High-sensitivity C-reactive protein is associated with clonal hematopoiesis of indeterminate potential Article Swipe
Lambert Busque
,
Maxine Sun
,
Manuel Buscarlet
,
Sami Ayachi
,
Yassamin Feroz Zada
,
Sylvie Provost
,
Vincent Bourgoin
,
Luigina Mollica
,
Marlies Meisel
,
Reinhard Hinterleitner
,
Bana Jabrì
,
Marie‐Pierre Dubé
,
Jean‐Claude Tardif
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1182/bloodadvances.2019000770
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.1182/bloodadvances.2019000770
Clonal hematopoiesis of indeterminate potential (CHIP) is predictive of hematological cancers and cardiovascular diseases, but the etiology of CHIP initiation and clonal expansion is unknown. Several lines of evidence suggest that proinflammatory cytokines may favor mutated hematopoietic stem cell expansion. To investigate the potential link between inflammation and CHIP, we performed targeted deep sequencing of 11 genes previously implicated in CHIP in 1887 subjects aged >70 years from the Montreal Heart Institute Biobank, of which 1359 had prior coronary artery disease (CAD), and 528 controls did not. We assessed association of CHIP with log transformed high-sensitivity C-reactive protein (hs-CRP), a validated biomarker of inflammation. CHIP was identified in 427 of the 1887 subjects (22.6%). CHIP mutations were more frequently identified in DNMT3A (11.6%) and TET2 (6.1%), with a higher proportion of TET2 mutations occurring in controls than in patients with CAD (9.0% vs 4.9%, P < .001). CHIP carriers had 21% higher hs-CRP levels compared with their noncarrier counterparts (eβ = 1.21, 95% confidence interval [CI]: 1.08 to 1.36; P = .001). A similar effect was observed in the subgroup of patients with known CAD (eβ = 1.22, 95% CI: 1.06 to 1.41; P = .005). These findings confirm the association between inflammation and CHIP. This association may open investigational avenues aimed at documenting mechanisms linking inflammation to clonal progression and ultimately supports prevention interventions to attenuate CHIP’s impact on cardiovascular disease and cancer.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1182/bloodadvances.2019000770
- https://ashpublications.org/bloodadvances/article-pdf/4/11/2430/1743436/advancesadv2019000770.pdf
- OA Status
- gold
- Cited By
- 90
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3032758825
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3032758825Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1182/bloodadvances.2019000770Digital Object Identifier
- Title
-
High-sensitivity C-reactive protein is associated with clonal hematopoiesis of indeterminate potentialWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-06-03Full publication date if available
- Authors
-
Lambert Busque, Maxine Sun, Manuel Buscarlet, Sami Ayachi, Yassamin Feroz Zada, Sylvie Provost, Vincent Bourgoin, Luigina Mollica, Marlies Meisel, Reinhard Hinterleitner, Bana Jabrì, Marie‐Pierre Dubé, Jean‐Claude TardifList of authors in order
- Landing page
-
https://doi.org/10.1182/bloodadvances.2019000770Publisher landing page
- PDF URL
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https://ashpublications.org/bloodadvances/article-pdf/4/11/2430/1743436/advancesadv2019000770.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://ashpublications.org/bloodadvances/article-pdf/4/11/2430/1743436/advancesadv2019000770.pdfDirect OA link when available
- Concepts
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Haematopoiesis, Indeterminate, Sensitivity (control systems), Biology, Cell biology, Immunology, Stem cell, Mathematics, Electronic engineering, Engineering, Pure mathematicsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
90Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 14, 2024: 16, 2023: 16, 2022: 20, 2021: 14Per-year citation counts (last 5 years)
- References (count)
-
48Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.(hs-CRP), | 99 |
| abstract_inverted_index.Institute | 72 |
| abstract_inverted_index.attenuate | 227 |
| abstract_inverted_index.biomarker | 102 |
| abstract_inverted_index.cytokines | 33 |
| abstract_inverted_index.diseases, | 14 |
| abstract_inverted_index.expansion | 23 |
| abstract_inverted_index.mutations | 116, 133 |
| abstract_inverted_index.occurring | 134 |
| abstract_inverted_index.performed | 51 |
| abstract_inverted_index.potential | 5, 44 |
| abstract_inverted_index.validated | 101 |
| abstract_inverted_index.&gt;70 | 66 |
| abstract_inverted_index.C-reactive | 97 |
| abstract_inverted_index.confidence | 164 |
| abstract_inverted_index.expansion. | 40 |
| abstract_inverted_index.frequently | 119 |
| abstract_inverted_index.identified | 107, 120 |
| abstract_inverted_index.implicated | 59 |
| abstract_inverted_index.initiation | 20 |
| abstract_inverted_index.mechanisms | 215 |
| abstract_inverted_index.noncarrier | 158 |
| abstract_inverted_index.predictive | 8 |
| abstract_inverted_index.prevention | 224 |
| abstract_inverted_index.previously | 58 |
| abstract_inverted_index.proportion | 130 |
| abstract_inverted_index.sequencing | 54 |
| abstract_inverted_index.ultimately | 222 |
| abstract_inverted_index.association | 90, 201, 207 |
| abstract_inverted_index.documenting | 214 |
| abstract_inverted_index.investigate | 42 |
| abstract_inverted_index.progression | 220 |
| abstract_inverted_index.transformed | 95 |
| abstract_inverted_index.counterparts | 159 |
| abstract_inverted_index.inflammation | 47, 203, 217 |
| abstract_inverted_index.hematological | 10 |
| abstract_inverted_index.hematopoiesis | 2 |
| abstract_inverted_index.hematopoietic | 37 |
| abstract_inverted_index.indeterminate | 4 |
| abstract_inverted_index.inflammation. | 104 |
| abstract_inverted_index.interventions | 225 |
| abstract_inverted_index.cardiovascular | 13, 231 |
| abstract_inverted_index.investigational | 210 |
| abstract_inverted_index.proinflammatory | 32 |
| abstract_inverted_index.high-sensitivity | 96 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 90 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 13 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8399999737739563 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.98111545 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |