High expression of L-GILZ transcript variant 1 (GILZ TV 1) is associated with increased 30-day sepsis mortality, and a high expression ratio possibly contraindicates hydrocortisone administration Article Swipe
Stefan Rusev
,
Patrick Thon
,
Birte Dyck
,
Dominik Ziehe
,
Tim Rahmel
,
Britta Marko
,
Lars Palmowski
,
Hartmuth Nowak
,
Björn Ellger
,
Ulrich Limper
,
Elke Schwier
,
Dietrich Henzler
,
Stefan Ehrentraut
,
Lars Bergmann
,
Matthias Unterberg
,
Michael Adamzik
,
Björn Koos
,
Katharina Rump
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1186/s13054-024-05056-1
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1186/s13054-024-05056-1
Background Sepsis presents a challenge due to its complex immune responses, where balance between inflammation and anti-inflammation is critical for survival. Glucocorticoid-induced leucine zipper (GILZ) is key protein in achieving this balance, suppressing inflammation and mediating glucocorticoid response. This study aims to investigate GILZ transcript variants in sepsis patients and explore their potential for patient stratification and optimizing glucocorticoid therapy. Methods Sepsis patients meeting the criteria outlined in Sepsis-3 were enrolled, and RNA was isolated from whole blood samples. Quantitative mRNA expression of GILZ transcript variants in both sepsis patient samples (n = 121) and the monocytic U937 cell line (n = 3), treated with hydrocortisone and lipopolysaccharides, was assessed using quantitative PCR (qPCR). Results Elevated expression of GILZ transcript variant 1 (GILZ TV 1) serves as a marker for heightened 30-day mortality in septic patients. Increased levels of GILZ TV 1 within the initial day of sepsis onset are associated with a 2.2-[95% CI 1.2–4.3] fold rise in mortality, escalating to an 8.5-[95% CI 2.0–36.4] fold increase by day eight. GILZ TV1 expression is enhanced by glucocorticoids in cell culture but remains unaffected by inflammatory stimuli such as LPS. In septic patients, GILZ TV 1 expression increases over the course of sepsis and in response to hydrocortisone treatment. Furthermore, a high expression ratio of transcript variant 1 relative to all GILZ mRNA TVs correlates with a 2.3-fold higher mortality rate in patients receiving hydrocortisone treatment. Conclusion High expression of GILZ TV 1 is associated with a higher 30-day sepsis mortality rate. Moreover, a high expression ratio of GILZ TV 1 relative to all GILZ transcript variants is a parameter for identifying patient subgroups in which hydrocortisone may be contraindicated.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1186/s13054-024-05056-1
- OA Status
- gold
- Cited By
- 1
- References
- 41
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4401521057
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4401521057Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1186/s13054-024-05056-1Digital Object Identifier
- Title
-
High expression of L-GILZ transcript variant 1 (GILZ TV 1) is associated with increased 30-day sepsis mortality, and a high expression ratio possibly contraindicates hydrocortisone administrationWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-08-12Full publication date if available
- Authors
-
Stefan Rusev, Patrick Thon, Birte Dyck, Dominik Ziehe, Tim Rahmel, Britta Marko, Lars Palmowski, Hartmuth Nowak, Björn Ellger, Ulrich Limper, Elke Schwier, Dietrich Henzler, Stefan Ehrentraut, Lars Bergmann, Matthias Unterberg, Michael Adamzik, Björn Koos, Katharina RumpList of authors in order
- Landing page
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https://doi.org/10.1186/s13054-024-05056-1Publisher landing page
- Open access
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YesWhether a free full text is available
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-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1186/s13054-024-05056-1Direct OA link when available
- Concepts
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Sepsis, Medicine, Hydrocortisone, Inflammation, Glucocorticoid, Immune system, Procalcitonin, Messenger RNA, Internal medicine, Immunology, Endocrinology, Biology, Gene, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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41Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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