High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri ): From Physiological Phenotypes to AltitudeOmics Article Swipe
Xue-Jing Zhang
,
Yonggang Niu
,
Shengkang Men
,
Yanghuilin Zhang
,
Xiaolong Tang
,
Kenneth B. Storey
,
Qiang Chen
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/1749-4877.70035
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1111/1749-4877.70035
High altitudes are challenging for the animals that inhabit these environments. The Xizang plateau frog ( Nanorana parkeri ), endemic to the Qinghai–Tibet Plateau and distributed between 2800 and 5100 m, represents an ideal model for studying high‐altitude adaptations. Here, we compared environmental differences between high‐ (4600 m) and low‐altitude (3400 m) habitats, characterized the physiological traits of high‐altitude frogs, and integrated metabolomic and proteomic data to elucidate adaptive mechanisms to extreme environments. High‐altitude habitats exhibited significantly lower water temperatures and dissolved oxygen levels. High‐altitude frogs showed a 31%–37% reduction in resting metabolic rate, decreased concentrations of metabolites (glucose and β‐hydroxybutyric acid), and 18%–56% lower activities of critical metabolic enzymes. This coordinated metabolic depression is indicative of an energy conservation strategy for surviving at high altitudes. Interestingly, hepatic glycogen (3.1‐fold increase) and pyruvate accumulated in high‐altitude frogs, suggesting enhanced energy storage and potential antioxidant utilization. Metabolomic profiling further revealed a remodeling of glycerophospholipid, indicating adaptive membrane stabilization. Proteomics analysis identified altered expression of proteins involved in stress response, energy metabolism, and translation, including chaperones (DNAJB6 and DNAJC22) and glutathione peroxidase (GPX4), which may be potential biomarkers for evaluating high‐altitude adaptation in ectothermic vertebrates. Collectively, these findings demonstrate that N. parkeri survives in high‐altitude environments through a synergistic strategy of metabolic remodeling and protein expression adjustment to optimize energy efficiency and enhance cellular protection. This study provides new insights into the mechanisms by which ectothermic vertebrates adapt to extreme environments.
Related Topics
Concepts
Ectotherm
Biology
Metabolomics
Adaptation (eye)
Phenotype
Phenotypic plasticity
Proteomics
Amphibian
Glycogen
Energy metabolism
Ecology
Metabolic pathway
Oxidative stress
Metabolic adaptation
Ecophysiology
Heat shock protein
Cell biology
Reactive oxygen species
Chaperone (clinical)
Protein expression
Evolutionary biology
Zoology
Salientia
Metabolism
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/1749-4877.70035
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1749-4877.70035
- OA Status
- hybrid
- References
- 70
- OpenAlex ID
- https://openalex.org/W7106306114
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W7106306114Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/1749-4877.70035Digital Object Identifier
- Title
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High‐Altitude Adaptation of Frogs (Case Study: Nanorana parkeri ): From Physiological Phenotypes to AltitudeOmicsWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-11-20Full publication date if available
- Authors
-
Xue-Jing Zhang, Yonggang Niu, Shengkang Men, Yanghuilin Zhang, Xiaolong Tang, Kenneth B. Storey, Qiang ChenList of authors in order
- Landing page
-
https://doi.org/10.1111/1749-4877.70035Publisher landing page
- PDF URL
-
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1749-4877.70035Direct link to full text PDF
- Open access
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YesWhether a free full text is available
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hybridOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1749-4877.70035Direct OA link when available
- Concepts
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Ectotherm, Biology, Metabolomics, Adaptation (eye), Phenotype, Phenotypic plasticity, Proteomics, Amphibian, Glycogen, Energy metabolism, Ecology, Metabolic pathway, Oxidative stress, Metabolic adaptation, Ecophysiology, Heat shock protein, Cell biology, Reactive oxygen species, Chaperone (clinical), Protein expression, Evolutionary biology, Zoology, Salientia, MetabolismTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
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70Number of works referenced by this work
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