Hippocampus- and neocortex-specific deletion of Aeg-1 causes learning memory impairment and depression in mice Article Swipe
Yupeng Wang
,
Ning Zhou
,
Panpan Wan
,
Xintong Li
,
Chunyang Yu
,
Jinjiang Chou
,
Feng Zhang
,
Liang Zhang
,
Juanjuan Li
,
B. X. Yu
,
Zhenning Tang
,
Kunmei Liu
,
Le Guo
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41419-025-07508-0
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1038/s41419-025-07508-0
Astrocyte elevated gene-1 (AEG-1) has been characterized as an oncogene promoting the progression of various tumors. The role of AEG-1 in neurological diseases was highlighted by recent researches. However, the physiological function of AEG-1 remains elusive. Our study aimed to investigate the physiological role of AEG-1 in the central nervous system by generating a mouse model with specific deletion of Aeg-1 in the hippocampus and neocortex ( Aeg-1 fl/fl Cre + mice). Behavioral assessments revealed that Aeg-1 deficiency caused impaired learning and memory capabilities in juvenile and adult mice. Depressive-like behaviors were also observed in Aeg-1 fl/fl Cre + mice. Gene Ontology (GO) enrichment analyses indicated that AEG-1 was involved in the neuronal morphogenesis. Interestingly, Aeg-1 knockout was irrelevant to the neuron loss but reduced the dendritic length and the dendritic spines density in hippocampus. Electrophysiological analyses showed a decreased response of paired-pulse facilitation (PPF) and a compromised efficiency of excitatory synaptic transmission following Aeg-1 deletion in hippocampus. In conclusion, our findings suggest that Aeg-1 deficiency in the hippocampus and neocortex leads to learning and memory impairments and depression in mice, which is mediated by the abnormalities of neuronal morphology and the impaired synaptic functions.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41419-025-07508-0
- https://www.nature.com/articles/s41419-025-07508-0.pdf
- OA Status
- gold
- Cited By
- 1
- References
- 32
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4408746859
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- OpenAlex ID
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https://openalex.org/W4408746859Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41419-025-07508-0Digital Object Identifier
- Title
-
Hippocampus- and neocortex-specific deletion of Aeg-1 causes learning memory impairment and depression in miceWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-03-23Full publication date if available
- Authors
-
Yupeng Wang, Ning Zhou, Panpan Wan, Xintong Li, Chunyang Yu, Jinjiang Chou, Feng Zhang, Liang Zhang, Juanjuan Li, B. X. Yu, Zhenning Tang, Kunmei Liu, Le GuoList of authors in order
- Landing page
-
https://doi.org/10.1038/s41419-025-07508-0Publisher landing page
- PDF URL
-
https://www.nature.com/articles/s41419-025-07508-0.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.nature.com/articles/s41419-025-07508-0.pdfDirect OA link when available
- Concepts
-
Neocortex, Hippocampus, Neuroscience, Dendritic spine, Biology, Astrocyte, Central nervous system, Psychology, Hippocampal formationTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
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32Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| corresponding_author_ids | https://openalex.org/A5062486649, https://openalex.org/A5005620369 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 13 |
| corresponding_institution_ids | https://openalex.org/I4210127460 |
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| sustainable_development_goals[0].display_name | Good health and well-being |
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| citation_normalized_percentile.is_in_top_10_percent | True |