HIV-1 infections with multiple founders associate with the development of neutralization breadth Article Swipe
Éric Lewitus
,
Samantha Townsley
,
Yifan Li
,
Gina Donofrio
,
Bethany L. Dearlove
,
Hongjun Bai
,
Eric Sanders‐Buell
,
Anne Marie O’Sullivan
,
Meera Bose
,
Hannah Kibuuka
,
Lucas Maganga
,
Sorachai Nitayaphan
,
Fred Sawe
,
Leigh Anne Eller
,
Nelson L. Michael
,
Victoria R. Polonis
,
Julie A. Ake
,
Sandhya Vasan
,
Merlin L. Robb
,
Sodsai Tovanabutra
,
Shelly J. Krebs
,
Morgane Rolland
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1371/journal.ppat.1010369
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1371/journal.ppat.1010369
Eliciting broadly neutralizing antibodies (bnAbs) is a cornerstone of HIV-1 vaccine strategies. Comparing HIV-1 envelope (env) sequences from the first weeks of infection to the breadth of antibody responses observed several years after infection can help define viral features critical to vaccine design. We investigated the relationship between HIV-1 env genetics and the development of neutralization breadth in 70 individuals enrolled in a prospective acute HIV-1 cohort. Half of the individuals who developed bnAbs were infected with multiple HIV-1 founder variants, whereas all individuals with limited neutralization breadth had been infected with single HIV-1 founders. Accordingly, at HIV-1 diagnosis, env diversity was significantly higher in participants who later developed bnAbs compared to those with limited breadth (p = 0.012). This association between founder multiplicity and the subsequent development of neutralization breadth was also observed in 56 placebo recipients in the RV144 vaccine efficacy trial. In addition, we found no evidence that neutralization breath was heritable when analyzing env sequences from the 126 participants. These results demonstrate that the presence of slightly different HIV-1 variants in acute infection could promote the induction of bnAbs, suggesting a novel vaccine strategy, whereby an initial immunization with a cocktail of minimally distant antigens would be able to initiate bnAb development towards breadth.
Related Topics
Concepts
Neutralization
HIV vaccine
Virology
AIDS Vaccines
Human immunodeficiency virus (HIV)
Antibody
Immunology
Biology
Neutralizing antibody
Vaccine trial
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1371/journal.ppat.1010369
- https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010369&type=printable
- OA Status
- gold
- Cited By
- 7
- References
- 81
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4221135676
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4221135676Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1371/journal.ppat.1010369Digital Object Identifier
- Title
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HIV-1 infections with multiple founders associate with the development of neutralization breadthWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
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2022Year of publication
- Publication date
-
2022-03-18Full publication date if available
- Authors
-
Éric Lewitus, Samantha Townsley, Yifan Li, Gina Donofrio, Bethany L. Dearlove, Hongjun Bai, Eric Sanders‐Buell, Anne Marie O’Sullivan, Meera Bose, Hannah Kibuuka, Lucas Maganga, Sorachai Nitayaphan, Fred Sawe, Leigh Anne Eller, Nelson L. Michael, Victoria R. Polonis, Julie A. Ake, Sandhya Vasan, Merlin L. Robb, Sodsai Tovanabutra, Shelly J. Krebs, Morgane RollandList of authors in order
- Landing page
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https://doi.org/10.1371/journal.ppat.1010369Publisher landing page
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010369&type=printableDirect link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1010369&type=printableDirect OA link when available
- Concepts
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Neutralization, HIV vaccine, Virology, AIDS Vaccines, Human immunodeficiency virus (HIV), Antibody, Immunology, Biology, Neutralizing antibody, Vaccine trialTop concepts (fields/topics) attached by OpenAlex
- Cited by
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7Total citation count in OpenAlex
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2025: 1, 2024: 2, 2023: 2, 2022: 2Per-year citation counts (last 5 years)
- References (count)
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81Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.cocktail | 194 |
| abstract_inverted_index.compared | 110 |
| abstract_inverted_index.critical | 39 |
| abstract_inverted_index.efficacy | 142 |
| abstract_inverted_index.enrolled | 60 |
| abstract_inverted_index.envelope | 14 |
| abstract_inverted_index.evidence | 149 |
| abstract_inverted_index.features | 38 |
| abstract_inverted_index.genetics | 50 |
| abstract_inverted_index.infected | 75, 90 |
| abstract_inverted_index.initiate | 203 |
| abstract_inverted_index.multiple | 77 |
| abstract_inverted_index.observed | 29, 133 |
| abstract_inverted_index.presence | 168 |
| abstract_inverted_index.slightly | 170 |
| abstract_inverted_index.variants | 173 |
| abstract_inverted_index.Comparing | 12 |
| abstract_inverted_index.Eliciting | 0 |
| abstract_inverted_index.addition, | 145 |
| abstract_inverted_index.analyzing | 156 |
| abstract_inverted_index.developed | 72, 108 |
| abstract_inverted_index.different | 171 |
| abstract_inverted_index.diversity | 100 |
| abstract_inverted_index.founders. | 94 |
| abstract_inverted_index.heritable | 154 |
| abstract_inverted_index.induction | 180 |
| abstract_inverted_index.infection | 22, 33, 176 |
| abstract_inverted_index.minimally | 196 |
| abstract_inverted_index.responses | 28 |
| abstract_inverted_index.sequences | 16, 158 |
| abstract_inverted_index.strategy, | 187 |
| abstract_inverted_index.variants, | 80 |
| abstract_inverted_index.antibodies | 3 |
| abstract_inverted_index.diagnosis, | 98 |
| abstract_inverted_index.recipients | 137 |
| abstract_inverted_index.subsequent | 126 |
| abstract_inverted_index.suggesting | 183 |
| abstract_inverted_index.association | 120 |
| abstract_inverted_index.cornerstone | 7 |
| abstract_inverted_index.demonstrate | 165 |
| abstract_inverted_index.development | 53, 127, 205 |
| abstract_inverted_index.individuals | 59, 70, 83 |
| abstract_inverted_index.prospective | 63 |
| abstract_inverted_index.strategies. | 11 |
| abstract_inverted_index.Accordingly, | 95 |
| abstract_inverted_index.immunization | 191 |
| abstract_inverted_index.investigated | 44 |
| abstract_inverted_index.multiplicity | 123 |
| abstract_inverted_index.neutralizing | 2 |
| abstract_inverted_index.participants | 105 |
| abstract_inverted_index.relationship | 46 |
| abstract_inverted_index.participants. | 162 |
| abstract_inverted_index.significantly | 102 |
| abstract_inverted_index.neutralization | 55, 86, 129, 151 |
| cited_by_percentile_year.max | 96 |
| cited_by_percentile_year.min | 91 |
| corresponding_author_ids | https://openalex.org/A5034888328, https://openalex.org/A5070877757, https://openalex.org/A5039272834, https://openalex.org/A5012064390, https://openalex.org/A5066315416, https://openalex.org/A5059676339, https://openalex.org/A5036265394, https://openalex.org/A5100427016, https://openalex.org/A5061342418, https://openalex.org/A5076820552, https://openalex.org/A5003078735, https://openalex.org/A5001063157, https://openalex.org/A5046264591, https://openalex.org/A5051742297, https://openalex.org/A5090782451, https://openalex.org/A5103467628, https://openalex.org/A5041344472, https://openalex.org/A5012110068, https://openalex.org/A5067755958, https://openalex.org/A5021655886, https://openalex.org/A5052150473, https://openalex.org/A5072696926 |
| countries_distinct_count | 5 |
| institutions_distinct_count | 22 |
| corresponding_institution_ids | https://openalex.org/I1280259254, https://openalex.org/I2800255189, https://openalex.org/I2802125050, https://openalex.org/I2841861, https://openalex.org/I4210112607, https://openalex.org/I4210164902, https://openalex.org/I92664306 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.7699999809265137 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.67032465 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |