Highly Synergistic Eradication of 143B Osteosarcoma CellsIn Vitroby the Combination of Recombinant Methioninase, Chloroquine, and Rapamycin Targeting Methionine Addiction, Autophagy, and mTOR, Respectively Article Swipe
Related Concepts
Autophagy
PI3K/AKT/mTOR pathway
Chloroquine
In vitro
Osteosarcoma
Recombinant DNA
Cancer research
Pharmacology
Medicine
Biology
Immunology
Apoptosis
Biochemistry
Malaria
Gene
Sei Morinaga
,
Qinghong Han
,
KOHEI MIZUTA
,
Byung Mo Kang
,
Michael Bouvet
,
Norio Yamamoto
,
Katsuhiro Hayashi
,
Hiroaki Kimura
,
Shinji Miwa
,
Kentaro Igarashi
,
Takashi Higuchi
,
Hiroyuki Tsuchiya
,
Satoru Demura
,
Robert M. Hoffman
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21873/anticanres.17481
· OA: W4408147053
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.21873/anticanres.17481
· OA: W4408147053
The triple combination of rMETase, CQ, and RAPA demonstrated strong synergy and effectively eradicated 143B osteosarcoma cells. Therefore, the triple treatment with rMETase, CQ, and RAPA has potential as a novel, effective therapeutic approach for osteosarcoma.
Related Topics
Finding more related topics…