Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling Pathway Article Swipe
Y.F. Song
,
Huixia Li
,
Ruiya Lian
,
Xueer Dou
,
Shasha Li
,
Jingying Xie
,
Xiangrong Li
,
Ruofei Feng
,
Zhiqiang Li
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/v16020174
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/v16020174
Histone H1.2 is a member of the linker histone family, which plays extensive and crucial roles not only in the regulation of chromatin dynamics, cell cycle, and cell apoptosis, but also in viral diseases and innate immunity response. Recently, it was discovered that H1.2 regulates interferon-β and inhibits influenza virus replication, whereas its role in other viral infections is poorly reported. Here, we first found the up-regulation of H1.2 during Encephalomyocarditis virus (EMCV) infection, implying that H1.2 was involved in EMCV infection. Overexpression of H1.2 inhibited EMCV proliferation, whereas knockdown of H1.2 showed a significant promotion of virus infection in HEK293T cells. Moreover, we demonstrated that overexpression of H1.2 remarkably enhanced the production of EMCV-induced type I interferon, which may be the crucial factor for H1.2 proliferation–inhibitory effects. We further found that H1.2 up-regulated the expression of the proteins of the MDA5 signaling pathway and interacted with MDA5 and IRF3 in EMCV infection. Further, we demonstrated that H1.2 facilitated EMCV-induced phosphorylation and nuclear translocation of IRF3. Briefly, our research uncovers the mechanism of H1.2 negatively regulating EMCV replication and provides new insight into antiviral targets for EMCV.
Related Topics
Concepts
IRF3
Biology
Chromatin
Gene knockdown
Interferon
MDA5
Viral replication
Histone
Cell biology
Histone H1
Virus
Signal transduction
Virology
Innate immune system
Apoptosis
RNA interference
RNA
Gene
Immune system
Immunology
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/v16020174
- https://www.mdpi.com/1999-4915/16/2/174/pdf?version=1706103854
- OA Status
- gold
- Cited By
- 2
- References
- 29
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4391175629
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4391175629Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/v16020174Digital Object Identifier
- Title
-
Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling PathwayWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-01-24Full publication date if available
- Authors
-
Y.F. Song, Huixia Li, Ruiya Lian, Xueer Dou, Shasha Li, Jingying Xie, Xiangrong Li, Ruofei Feng, Zhiqiang LiList of authors in order
- Landing page
-
https://doi.org/10.3390/v16020174Publisher landing page
- PDF URL
-
https://www.mdpi.com/1999-4915/16/2/174/pdf?version=1706103854Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1999-4915/16/2/174/pdf?version=1706103854Direct OA link when available
- Concepts
-
IRF3, Biology, Chromatin, Gene knockdown, Interferon, MDA5, Viral replication, Histone, Cell biology, Histone H1, Virus, Signal transduction, Virology, Innate immune system, Apoptosis, RNA interference, RNA, Gene, Immune system, Immunology, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
29Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4391175629 |
|---|---|
| doi | https://doi.org/10.3390/v16020174 |
| ids.doi | https://doi.org/10.3390/v16020174 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/38399950 |
| ids.openalex | https://openalex.org/W4391175629 |
| fwci | 0.95736906 |
| mesh[0].qualifier_ui | |
| mesh[0].descriptor_ui | D006801 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | |
| mesh[0].descriptor_name | Humans |
| mesh[1].qualifier_ui | |
| mesh[1].descriptor_ui | D004686 |
| mesh[1].is_major_topic | True |
| mesh[1].qualifier_name | |
| mesh[1].descriptor_name | Encephalomyocarditis virus |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D057809 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | HEK293 Cells |
| mesh[3].qualifier_ui | |
| mesh[3].descriptor_ui | D006657 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | |
| mesh[3].descriptor_name | Histones |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D007113 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Immunity, Innate |
| mesh[5].qualifier_ui | Q000235 |
| mesh[5].descriptor_ui | D000072640 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | genetics |
| mesh[5].descriptor_name | Interferon-Induced Helicase, IFIH1 |
| mesh[6].qualifier_ui | |
| mesh[6].descriptor_ui | D015398 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | |
| mesh[6].descriptor_name | Signal Transduction |
| mesh[7].qualifier_ui | |
| mesh[7].descriptor_ui | D014779 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | |
| mesh[7].descriptor_name | Virus Replication |
| mesh[8].qualifier_ui | |
| mesh[8].descriptor_ui | D006801 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | |
| mesh[8].descriptor_name | Humans |
| mesh[9].qualifier_ui | |
| mesh[9].descriptor_ui | D006657 |
| mesh[9].is_major_topic | True |
| mesh[9].qualifier_name | |
| mesh[9].descriptor_name | Histones |
| mesh[10].qualifier_ui | |
| mesh[10].descriptor_ui | D004686 |
| mesh[10].is_major_topic | True |
| mesh[10].qualifier_name | |
| mesh[10].descriptor_name | Encephalomyocarditis virus |
| mesh[11].qualifier_ui | |
| mesh[11].descriptor_ui | D057809 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | |
| mesh[11].descriptor_name | HEK293 Cells |
| mesh[12].qualifier_ui | Q000235 |
| mesh[12].descriptor_ui | D000072640 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | genetics |
| mesh[12].descriptor_name | Interferon-Induced Helicase, IFIH1 |
| mesh[13].qualifier_ui | |
| mesh[13].descriptor_ui | D015398 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | |
| mesh[13].descriptor_name | Signal Transduction |
| mesh[14].qualifier_ui | |
| mesh[14].descriptor_ui | D007113 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | |
| mesh[14].descriptor_name | Immunity, Innate |
| mesh[15].qualifier_ui | |
| mesh[15].descriptor_ui | D014779 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | |
| mesh[15].descriptor_name | Virus Replication |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D006801 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Humans |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D004686 |
| mesh[17].is_major_topic | True |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Encephalomyocarditis virus |
| mesh[18].qualifier_ui | |
| mesh[18].descriptor_ui | D057809 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | |
| mesh[18].descriptor_name | HEK293 Cells |
| mesh[19].qualifier_ui | |
| mesh[19].descriptor_ui | D006657 |
| mesh[19].is_major_topic | True |
| mesh[19].qualifier_name | |
| mesh[19].descriptor_name | Histones |
| mesh[20].qualifier_ui | |
| mesh[20].descriptor_ui | D007113 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | |
| mesh[20].descriptor_name | Immunity, Innate |
| mesh[21].qualifier_ui | Q000235 |
| mesh[21].descriptor_ui | D000072640 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | genetics |
| mesh[21].descriptor_name | Interferon-Induced Helicase, IFIH1 |
| mesh[22].qualifier_ui | |
| mesh[22].descriptor_ui | D015398 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | |
| mesh[22].descriptor_name | Signal Transduction |
| mesh[23].qualifier_ui | |
| mesh[23].descriptor_ui | D014779 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | |
| mesh[23].descriptor_name | Virus Replication |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D006801 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Humans |
| mesh[25].qualifier_ui | |
| mesh[25].descriptor_ui | D004686 |
| mesh[25].is_major_topic | True |
| mesh[25].qualifier_name | |
| mesh[25].descriptor_name | Encephalomyocarditis virus |
| mesh[26].qualifier_ui | |
| mesh[26].descriptor_ui | D057809 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | |
| mesh[26].descriptor_name | HEK293 Cells |
| mesh[27].qualifier_ui | |
| mesh[27].descriptor_ui | D006657 |
| mesh[27].is_major_topic | True |
| mesh[27].qualifier_name | |
| mesh[27].descriptor_name | Histones |
| mesh[28].qualifier_ui | |
| mesh[28].descriptor_ui | D007113 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | |
| mesh[28].descriptor_name | Immunity, Innate |
| mesh[29].qualifier_ui | Q000235 |
| mesh[29].descriptor_ui | D000072640 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | genetics |
| mesh[29].descriptor_name | Interferon-Induced Helicase, IFIH1 |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D015398 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Signal Transduction |
| mesh[31].qualifier_ui | |
| mesh[31].descriptor_ui | D014779 |
| mesh[31].is_major_topic | False |
| mesh[31].qualifier_name | |
| mesh[31].descriptor_name | Virus Replication |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D006801 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Humans |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D006657 |
| mesh[33].is_major_topic | True |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Histones |
| mesh[34].qualifier_ui | |
| mesh[34].descriptor_ui | D004686 |
| mesh[34].is_major_topic | True |
| mesh[34].qualifier_name | |
| mesh[34].descriptor_name | Encephalomyocarditis virus |
| mesh[35].qualifier_ui | |
| mesh[35].descriptor_ui | D057809 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | |
| mesh[35].descriptor_name | HEK293 Cells |
| mesh[36].qualifier_ui | Q000235 |
| mesh[36].descriptor_ui | D000072640 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | genetics |
| mesh[36].descriptor_name | Interferon-Induced Helicase, IFIH1 |
| mesh[37].qualifier_ui | |
| mesh[37].descriptor_ui | D015398 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | |
| mesh[37].descriptor_name | Signal Transduction |
| mesh[38].qualifier_ui | |
| mesh[38].descriptor_ui | D007113 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | |
| mesh[38].descriptor_name | Immunity, Innate |
| mesh[39].qualifier_ui | |
| mesh[39].descriptor_ui | D014779 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | |
| mesh[39].descriptor_name | Virus Replication |
| type | article |
| title | Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling Pathway |
| biblio.issue | 2 |
| biblio.volume | 16 |
| biblio.last_page | 174 |
| biblio.first_page | 174 |
| grants[0].funder | https://openalex.org/F4320321001 |
| grants[0].award_id | 32260037 |
| grants[0].funder_display_name | National Natural Science Foundation of China |
| grants[1].funder | https://openalex.org/F4320335787 |
| grants[1].award_id | 31920230062 |
| grants[1].funder_display_name | Fundamental Research Funds for the Central Universities |
| topics[0].id | https://openalex.org/T11668 |
| topics[0].field.id | https://openalex.org/fields/24 |
| topics[0].field.display_name | Immunology and Microbiology |
| topics[0].score | 1.0 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2403 |
| topics[0].subfield.display_name | Immunology |
| topics[0].display_name | interferon and immune responses |
| topics[1].id | https://openalex.org/T10371 |
| topics[1].field.id | https://openalex.org/fields/24 |
| topics[1].field.display_name | Immunology and Microbiology |
| topics[1].score | 0.9991999864578247 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2403 |
| topics[1].subfield.display_name | Immunology |
| topics[1].display_name | Immune Response and Inflammation |
| topics[2].id | https://openalex.org/T11020 |
| topics[2].field.id | https://openalex.org/fields/24 |
| topics[2].field.display_name | Immunology and Microbiology |
| topics[2].score | 0.9976999759674072 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2403 |
| topics[2].subfield.display_name | Immunology |
| topics[2].display_name | Immune Cell Function and Interaction |
| funders[0].id | https://openalex.org/F4320321001 |
| funders[0].ror | https://ror.org/01h0zpd94 |
| funders[0].display_name | National Natural Science Foundation of China |
| funders[1].id | https://openalex.org/F4320335787 |
| funders[1].ror | |
| funders[1].display_name | Fundamental Research Funds for the Central Universities |
| is_xpac | False |
| apc_list.value | 2600 |
| apc_list.currency | CHF |
| apc_list.value_usd | 2815 |
| apc_paid.value | 2600 |
| apc_paid.currency | CHF |
| apc_paid.value_usd | 2815 |
| concepts[0].id | https://openalex.org/C2780209191 |
| concepts[0].level | 4 |
| concepts[0].score | 0.7320854067802429 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q14914339 |
| concepts[0].display_name | IRF3 |
| concepts[1].id | https://openalex.org/C86803240 |
| concepts[1].level | 0 |
| concepts[1].score | 0.625296413898468 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[1].display_name | Biology |
| concepts[2].id | https://openalex.org/C83640560 |
| concepts[2].level | 3 |
| concepts[2].score | 0.5692028999328613 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q180951 |
| concepts[2].display_name | Chromatin |
| concepts[3].id | https://openalex.org/C173396325 |
| concepts[3].level | 3 |
| concepts[3].score | 0.564395546913147 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q1501275 |
| concepts[3].display_name | Gene knockdown |
| concepts[4].id | https://openalex.org/C2776178377 |
| concepts[4].level | 2 |
| concepts[4].score | 0.5479906797409058 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q188269 |
| concepts[4].display_name | Interferon |
| concepts[5].id | https://openalex.org/C134474686 |
| concepts[5].level | 5 |
| concepts[5].score | 0.5407822132110596 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q21111069 |
| concepts[5].display_name | MDA5 |
| concepts[6].id | https://openalex.org/C140704245 |
| concepts[6].level | 3 |
| concepts[6].score | 0.520964503288269 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q3933202 |
| concepts[6].display_name | Viral replication |
| concepts[7].id | https://openalex.org/C64927066 |
| concepts[7].level | 3 |
| concepts[7].score | 0.5135093331336975 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q36293 |
| concepts[7].display_name | Histone |
| concepts[8].id | https://openalex.org/C95444343 |
| concepts[8].level | 1 |
| concepts[8].score | 0.468252032995224 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[8].display_name | Cell biology |
| concepts[9].id | https://openalex.org/C101152365 |
| concepts[9].level | 4 |
| concepts[9].score | 0.4676259160041809 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q838135 |
| concepts[9].display_name | Histone H1 |
| concepts[10].id | https://openalex.org/C2522874641 |
| concepts[10].level | 2 |
| concepts[10].score | 0.45298653841018677 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q808 |
| concepts[10].display_name | Virus |
| concepts[11].id | https://openalex.org/C62478195 |
| concepts[11].level | 2 |
| concepts[11].score | 0.442588746547699 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q828130 |
| concepts[11].display_name | Signal transduction |
| concepts[12].id | https://openalex.org/C159047783 |
| concepts[12].level | 1 |
| concepts[12].score | 0.43381911516189575 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q7215 |
| concepts[12].display_name | Virology |
| concepts[13].id | https://openalex.org/C136449434 |
| concepts[13].level | 3 |
| concepts[13].score | 0.42815566062927246 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q428253 |
| concepts[13].display_name | Innate immune system |
| concepts[14].id | https://openalex.org/C190283241 |
| concepts[14].level | 2 |
| concepts[14].score | 0.2762220501899719 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q14599311 |
| concepts[14].display_name | Apoptosis |
| concepts[15].id | https://openalex.org/C166703698 |
| concepts[15].level | 4 |
| concepts[15].score | 0.2680743634700775 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q201993 |
| concepts[15].display_name | RNA interference |
| concepts[16].id | https://openalex.org/C67705224 |
| concepts[16].level | 3 |
| concepts[16].score | 0.1783633530139923 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q11053 |
| concepts[16].display_name | RNA |
| concepts[17].id | https://openalex.org/C104317684 |
| concepts[17].level | 2 |
| concepts[17].score | 0.16445502638816833 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[17].display_name | Gene |
| concepts[18].id | https://openalex.org/C8891405 |
| concepts[18].level | 2 |
| concepts[18].score | 0.1516265869140625 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q1059 |
| concepts[18].display_name | Immune system |
| concepts[19].id | https://openalex.org/C203014093 |
| concepts[19].level | 1 |
| concepts[19].score | 0.12957990169525146 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q101929 |
| concepts[19].display_name | Immunology |
| concepts[20].id | https://openalex.org/C54355233 |
| concepts[20].level | 1 |
| concepts[20].score | 0.10030344128608704 |
| concepts[20].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[20].display_name | Genetics |
| keywords[0].id | https://openalex.org/keywords/irf3 |
| keywords[0].score | 0.7320854067802429 |
| keywords[0].display_name | IRF3 |
| keywords[1].id | https://openalex.org/keywords/biology |
| keywords[1].score | 0.625296413898468 |
| keywords[1].display_name | Biology |
| keywords[2].id | https://openalex.org/keywords/chromatin |
| keywords[2].score | 0.5692028999328613 |
| keywords[2].display_name | Chromatin |
| keywords[3].id | https://openalex.org/keywords/gene-knockdown |
| keywords[3].score | 0.564395546913147 |
| keywords[3].display_name | Gene knockdown |
| keywords[4].id | https://openalex.org/keywords/interferon |
| keywords[4].score | 0.5479906797409058 |
| keywords[4].display_name | Interferon |
| keywords[5].id | https://openalex.org/keywords/mda5 |
| keywords[5].score | 0.5407822132110596 |
| keywords[5].display_name | MDA5 |
| keywords[6].id | https://openalex.org/keywords/viral-replication |
| keywords[6].score | 0.520964503288269 |
| keywords[6].display_name | Viral replication |
| keywords[7].id | https://openalex.org/keywords/histone |
| keywords[7].score | 0.5135093331336975 |
| keywords[7].display_name | Histone |
| keywords[8].id | https://openalex.org/keywords/cell-biology |
| keywords[8].score | 0.468252032995224 |
| keywords[8].display_name | Cell biology |
| keywords[9].id | https://openalex.org/keywords/histone-h1 |
| keywords[9].score | 0.4676259160041809 |
| keywords[9].display_name | Histone H1 |
| keywords[10].id | https://openalex.org/keywords/virus |
| keywords[10].score | 0.45298653841018677 |
| keywords[10].display_name | Virus |
| keywords[11].id | https://openalex.org/keywords/signal-transduction |
| keywords[11].score | 0.442588746547699 |
| keywords[11].display_name | Signal transduction |
| keywords[12].id | https://openalex.org/keywords/virology |
| keywords[12].score | 0.43381911516189575 |
| keywords[12].display_name | Virology |
| keywords[13].id | https://openalex.org/keywords/innate-immune-system |
| keywords[13].score | 0.42815566062927246 |
| keywords[13].display_name | Innate immune system |
| keywords[14].id | https://openalex.org/keywords/apoptosis |
| keywords[14].score | 0.2762220501899719 |
| keywords[14].display_name | Apoptosis |
| keywords[15].id | https://openalex.org/keywords/rna-interference |
| keywords[15].score | 0.2680743634700775 |
| keywords[15].display_name | RNA interference |
| keywords[16].id | https://openalex.org/keywords/rna |
| keywords[16].score | 0.1783633530139923 |
| keywords[16].display_name | RNA |
| keywords[17].id | https://openalex.org/keywords/gene |
| keywords[17].score | 0.16445502638816833 |
| keywords[17].display_name | Gene |
| keywords[18].id | https://openalex.org/keywords/immune-system |
| keywords[18].score | 0.1516265869140625 |
| keywords[18].display_name | Immune system |
| keywords[19].id | https://openalex.org/keywords/immunology |
| keywords[19].score | 0.12957990169525146 |
| keywords[19].display_name | Immunology |
| keywords[20].id | https://openalex.org/keywords/genetics |
| keywords[20].score | 0.10030344128608704 |
| keywords[20].display_name | Genetics |
| language | en |
| locations[0].id | doi:10.3390/v16020174 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S55776271 |
| locations[0].source.issn | 1999-4915 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | True |
| locations[0].source.issn_l | 1999-4915 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | True |
| locations[0].source.display_name | Viruses |
| locations[0].source.host_organization | https://openalex.org/P4310310987 |
| locations[0].source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310310987 |
| locations[0].license | cc-by |
| locations[0].pdf_url | https://www.mdpi.com/1999-4915/16/2/174/pdf?version=1706103854 |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | https://openalex.org/licenses/cc-by |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Viruses |
| locations[0].landing_page_url | https://doi.org/10.3390/v16020174 |
| locations[1].id | pmid:38399950 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Viruses |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/38399950 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:10892618 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | cc-by |
| locations[2].pdf_url | https://pmc.ncbi.nlm.nih.gov/articles/PMC10892618/pdf/viruses-16-00174.pdf |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | https://openalex.org/licenses/cc-by |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | Viruses |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/10892618 |
| locations[3].id | pmh:oai:doaj.org/article:e68ddc934f6b468b916b8a7704cac36b |
| locations[3].is_oa | False |
| locations[3].source.id | https://openalex.org/S4306401280 |
| locations[3].source.issn | |
| locations[3].source.type | repository |
| locations[3].source.is_oa | False |
| locations[3].source.issn_l | |
| locations[3].source.is_core | False |
| locations[3].source.is_in_doaj | False |
| locations[3].source.display_name | DOAJ (DOAJ: Directory of Open Access Journals) |
| locations[3].source.host_organization | |
| locations[3].source.host_organization_name | |
| locations[3].source.host_organization_lineage | |
| locations[3].license | |
| locations[3].pdf_url | |
| locations[3].version | submittedVersion |
| locations[3].raw_type | article |
| locations[3].license_id | |
| locations[3].is_accepted | False |
| locations[3].is_published | False |
| locations[3].raw_source_name | Viruses, Vol 16, Iss 2, p 174 (2024) |
| locations[3].landing_page_url | https://doaj.org/article/e68ddc934f6b468b916b8a7704cac36b |
| indexed_in | crossref, doaj, pubmed |
| authorships[0].author.id | https://openalex.org/A5113103611 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Y.F. Song |
| authorships[0].countries | CN |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I145897649 |
| authorships[0].affiliations[0].raw_affiliation_string | College of Life Science and Engineering, Northwest Minzu University, Lanzhou 730030, China |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I2799449666 |
| authorships[0].affiliations[1].raw_affiliation_string | Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[0].institutions[0].id | https://openalex.org/I145897649 |
| authorships[0].institutions[0].ror | https://ror.org/0044e2g62 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I145897649 |
| authorships[0].institutions[0].country_code | CN |
| authorships[0].institutions[0].display_name | Minzu University of China |
| authorships[0].institutions[1].id | https://openalex.org/I2799449666 |
| authorships[0].institutions[1].ror | https://ror.org/01p9g6b97 |
| authorships[0].institutions[1].type | government |
| authorships[0].institutions[1].lineage | https://openalex.org/I2799449666 |
| authorships[0].institutions[1].country_code | CN |
| authorships[0].institutions[1].display_name | State Ethnic Affairs Commission |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Yangran Song |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | College of Life Science and Engineering, Northwest Minzu University, Lanzhou 730030, China, Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[1].author.id | https://openalex.org/A5100673058 |
| authorships[1].author.orcid | https://orcid.org/0000-0001-5080-1912 |
| authorships[1].author.display_name | Huixia Li |
| authorships[1].countries | CN |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I145897649 |
| authorships[1].affiliations[0].raw_affiliation_string | Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I2799449666 |
| authorships[1].affiliations[1].raw_affiliation_string | Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[1].institutions[0].id | https://openalex.org/I145897649 |
| authorships[1].institutions[0].ror | https://ror.org/0044e2g62 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I145897649 |
| authorships[1].institutions[0].country_code | CN |
| authorships[1].institutions[0].display_name | Minzu University of China |
| authorships[1].institutions[1].id | https://openalex.org/I2799449666 |
| authorships[1].institutions[1].ror | https://ror.org/01p9g6b97 |
| authorships[1].institutions[1].type | government |
| authorships[1].institutions[1].lineage | https://openalex.org/I2799449666 |
| authorships[1].institutions[1].country_code | CN |
| authorships[1].institutions[1].display_name | State Ethnic Affairs Commission |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Huixia Li |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China, Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[2].author.id | https://openalex.org/A5109689331 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Ruiya Lian |
| authorships[2].countries | CN |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I2799449666 |
| authorships[2].affiliations[0].raw_affiliation_string | Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I145897649 |
| authorships[2].affiliations[1].raw_affiliation_string | College of Life Science and Engineering, Northwest Minzu University, Lanzhou 730030, China |
| authorships[2].institutions[0].id | https://openalex.org/I145897649 |
| authorships[2].institutions[0].ror | https://ror.org/0044e2g62 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I145897649 |
| authorships[2].institutions[0].country_code | CN |
| authorships[2].institutions[0].display_name | Minzu University of China |
| authorships[2].institutions[1].id | https://openalex.org/I2799449666 |
| authorships[2].institutions[1].ror | https://ror.org/01p9g6b97 |
| authorships[2].institutions[1].type | government |
| authorships[2].institutions[1].lineage | https://openalex.org/I2799449666 |
| authorships[2].institutions[1].country_code | CN |
| authorships[2].institutions[1].display_name | State Ethnic Affairs Commission |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Ruiya Lian |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | College of Life Science and Engineering, Northwest Minzu University, Lanzhou 730030, China, Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[3].author.id | https://openalex.org/A5104233648 |
| authorships[3].author.orcid | |
| authorships[3].author.display_name | Xueer Dou |
| authorships[3].countries | CN |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I145897649 |
| authorships[3].affiliations[0].raw_affiliation_string | Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[3].affiliations[1].institution_ids | https://openalex.org/I2799449666 |
| authorships[3].affiliations[1].raw_affiliation_string | Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[3].institutions[0].id | https://openalex.org/I145897649 |
| authorships[3].institutions[0].ror | https://ror.org/0044e2g62 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I145897649 |
| authorships[3].institutions[0].country_code | CN |
| authorships[3].institutions[0].display_name | Minzu University of China |
| authorships[3].institutions[1].id | https://openalex.org/I2799449666 |
| authorships[3].institutions[1].ror | https://ror.org/01p9g6b97 |
| authorships[3].institutions[1].type | government |
| authorships[3].institutions[1].lineage | https://openalex.org/I2799449666 |
| authorships[3].institutions[1].country_code | CN |
| authorships[3].institutions[1].display_name | State Ethnic Affairs Commission |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Xueer Dou |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China, Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[4].author.id | https://openalex.org/A5100376016 |
| authorships[4].author.orcid | https://orcid.org/0000-0003-4198-2314 |
| authorships[4].author.display_name | Shasha Li |
| authorships[4].countries | CN |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I145897649 |
| authorships[4].affiliations[0].raw_affiliation_string | College of Life Science and Engineering, Northwest Minzu University, Lanzhou 730030, China |
| authorships[4].affiliations[1].institution_ids | https://openalex.org/I2799449666 |
| authorships[4].affiliations[1].raw_affiliation_string | Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[4].institutions[0].id | https://openalex.org/I145897649 |
| authorships[4].institutions[0].ror | https://ror.org/0044e2g62 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I145897649 |
| authorships[4].institutions[0].country_code | CN |
| authorships[4].institutions[0].display_name | Minzu University of China |
| authorships[4].institutions[1].id | https://openalex.org/I2799449666 |
| authorships[4].institutions[1].ror | https://ror.org/01p9g6b97 |
| authorships[4].institutions[1].type | government |
| authorships[4].institutions[1].lineage | https://openalex.org/I2799449666 |
| authorships[4].institutions[1].country_code | CN |
| authorships[4].institutions[1].display_name | State Ethnic Affairs Commission |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Shasha Li |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | College of Life Science and Engineering, Northwest Minzu University, Lanzhou 730030, China, Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[5].author.id | https://openalex.org/A5101577264 |
| authorships[5].author.orcid | https://orcid.org/0009-0003-4268-8069 |
| authorships[5].author.display_name | Jingying Xie |
| authorships[5].countries | CN |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I2799449666 |
| authorships[5].affiliations[0].raw_affiliation_string | Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[5].affiliations[1].institution_ids | https://openalex.org/I145897649 |
| authorships[5].affiliations[1].raw_affiliation_string | College of Life Science and Engineering, Northwest Minzu University, Lanzhou 730030, China |
| authorships[5].institutions[0].id | https://openalex.org/I145897649 |
| authorships[5].institutions[0].ror | https://ror.org/0044e2g62 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I145897649 |
| authorships[5].institutions[0].country_code | CN |
| authorships[5].institutions[0].display_name | Minzu University of China |
| authorships[5].institutions[1].id | https://openalex.org/I2799449666 |
| authorships[5].institutions[1].ror | https://ror.org/01p9g6b97 |
| authorships[5].institutions[1].type | government |
| authorships[5].institutions[1].lineage | https://openalex.org/I2799449666 |
| authorships[5].institutions[1].country_code | CN |
| authorships[5].institutions[1].display_name | State Ethnic Affairs Commission |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Jingying Xie |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | College of Life Science and Engineering, Northwest Minzu University, Lanzhou 730030, China, Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[6].author.id | https://openalex.org/A5100642247 |
| authorships[6].author.orcid | https://orcid.org/0009-0008-5390-0455 |
| authorships[6].author.display_name | Xiangrong Li |
| authorships[6].countries | CN |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I145897649 |
| authorships[6].affiliations[0].raw_affiliation_string | Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I2799449666 |
| authorships[6].affiliations[1].raw_affiliation_string | Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[6].institutions[0].id | https://openalex.org/I145897649 |
| authorships[6].institutions[0].ror | https://ror.org/0044e2g62 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I145897649 |
| authorships[6].institutions[0].country_code | CN |
| authorships[6].institutions[0].display_name | Minzu University of China |
| authorships[6].institutions[1].id | https://openalex.org/I2799449666 |
| authorships[6].institutions[1].ror | https://ror.org/01p9g6b97 |
| authorships[6].institutions[1].type | government |
| authorships[6].institutions[1].lineage | https://openalex.org/I2799449666 |
| authorships[6].institutions[1].country_code | CN |
| authorships[6].institutions[1].display_name | State Ethnic Affairs Commission |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Xiangrong Li |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China, Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[7].author.id | https://openalex.org/A5100766730 |
| authorships[7].author.orcid | https://orcid.org/0000-0001-9647-2827 |
| authorships[7].author.display_name | Ruofei Feng |
| authorships[7].countries | CN |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I145897649 |
| authorships[7].affiliations[0].raw_affiliation_string | Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[7].affiliations[1].institution_ids | https://openalex.org/I2799449666 |
| authorships[7].affiliations[1].raw_affiliation_string | Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[7].institutions[0].id | https://openalex.org/I145897649 |
| authorships[7].institutions[0].ror | https://ror.org/0044e2g62 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I145897649 |
| authorships[7].institutions[0].country_code | CN |
| authorships[7].institutions[0].display_name | Minzu University of China |
| authorships[7].institutions[1].id | https://openalex.org/I2799449666 |
| authorships[7].institutions[1].ror | https://ror.org/01p9g6b97 |
| authorships[7].institutions[1].type | government |
| authorships[7].institutions[1].lineage | https://openalex.org/I2799449666 |
| authorships[7].institutions[1].country_code | CN |
| authorships[7].institutions[1].display_name | State Ethnic Affairs Commission |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Ruofei Feng |
| authorships[7].is_corresponding | True |
| authorships[7].raw_affiliation_strings | Gansu Tech Innovation Center of Animal Cell, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China, Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030, China |
| authorships[8].author.id | https://openalex.org/A5100438067 |
| authorships[8].author.orcid | https://orcid.org/0000-0002-5341-7630 |
| authorships[8].author.display_name | Zhiqiang Li |
| authorships[8].countries | CN |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I145897649 |
| authorships[8].affiliations[0].raw_affiliation_string | Department of Medicine, Northwest Minzu University, Lanzhou 730030, China |
| authorships[8].institutions[0].id | https://openalex.org/I145897649 |
| authorships[8].institutions[0].ror | https://ror.org/0044e2g62 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I145897649 |
| authorships[8].institutions[0].country_code | CN |
| authorships[8].institutions[0].display_name | Minzu University of China |
| authorships[8].author_position | last |
| authorships[8].raw_author_name | Zhiqiang Li |
| authorships[8].is_corresponding | True |
| authorships[8].raw_affiliation_strings | Department of Medicine, Northwest Minzu University, Lanzhou 730030, China |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.mdpi.com/1999-4915/16/2/174/pdf?version=1706103854 |
| open_access.oa_status | gold |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Histone H1.2 Inhibited EMCV Replication through Enhancing MDA5-Mediated IFN-β Signaling Pathway |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T11668 |
| primary_topic.field.id | https://openalex.org/fields/24 |
| primary_topic.field.display_name | Immunology and Microbiology |
| primary_topic.score | 1.0 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2403 |
| primary_topic.subfield.display_name | Immunology |
| primary_topic.display_name | interferon and immune responses |
| related_works | https://openalex.org/W4205352901, https://openalex.org/W4327680970, https://openalex.org/W2589699231, https://openalex.org/W2080778613, https://openalex.org/W2279656743, https://openalex.org/W3151244541, https://openalex.org/W2056818610, https://openalex.org/W2359798778, https://openalex.org/W2051895793, https://openalex.org/W2147168547 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| locations_count | 4 |
| best_oa_location.id | doi:10.3390/v16020174 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S55776271 |
| best_oa_location.source.issn | 1999-4915 |
| best_oa_location.source.type | journal |
| best_oa_location.source.is_oa | True |
| best_oa_location.source.issn_l | 1999-4915 |
| best_oa_location.source.is_core | True |
| best_oa_location.source.is_in_doaj | True |
| best_oa_location.source.display_name | Viruses |
| best_oa_location.source.host_organization | https://openalex.org/P4310310987 |
| best_oa_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| best_oa_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| best_oa_location.license | cc-by |
| best_oa_location.pdf_url | https://www.mdpi.com/1999-4915/16/2/174/pdf?version=1706103854 |
| best_oa_location.version | publishedVersion |
| best_oa_location.raw_type | journal-article |
| best_oa_location.license_id | https://openalex.org/licenses/cc-by |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | True |
| best_oa_location.raw_source_name | Viruses |
| best_oa_location.landing_page_url | https://doi.org/10.3390/v16020174 |
| primary_location.id | doi:10.3390/v16020174 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S55776271 |
| primary_location.source.issn | 1999-4915 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | True |
| primary_location.source.issn_l | 1999-4915 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | True |
| primary_location.source.display_name | Viruses |
| primary_location.source.host_organization | https://openalex.org/P4310310987 |
| primary_location.source.host_organization_name | Multidisciplinary Digital Publishing Institute |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310310987 |
| primary_location.license | cc-by |
| primary_location.pdf_url | https://www.mdpi.com/1999-4915/16/2/174/pdf?version=1706103854 |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | https://openalex.org/licenses/cc-by |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Viruses |
| primary_location.landing_page_url | https://doi.org/10.3390/v16020174 |
| publication_date | 2024-01-24 |
| publication_year | 2024 |
| referenced_works | https://openalex.org/W1970689489, https://openalex.org/W2151067022, https://openalex.org/W2559537764, https://openalex.org/W4321786489, https://openalex.org/W4315641748, https://openalex.org/W2148985310, https://openalex.org/W2788959706, https://openalex.org/W3043508906, https://openalex.org/W2897501065, https://openalex.org/W2614069316, https://openalex.org/W3111065404, https://openalex.org/W2990028905, https://openalex.org/W2968696613, https://openalex.org/W3137330726, https://openalex.org/W3194208587, https://openalex.org/W3014126950, https://openalex.org/W2034283391, https://openalex.org/W3217069900, https://openalex.org/W4361216765, https://openalex.org/W4206078780, https://openalex.org/W2763769301, https://openalex.org/W2154705750, https://openalex.org/W6735255118, https://openalex.org/W1875007111, https://openalex.org/W4213044685, https://openalex.org/W4295280477, https://openalex.org/W1902742304, https://openalex.org/W1970775321, https://openalex.org/W2600044946 |
| referenced_works_count | 29 |
| abstract_inverted_index.I | 116 |
| abstract_inverted_index.a | 3, 93 |
| abstract_inverted_index.We | 128 |
| abstract_inverted_index.be | 120 |
| abstract_inverted_index.in | 18, 31, 54, 79, 99, 150 |
| abstract_inverted_index.is | 2, 58 |
| abstract_inverted_index.it | 39 |
| abstract_inverted_index.of | 5, 21, 67, 83, 90, 96, 107, 113, 136, 139, 164, 172 |
| abstract_inverted_index.we | 62, 103, 154 |
| abstract_inverted_index.and | 13, 26, 34, 46, 144, 148, 161, 178 |
| abstract_inverted_index.but | 29 |
| abstract_inverted_index.for | 124, 185 |
| abstract_inverted_index.its | 52 |
| abstract_inverted_index.may | 119 |
| abstract_inverted_index.new | 180 |
| abstract_inverted_index.not | 16 |
| abstract_inverted_index.our | 167 |
| abstract_inverted_index.the | 6, 19, 65, 111, 121, 134, 137, 140, 170 |
| abstract_inverted_index.was | 40, 77 |
| abstract_inverted_index.EMCV | 80, 86, 151, 176 |
| abstract_inverted_index.H1.2 | 1, 43, 68, 76, 84, 91, 108, 125, 132, 157, 173 |
| abstract_inverted_index.IRF3 | 149 |
| abstract_inverted_index.MDA5 | 141, 147 |
| abstract_inverted_index.also | 30 |
| abstract_inverted_index.cell | 24, 27 |
| abstract_inverted_index.into | 182 |
| abstract_inverted_index.only | 17 |
| abstract_inverted_index.role | 53 |
| abstract_inverted_index.that | 42, 75, 105, 131, 156 |
| abstract_inverted_index.type | 115 |
| abstract_inverted_index.with | 146 |
| abstract_inverted_index.EMCV. | 186 |
| abstract_inverted_index.Here, | 61 |
| abstract_inverted_index.IRF3. | 165 |
| abstract_inverted_index.first | 63 |
| abstract_inverted_index.found | 64, 130 |
| abstract_inverted_index.other | 55 |
| abstract_inverted_index.plays | 11 |
| abstract_inverted_index.roles | 15 |
| abstract_inverted_index.viral | 32, 56 |
| abstract_inverted_index.virus | 49, 71, 97 |
| abstract_inverted_index.which | 10, 118 |
| abstract_inverted_index.(EMCV) | 72 |
| abstract_inverted_index.cells. | 101 |
| abstract_inverted_index.cycle, | 25 |
| abstract_inverted_index.during | 69 |
| abstract_inverted_index.factor | 123 |
| abstract_inverted_index.innate | 35 |
| abstract_inverted_index.linker | 7 |
| abstract_inverted_index.member | 4 |
| abstract_inverted_index.poorly | 59 |
| abstract_inverted_index.showed | 92 |
| abstract_inverted_index.HEK293T | 100 |
| abstract_inverted_index.Histone | 0 |
| abstract_inverted_index.crucial | 14, 122 |
| abstract_inverted_index.family, | 9 |
| abstract_inverted_index.further | 129 |
| abstract_inverted_index.histone | 8 |
| abstract_inverted_index.insight | 181 |
| abstract_inverted_index.nuclear | 162 |
| abstract_inverted_index.pathway | 143 |
| abstract_inverted_index.targets | 184 |
| abstract_inverted_index.whereas | 51, 88 |
| abstract_inverted_index.Briefly, | 166 |
| abstract_inverted_index.Further, | 153 |
| abstract_inverted_index.diseases | 33 |
| abstract_inverted_index.effects. | 127 |
| abstract_inverted_index.enhanced | 110 |
| abstract_inverted_index.immunity | 36 |
| abstract_inverted_index.implying | 74 |
| abstract_inverted_index.inhibits | 47 |
| abstract_inverted_index.involved | 78 |
| abstract_inverted_index.proteins | 138 |
| abstract_inverted_index.provides | 179 |
| abstract_inverted_index.research | 168 |
| abstract_inverted_index.uncovers | 169 |
| abstract_inverted_index.Moreover, | 102 |
| abstract_inverted_index.Recently, | 38 |
| abstract_inverted_index.antiviral | 183 |
| abstract_inverted_index.chromatin | 22 |
| abstract_inverted_index.dynamics, | 23 |
| abstract_inverted_index.extensive | 12 |
| abstract_inverted_index.infection | 98 |
| abstract_inverted_index.influenza | 48 |
| abstract_inverted_index.inhibited | 85 |
| abstract_inverted_index.knockdown | 89 |
| abstract_inverted_index.mechanism | 171 |
| abstract_inverted_index.promotion | 95 |
| abstract_inverted_index.regulates | 44 |
| abstract_inverted_index.reported. | 60 |
| abstract_inverted_index.response. | 37 |
| abstract_inverted_index.signaling | 142 |
| abstract_inverted_index.apoptosis, | 28 |
| abstract_inverted_index.discovered | 41 |
| abstract_inverted_index.expression | 135 |
| abstract_inverted_index.infection, | 73 |
| abstract_inverted_index.infection. | 81, 152 |
| abstract_inverted_index.infections | 57 |
| abstract_inverted_index.interacted | 145 |
| abstract_inverted_index.negatively | 174 |
| abstract_inverted_index.production | 112 |
| abstract_inverted_index.regulating | 175 |
| abstract_inverted_index.regulation | 20 |
| abstract_inverted_index.remarkably | 109 |
| abstract_inverted_index.facilitated | 158 |
| abstract_inverted_index.interferon, | 117 |
| abstract_inverted_index.replication | 177 |
| abstract_inverted_index.significant | 94 |
| abstract_inverted_index.EMCV-induced | 114, 159 |
| abstract_inverted_index.demonstrated | 104, 155 |
| abstract_inverted_index.replication, | 50 |
| abstract_inverted_index.up-regulated | 133 |
| abstract_inverted_index.interferon-β | 45 |
| abstract_inverted_index.translocation | 163 |
| abstract_inverted_index.up-regulation | 66 |
| abstract_inverted_index.Overexpression | 82 |
| abstract_inverted_index.overexpression | 106 |
| abstract_inverted_index.proliferation, | 87 |
| abstract_inverted_index.phosphorylation | 160 |
| abstract_inverted_index.Encephalomyocarditis | 70 |
| abstract_inverted_index.proliferation–inhibitory | 126 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| corresponding_author_ids | https://openalex.org/A5100438067, https://openalex.org/A5100766730 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I145897649, https://openalex.org/I2799449666 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7200000286102295 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.66101192 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |