Histopathological Changes of the Corticospinal Tract Following Hemorrhagic and Ischemic Stroke Article Swipe
Sarolta Kollai
,
Dániel Bereczki
,
Balázs Dobi
,
Tibor Glasz
,
Tibor Kovács
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/brainsci15080864
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/brainsci15080864
Previous data on the time course of corticospinal tract (CST) degeneration after stroke are scarce, especially in the early phase. Using post-mortem histomorphological and immunohistochemical methods, CST degeneration (its temporal dynamics and its association with stroke type) was investigated in the medulla oblongata pyramids in twenty-two cases: nine patients with ischemic stroke and eleven with hemorrhagic stroke and two patients with very long survival after multiple strokes. CD68 and neurofilament immunohistochemistry and Klüver–Barrera staining were applied to assess microglial activation and axonal and myelin degeneration, respectively, and statistical methods were used to investigate the relationship between microglial density, stroke type, and survival time. Strong microglial activation starts on day 3 after stroke and increases over time, with the first signs of axon degeneration and myelin degradation observed from day 7 after stroke. Histological changes and their temporal dynamics do not differ between hemorrhagic and ischemic stroke. Our results show that myelin degeneration starts earlier than previously suggested and is observed almost simultaneously with axon degeneration, whereas microglial activation increases steadily from day 3 onwards in both ischemic and hemorrhagic stroke.
Related Topics
Concepts
Corticospinal tract
Stroke (engine)
Medicine
Pathology
Luxol fast blue stain
Axon
Myelin
Degeneration (medical)
Pyramidal tracts
Immunohistochemistry
Medulla oblongata
Central nervous system
Anatomy
Internal medicine
Magnetic resonance imaging
Radiology
Diffusion MRI
Mechanical engineering
Engineering
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/brainsci15080864
- OA Status
- gold
- References
- 47
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4413158801
All OpenAlex metadata
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https://openalex.org/W4413158801Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/brainsci15080864Digital Object Identifier
- Title
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Histopathological Changes of the Corticospinal Tract Following Hemorrhagic and Ischemic StrokeWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-08-13Full publication date if available
- Authors
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Sarolta Kollai, Dániel Bereczki, Balázs Dobi, Tibor Glasz, Tibor KovácsList of authors in order
- Landing page
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https://doi.org/10.3390/brainsci15080864Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3390/brainsci15080864Direct OA link when available
- Concepts
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Corticospinal tract, Stroke (engine), Medicine, Pathology, Luxol fast blue stain, Axon, Myelin, Degeneration (medical), Pyramidal tracts, Immunohistochemistry, Medulla oblongata, Central nervous system, Anatomy, Internal medicine, Magnetic resonance imaging, Radiology, Diffusion MRI, Mechanical engineering, EngineeringTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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