High factor VIII concentrations interfere with glycoprotein VI-mediated platelet activation in vitro Article Swipe
Rohini Sekar
,
Angélina Mimoun
,
Mélissa Bou-Jaoudeh
,
Stéphane Loyau
,
Sandrine Delignat
,
Victoria Daventure
,
Perrine Bonilla
,
Aishwarya Sudam Bhale
,
Krishnan Venkataraman
,
Julie Rayes
,
Yacine Boulaftali
,
Martine Jandrot‐Perrus
,
Valérie Proulle
,
Sébastien Lacroix‐Desmazes
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.jtha.2024.01.021
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1016/j.jtha.2024.01.021
We showed that VWF-free FVIII binding to, or close to, GPVI modulates platelet activation in vitro. This may represent an uncharacterized negative feedback loop to control overt platelet activation. Whether locally activated FVIII concentrations achieved during platelet accumulation and thrombus formation at the site of vascular injury in vivo are compatible with such a function remains to be determined.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.jtha.2024.01.021
- http://www.jthjournal.org/article/S153878362400062X/pdf
- OA Status
- hybrid
- Cited By
- 4
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391542946
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4391542946Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.jtha.2024.01.021Digital Object Identifier
- Title
-
High factor VIII concentrations interfere with glycoprotein VI-mediated platelet activation in vitroWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-02-05Full publication date if available
- Authors
-
Rohini Sekar, Angélina Mimoun, Mélissa Bou-Jaoudeh, Stéphane Loyau, Sandrine Delignat, Victoria Daventure, Perrine Bonilla, Aishwarya Sudam Bhale, Krishnan Venkataraman, Julie Rayes, Yacine Boulaftali, Martine Jandrot‐Perrus, Valérie Proulle, Sébastien Lacroix‐DesmazesList of authors in order
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https://doi.org/10.1016/j.jtha.2024.01.021Publisher landing page
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https://www.jthjournal.org/article/S153878362400062X/pdfDirect link to full text PDF
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://www.jthjournal.org/article/S153878362400062X/pdfDirect OA link when available
- Concepts
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In vitro, Platelet, Glycoprotein, Platelet activation, Chemistry, Platelet membrane glycoprotein, Platelet factor 4, Cell biology, Immunology, Biochemistry, Medicine, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
4Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2, 2024: 2Per-year citation counts (last 5 years)
- References (count)
-
24Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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