/I91369620 |
| authorships[1].institutions[3].country_code | UG |
| authorships[1].institutions[3].display_name | Uganda Virus Research Institute |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Fiona V Cresswell |
| authorships[1].is_corresponding | True |
| authorships[1].raw_affiliation_strings | Clinical Research Department, London School of Hygiene & Tropical Medicine, London, WC1E 7HT, UK, Infectious Diseases Institute, Mulago College of Health Sciences, Kampala, PO Box 22418, Uganda, MRC-UVRI, London School of Hygiene & Tropical Medicine Uganda Research Unit, Entebbe, Uganda |
| authorships[2].author.id | https://openalex.org/A5080859236 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-5007-7896 |
| authorships[2].author.display_name | Raph L Hamers |
| authorships[2].countries | GB, ID |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I2800477803, https://openalex.org/I4389425243 |
| authorships[2].affiliations[0].raw_affiliation_string | Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I40120149 |
| authorships[2].affiliations[1].raw_affiliation_string | Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK |
| authorships[2].institutions[0].id | https://openalex.org/I4389425243 |
| authorships[2].institutions[0].ror | https://ror.org/0139c4536 |
| authorships[2].institutions[0].type | healthcare |
| authorships[2].institutions[0].lineage | https://openalex.org/I40120149, https://openalex.org/I4210150114, https://openalex.org/I4389425243, https://openalex.org/I87048295 |
| authorships[2].institutions[0].country_code | |
| authorships[2].institutions[0].display_name | Oxford University Clinical Research Unit Indonesia |
| authorships[2].institutions[1].id | https://openalex.org/I40120149 |
| authorships[2].institutions[1].ror | https://ror.org/052gg0110 |
| authorships[2].institutions[1].type | education |
| authorships[2].institutions[1].lineage | https://openalex.org/I40120149 |
| authorships[2].institutions[1].country_code | GB |
| authorships[2].institutions[1].display_name | University of Oxford |
| authorships[2].institutions[2].id | https://openalex.org/I2800477803 |
| authorships[2].institutions[2].ror | https://ror.org/0308s4091 |
| authorships[2].institutions[2].type | nonprofit |
| authorships[2].institutions[2].lineage | https://openalex.org/I2800477803 |
| authorships[2].institutions[2].country_code | ID |
| authorships[2].institutions[2].display_name | Eijkman Institute for Molecular Biology |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Raph L. Hamers |
| authorships[2].is_corresponding | True |
| authorships[2].raw_affiliation_strings | Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK, Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia |
| authorships[3].author.id | https://openalex.org/A5041205666 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-7727-2846 |
| authorships[3].author.display_name | Lindsey H. M. te Brake |
| authorships[3].countries | NL |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I145872427, https://openalex.org/I2802934949 |
| authorships[3].affiliations[0].raw_affiliation_string | Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands |
| authorships[3].institutions[0].id | https://openalex.org/I2802934949 |
| authorships[3].institutions[0].ror | https://ror.org/05wg1m734 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I2802934949 |
| authorships[3].institutions[0].country_code | NL |
| authorships[3].institutions[0].display_name | Radboud University Medical Center |
| authorships[3].institutions[1].id | https://openalex.org/I145872427 |
| authorships[3].institutions[1].ror | https://ror.org/016xsfp80 |
| authorships[3].institutions[1].type | education |
| authorships[3].institutions[1].lineage | https://openalex.org/I145872427 |
| authorships[3].institutions[1].country_code | NL |
| authorships[3].institutions[1].display_name | Radboud University Nijmegen |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Lindsey H.M. te Brake |
| authorships[3].is_corresponding | True |
| authorships[3].raw_affiliation_strings | Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands |
| authorships[4].author.id | https://openalex.org/A5038674908 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-0290-2759 |
| authorships[4].author.display_name | Ahmad Rizal Ganiem |
| authorships[4].countries | ID |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I91819753 |
| authorships[4].affiliations[0].raw_affiliation_string | Infectious Disease Research Centre, Faculty of Medicine, Universitas Padjadaran, Bandung, 40161, Indonesia |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I4210086620, https://openalex.org/I91819753 |
| authorships[4].affiliations[1].raw_affiliation_string | Department of Neurology, Faculty of Medicine, Universitas Padjadjaran/ Hasan Sadikin Hospital, Bandung, 40161, Indonesia |
| authorships[4].institutions[0].id | https://openalex.org/I4210086620 |
| authorships[4].institutions[0].ror | https://ror.org/003392690 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210086620 |
| authorships[4].institutions[0].country_code | ID |
| authorships[4].institutions[0].display_name | Dr. Hasan Sadikin General Hospital |
| authorships[4].institutions[1].id | https://openalex.org/I91819753 |
| authorships[4].institutions[1].ror | https://ror.org/00xqf8t64 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I91819753 |
| authorships[4].institutions[1].country_code | ID |
| authorships[4].institutions[1].display_name | Padjadjaran University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Ahmad R. Ganiem |
| authorships[4].is_corresponding | True |
| authorships[4].raw_affiliation_strings | Department of Neurology, Faculty of Medicine, Universitas Padjadjaran/ Hasan Sadikin Hospital, Bandung, 40161, Indonesia, Infectious Disease Research Centre, Faculty of Medicine, Universitas Padjadaran, Bandung, 40161, Indonesia |
| authorships[5].author.id | https://openalex.org/A5057092730 |
| authorships[5].author.orcid | https://orcid.org/0000-0002-4109-4192 |
| authorships[5].author.display_name | Darma Imran |
| authorships[5].countries | ID |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I29617571 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Neurology, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangukusumo Hospital, Jakarta, 10430, Indonesia |
| authorships[5].institutions[0].id | https://openalex.org/I29617571 |
| authorships[5].institutions[0].ror | https://ror.org/0116zj450 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I29617571 |
| authorships[5].institutions[0].country_code | ID |
| authorships[5].institutions[0].display_name | University of Indonesia |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Darma Imran |
| authorships[5].is_corresponding | True |
| authorships[5].raw_affiliation_strings | Department of Neurology, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangukusumo Hospital, Jakarta, 10430, Indonesia |
| authorships[6].author.id | https://openalex.org/A5003850875 |
| authorships[6].author.orcid | https://orcid.org/0000-0003-0062-9434 |
| authorships[6].author.display_name | Ananta Bangdiwala |
| authorships[6].countries | US |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I130238516 |
| authorships[6].affiliations[0].raw_affiliation_string | Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA |
| authorships[6].institutions[0].id | https://openalex.org/I130238516 |
| authorships[6].institutions[0].ror | https://ror.org/017zqws13 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I130238516 |
| authorships[6].institutions[0].country_code | US |
| authorships[6].institutions[0].display_name | University of Minnesota |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Ananta Bangdiwala |
| authorships[6].is_corresponding | True |
| authorships[6].raw_affiliation_strings | Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA |
| authorships[7].author.id | https://openalex.org/A5004729258 |
| authorships[7].author.orcid | https://orcid.org/0000-0003-4981-9298 |
| authorships[7].author.display_name | Emily Martyn |
| authorships[7].countries | UG |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I2800872281, https://openalex.org/I4210116188 |
| authorships[7].affiliations[0].raw_affiliation_string | Infectious Diseases Institute, Mulago College of Health Sciences, Kampala, PO Box 22418, Uganda |
| authorships[7].institutions[0].id | https://openalex.org/I4210116188 |
| authorships[7].institutions[0].ror | https://ror.org/02caa0269 |
| authorships[7].institutions[0].type | nonprofit |
| authorships[7].institutions[0].lineage | https://openalex.org/I4210116188 |
| authorships[7].institutions[0].country_code | UG |
| authorships[7].institutions[0].display_name | Infectious Diseases Institute |
| authorships[7].institutions[1].id | https://openalex.org/I2800872281 |
| authorships[7].institutions[1].ror | https://ror.org/02rhp5f96 |
| authorships[7].institutions[1].type | healthcare |
| authorships[7].institutions[1].lineage | https://openalex.org/I2800872281 |
| authorships[7].institutions[1].country_code | UG |
| authorships[7].institutions[1].display_name | Mulago Hospital |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Emily Martyn |
| authorships[7].is_corresponding | True |
| authorships[7].raw_affiliation_strings | Infectious Diseases Institute, Mulago College of Health Sciences, Kampala, PO Box 22418, Uganda |
| authorships[8].author.id | https://openalex.org/A5059309211 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-7252-4052 |
| authorships[8].author.display_name | John Kasibante |
| authorships[8].countries | UG |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I2800872281, https://openalex.org/I4210116188 |
| authorships[8].affiliations[0].raw_affiliation_string | Infectious Diseases Institute, Mulago College of Health Sciences, Kampala, PO Box 22418, Uganda |
| authorships[8].institutions[0].id | https://openalex.org/I4210116188 |
| authorships[8].institutions[0].ror | https://ror.org/02caa0269 |
| authorships[8].institutions[0].type | nonprofit |
| authorships[8].institutions[0].lineage | https://openalex.org/I4210116188 |
| authorships[8].institutions[0].country_code | UG |
| authorships[8].institutions[0].display_name | Infectious Diseases Institute |
| authorships[8].institutions[1].id | https://openalex.org/I2800872281 |
| authorships[8].institutions[1].ror | https://ror.org/02rhp5f96 |
| authorships[8].institutions[1].type | healthcare |
| authorships[8].institutions[1].lineage | https://openalex.org/I2800872281 |
| authorships[8].institutions[1].country_code | UG |
| authorships[8].institutions[1].display_name | Mulago Hospital |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | John Kasibante |
| authorships[8].is_corresponding | True |
| authorships[8].raw_affiliation_strings | Infectious Diseases Institute, Mulago College of Health Sciences, Kampala, PO Box 22418, Uganda |
| authorships[9].author.id | https://openalex.org/A5021184158 |
| authorships[9].author.orcid | https://orcid.org/0000-0002-0291-651X |
| authorships[9].author.display_name | Enock Kagimu |
| authorships[9].countries | UG |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I2800872281, https://openalex.org/I4210116188 |
| authorships[9].affiliations[0].raw_affiliation_string | Infectious Diseases Institute, Mulago College of Health Sciences, Kampala, PO Box 22418, Uganda |
| authorships[9].institutions[0].id | https://openalex.org/I4210116188 |
| authorships[9].institutions[0].ror | https://ror.org/02caa0269 |
| authorships[9].institutions[0].type | nonprofit |
| authorships[9].institutions[0].lineage | https://openalex.org/I4210116188 |
| authorships[9].institutions[0].country_code | UG |
| authorships[9].institutions[0].display_name | Infectious Diseases Institute |
| authorships[9].institutions[1].id | https://openalex.org/I2800872281 |
| authorships[9].institutions[1].ror | https://ror.org/02rhp5f96 |
| authorships[9].institutions[1].type | healthcare |
| authorships[9].institutions[1].lineage | https://openalex.org/I2800872281 |
| authorships[9].institutions[1].country_code | UG |
| authorships[9].institutions[1].display_name | Mulago Hospital |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Enock Kagimu |
| authorships[9].is_corresponding | True |
| authorships[9].raw_affiliation_strings | Infectious Diseases Institute, Mulago College of Health Sciences, Kampala, PO Box 22418, Uganda |
| authorships[10].author.id | https://openalex.org/A5064371778 |
| authorships[10].author.orcid | https://orcid.org/0000-0003-2410-5344 |
| authorships[10].author.display_name | Abdu K Musubire |
| authorships[10].countries | UG |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I2800872281, https://openalex.org/I4210116188 |
| authorships[10].affiliations[0].raw_affiliation_string | Infectious Diseases Institute, Mulago College of Health Sciences, Kampala, PO Box 22418, Uganda |
| authorships[10].institutions[0].id | https://openalex.org/I4210116188 |
| authorships[10].institutions[0].ror | https://ror.org/02caa0269 |
| authorships[10].institutions[0].type | nonprofit |
| authorships[10].institutions[0].lineage | https://openalex.org/I4210116188 |
| authorships[10].institutions[0].country_code | UG |
| authorships[10].institutions[0].display_name | Infectious Diseases Institute |
| authorships[10].institutions[1].id | https://openalex.org/I2800872281 |
| authorships[10].institutions[1].ror | https://ror.org/02rhp5f96 |
| authorships[10].institutions[1].type | healthcare |
| authorships[10].institutions[1].lineage | https://openalex.org/I2800872281 |
| authorships[10].institutions[1].country_code | UG |
| authorships[10].institutions[1].display_name | Mulago Hospital |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Abdu Musubire |
| authorships[10].is_corresponding | True |
| authorships[10].raw_affiliation_strings | Infectious Diseases Institute, Mulago College of Health Sciences, Kampala, PO Box 22418, Uganda |
| authorships[11].author.id | https://openalex.org/A5076735314 |
| authorships[11].author.orcid | https://orcid.org/0000-0003-2777-7015 |
| authorships[11].author.display_name | Kartika Maharani |
| authorships[11].countries | ID |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I29617571 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Neurology, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangukusumo Hospital, Jakarta, 10430, Indonesia |
| authorships[11].institutions[0].id | https://openalex.org/I29617571 |
| authorships[11].institutions[0].ror | https://ror.org/0116zj450 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I29617571 |
| authorships[11].institutions[0].country_code | ID |
| authorships[11].institutions[0].display_name | University of Indonesia |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Kartika Maharani |
| authorships[11].is_corresponding | True |
| authorships[11].raw_affiliation_strings | Department of Neurology, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangukusumo Hospital, Jakarta, 10430, Indonesia |
| authorships[12].author.id | https://openalex.org/A5001357563 |
| authorships[12].author.orcid | https://orcid.org/0000-0003-1982-8716 |
| authorships[12].author.display_name | Riwanti Estiasari |
| authorships[12].countries | ID |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I29617571 |
| authorships[12].affiliations[0].raw_affiliation_string | Department of Neurology, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangukusumo Hospital, Jakarta, 10430, Indonesia |
| authorships[12].institutions[0].id | https://openalex.org/I29617571 |
| authorships[12].institutions[0].ror | https://ror.org/0116zj450 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I29617571 |
| authorships[12].institutions[0].country_code | ID |
| authorships[12].institutions[0].display_name | University of Indonesia |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Riwanti Estiasari |
| authorships[12].is_corresponding | True |
| authorships[12].raw_affiliation_strings | Department of Neurology, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangukusumo Hospital, Jakarta, 10430, Indonesia |
| authorships[13].author.id | https://openalex.org/A5090563832 |
| authorships[13].author.orcid | https://orcid.org/0000-0001-6365-5993 |
| authorships[13].author.display_name | Ardiana Kusumaningrum |
| authorships[13].countries | ID |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I29617571 |
| authorships[13].affiliations[0].raw_affiliation_string | Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangukusumo Hospital, Jakarta, 10430, Indonesia |
| authorships[13].institutions[0].id | https://openalex.org/I29617571 |
| authorships[13].institutions[0].ror | https://ror.org/0116zj450 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I29617571 |
| authorships[13].institutions[0].country_code | ID |
| authorships[13].institutions[0].display_name | University of Indonesia |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Ardiana Kusumaningrum |
| authorships[13].is_corresponding | True |
| authorships[13].raw_affiliation_strings | Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangukusumo Hospital, Jakarta, 10430, Indonesia |
| authorships[14].author.id | https://openalex.org/A5039593798 |
| authorships[14].author.orcid | |
| authorships[14].author.display_name | Nadytia Kusumadjayanti |
| authorships[14].countries | ID |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I91819753 |
| authorships[14].affiliations[0].raw_affiliation_string | Infectious Disease Research Centre, Faculty of Medicine, Universitas Padjadaran, Bandung, 40161, Indonesia |
| authorships[14].institutions[0].id | https://openalex.org/I91819753 |
| authorships[14].institutions[0].ror | https://ror.org/00xqf8t64 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I91819753 |
| authorships[14].institutions[0].country_code | ID |
| authorships[14].institutions[0].display_name | Padjadjaran University |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Nadytia Kusumadjayanti |
| authorships[14].is_corresponding | True |
| authorships[14].raw_affiliation_strings | Infectious Disease Research Centre, Faculty of Medicine, Universitas Padjadaran, Bandung, 40161, Indonesia |
| authorships[15].author.id | https://openalex.org/A5014391406 |
| authorships[15].author.orcid | https://orcid.org/0000-0001-7448-8684 |
| authorships[15].author.display_name | Vycke Yunivita |
| authorships[15].countries | ID |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I91819753 |
| authorships[15].affiliations[0].raw_affiliation_string | Infectious Disease Research Centre, Faculty of Medicine, Universitas Padjadaran, Bandung, 40161, Indonesia |
| authorships[15].affiliations[1].institution_ids | https://openalex.org/I4210086620, https://openalex.org/I91819753 |
| authorships[15].affiliations[1].raw_affiliation_string | Department of Neurology, Faculty of Medicine, Universitas Padjadjaran/ Hasan Sadikin Hospital, Bandung, 40161, Indonesia |
| authorships[15].institutions[0].id | https://openalex.org/I4210086620 |
| authorships[15].institutions[0].ror | https://ror.org/003392690 |
| authorships[15].institutions[0].type | healthcare |
| authorships[15].institutions[0].lineage | https://openalex.org/I4210086620 |
| authorships[15].institutions[0].country_code | ID |
| authorships[15].institutions[0].display_name | Dr. Hasan Sadikin General Hospital |
| authorships[15].institutions[1].id | https://openalex.org/I91819753 |
| authorships[15].institutions[1].ror | https://ror.org/00xqf8t64 |
| authorships[15].institutions[1].type | education |
| authorships[15].institutions[1].lineage | https://openalex.org/I91819753 |
| authorships[15].institutions[1].country_code | ID |
| authorships[15].institutions[1].display_name | Padjadjaran University |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Vycke Yunivita |
| authorships[15].is_corresponding | True |
| authorships[15].raw_affiliation_strings | Department of Neurology, Faculty of Medicine, Universitas Padjadjaran/ Hasan Sadikin Hospital, Bandung, 40161, Indonesia, Infectious Disease Research Centre, Faculty of Medicine, Universitas Padjadaran, Bandung, 40161, Indonesia |
| authorships[16].author.id | https://openalex.org/A5058948786 |
| authorships[16].author.orcid | https://orcid.org/0000-0002-8874-6661 |
| authorships[16].author.display_name | Kogieleum Naidoo |
| authorships[16].countries | ZA |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I2800715850 |
| authorships[16].affiliations[0].raw_affiliation_string | Centre for the AIDS programme of research in South Africa (CAPRISA), Doris Duke Medical Research Institute, Durban, 4041, South Africa |
| authorships[16].affiliations[1].institution_ids | https://openalex.org/I10947320, https://openalex.org/I2800715850, https://openalex.org/I95023434 |
| authorships[16].affiliations[1].raw_affiliation_string | CAPRISA-MRC HIV-TB Pathogenesis and Treatment Research Unit, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban, South Africa |
| authorships[16].institutions[0].id | https://openalex.org/I2800715850 |
| authorships[16].institutions[0].ror | https://ror.org/04qkg4668 |
| authorships[16].institutions[0].type | other |
| authorships[16].institutions[0].lineage | https://openalex.org/I2800715850 |
| authorships[16].institutions[0].country_code | ZA |
| authorships[16].institutions[0].display_name | Centre for the AIDS Programme of Research in South Africa |
| authorships[16].institutions[1].id | https://openalex.org/I10947320 |
| authorships[16].institutions[1].ror | https://ror.org/05q60vz69 |
| authorships[16].institutions[1].type | other |
| authorships[16].institutions[1].lineage | https://openalex.org/I10947320 |
| authorships[16].institutions[1].country_code | ZA |
| authorships[16].institutions[1].display_name | South African Medical Research Council |
| authorships[16].institutions[2].id | https://openalex.org/I95023434 |
| authorships[16].institutions[2].ror | https://ror.org/04qzfn040 |
| authorships[16].institutions[2].type | education |
| authorships[16].institutions[2].lineage | https://openalex.org/I95023434 |
| authorships[16].institutions[2].country_code | ZA |
| authorships[16].institutions[2].display_name | University of KwaZulu-Natal |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Kogieleum Naidoo |
| authorships[16].is_corresponding | True |
| authorships[16].raw_affiliation_strings | CAPRISA-MRC HIV-TB Pathogenesis and Treatment Research Unit, Doris Duke Medical Research Institute, University of KwaZulu Natal, Durban, South Africa, Centre for the AIDS programme of research in South Africa (CAPRISA), Doris Duke Medical Research Institute, Durban, 4041, South Africa |
| authorships[17].author.id | https://openalex.org/A5062343676 |
| authorships[17].author.orcid | https://orcid.org/0000-0003-0926-710X |
| authorships[17].author.display_name | Richard Lessells |
| authorships[17].countries | ZA |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I95023434 |
| authorships[17].affiliations[0].raw_affiliation_string | KwaZulu-Natal Research Innovation and Sequencing Platform, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, 4001, South Africa |
| authorships[17].affiliations[1].institution_ids | https://openalex.org/I2800715850 |
| authorships[17].affiliations[1].raw_affiliation_string | Centre for the AIDS programme of research in South Africa (CAPRISA), Doris Duke Medical Research Institute, Durban, 4041, South Africa |
| authorships[17].institutions[0].id | https://openalex.org/I2800715850 |
| authorships[17].institutions[0].ror | https://ror.org/04qkg4668 |
| authorships[17].institutions[0].type | other |
| authorships[17].institutions[0].lineage | https://openalex.org/I2800715850 |
| authorships[17].institutions[0].country_code | ZA |
| authorships[17].institutions[0].display_name | Centre for the AIDS Programme of Research in South Africa |
| authorships[17].institutions[1].id | https://openalex.org/I95023434 |
| authorships[17].institutions[1].ror | https://ror.org/04qzfn040 |
| authorships[17].institutions[1].type | education |
| authorships[17].institutions[1].lineage | https://openalex.org/I95023434 |
| authorships[17].institutions[1].country_code | ZA |
| authorships[17].institutions[1].display_name | University of KwaZulu-Natal |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Richard Lessells |
| authorships[17].is_corresponding | True |
| authorships[17].raw_affiliation_strings | Centre for the AIDS programme of research in South Africa (CAPRISA), Doris Duke Medical Research Institute, Durban, 4041, South Africa, KwaZulu-Natal Research Innovation and Sequencing Platform, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, 4001, South Africa |
| authorships[18].author.id | https://openalex.org/A5035982137 |
| authorships[18].author.orcid | https://orcid.org/0000-0001-6191-4023 |
| authorships[18].author.display_name | Mahomed‐Yunus S. Moosa |
| authorships[18].countries | ZA |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I95023434 |
| authorships[18].affiliations[0].raw_affiliation_string | Department of Infectious Diseases, Division of Internal Medicine, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, 4013, South Africa |
| authorships[18].institutions[0].id | https://openalex.org/I95023434 |
| authorships[18].institutions[0].ror | https://ror.org/04qzfn040 |
| authorships[18].institutions[0].type | education |
| authorships[18].institutions[0].lineage | https://openalex.org/I95023434 |
| authorships[18].institutions[0].country_code | ZA |
| authorships[18].institutions[0].display_name | University of KwaZulu-Natal |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Yunus Moosa |
| authorships[18].is_corresponding | True |
| authorships[18].raw_affiliation_strings | Department of Infectious Diseases, Division of Internal Medicine, Nelson R Mandela School of Medicine, University of KwaZulu-Natal, Durban, 4013, South Africa |
| authorships[19].author.id | https://openalex.org/A5018480886 |
| authorships[19].author.orcid | https://orcid.org/0000-0002-0093-6445 |
| authorships[19].author.display_name | Elin M. Svensson |
| authorships[19].countries | NL, SE |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I145872427, https://openalex.org/I2802934949 |
| authorships[19].affiliations[0].raw_affiliation_string | Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands |
| authorships[19].affiliations[1].institution_ids | https://openalex.org/I123387679 |
| authorships[19].affiliations[1].raw_affiliation_string | Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden |
| authorships[19].institutions[0].id | https://openalex.org/I2802934949 |
| authorships[19].institutions[0].ror | https://ror.org/05wg1m734 |
| authorships[19].institutions[0].type | healthcare |
| authorships[19].institutions[0].lineage | https://openalex.org/I2802934949 |
| authorships[19].institutions[0].country_code | NL |
| authorships[19].institutions[0].display_name | Radboud University Medical Center |
| authorships[19].institutions[1].id | https://openalex.org/I145872427 |
| authorships[19].institutions[1].ror | https://ror.org/016xsfp80 |
| authorships[19].institutions[1].type | education |
| authorships[19].institutions[1].lineage | https://openalex.org/I145872427 |
| authorships[19].institutions[1].country_code | NL |
| authorships[19].institutions[1].display_name | Radboud University Nijmegen |
| authorships[19].institutions[2].id | https://openalex.org/I123387679 |
| authorships[19].institutions[2].ror | https://ror.org/048a87296 |
| authorships[19].institutions[2].type | education |
| authorships[19].institutions[2].lineage | https://openalex.org/I123387679 |
| authorships[19].institutions[2].country_code | SE |
| authorships[19].institutions[2].display_name | Uppsala University |
| authorships[19].author_position | middle |
| authorships[19].raw_author_name | Elin M. Svensson |
| authorships[19].is_corresponding | True |
| authorships[19].raw_affiliation_strings | Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden, Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands |
| authorships[20].author.id | https://openalex.org/A5067576735 |
| authorships[20].author.orcid | |
| authorships[20].author.display_name | Katherine Huppler Hullsiek |
| authorships[20].countries | US |
| authorships[20].affiliations[0].institution_ids | https://openalex.org/I130238516 |
| authorships[20].affiliations[0].raw_affiliation_string | Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA |
| authorships[20].institutions[0].id | https://openalex.org/I130238516 |
| authorships[20].institutions[0].ror | https://ror.org/017zqws13 |
| authorships[20].institutions[0].type | education |
| authorships[20].institutions[0].lineage | https://openalex.org/I130238516 |
| authorships[20].institutions[0].country_code | US |
| authorships[20].institutions[0].display_name | University of Minnesota |
| authorships[20].author_position | middle |
| authorships[20].raw_author_name | Katherine Huppler Hullsiek |
| authorships[20].is_corresponding | True |
| authorships[20].raw_affiliation_strings | Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, 55455, USA |
| authorships[21].author.id | https://openalex.org/A5078789624 |
| authorships[21].author.orcid | https://orcid.org/0000-0001-8925-969X |
| authorships[21].author.display_name | Rob E. Aarnoutse |
| authorships[21].countries | NL |
| authorships[21].affiliations[0].institution_ids | https://openalex.org/I145872427, https://openalex.org/I2802934949 |
| authorships[21].affiliations[0].raw_affiliation_string | Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands |
| authorships[21].institutions[0].id | https://openalex.org/I2802934949 |
| authorships[21].institutions[0].ror | https://ror.org/05wg1m734 |
| authorships[21].institutions[0].type | healthcare |
| authorships[21].institutions[0].lineage | https://openalex.org/I2802934949 |
| authorships[21].institutions[0].country_code | NL |
| authorships[21].institutions[0].display_name | Radboud University Medical Center |
| authorships[21].institutions[1].id | https://openalex.org/I145872427 |
| authorships[21].institutions[1].ror | https://ror.org/016xsfp80 |
| authorships[21].institutions[1].type | education |
| authorships[21].institutions[1].lineage | https://openalex.org/I145872427 |
| authorships[21].institutions[1].country_code | NL |
| authorships[21].institutions[1].display_name | Radboud University Nijmegen |
| authorships[21].author_position | middle |
| authorships[21].raw_author_name | Rob E. Aarnoutse |
| authorships[21].is_corresponding | True |
| authorships[21].raw_affiliation_strings | Department of Pharmacy, Radboud Institute for Health Sciences, Radboud University Medical Centre, Nijmegen, The Netherlands |
| authorships[22].author.id | https://openalex.org/A5027410574 |
| authorships[22].author.orcid | https://orcid.org/0000-0002-4715-0060 |
| authorships[22].author.display_name | David R. Boulware |
| authorships[22].countries | US |
| authorships[22].affiliations[0].institution_ids | https://openalex.org/I130238516 |
| authorships[22].affiliations[0].raw_affiliation_string | Division of Medicine, University of Minnesota, Minneapolis, MN, 55455, USA |
| authorships[22].institutions[0].id | https://openalex.org/I130238516 |
| authorships[22].institutions[0].ror | https://ror.org/017zqws13 |
| authorships[22].institutions[0].type | education |
| authorships[22].institutions[0].lineage | https://openalex.org/I130238516 |
| authorships[22].institutions[0].country_code | US |
| authorships[22].institutions[0].display_name | University of Minnesota |
| authorships[22].author_position | middle |
| authorships[22].raw_author_name | David R. Boulware |
| authorships[22].is_corresponding | True |
| authorships[22].raw_affiliation_strings | Division of Medicine, University of Minnesota, Minneapolis, MN, 55455, USA |
| authorships[23].author.id | https://openalex.org/A5025258723 |
| authorships[23].author.orcid | |
| authorships[23].author.display_name | Reinout van Crevel |
| authorships[23].countries | GB, NL |
| authorships[23].affiliations[0].institution_ids | https://openalex.org/I145872427, https://openalex.org/I2802934949 |
| authorships[23].affiliations[0].raw_affiliation_string | Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands |
| authorships[23].affiliations[1].institution_ids | https://openalex.org/I40120149 |
| authorships[23].affiliations[1].raw_affiliation_string | Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK |
| authorships[23].institutions[0].id | https://openalex.org/I40120149 |
| authorships[23].institutions[0].ror | https://ror.org/052gg0110 |
| authorships[23].institutions[0].type | education |
| authorships[23].institutions[0].lineage | https://openalex.org/I40120149 |
| authorships[23].institutions[0].country_code | GB |
| authorships[23].institutions[0].display_name | University of Oxford |
| authorships[23].institutions[1].id | https://openalex.org/I2802934949 |
| authorships[23].institutions[1].ror | https://ror.org/05wg1m734 |
| authorships[23].institutions[1].type | healthcare |
| authorships[23].institutions[1].lineage | https://openalex.org/I2802934949 |
| authorships[23].institutions[1].country_code | NL |
| authorships[23].institutions[1].display_name | Radboud University Medical Center |
| authorships[23].institutions[2].id | https://openalex.org/I145872427 |
| authorships[23].institutions[2].ror | https://ror.org/016xsfp80 |
| authorships[23].institutions[2].type | education |
| authorships[23].institutions[2].lineage | https://openalex.org/I145872427 |
| authorships[23].institutions[2].country_code | NL |
| authorships[23].institutions[2].display_name | Radboud University Nijmegen |
| authorships[23].author_position | middle |
| authorships[23].raw_author_name | Reinout van Crevel |
| authorships[23].is_corresponding | True |
| authorships[23].raw_affiliation_strings | Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, UK, Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands |
| authorships[24].author.id | https://openalex.org/A5083211402 |
| authorships[24].author.orcid | https://orcid.org/0000-0003-4995-5054 |
| authorships[24].author.display_name | Rovina Ruslami |
| authorships[24].countries | ID |
| authorships[24].affiliations[0].institution_ids | https://openalex.org/I91819753 |
| authorships[24].affiliations[0].raw_affiliation_string | Department of Biomedical Sciences, Division of Pharmacology and Therapy, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, Indonesia |
| authorships[24].affiliations[1].institution_ids | https://openalex.org/I91819753 |
| authorships[24].affiliations[1].raw_affiliation_string | Infectious Disease Research Centre, Faculty of Medicine, Universitas Padjadaran, Bandung, 40161, Indonesia |
| authorships[24].institutions[0].id | https://openalex.org/I91819753 |
| authorships[24].institutions[0].ror | https://ror.org/00xqf8t64 |
| authorships[24].institutions[0].type | education |
| authorships[24].institutions[0].lineage | https://openalex.org/I91819753 |
| authorships[24].institutions[0].country_code | ID |
| authorships[24].institutions[0].display_name | Padjadjaran University |
| authorships[24].author_position | middle |
| authorships[24].raw_author_name | Rovina Ruslami |
| authorships[24].is_corresponding | True |
| authorships[24].raw_affiliation_strings | Department of Biomedical Sciences, Division of Pharmacology and Therapy, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, Indonesia, Infectious Disease Research Centre, Faculty of Medicine, Universitas Padjadaran, Bandung, 40161, Indonesia |
| authorships[25].author.id | https://openalex.org/A5064975634 |
| authorships[25].author.orcid | https://orcid.org/0000-0002-8854-0321 |
| authorships[25].author.display_name | David B. Meya |
| authorships[25].countries | UG |
| authorships[25].affiliations[0].institution_ids | https://openalex.org/I2800872281, https://openalex.org/I4210116188 |
| authorships[25].affiliations[0].raw_affiliation_string | Infectious Diseases Institute, Mulago College of Health Sciences, Kampala, PO Box 22418, Uganda |
| authorships[25].institutions[0].id | https://openalex.org/I4210116188 |
| authorships[25].institutions[0].ror | https://ror.org/02caa0269 |
| authorships[25].institutions[0].type | nonprofit |
| authorships[25].institutions[0].lineage | https://openalex.org/I4210116188 |
| authorships[25].institutions[0].country_code | UG |
| authorships[25].institutions[0].display_name | Infectious Diseases Institute |
| authorships[25].institutions[1].id | https://openalex.org/I2800872281 |
| authorships[25].institutions[1].ror | https://ror.org/02rhp5f96 |
| authorships[25].institutions[1].type | healthcare |
| authorships[25].institutions[1].lineage | https://openalex.org/I2800872281 |
| authorships[25].institutions[1].country_code | UG |
| authorships[25].institutions[1].display_name | Mulago Hospital |
| authorships[25].author_position | last |
| authorships[25].raw_author_name | David B. Meya |
| authorships[25].is_corresponding | True |
| authorships[25].raw_affiliation_strings | Infectious Diseases Institute, Mulago College of Health Sciences, Kampala, PO Box 22418, Uganda |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://wellcomeopenresearch.org/articles/4-190/v2/pdf |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | High dose oral rifampicin to improve survival from adult tuberculous meningitis: A randomised placebo-controlled double-blinded phase III trial (the HARVEST study) |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11381 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2746 |
| primary_topic.subfield.display_name | Surgery |
| primary_topic.display_name | Infectious Diseases and Tuberculosis |
| related_works | https://openalex.org/W2887184336, https://openalex.org/W2336722287, https://openalex.org/W2039560665, https://openalex.org/W2979351381, https://openalex.org/W3127573442, https://openalex.org/W2406006765, https://openalex.org/W2589546365, https://openalex.org/W111109934, https://openalex.org/W2124299334, https://openalex.org/W2430040642 |
| cited_by_count | 20 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 5 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 2 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 5 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 4 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 3 |
| counts_by_year[5].year | 2013 |
| counts_by_year[5].cited_by_count | 1 |
| locations_count | 8 |
| best_oa_location.id | doi:10.12688/wellcomeopenres.15565.2 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4210218052 |
| best_oa_location.source.issn | 2398-502X |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 2398-502X |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Wellcome Open Research |
| best_oa_location.source.host_organization | https://openalex.org/P4310311838 |
| best_oa_location.source.host_organization_name | Wellcome |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310311838 |
| best_oa_location.source.host_organization_lineage_names | Wellcome |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://wellcomeopenresearch.org/articles/4-190/v2/pdf |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Wellcome Open Research |
| best_oa_location.landing_page_url | https://doi.org/10.12688/wellcomeopenres.15565.2 |
| primary_location.id | doi:10.12688/wellcomeopenres.15565.2 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4210218052 |
| primary_location.source.issn | 2398-502X |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 2398-502X |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Wellcome Open Research |
| primary_location.source.host_organization | https://openalex.org/P4310311838 |
| primary_location.source.host_organization_name | Wellcome |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310311838 |
| primary_location.source.host_organization_lineage_names | Wellcome |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://wellcomeopenresearch.org/articles/4-190/v2/pdf |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Wellcome Open Research |
| primary_location.landing_page_url | https://doi.org/10.12688/wellcomeopenres.15565.2 |
| publication_date | 2020-08-25 |
| publication_year | 2020 |
| referenced_works | https://openalex.org/W4206815970, https://openalex.org/W1986607793, https://openalex.org/W2150492824, https://openalex.org/W2131178604, https://openalex.org/W2051140037, https://openalex.org/W2110728266, https://openalex.org/W2050108097, https://openalex.org/W2150241610, https://openalex.org/W2890018358, https://openalex.org/W2160408047, https://openalex.org/W2140809531, https://openalex.org/W3031010947, https://openalex.org/W2102697636, https://openalex.org/W2096975879, https://openalex.org/W2128705134, https://openalex.org/W2560803227, https://openalex.org/W2141228465, https://openalex.org/W2068357196, https://openalex.org/W2901326007, https://openalex.org/W2799300912, https://openalex.org/W2129441585, https://openalex.org/W2148205948, https://openalex.org/W2120484996, https://openalex.org/W6979069192, https://openalex.org/W2982547672, https://openalex.org/W2901975519, https://openalex.org/W2903100299, https://openalex.org/W2143942591, https://openalex.org/W2120390077, https://openalex.org/W2811190177, https://openalex.org/W2789528825, https://openalex.org/W2543303947, https://openalex.org/W2802200589, https://openalex.org/W2726956036, https://openalex.org/W2090659484, https://openalex.org/W2495038207, https://openalex.org/W2333921168, https://openalex.org/W2610512505, https://openalex.org/W2999765377, https://openalex.org/W2228757293, https://openalex.org/W2104536572, https://openalex.org/W2113471422, https://openalex.org/W2163117709, https://openalex.org/W2004815652 |
| referenced_works_count | 44 |
| abstract_inverted_index.8 | 79, 161 |
| abstract_inverted_index.a | 99, 282 |
| abstract_inverted_index.10 | 182 |
| abstract_inverted_index.12 | 232 |
| abstract_inverted_index.35 | 155 |
| abstract_inverted_index.II | 41 |
| abstract_inverted_index.TB | 35 |
| abstract_inverted_index.We | 65, 220 |
| abstract_inverted_index.be | 123, 147 |
| abstract_inverted_index.i) | 195, 211 |
| abstract_inverted_index.in | 12, 17, 129, 242, 285, 287 |
| abstract_inverted_index.is | 188, 266 |
| abstract_inverted_index.of | 8, 87, 118, 152, 177, 217, 256, 275 |
| abstract_inverted_index.on | 31 |
| abstract_inverted_index.or | 14, 52, 138, 175 |
| abstract_inverted_index.to | 85, 116, 150 |
| abstract_inverted_index.(10 | 89 |
| abstract_inverted_index.(35 | 76 |
| abstract_inverted_index.(R) | 49 |
| abstract_inverted_index.(in | 163 |
| abstract_inverted_index.2.5 | 226 |
| abstract_inverted_index.500 | 223 |
| abstract_inverted_index.III | 107 |
| abstract_inverted_index.Our | 236 |
| abstract_inverted_index.TBM | 26, 62, 238, 286 |
| abstract_inverted_index.The | 120, 185 |
| abstract_inverted_index.[Z] | 171 |
| abstract_inverted_index.and | 59, 133, 172, 200, 203, 206, 214, 246, 289, 294 |
| abstract_inverted_index.are | 29, 136 |
| abstract_inverted_index.end | 192 |
| abstract_inverted_index.for | 78, 160 |
| abstract_inverted_index.ii) | 198, 215 |
| abstract_inverted_index.may | 60 |
| abstract_inverted_index.one | 151 |
| abstract_inverted_index.the | 4, 218, 251, 272 |
| abstract_inverted_index.two | 153 |
| abstract_inverted_index.who | 145 |
| abstract_inverted_index.TBM, | 71, 144 |
| abstract_inverted_index.This | 268 |
| abstract_inverted_index.[E]) | 174 |
| abstract_inverted_index.[H], | 169 |
| abstract_inverted_index.are: | 194, 210 |
| abstract_inverted_index.best | 237 |
| abstract_inverted_index.care | 88, 178 |
| abstract_inverted_index.data | 32 |
| abstract_inverted_index.dose | 47, 73, 113, 167, 258, 278 |
| abstract_inverted_index.five | 126 |
| abstract_inverted_index.form | 7 |
| abstract_inverted_index.from | 33, 38, 292 |
| abstract_inverted_index.high | 46, 72, 112, 244, 257, 277 |
| abstract_inverted_index.iii) | 204 |
| abstract_inverted_index.most | 5 |
| abstract_inverted_index.oral | 74, 114, 157, 279 |
| abstract_inverted_index.over | 225 |
| abstract_inverted_index.that | 45 |
| abstract_inverted_index.will | 81, 97, 122, 146, 221, 270 |
| abstract_inverted_index.with | 70, 141, 165, 228 |
| abstract_inverted_index.(1:1) | 149 |
| abstract_inverted_index.(TB), | 10 |
| abstract_inverted_index.(oral | 179 |
| abstract_inverted_index.HRZE, | 180 |
| abstract_inverted_index.South | 131 |
| abstract_inverted_index.World | 20 |
| abstract_inverted_index.among | 68 |
| abstract_inverted_index.arms: | 154 |
| abstract_inverted_index.based | 30 |
| abstract_inverted_index.care. | 119 |
| abstract_inverted_index.daily | 159 |
| abstract_inverted_index.death | 13 |
| abstract_inverted_index.enrol | 222 |
| abstract_inverted_index.fluid | 254 |
| abstract_inverted_index.mg/kg | 156 |
| abstract_inverted_index.phase | 40, 106 |
| abstract_inverted_index.sites | 128 |
| abstract_inverted_index.still | 240 |
| abstract_inverted_index.study | 269 |
| abstract_inverted_index.that, | 67 |
| abstract_inverted_index.trial | 110, 121 |
| abstract_inverted_index.until | 231 |
| abstract_inverted_index.weeks | 80, 162 |
| abstract_inverted_index.(TBM), | 3 |
| abstract_inverted_index.Africa | 132, 293 |
| abstract_inverted_index.Health | 21 |
| abstract_inverted_index.Strong | 248 |
| abstract_inverted_index.across | 125 |
| abstract_inverted_index.adults | 140 |
| abstract_inverted_index.alone. | 36 |
| abstract_inverted_index.answer | 271 |
| abstract_inverted_index.blind, | 105 |
| abstract_inverted_index.double | 104 |
| abstract_inverted_index.excess | 92 |
| abstract_inverted_index.group, | 101 |
| abstract_inverted_index.mg/kg) | 77 |
| abstract_inverted_index.months | 233 |
| abstract_inverted_index.orally | 53 |
| abstract_inverted_index.points | 193 |
| abstract_inverted_index.recent | 39 |
| abstract_inverted_index.reduce | 61 |
| abstract_inverted_index.safety | 205 |
| abstract_inverted_index.severe | 6 |
| abstract_inverted_index.system | 57 |
| abstract_inverted_index.years, | 227 |
| abstract_inverted_index.6-month | 189 |
| abstract_inverted_index.Current | 25 |
| abstract_inverted_index.Uganda, | 130 |
| abstract_inverted_index.adverse | 93 |
| abstract_inverted_index.benefit | 265, 284 |
| abstract_inverted_index.central | 55 |
| abstract_inverted_index.conveys | 281 |
| abstract_inverted_index.despite | 19 |
| abstract_inverted_index.dosages | 28 |
| abstract_inverted_index.however | 260 |
| abstract_inverted_index.improve | 82 |
| abstract_inverted_index.mg/kg), | 90 |
| abstract_inverted_index.nervous | 56 |
| abstract_inverted_index.perform | 98 |
| abstract_inverted_index.persons | 69 |
| abstract_inverted_index.primary | 186 |
| abstract_inverted_index.regimen | 27 |
| abstract_inverted_index.results | 11, 241 |
| abstract_inverted_index.studies | 43 |
| abstract_inverted_index.whether | 276 |
| abstract_inverted_index.without | 91 |
| abstract_inverted_index.>50%, | 18 |
| abstract_inverted_index.12-month | 196 |
| abstract_inverted_index.Evidence | 37 |
| abstract_inverted_index.Tertiary | 208 |
| abstract_inverted_index.clinical | 109, 127 |
| abstract_inverted_index.compared | 84 |
| abstract_inverted_index.enhances | 54 |
| abstract_inverted_index.evidence | 249, 262 |
| abstract_inverted_index.lacking. | 267 |
| abstract_inverted_index.negative | 139 |
| abstract_inverted_index.outcomes | 202, 209, 213 |
| abstract_inverted_index.parallel | 100 |
| abstract_inverted_index.question | 274 |
| abstract_inverted_index.standard | 86, 117, 166, 176 |
| abstract_inverted_index.suggests | 44 |
| abstract_inverted_index.supports | 250 |
| abstract_inverted_index.survival | 83, 197, 264, 283 |
| abstract_inverted_index.therapy. | 24 |
| abstract_inverted_index.-negative | 290 |
| abstract_inverted_index.Secondary | 191 |
| abstract_inverted_index.comparing | 111 |
| abstract_inverted_index.conducted | 124 |
| abstract_inverted_index.end-point | 187 |
| abstract_inverted_index.follow-up | 229 |
| abstract_inverted_index.important | 273 |
| abstract_inverted_index.increased | 252 |
| abstract_inverted_index.isoniazid | 168 |
| abstract_inverted_index.mg/kg/day | 183 |
| abstract_inverted_index.mortality | 245 |
| abstract_inverted_index.pulmonary | 34 |
| abstract_inverted_index.regarding | 263 |
| abstract_inverted_index.survival. | 190 |
| abstract_inverted_index.suspected | 143 |
| abstract_inverted_index.treatment | 239 |
| abstract_inverted_index.Indonesia. | 134 |
| abstract_inverted_index.associated | 63 |
| abstract_inverted_index.clinically | 142 |
| abstract_inverted_index.conclusive | 261 |
| abstract_inverted_index.containing | 181 |
| abstract_inverted_index.continuing | 230 |
| abstract_inverted_index.disability | 16 |
| abstract_inverted_index.ethambutol | 173 |
| abstract_inverted_index.functional | 199 |
| abstract_inverted_index.meningitis | 2 |
| abstract_inverted_index.morbidity. | 247 |
| abstract_inverted_index.mortality. | 64 |
| abstract_inverted_index.randomised | 148 |
| abstract_inverted_index.rifampicin | 48, 75, 115, 158, 280 |
| abstract_inverted_index.combination | 164 |
| abstract_inverted_index.hypothesize | 66 |
| abstract_inverted_index.individuals | 291 |
| abstract_inverted_index.multicentre | 108 |
| abstract_inverted_index.penetration | 58, 255 |
| abstract_inverted_index.randomised, | 102 |
| abstract_inverted_index.recommended | 23 |
| abstract_inverted_index.rifampicin, | 259 |
| abstract_inverted_index.HIV-positive | 137, 288 |
| abstract_inverted_index.Organisation | 22 |
| abstract_inverted_index.Participants | 135 |
| abstract_inverted_index.administered | 50 |
| abstract_inverted_index.neurological | 15 |
| abstract_inverted_index.participants | 224 |
| abstract_inverted_index.pyrazinamide | 170 |
| abstract_inverted_index.rifampicin). | 184 |
| abstract_inverted_index.tuberculosis | 9 |
| abstract_inverted_index.unacceptably | 243 |
| abstract_inverted_index.</ns4:bold>We | 96 |
| abstract_inverted_index.cerebrospinal | 253 |
| abstract_inverted_index.intervention. | 219 |
| abstract_inverted_index.intravenously | 51 |
| abstract_inverted_index.registration: | 297 |
| abstract_inverted_index.tolerability. | 207 |
| abstract_inverted_index.neurocognitive | 201 |
| abstract_inverted_index.<ns4:bold>Trial | 296 |
| abstract_inverted_index.pharmacokinetic | 42, 212 |
| abstract_inverted_index.cost-effectiveness | 216 |
| abstract_inverted_index.<ns4:bold>Protocol: | 95 |
| abstract_inverted_index.ext-link-type="uri" | 300 |
| abstract_inverted_index.placebo-controlled, | 103 |
| abstract_inverted_index.(17/06/2019)</ns4:p> | 302 |
| abstract_inverted_index.Asia.</ns4:p><ns4:p> | 295 |
| abstract_inverted_index.</ns4:bold>Tuberculous | 1 |
| abstract_inverted_index.events.</ns4:p><ns4:p> | 94 |
| abstract_inverted_index.</ns4:bold><ns4:ext-link | 298 |
| abstract_inverted_index.<ns4:p><ns4:bold>Background: | 0 |
| abstract_inverted_index.post-enrolment.</ns4:p><ns4:p> | 234 |
| abstract_inverted_index.<ns4:bold>Discussion:</ns4:bold> | 235 |
| abstract_inverted_index.xmlns:ns3="http://www.w3.org/1999/xlink" | 299 |
| abstract_inverted_index.ns3:href="http://www.isrctn.com/ISRCTN15668391">ISRCTN15668391</ns4:ext-link> | 301 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5070324473, https://openalex.org/A5003850875, https://openalex.org/A5035982137, https://openalex.org/A5058948786, https://openalex.org/A5062343676, https://openalex.org/A5021184158, https://openalex.org/A5018480886, https://openalex.org/A5014391406, https://openalex.org/A5041205666, https://openalex.org/A5025258723, https://openalex.org/A5064975634, https://openalex.org/A5076735314, https://openalex.org/A5004729258, https://openalex.org/A5064371778, https://openalex.org/A5057092730, https://openalex.org/A5083211402, https://openalex.org/A5038674908, https://openalex.org/A5001357563, https://openalex.org/A5078789624, https://openalex.org/A5039593798, https://openalex.org/A5067576735, https://openalex.org/A5059309211, https://openalex.org/A5090563832, https://openalex.org/A5080859236, https://openalex.org/A5084914479, https://openalex.org/A5027410574 |
| countries_distinct_count | 7 |
| institutions_distinct_count | 26 |
| corresponding_institution_ids | https://openalex.org/I10947320, https://openalex.org/I123387679, https://openalex.org/I130238516, https://openalex.org/I145872427, https://openalex.org/I2800477803, https://openalex.org/I2800715850, https://openalex.org/I2800872281, https://openalex.org/I2802934949, https://openalex.org/I29617571, https://openalex.org/I40120149, https://openalex.org/I4210086620, https://openalex.org/I4210089966, https://openalex.org/I4210116188, https://openalex.org/I4389425243, https://openalex.org/I91369620, https://openalex.org/I91819753, https://openalex.org/I95023434 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8799999952316284 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.89005655 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |