High incidence of the hepatitis C virus recombinant 2k/1b in Georgia: Recommendations for testing and treatment Article Swipe
Marine Karchava
,
J. Waldenström
,
Monica M. Parker
,
Renee Hallack
,
Lali Sharvadze
,
Lana Gatserelia
,
Nikoloz Chkhartishvili
,
Natia Dvali
,
Lela Dzigua
,
E Dolmazashvili
,
Heléne Norder
,
Tengiz Tsertsvadze
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1111/hepr.12505
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1111/hepr.12505
Aim The first hepatitis C virus (HCV) recombinant, RF2k/1b, was initially described from Russia and has since then been identified from patients in Ireland, Estonia, Uzbekistan and Cyprus. Many of these patients originated from Georgia; however, there is no information on its prevalence in Georgia or its susceptibility to antiviral treatment. Methods We retrospectively sequenced the non‐structural region 5B (NS5B) of the HCV genome in samples from 72 Georgian patients, 36 of whom had been treated with pegylated interferon and ribavirin. Results The HCV genotype was determined using the Versant HCV Genotype v2 kit. Based on this typing, 32 patients (44.4%) were infected with genotype 1, 21 (29.1%) genotype 2 and 19 (26.3%) genotype 3. Partial NS5B of these strains was sequenced and analyzed for type, with concordant genotype results for all type 1 and 3 strains. Discrepant results were observed for genotyped 2 strains, with 16 (76%) having NS5B of subtype 1b. On phylogenetic analysis, 15 NS5B sequences of these strains were found in a clade formed by recombinant RF2k/1b strains. The remaining discordant sequence was found within a clade formed by 1b strains. Conclusion Our findings show that the RF2k/1b recombinant strain is common among Georgian patients previously assumed to be infected with genotype 2. Because genotyping is mainly performed to decide treatment strategies, there is a need to determine the genotype by analysis of at least two genomic regions in strains from Georgian patients considered infected with genotype 2 based on standard HCV genotyping methods.
Related Topics
Concepts
Genotype
NS5B
Genotyping
Virology
Hepatitis C virus
Biology
Clade
Ribavirin
Typing
Recombinant DNA
Hepatitis C
Phylogenetic tree
Virus
Hepacivirus
Genetics
Gene
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/hepr.12505
- OA Status
- green
- Cited By
- 27
- References
- 33
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2164484094
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2164484094Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/hepr.12505Digital Object Identifier
- Title
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High incidence of the hepatitis C virus recombinant 2k/1b in Georgia: Recommendations for testing and treatmentWork title
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2015Year of publication
- Publication date
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2015-02-16Full publication date if available
- Authors
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Marine Karchava, J. Waldenström, Monica M. Parker, Renee Hallack, Lali Sharvadze, Lana Gatserelia, Nikoloz Chkhartishvili, Natia Dvali, Lela Dzigua, E Dolmazashvili, Heléne Norder, Tengiz TsertsvadzeList of authors in order
- Landing page
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https://doi.org/10.1111/hepr.12505Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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greenOpen access status per OpenAlex
- OA URL
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https://www.ncbi.nlm.nih.gov/pmc/articles/4787595Direct OA link when available
- Concepts
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Genotype, NS5B, Genotyping, Virology, Hepatitis C virus, Biology, Clade, Ribavirin, Typing, Recombinant DNA, Hepatitis C, Phylogenetic tree, Virus, Hepacivirus, Genetics, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
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27Total citation count in OpenAlex
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2021: 3, 2020: 2, 2019: 5, 2018: 5, 2017: 4Per-year citation counts (last 5 years)
- References (count)
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33Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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