Highlights on Genetic Polymorphism Associated with Thromboembolic Risk; Implications in Ophthalmic and Autoimmune Disorders—A Review Article Swipe
Mihaela Oana Romanitan
,
Alina Popa‐Cherecheanu
,
Victor A. Vasile
,
Simona Stanca
,
George Iancu
,
Mihail Zemba
,
Daniel Brănișteanu
,
Raluca Iancu
,
Ruxandra Pîrvulescu
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/diagnostics13071267
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3390/diagnostics13071267
The present paper explores genetic polymorphism and its association with thromboembolic retinal venous disorders, such as central/hemi-retinal vein occlusion, as well as possible correlations with other ocular findings, such as closed angle glaucoma, but also with autoimmune general disorders. In this review, we are highlighting the importance of establishing a correspondence between all of the above, since they all have complex etiopathogeneses; sometimes, when all coexist together, they could generate effects that may be very difficult to manage. There are studies supporting that genetic polymorphism, such as the variant MTHFR A1298C, may increase the risk for developing glaucoma, especially in the heterozygote model. Being aware of all these aspects may prove to be useful in patients with several associated diseases, as a combined effort between several medical specialties may prove to the benefit of these patients. Our review, completed with an exemplifying clinical case, shows that it is necessary to raise awareness of all aspects of a complex medical situation, including the genetic one, of a patient being at risk for thromboembolic episodes, for preventing them or managing them promptly and properly in the future.
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Metadata
- Type
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- Language
- en
- Landing Page
- https://doi.org/10.3390/diagnostics13071267
- https://www.mdpi.com/2075-4418/13/7/1267/pdf?version=1679929677
- OA Status
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- Cited By
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- References
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- Related Works
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- OpenAlex ID
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Highlights on Genetic Polymorphism Associated with Thromboembolic Risk; Implications in Ophthalmic and Autoimmune Disorders—A ReviewWork title
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enPrimary language
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2023Year of publication
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2023-03-27Full publication date if available
- Authors
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Mihaela Oana Romanitan, Alina Popa‐Cherecheanu, Victor A. Vasile, Simona Stanca, George Iancu, Mihail Zemba, Daniel Brănișteanu, Raluca Iancu, Ruxandra PîrvulescuList of authors in order
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https://doi.org/10.3390/diagnostics13071267Publisher landing page
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https://www.mdpi.com/2075-4418/13/7/1267/pdf?version=1679929677Direct link to full text PDF
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goldOpen access status per OpenAlex
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Medicine, Retinal Vein, Glaucoma, Intensive care medicine, Bioinformatics, Retinal, Ophthalmology, BiologyTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 1, 2024: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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