High Expression of GABAA Receptor β Subunit Genes Is Associated with Longer Overall Survival in Medulloblastoma Article Swipe
Jander Moreira Monteiro
,
Matheus Dalmolin
,
Marcelo A. C. Fernandes
,
Jaqueline Isadora Reis Ramos
,
Carmen Austrália Paredes Marcondes Ribas
,
Fernando Issamu Tabushi
,
Rafael Roesler
,
Gustavo Rassier Isolan
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/brainsci14111146
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/brainsci14111146
Background/Objectives: Most of the rapid inhibitory neurotransmission in the brain is mediated through activation of the γ-aminobutyric acid (GABA) type A (GABAA) receptor, which is a ligand-gated ion channel. GABAA receptor activation via GABA binding allows for an intracellular influx of Cl− ions, thus inducing cellular hyperpolarization. Each GABAA receptor consists of a combination of five subunits, and several subunits have been proposed as biomarkers and therapeutic targets in cancer. Here, we show the expression of genes encoding β subunits of the GABAA receptor, namely GABRB1, GABRB2, and GABRB3, across the four different molecular subgroups of medulloblastoma (MB), which is the most common malignant pediatric brain tumor. We also show the associations of GABAA receptor β subunits with MB patients’ overall survival (OS). Methods: The expression of genes encoding GABAA receptor β subunits was analyzed using a previously described dataset comprising 763 MB tumor samples. Patients were classified into high- and low-gene-expression groups, and the Kaplan–Meier estimate was used to examine the relationship between gene expression levels and patient OS. Results: High GABRB1 expression was associated with better OS within each of the four molecular subgroups. The GABRB2 gene showed higher transcript levels in Group 3 MB compared to all other subgroups, and high expression was associated with better prognosis in Group 3 tumors. GABRB3 expression was significantly higher in Group 3 and Group 4 MB, and high expression of GABRB3 genes was associated with longer OS in the sonic hedgehog (SHH) subgroup. The high expression of GABRB1, GABRB2, and GABRB3 is associated with longer patient OS in a subgroup-specific manner. Conclusions: These results indicate a role for GABAA receptors containing β subunits in influencing MB progression.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/brainsci14111146
- OA Status
- gold
- Cited By
- 4
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404417537
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4404417537Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/brainsci14111146Digital Object Identifier
- Title
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High Expression of GABAA Receptor β Subunit Genes Is Associated with Longer Overall Survival in MedulloblastomaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-11-15Full publication date if available
- Authors
-
Jander Moreira Monteiro, Matheus Dalmolin, Marcelo A. C. Fernandes, Jaqueline Isadora Reis Ramos, Carmen Austrália Paredes Marcondes Ribas, Fernando Issamu Tabushi, Rafael Roesler, Gustavo Rassier IsolanList of authors in order
- Landing page
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https://doi.org/10.3390/brainsci14111146Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3390/brainsci14111146Direct OA link when available
- Concepts
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GABAA receptor, Protein subunit, Neurotransmission, Inhibitory postsynaptic potential, Medulloblastoma, GABAA-rho receptor, Receptor, Neuroscience, gamma-Aminobutyric acid, Biology, Chemistry, Gene, Internal medicine, Cell biology, Genetics, MedicineTop concepts (fields/topics) attached by OpenAlex
- Cited by
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4Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4Per-year citation counts (last 5 years)
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32Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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