High-resolution structure-function mapping of intact hearts reveals altered sympathetic control of infarct border zones Article Swipe
Ching Zhu
,
Pradeep S. Rajendran
,
Peter Hanna
,
Igor R. Efimov
,
Guy Salama
,
Charless C. Fowlkes
,
Kalyanam Shivkumar
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1172/jci.insight.153913
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1172/jci.insight.153913
Remodeling of injured sympathetic nerves on the heart after myocardial infarction (MI) contributes to adverse outcomes such as sudden arrhythmic death, yet the underlying structural mechanisms are poorly understood. We sought to examine microstructural changes on the heart after MI and to directly link these changes with electrical dysfunction. We developed a high-resolution pipeline for anatomically precise alignment of electrical maps with structural myofiber and nerve-fiber maps created by customized computer vision algorithms. Using this integrative approach in a mouse model, we identified distinct structure-function correlates to objectively delineate the infarct border zone, a known source of arrhythmias after MI. During tyramine-induced sympathetic nerve activation, we demonstrated regional patterns of altered electrical conduction aligned directly with altered neuroeffector junction distribution, pointing to potential neural substrates for cardiac arrhythmia. This study establishes a synergistic framework for examining structure-function relationships after MI with microscopic precision that has potential to advance understanding of arrhythmogenic mechanisms.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1172/jci.insight.153913
- http://insight.jci.org/articles/view/153913/files/pdf
- OA Status
- gold
- Cited By
- 28
- References
- 63
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4210595085
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4210595085Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1172/jci.insight.153913Digital Object Identifier
- Title
-
High-resolution structure-function mapping of intact hearts reveals altered sympathetic control of infarct border zonesWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-02-07Full publication date if available
- Authors
-
Ching Zhu, Pradeep S. Rajendran, Peter Hanna, Igor R. Efimov, Guy Salama, Charless C. Fowlkes, Kalyanam ShivkumarList of authors in order
- Landing page
-
https://doi.org/10.1172/jci.insight.153913Publisher landing page
- PDF URL
-
https://insight.jci.org/articles/view/153913/files/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://insight.jci.org/articles/view/153913/files/pdfDirect OA link when available
- Concepts
-
Neuroeffector, Myocardial infarction, Electrical conduction system of the heart, Optical mapping, Neuroscience, Cardiology, Border zone, Internal medicine, Medicine, Electrocardiography, Biology, ReceptorTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
28Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 9, 2024: 7, 2023: 10, 2022: 2Per-year citation counts (last 5 years)
- References (count)
-
63Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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