Histological Correlation between Tonsillar and Glomerular Lesions in Patients with IgA Nephropathy Justifying Tonsillectomy: A Retrospective Cohort Study Article Swipe
Kensuke Joh
,
Hiroyuki Ueda
,
Kan Katayama
,
Hiroshi Kitamura
,
Kenichi Watanabe
,
Osamu Hotta
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25105298
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/ijms25105298
Tonsillectomy with steroid pulse therapy (SPT) has been established as an effective treatment for immunoglobulin A nephropathy (IgAN) in Japan. However, the underlying mechanisms supporting tonsillectomy remain unclear. This study assessed palatine tonsils from 77 patients with IgAN, including 14 and 63 who received SPT before and after tonsillectomy, respectively. Tonsils from 21 patients with chronic tonsillitis were analyzed as controls. Specific tonsillar lesions were confirmed in patients with IgAN, correlating with active or chronic renal glomerular lesions and SPT. T-nodule and involution of lymphoepithelial symbiosis scores in tonsils correlated with the incidence of active crescents and segmental sclerosis in the glomeruli, respectively. The study revealed an essential role of the tonsil–glomerular axis in early active and late chronic phases. Moreover, the SPT-preceding group demonstrated no changes in the T-nodule score, which correlated with active crescent formation, but exhibited a considerable shrinkage of lymphatic follicles that produced aberrant IgA1. The study underscores the involvement of innate and cellular immunity in IgAN and advocates for tonsillectomy as a necessary treatment alongside SPT for IgAN, based on a stepwise process.
Related Topics
Concepts
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms25105298
- https://www.mdpi.com/1422-0067/25/10/5298/pdf?version=1715761000
- OA Status
- gold
- Cited By
- 2
- References
- 39
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4396891414
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4396891414Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms25105298Digital Object Identifier
- Title
-
Histological Correlation between Tonsillar and Glomerular Lesions in Patients with IgA Nephropathy Justifying Tonsillectomy: A Retrospective Cohort StudyWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-05-13Full publication date if available
- Authors
-
Kensuke Joh, Hiroyuki Ueda, Kan Katayama, Hiroshi Kitamura, Kenichi Watanabe, Osamu HottaList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms25105298Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/25/10/5298/pdf?version=1715761000Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/25/10/5298/pdf?version=1715761000Direct OA link when available
- Concepts
-
Tonsillectomy, Medicine, Tonsil, Nephropathy, Tonsillitis, Pathology, Gastroenterology, Endocrinology, Diabetes mellitusTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
39Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4396891414 |
|---|---|
| doi | https://doi.org/10.3390/ijms25105298 |
| ids.doi | https://doi.org/10.3390/ijms25105298 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38791337 |
| ids.openalex | https://openalex.org/W4396891414 |
| fwci | 1.41367121 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | Q000473 |
| mesh[1].descriptor_ui | D005922 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | pathology |
| mesh[1].descriptor_name | Glomerulonephritis, IGA |
| mesh[2].qualifier_ui | Q000601 |
| mesh[2].descriptor_ui | D005922 |
| mesh[2].is_major_topic | True |
| mesh[2].qualifier_name | surgery |
| mesh[2].descriptor_name | Glomerulonephritis, IGA |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D014068 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Tonsillectomy |
| mesh[4].qualifier_ui | Q000601 |
| mesh[4].descriptor_ui | D014066 |
| mesh[4].is_major_topic | True |
| mesh[4].qualifier_name | surgery |
| mesh[4].descriptor_name | Palatine Tonsil |
| mesh[5].qualifier_ui | Q000473 |
| mesh[5].descriptor_ui | D014066 |
| mesh[5].is_major_topic | True |
| mesh[5].qualifier_name | pathology |
| mesh[5].descriptor_name | Palatine Tonsil |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D005260 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Female |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D008297 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Male |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D000328 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Adult |
| mesh[9].qualifier_ui | Q000473 |
| mesh[9].descriptor_ui | D007678 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | pathology |
| mesh[9].descriptor_name | Kidney Glomerulus |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D012189 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Retrospective Studies |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D008875 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | Middle Aged |
| mesh[12].qualifier_ui | Q000601 |
| mesh[12].descriptor_ui | D014069 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | surgery |
| mesh[12].descriptor_name | Tonsillitis |
| mesh[13].qualifier_ui | Q000473 |
| mesh[13].descriptor_ui | D014069 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | pathology |
| mesh[13].descriptor_name | Tonsillitis |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D055815 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Young Adult |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D007070 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Immunoglobulin A |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D006801 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Humans |
| mesh[17].qualifier_ui | Q000473 |
| mesh[17].descriptor_ui | D005922 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | pathology |
| mesh[17].descriptor_name | Glomerulonephritis, IGA |
| mesh[18].qualifier_ui | Q000601 |
| mesh[18].descriptor_ui | D005922 |
| mesh[18].is_major_topic | True |
| mesh[18].qualifier_name | surgery |
| mesh[18].descriptor_name | Glomerulonephritis, IGA |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D014068 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Tonsillectomy |
| mesh[20].qualifier_ui | Q000601 |
| mesh[20].descriptor_ui | D014066 |
| mesh[20].is_major_topic | True |
| mesh[20].qualifier_name | surgery |
| mesh[20].descriptor_name | Palatine Tonsil |
| mesh[21].qualifier_ui | Q000473 |
| mesh[21].descriptor_ui | D014066 |
| mesh[21].is_major_topic | True |
| mesh[21].qualifier_name | pathology |
| mesh[21].descriptor_name | Palatine Tonsil |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D005260 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Female |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D008297 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Male |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D000328 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Adult |
| mesh[25].qualifier_ui | Q000473 |
| mesh[25].descriptor_ui | D007678 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | pathology |
| mesh[25].descriptor_name | Kidney Glomerulus |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D012189 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | Retrospective Studies |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D008875 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Middle Aged |
| mesh[28].qualifier_ui | Q000601 |
| mesh[28].descriptor_ui | D014069 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | surgery |
| mesh[28].descriptor_name | Tonsillitis |
| mesh[29].qualifier_ui | Q000473 |
| mesh[29].descriptor_ui | D014069 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | pathology |
| mesh[29].descriptor_name | Tonsillitis |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D055815 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Young Adult |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D007070 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Immunoglobulin A |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D006801 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Humans |
| mesh[33].qualifier_ui | Q000473 |
| mesh[33].descriptor_ui | D005922 |
| mesh[33].is_major_topic | True |
| mesh[33].qualifier_name | pathology |
| mesh[33].descriptor_name | Glomerulonephritis, IGA |
| mesh[34].qualifier_ui | Q000601 |
| mesh[34].descriptor_ui | D005922 |
| mesh[34].is_major_topic | True |
| mesh[34].qualifier_name | surgery |
| mesh[34].descriptor_name | Glomerulonephritis, IGA |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D014068 |
| mesh[35].is_major_topic | True |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | Tonsillectomy |
| mesh[36].qualifier_ui | Q000601 |
| mesh[36].descriptor_ui | D014066 |
| mesh[36].is_major_topic | True |
| mesh[36].qualifier_name | surgery |
| mesh[36].descriptor_name | Palatine Tonsil |
| mesh[37].qualifier_ui | Q000473 |
| mesh[37].descriptor_ui | D014066 |
| mesh[37].is_major_topic | True |
| mesh[37].qualifier_name | pathology |
| mesh[37].descriptor_name | Palatine Tonsil |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D005260 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Female |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D008297 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Male |
| mesh[40].qualifier_ui | |
| mesh[40].descriptor_ui | D000328 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | |
| mesh[40].descriptor_name | Adult |
| mesh[41].qualifier_ui | Q000473 |
| mesh[41].descriptor_ui | D007678 |
| mesh[41].is_major_topic | True |
| mesh[41].qualifier_name | pathology |
| mesh[41].descriptor_name | Kidney Glomerulus |
| mesh[42].qualifier_ui | |
| mesh[42].descriptor_ui | D012189 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | |
| mesh[42].descriptor_name | Retrospective Studies |
| mesh[43].qualifier_ui | |
| mesh[43].descriptor_ui | D008875 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | |
| mesh[43].descriptor_name | Middle Aged |
| mesh[44].qualifier_ui | Q000601 |
| mesh[44].descriptor_ui | D014069 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | surgery |
| mesh[44].descriptor_name | Tonsillitis |
| mesh[45].qualifier_ui | Q000473 |
| mesh[45].descriptor_ui | D014069 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | pathology |
| mesh[45].descriptor_name | Tonsillitis |
| mesh[46].qualifier_ui | |
| mesh[46].descriptor_ui | D055815 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | |
| mesh[46].descriptor_name | Young Adult |
| mesh[47].qualifier_ui | |
| mesh[47].descriptor_ui | D007070 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | |
| mesh[47].descriptor_name | Immunoglobulin A |
| mesh[48].qualifier_ui | |
| mesh[48].descriptor_ui | D006801 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | |
| mesh[48].descriptor_name | Humans |
| mesh[49].qualifier_ui | Q000473 |
| mesh[49].descriptor_ui | D005922 |
| mesh[49].is_major_topic | True |
| mesh[49].qualifier_name | pathology |
| mesh[49].descriptor_name | Glomerulonephritis, IGA |
| type | article |
| title | Histological Correlation between Tonsillar and Glomerular Lesions in Patients with IgA Nephropathy Justifying Tonsillectomy: A Retrospective Cohort Study |
| biblio.issue | 10 |
| biblio.volume | 25 |
| biblio.last_page | 5298 |
| biblio.first_page | 5298 |
| topics[0].id | https://openalex.org/T11029 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.995199978351593 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2727 |
| topics[0].subfield.display_name | Nephrology |
| topics[0].display_name | Renal Diseases and Glomerulopathies |
| topics[1].id | https://openalex.org/T11730 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9889000058174133 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2734 |
| topics[1].subfield.display_name | Pathology and Forensic Medicine |
| topics[1].display_name | Autoimmune Bullous Skin Diseases |
| topics[2].id | https://openalex.org/T10746 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9678999781608582 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2720 |
| topics[2].subfield.display_name | Hematology |
| topics[2].display_name | Platelet Disorders and Treatments |
| is_xpac | False |
| apc_list.value | 2300 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2490 |
| apc_paid.value | 2300 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2490 |
| concepts[0].id | https://openalex.org/C2779073326 |
| concepts[0].level | 2 |
| concepts[0].score | 0.9192570447921753 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q170381 |
| concepts[0].display_name | Tonsillectomy |
| concepts[1].id | https://openalex.org/C71924100 |
| concepts[1].level | 0 |
| concepts[1].score | 0.788745641708374 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[1].display_name | Medicine |
| concepts[2].id | https://openalex.org/C2779419017 |
| concepts[2].level | 2 |
| concepts[2].score | 0.7696995735168457 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q180569 |
| concepts[2].display_name | Tonsil |
| concepts[3].id | https://openalex.org/C2781184683 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5906037092208862 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q1054718 |
| concepts[3].display_name | Nephropathy |
| concepts[4].id | https://openalex.org/C2778660654 |
| concepts[4].level | 2 |
| concepts[4].score | 0.4456426203250885 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q186470 |
| concepts[4].display_name | Tonsillitis |
| concepts[5].id | https://openalex.org/C142724271 |
| concepts[5].level | 1 |
| concepts[5].score | 0.4155856966972351 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[5].display_name | Pathology |
| concepts[6].id | https://openalex.org/C90924648 |
| concepts[6].level | 1 |
| concepts[6].score | 0.3939623236656189 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q120569 |
| concepts[6].display_name | Gastroenterology |
| concepts[7].id | https://openalex.org/C134018914 |
| concepts[7].level | 1 |
| concepts[7].score | 0.10567188262939453 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q162606 |
| concepts[7].display_name | Endocrinology |
| concepts[8].id | https://openalex.org/C555293320 |
| concepts[8].level | 2 |
| concepts[8].score | 0.0 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q12206 |
| concepts[8].display_name | Diabetes mellitus |
| keywords[0].id | https://openalex.org/keywords/tonsillectomy |
| keywords[0].score | 0.9192570447921753 |
| keywords[0].display_name | Tonsillectomy |
| keywords[1].id | https://openalex.org/keywords/medicine |
| keywords[1].score | 0.788745641708374 |
| keywords[1].display_name | Medicine |
| keywords[2].id | https://openalex.org/keywords/tonsil |
| keywords[2].score | 0.7696995735168457 |
| keywords[2].display_name | Tonsil |
| keywords[3].id | https://openalex.org/keywords/nephropathy |
| keywords[3].score | 0.5906037092208862 |
| keywords[3].display_name | Nephropathy |
| keywords[4].id | https://openalex.org/keywords/tonsillitis |
| keywords[4].score | 0.4456426203250885 |
| keywords[4].display_name | Tonsillitis |
| keywords[5].id | https://openalex.org/keywords/pathology |
| keywords[5].score | 0.4155856966972351 |
| keywords[5].display_name | Pathology |
| keywords[6].id | https://openalex.org/keywords/gastroenterology |
| keywords[6].score | 0.3939623236656189 |
| keywords[6].display_name | Gastroenterology |
| keywords[7].id | https://openalex.org/keywords/endocrinology |
| keywords[7].score | 0.10567188262939453 |
| keywords[7].display_name | Endocrinology |
| language | en |
| locations[0].id | doi:10.3390/ijms25105298 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S10623703 |
| locations[0].source.issn | 1422-0067, 1661-6596 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1422-0067 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | International Journal of Molecular Sciences |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/1422-0067/25/10/5298/pdf?version=1715761000 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | International Journal of Molecular Sciences |
| locations[0].landing_page_url | https://doi.org/10.3390/ijms25105298 |
| locations[1].id | pmid:38791337 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | International journal of molecular sciences |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38791337 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:11120689 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | other-oa |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/other-oa |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Int J Mol Sci |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/11120689 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5057686518 |
| authorships[0].author.orcid | https://orcid.org/0000-0002-9334-3664 |
| authorships[0].author.display_name | Kensuke Joh |
| authorships[0].countries | JP |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I115498069 |
| authorships[0].affiliations[0].raw_affiliation_string | Department of Pathology, The Jikei University School of Medicine, Tokyo 105-8461, Japan |
| authorships[0].institutions[0].id | https://openalex.org/I115498069 |
| authorships[0].institutions[0].ror | https://ror.org/039ygjf22 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I115498069 |
| authorships[0].institutions[0].country_code | JP |
| authorships[0].institutions[0].display_name | Jikei University School of Medicine |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Kensuke Joh |
| authorships[0].is_corresponding | True |
| authorships[0].raw_affiliation_strings | Department of Pathology, The Jikei University School of Medicine, Tokyo 105-8461, Japan |
| authorships[1].author.id | https://openalex.org/A5077739319 |
| authorships[1].author.orcid | https://orcid.org/0000-0002-3938-2208 |
| authorships[1].author.display_name | Hiroyuki Ueda |
| authorships[1].countries | JP |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I115498069 |
| authorships[1].affiliations[0].raw_affiliation_string | Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan |
| authorships[1].institutions[0].id | https://openalex.org/I115498069 |
| authorships[1].institutions[0].ror | https://ror.org/039ygjf22 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I115498069 |
| authorships[1].institutions[0].country_code | JP |
| authorships[1].institutions[0].display_name | Jikei University School of Medicine |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Hiroyuki Ueda |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Division of Nephrology and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, Tokyo 105-8461, Japan |
| authorships[2].author.id | https://openalex.org/A5009821512 |
| authorships[2].author.orcid | https://orcid.org/0000-0001-6663-133X |
| authorships[2].author.display_name | Kan Katayama |
| authorships[2].countries | JP |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I178574317 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu 514-8507, Japan |
| authorships[2].institutions[0].id | https://openalex.org/I178574317 |
| authorships[2].institutions[0].ror | https://ror.org/01529vy56 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I178574317 |
| authorships[2].institutions[0].country_code | JP |
| authorships[2].institutions[0].display_name | Mie University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Kan Katayama |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu 514-8507, Japan |
| authorships[3].author.id | https://openalex.org/A5027603182 |
| authorships[3].author.orcid | https://orcid.org/0000-0001-9643-3211 |
| authorships[3].author.display_name | Hiroshi Kitamura |
| authorships[3].countries | JP |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I4210132540 |
| authorships[3].affiliations[0].raw_affiliation_string | Division of Research Center, Japan Community Health Organization (JCHO) Sendai, Sendai 981-3281, Japan |
| authorships[3].institutions[0].id | https://openalex.org/I4210132540 |
| authorships[3].institutions[0].ror | https://ror.org/03q11y497 |
| authorships[3].institutions[0].type | government |
| authorships[3].institutions[0].lineage | https://openalex.org/I4210132540 |
| authorships[3].institutions[0].country_code | JP |
| authorships[3].institutions[0].display_name | Japan Community Healthcare Organization |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Hiroshi Kitamura |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Division of Research Center, Japan Community Health Organization (JCHO) Sendai, Sendai 981-3281, Japan |
| authorships[4].author.id | https://openalex.org/A5100739385 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-5269-146X |
| authorships[4].author.display_name | Kenichi Watanabe |
| authorships[4].countries | JP |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I4210135094 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Otolaryngology, Tohoku Rosai Hospital, Sendai 981-8563, Japan |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I201537933 |
| authorships[4].affiliations[1].raw_affiliation_string | Department of Otolaryngology, Head and Neck Surgery, Tohoku University School of Medicine, Sendai, Sendai 980-8575, Japan |
| authorships[4].institutions[0].id | https://openalex.org/I4210135094 |
| authorships[4].institutions[0].ror | https://ror.org/037p13728 |
| authorships[4].institutions[0].type | healthcare |
| authorships[4].institutions[0].lineage | https://openalex.org/I4210135094 |
| authorships[4].institutions[0].country_code | JP |
| authorships[4].institutions[0].display_name | Tohoku Rosai Hospital |
| authorships[4].institutions[1].id | https://openalex.org/I201537933 |
| authorships[4].institutions[1].ror | https://ror.org/01dq60k83 |
| authorships[4].institutions[1].type | education |
| authorships[4].institutions[1].lineage | https://openalex.org/I201537933 |
| authorships[4].institutions[1].country_code | JP |
| authorships[4].institutions[1].display_name | Tohoku University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Kenichi Watanabe |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Otolaryngology, Head and Neck Surgery, Tohoku University School of Medicine, Sendai, Sendai 980-8575, Japan, Department of Otolaryngology, Tohoku Rosai Hospital, Sendai 981-8563, Japan |
| authorships[5].author.id | https://openalex.org/A5113620684 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Osamu Hotta |
| authorships[5].affiliations[0].raw_affiliation_string | Division of Internal Medicine, Hotta Osamu Clinic (HOC), Sendai 984-0013, Japan |
| authorships[5].author_position | last |
| authorships[5].raw_author_name | Osamu Hotta |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Division of Internal Medicine, Hotta Osamu Clinic (HOC), Sendai 984-0013, Japan |
| has_content.pdf | True |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/1422-0067/25/10/5298/pdf?version=1715761000 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Histological Correlation between Tonsillar and Glomerular Lesions in Patients with IgA Nephropathy Justifying Tonsillectomy: A Retrospective Cohort Study |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11029 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.995199978351593 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2727 |
| primary_topic.subfield.display_name | Nephrology |
| primary_topic.display_name | Renal Diseases and Glomerulopathies |
| related_works | https://openalex.org/W2290170302, https://openalex.org/W3134414468, https://openalex.org/W2000986143, https://openalex.org/W4255626303, https://openalex.org/W2532288520, https://openalex.org/W2133922093, https://openalex.org/W2146749770, https://openalex.org/W2903413987, https://openalex.org/W3118615413, https://openalex.org/W2518201144 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| locations_count | 3 |
| best_oa_location.id | doi:10.3390/ijms25105298 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S10623703 |
| best_oa_location.source.issn | 1422-0067, 1661-6596 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1422-0067 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | International Journal of Molecular Sciences |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/1422-0067/25/10/5298/pdf?version=1715761000 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | International Journal of Molecular Sciences |
| best_oa_location.landing_page_url | https://doi.org/10.3390/ijms25105298 |
| primary_location.id | doi:10.3390/ijms25105298 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S10623703 |
| primary_location.source.issn | 1422-0067, 1661-6596 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1422-0067 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | International Journal of Molecular Sciences |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_lineage_names | Multidisciplinary Digital Publishing Institute |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/1422-0067/25/10/5298/pdf?version=1715761000 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | International Journal of Molecular Sciences |
| primary_location.landing_page_url | https://doi.org/10.3390/ijms25105298 |
| publication_date | 2024-05-13 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W4383484447, https://openalex.org/W2947030778, https://openalex.org/W1969130417, https://openalex.org/W1975331802, https://openalex.org/W4387996807, https://openalex.org/W2213498457, https://openalex.org/W2994767753, https://openalex.org/W2055437758, https://openalex.org/W2065175763, https://openalex.org/W1996812064, https://openalex.org/W1218236954, https://openalex.org/W6634336682, https://openalex.org/W4206298875, https://openalex.org/W2937033515, https://openalex.org/W2034602599, https://openalex.org/W2159732692, https://openalex.org/W2082249665, https://openalex.org/W2161948436, https://openalex.org/W2494019567, https://openalex.org/W1983995450, https://openalex.org/W6600173944, https://openalex.org/W2150560078, https://openalex.org/W1985502949, https://openalex.org/W2005792614, https://openalex.org/W2587396242, https://openalex.org/W2156932746, https://openalex.org/W6628097122, https://openalex.org/W4391444142, https://openalex.org/W2944382069, https://openalex.org/W2035460771, https://openalex.org/W4224286196, https://openalex.org/W3958341, https://openalex.org/W2892019214, https://openalex.org/W2181240763, https://openalex.org/W1994582450, https://openalex.org/W2053205703, https://openalex.org/W2152853007, https://openalex.org/W1572286415, https://openalex.org/W2912059101 |
| referenced_works_count | 39 |
| abstract_inverted_index.A | 15 |
| abstract_inverted_index.a | 139, 166, 175 |
| abstract_inverted_index.14 | 39 |
| abstract_inverted_index.21 | 52 |
| abstract_inverted_index.63 | 41 |
| abstract_inverted_index.77 | 34 |
| abstract_inverted_index.an | 10, 106 |
| abstract_inverted_index.as | 9, 59, 165 |
| abstract_inverted_index.in | 18, 66, 87, 99, 113, 127, 159 |
| abstract_inverted_index.no | 125 |
| abstract_inverted_index.of | 83, 93, 109, 142, 154 |
| abstract_inverted_index.on | 174 |
| abstract_inverted_index.or | 73 |
| abstract_inverted_index.SPT | 44, 170 |
| abstract_inverted_index.The | 103, 149 |
| abstract_inverted_index.and | 40, 46, 78, 81, 96, 116, 156, 161 |
| abstract_inverted_index.but | 137 |
| abstract_inverted_index.for | 13, 163, 171 |
| abstract_inverted_index.has | 6 |
| abstract_inverted_index.the | 21, 91, 100, 110, 121, 128, 152 |
| abstract_inverted_index.who | 42 |
| abstract_inverted_index.IgAN | 160 |
| abstract_inverted_index.SPT. | 79 |
| abstract_inverted_index.This | 28 |
| abstract_inverted_index.axis | 112 |
| abstract_inverted_index.been | 7 |
| abstract_inverted_index.from | 33, 51 |
| abstract_inverted_index.late | 117 |
| abstract_inverted_index.role | 108 |
| abstract_inverted_index.that | 145 |
| abstract_inverted_index.were | 57, 64 |
| abstract_inverted_index.with | 1, 36, 54, 68, 71, 90, 133 |
| abstract_inverted_index.(SPT) | 5 |
| abstract_inverted_index.IgA1. | 148 |
| abstract_inverted_index.IgAN, | 37, 69, 172 |
| abstract_inverted_index.after | 47 |
| abstract_inverted_index.based | 173 |
| abstract_inverted_index.early | 114 |
| abstract_inverted_index.group | 123 |
| abstract_inverted_index.pulse | 3 |
| abstract_inverted_index.renal | 75 |
| abstract_inverted_index.study | 29, 104, 150 |
| abstract_inverted_index.which | 131 |
| abstract_inverted_index.(IgAN) | 17 |
| abstract_inverted_index.Japan. | 19 |
| abstract_inverted_index.active | 72, 94, 115, 134 |
| abstract_inverted_index.before | 45 |
| abstract_inverted_index.innate | 155 |
| abstract_inverted_index.remain | 26 |
| abstract_inverted_index.score, | 130 |
| abstract_inverted_index.scores | 86 |
| abstract_inverted_index.Tonsils | 50 |
| abstract_inverted_index.changes | 126 |
| abstract_inverted_index.chronic | 55, 74, 118 |
| abstract_inverted_index.lesions | 63, 77 |
| abstract_inverted_index.phases. | 119 |
| abstract_inverted_index.steroid | 2 |
| abstract_inverted_index.therapy | 4 |
| abstract_inverted_index.tonsils | 32, 88 |
| abstract_inverted_index.However, | 20 |
| abstract_inverted_index.Specific | 61 |
| abstract_inverted_index.T-nodule | 80, 129 |
| abstract_inverted_index.aberrant | 147 |
| abstract_inverted_index.analyzed | 58 |
| abstract_inverted_index.assessed | 30 |
| abstract_inverted_index.cellular | 157 |
| abstract_inverted_index.crescent | 135 |
| abstract_inverted_index.immunity | 158 |
| abstract_inverted_index.palatine | 31 |
| abstract_inverted_index.patients | 35, 53, 67 |
| abstract_inverted_index.process. | 177 |
| abstract_inverted_index.produced | 146 |
| abstract_inverted_index.received | 43 |
| abstract_inverted_index.revealed | 105 |
| abstract_inverted_index.stepwise | 176 |
| abstract_inverted_index.unclear. | 27 |
| abstract_inverted_index.Moreover, | 120 |
| abstract_inverted_index.advocates | 162 |
| abstract_inverted_index.alongside | 169 |
| abstract_inverted_index.confirmed | 65 |
| abstract_inverted_index.controls. | 60 |
| abstract_inverted_index.crescents | 95 |
| abstract_inverted_index.effective | 11 |
| abstract_inverted_index.essential | 107 |
| abstract_inverted_index.exhibited | 138 |
| abstract_inverted_index.follicles | 144 |
| abstract_inverted_index.incidence | 92 |
| abstract_inverted_index.including | 38 |
| abstract_inverted_index.lymphatic | 143 |
| abstract_inverted_index.necessary | 167 |
| abstract_inverted_index.sclerosis | 98 |
| abstract_inverted_index.segmental | 97 |
| abstract_inverted_index.shrinkage | 141 |
| abstract_inverted_index.symbiosis | 85 |
| abstract_inverted_index.tonsillar | 62 |
| abstract_inverted_index.treatment | 12, 168 |
| abstract_inverted_index.correlated | 89, 132 |
| abstract_inverted_index.formation, | 136 |
| abstract_inverted_index.glomerular | 76 |
| abstract_inverted_index.glomeruli, | 101 |
| abstract_inverted_index.involution | 82 |
| abstract_inverted_index.mechanisms | 23 |
| abstract_inverted_index.supporting | 24 |
| abstract_inverted_index.underlying | 22 |
| abstract_inverted_index.correlating | 70 |
| abstract_inverted_index.established | 8 |
| abstract_inverted_index.involvement | 153 |
| abstract_inverted_index.nephropathy | 16 |
| abstract_inverted_index.tonsillitis | 56 |
| abstract_inverted_index.underscores | 151 |
| abstract_inverted_index.considerable | 140 |
| abstract_inverted_index.demonstrated | 124 |
| abstract_inverted_index.SPT-preceding | 122 |
| abstract_inverted_index.Tonsillectomy | 0 |
| abstract_inverted_index.respectively. | 49, 102 |
| abstract_inverted_index.tonsillectomy | 25, 164 |
| abstract_inverted_index.immunoglobulin | 14 |
| abstract_inverted_index.tonsillectomy, | 48 |
| abstract_inverted_index.lymphoepithelial | 84 |
| abstract_inverted_index.tonsil–glomerular | 111 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| corresponding_author_ids | https://openalex.org/A5057686518 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 6 |
| corresponding_institution_ids | https://openalex.org/I115498069 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7900000214576721 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.74744676 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |