Histatin‐1 is an endogenous ligand of the sigma‐2 receptor Article Swipe
Kyung‐No Son
,
Hyun Lee
,
Dhara Shah
,
Sushma Kalmodia
,
Ryan C. Miller
,
Marwan Ali
,
Arun Balasubramaniam
,
Stephanie M. Cologna
,
Hyunjoon Kong
,
Deepak Shukla
,
Vinay K. Aakalu
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1111/febs.16108
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1111/febs.16108
The Sigma‐2 receptor (S2R) (a.k.a TMEM97) is an important endoplasmic reticular protein involved in cancer, cholesterol processing, cell migration, and neurodegenerative diseases, including Niemann–Pick Type C. While several S2R pharmacologic agents have been discovered, its recent (2017) cloning has limited biological investigation, and no endogenous ligands of the S2R are known. Histatins are a family of endogenous antimicrobial peptides that have numerous important effects in multiple biological systems, including antifungal, antibacterial, cancer pathogenesis, immunomodulation, and wound healing. Histatin‐1 (Hst1) has important roles in epithelial wound healing and cell migration, and is the primary wound healing agent in saliva. Little is understood about the downstream machinery that underpins the effects of histatins, and no mammalian receptor is known to date. In this study, we show, using biophysical methods and functional assays, that Hst1 is an endogenous ligand for S2R and that S2R is a mammalian receptor for Hst1.
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- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1111/febs.16108
- OA Status
- green
- Cited By
- 14
- References
- 42
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3182267031
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W3182267031Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1111/febs.16108Digital Object Identifier
- Title
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Histatin‐1 is an endogenous ligand of the sigma‐2 receptorWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2021Year of publication
- Publication date
-
2021-07-07Full publication date if available
- Authors
-
Kyung‐No Son, Hyun Lee, Dhara Shah, Sushma Kalmodia, Ryan C. Miller, Marwan Ali, Arun Balasubramaniam, Stephanie M. Cologna, Hyunjoon Kong, Deepak Shukla, Vinay K. AakaluList of authors in order
- Landing page
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https://doi.org/10.1111/febs.16108Publisher landing page
- Open access
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YesWhether a free full text is available
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-
greenOpen access status per OpenAlex
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https://www.ncbi.nlm.nih.gov/pmc/articles/8648968Direct OA link when available
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Endogeny, Receptor, Biology, Pharmacology, Genetics, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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14Total citation count in OpenAlex
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2025: 4, 2024: 3, 2023: 5, 2022: 2Per-year citation counts (last 5 years)
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42Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.migration, | 18, 88 |
| abstract_inverted_index.understood | 100 |
| abstract_inverted_index.antifungal, | 69 |
| abstract_inverted_index.biophysical | 125 |
| abstract_inverted_index.cholesterol | 15 |
| abstract_inverted_index.discovered, | 33 |
| abstract_inverted_index.endoplasmic | 9 |
| abstract_inverted_index.processing, | 16 |
| abstract_inverted_index.Histatin‐1 | 77 |
| abstract_inverted_index.antimicrobial | 57 |
| abstract_inverted_index.pathogenesis, | 72 |
| abstract_inverted_index.pharmacologic | 29 |
| abstract_inverted_index.Niemann–Pick | 23 |
| abstract_inverted_index.antibacterial, | 70 |
| abstract_inverted_index.investigation, | 41 |
| abstract_inverted_index.immunomodulation, | 73 |
| abstract_inverted_index.neurodegenerative | 20 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5043137201 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 11 |
| corresponding_institution_ids | https://openalex.org/I39422238 |
| citation_normalized_percentile.value | 0.72762713 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |