High fat diet attenuates glucose‐dependent facilitation of 5‐HT3‐mediated responses in rat gastric vagal afferents Article Swipe
Amanda Troy
,
Sarah Simmonds
,
Sean D. Stocker
,
Kirsteen N. Browning
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1113/jp271558
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1113/jp271558
Key points Glucose regulates the density and function of 5‐HT 3 receptors on gastric vagal afferent neurones. Diet‐induced obesity compromises the excitability and responsiveness of vagal afferents. In this study, we assessed whether exposure to a high fat diet (HFD) compromises the glucose‐dependent modulation of 5‐HT responses in gastric vagal afferents prior to the development of obesity. We show that HFD does not alter the response of gastric vagal afferent nerves and neurones to 5‐HT but attenuates the ability of glucose to amplify 5‐HT 3 ‐induced responses. These results suggest that glucose‐dependent vagal afferent signalling is compromised by relatively short periods of exposure to HFD well in advance of the development of obesity or glycaemic dysregulation. Abstract Glucose regulates the density and function of 5‐HT 3 receptors on gastric vagal afferent neurones. Since diet‐induced obesity attenuates the responsiveness of gastric vagal afferents to several neurohormones, the aim of the present study was to determine whether high fat diet (HFD) compromises the glucose‐dependent modulation of 5‐HT responses in gastric vagal afferents prior to the development of obesity. Rats were fed control or HFD (14% or 60% kilocalories from fat, respectively) for up to 8 weeks. Neurophysiological recordings assessed the ability of 5‐HT to increase anterior gastric vagal afferent nerve (VAN) activity in vivo before and after acute hyperglycaemia, while electrophysiological recordings from gastric‐projecting nodose neurones assessed the ability of glucose to modulate the 5‐HT response in vitro . Immunocytochemical studies determined alterations in the neuronal distribution of 5‐HT 3 receptors. 5‐HT and cholecystokinin (CCK) induced dose‐dependent increases in VAN activity in all rats; HFD attenuated the response to CCK, but not 5‐HT. The 5‐HT‐induced response was amplified by acute hyperglycaemia in control, but not HFD, rats. Similarly, although 5‐HT induced an inward current in both control and HFD gastric nodose neurones in vitro , the 5‐HT response and receptor distribution was amplified by acute hyperglycaemia only in control rats. These data suggest that, while HFD does not affect the response of gastric‐projecting vagal afferents to 5‐HT, it attenuates the ability of glucose to amplify 5‐HT effects. This suggests that glucose‐dependent vagal afferent signalling is compromised by short periods of exposure to HFD well in advance of obesity or glycaemic dysregulation.
Related Topics
Concepts
Endocrinology
Internal medicine
Vagus nerve
Nodose Ganglion
Electrophysiology
Receptor
Medicine
Biology
Stimulation
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1113/jp271558
- OA Status
- green
- Cited By
- 38
- References
- 89
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2166097552
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2166097552Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1113/jp271558Digital Object Identifier
- Title
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High fat diet attenuates glucose‐dependent facilitation of 5‐HT3‐mediated responses in rat gastric vagal afferentsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2015Year of publication
- Publication date
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2015-10-13Full publication date if available
- Authors
-
Amanda Troy, Sarah Simmonds, Sean D. Stocker, Kirsteen N. BrowningList of authors in order
- Landing page
-
https://doi.org/10.1113/jp271558Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1113/JP271558Direct OA link when available
- Concepts
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Endocrinology, Internal medicine, Vagus nerve, Nodose Ganglion, Electrophysiology, Receptor, Medicine, Biology, StimulationTop concepts (fields/topics) attached by OpenAlex
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38Total citation count in OpenAlex
- Citations by year (recent)
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2024: 4, 2023: 4, 2022: 4, 2021: 8, 2019: 5Per-year citation counts (last 5 years)
- References (count)
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89Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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