Higher Mass Accuracy MALDI‐TOF/TOF Lipid Imaging of Human Brain Tissue in Alzheimer's Disease Article Swipe
Matthew B. O’Rourke
,
Caine C. Smith
,
Suzanne M. de la Monte
,
Greg T. Sutherland
,
Matthew P. Padula
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1002/cpmb.86
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.1002/cpmb.86
Matrix‐assisted laser desorption/ionization imaging mass spectrometry (MALDI‐IMS) is a well‐established technique for elucidating the location and relative abundance of a range of biomolecules. More recently, research into this technique has shifted from simple discovery and demonstration of utility to application in biomedical research. Here, we describe a protocol utilizing MALDI‐IMS for the spatial mapping of lipids in brain tissue from normal human brains and brains from patients with Alzheimer's disease, in the context of Alzheimer's disease. Improved accuracy calibration of the instrument from the tissue surface is emphasized, as this allows for significantly improved mass determination in time of flight (TOF)‐based instruments enabling more confident preliminary lipid identification. This improved initial result allows MALDI‐IMS data to be complemented with additional instrumentation, such as liquid chromatography mass spectrometry workflows or specialized non‐TOF systems such as Fourier transform cyclotron resonance instruments. This method is not limited to human tissue and can be applied to virtually any lipid‐rich formalin‐fixed tissue. © 2019 by John Wiley & Sons, Inc.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/cpmb.86
- OA Status
- green
- Cited By
- 13
- References
- 23
- Related Works
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- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W2914951513Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/cpmb.86Digital Object Identifier
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Higher Mass Accuracy MALDI‐TOF/TOF Lipid Imaging of Human Brain Tissue in Alzheimer's DiseaseWork title
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articleOpenAlex work type
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enPrimary language
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2019Year of publication
- Publication date
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2019-02-08Full publication date if available
- Authors
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Matthew B. O’Rourke, Caine C. Smith, Suzanne M. de la Monte, Greg T. Sutherland, Matthew P. PadulaList of authors in order
- Landing page
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https://doi.org/10.1002/cpmb.86Publisher landing page
- Open access
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YesWhether a free full text is available
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greenOpen access status per OpenAlex
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https://pmc.ncbi.nlm.nih.gov/articles/PMC10867813/pdf/nihms-1965985.pdfDirect OA link when available
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Brain tissue, Human brain, Mass spectrometry imaging, Pathology, Medicine, Biology, Chemistry, Mass spectrometry, Internal medicine, Chromatography, NeuroscienceTop concepts (fields/topics) attached by OpenAlex
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13Total citation count in OpenAlex
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2024: 2, 2023: 5, 2022: 1, 2021: 4, 2019: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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