High‐resolution analysis of individual spike peptide‐specific CD4 + T‐cell responses in vaccine recipients and COVID ‐19 patients
Article Swipe
Hendrik Karsten
,
Leon Cords
,
Tim Westphal
,
Maximilian Knapp
,
Thomas Theo Brehm
,
Lennart Hermanussen
,
Till F. Omansen
,
Stefan Schmiedel
,
Robin Woost
,
Vanessa Ditt
,
Sven Peine
,
Marc Lütgehetmann
,
Samuel Huber
,
Christin Ackermann
,
Melanie Wittner
,
Marylyn M. Addo
,
Alessandro Sette
,
John Sidney
,
Julian Schulze zur Wiesch
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/cti2.1410
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1002/cti2.1410
Objectives Potential differences in the breadth, distribution and magnitude of CD4 + T‐cell responses directed against the SARS‐CoV‐2 spike glycoprotein between vaccinees, COVID‐19 patients and subjects who experienced both ways of immunisation have not been comprehensively compared on a peptide level. Methods Following virus‐specific in vitro cultivation, we determined the T‐cell responses directed against 253 individual overlapping 15‐mer peptides covering the entire SARS‐CoV‐2 spike glycoprotein using IFN‐γ ELISpot and intracellular cytokine staining. In vitro HLA binding was determined for selected peptides. Results We mapped 955 single peptide‐specific CD4 + T‐cell responses in a cohort of COVID‐19 patients ( n = 8), uninfected vaccinees ( n = 16) and individuals who experienced both infection and vaccination ( n = 11). Patients and vaccinees (two‐time and three‐time vaccinees alike) had a comparable number of CD4 + T‐cell responses (median 26 vs. 29, P = 0.7289). Most of these specificities were conserved in B.1.1.529 and the BA.4 and BA.5 sublineages. The highest magnitude of these in vitro IFN‐γ CD4 + T‐cell responses was observed in COVID‐19 patients (median 0.35%), and three‐time vaccinees showed a higher magnitude than two‐time vaccinees (median 0.091% vs. 0.175%, P < 0.0001). Twelve peptide specificities were each detected in at least 40% of subjects. In vitro HLA binding showed promiscuous presentation by DRB1 molecules for several peptides. Conclusion Both SARS‐CoV‐2 infection and vaccination prime broadly directed T‐cell responses directed against the SARS‐CoV‐2 spike glycoprotein. This comprehensive high‐resolution analysis of spike peptide specificities will be a useful resource for further investigation of spike‐specific T‐cell responses.
Related Topics
Concepts
Peptide
Coronavirus disease 2019 (COVID-19)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
Virology
2019-20 coronavirus outbreak
Chemistry
Microbiology
Biology
Medicine
Biochemistry
Outbreak
Infectious disease (medical specialty)
Pathology
Disease
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/cti2.1410
- OA Status
- gold
- Cited By
- 16
- References
- 101
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4291709081
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4291709081Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/cti2.1410Digital Object Identifier
- Title
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High‐resolution analysis of individual spike peptide‐specific
CD4 + T‐cell responses in vaccine recipients andCOVID ‐19 patientsWork title - Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
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2022-01-01Full publication date if available
- Authors
-
Hendrik Karsten, Leon Cords, Tim Westphal, Maximilian Knapp, Thomas Theo Brehm, Lennart Hermanussen, Till F. Omansen, Stefan Schmiedel, Robin Woost, Vanessa Ditt, Sven Peine, Marc Lütgehetmann, Samuel Huber, Christin Ackermann, Melanie Wittner, Marylyn M. Addo, Alessandro Sette, John Sidney, Julian Schulze zur WieschList of authors in order
- Landing page
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https://doi.org/10.1002/cti2.1410Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1002/cti2.1410Direct OA link when available
- Concepts
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Peptide, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Virology, 2019-20 coronavirus outbreak, Chemistry, Microbiology, Biology, Medicine, Biochemistry, Outbreak, Infectious disease (medical specialty), Pathology, DiseaseTop concepts (fields/topics) attached by OpenAlex
- Cited by
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16Total citation count in OpenAlex
- Citations by year (recent)
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2025: 4, 2024: 6, 2023: 4, 2022: 2Per-year citation counts (last 5 years)
- References (count)
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101Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5026399951 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 19 |
| corresponding_institution_ids | https://openalex.org/I159176309, https://openalex.org/I4210108711, https://openalex.org/I4210115305 |
| citation_normalized_percentile.value | 0.85950019 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |