HIV Drug Resistance Patterns and Characteristics Associated with Clinically Significant Drug Resistance among Children with Virologic Failure on Antiretroviral Treatment in Kenya: Findings from the Opt4Kids Randomized Controlled Trial Article Swipe
Lisa Abuogi
,
Patrick Oyaro
,
Garoma Wakjira
,
Katherine K. Thomas
,
Andrea J. Scallon
,
Irene Mukui
,
Bhavna Chohan
,
Evelyn Brown
,
Enericah Karauki
,
Nashon Yongo
,
Bilaal Ahmed
,
Shukri A. Hassan
,
James Wagude
,
Eunice Kinywa
,
Lindah Otieno
,
Leonard Kingwara
,
Boaz Oyaro
,
Lisa M. Frenkel
,
Grace John‐Stewart
,
Rena C. Patel
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202308.2148.v1
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.20944/preprints202308.2148.v1
Increasing HIV drug resistance (DR) among children with HIV (CHIV) on antiretroviral treatment (ART) is concerning. CHIV ages 1-14 years enrolled March 2019 to December 2020 from five facilities in Kisumu County, Kenya were included. Children were randomized 1:1 to control (standard-of-care) or intervention (point-of-care viral load (POC VL) testing every three months with targeted genotypic drug resistance testing (DRT) for VF (> 1000 copies/ml)). A multidisciplinary committee reviewed CHIV with DRT results and offered treatment recommendations. We describe DR mutations and present logistic regression models to identify factors associated with clinically significant DR. We enrolled 704 children in the study; median age was 9 years (interquartile range (IQR) 7,12), 344 (49%) were female and median time on ART was 5 years (IQR 3, 8). During the study period, 106 (15%) children had DRT results (84 intervention and 22 control). DRT detected mutations associate with DR in all participants tested, with 93 (88%) having major mutations, including 51 (54%) with dual class resistance. A history of VF in prior 2 years (adjusted odds ratio (aOR) 11.1; 95% confidence interval (CI) 6.3, 20.0) and less than 2 years on ART at enrollment (aOR 2.2; 95% CI 1.1, 4.4) were associated with increased odds of major DR. DR is highly prevalent among CHIV on ART with VF in Kenya. Factors associated with drug resistance may be used to determine which children should be prioritized for DRT.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.20944/preprints202308.2148.v1
- https://www.preprints.org/manuscript/202308.2148/v1/download
- OA Status
- green
- Cited By
- 1
- References
- 22
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386377428
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4386377428Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.20944/preprints202308.2148.v1Digital Object Identifier
- Title
-
HIV Drug Resistance Patterns and Characteristics Associated with Clinically Significant Drug Resistance among Children with Virologic Failure on Antiretroviral Treatment in Kenya: Findings from the Opt4Kids Randomized Controlled TrialWork title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-08-31Full publication date if available
- Authors
-
Lisa Abuogi, Patrick Oyaro, Garoma Wakjira, Katherine K. Thomas, Andrea J. Scallon, Irene Mukui, Bhavna Chohan, Evelyn Brown, Enericah Karauki, Nashon Yongo, Bilaal Ahmed, Shukri A. Hassan, James Wagude, Eunice Kinywa, Lindah Otieno, Leonard Kingwara, Boaz Oyaro, Lisa M. Frenkel, Grace John‐Stewart, Rena C. PatelList of authors in order
- Landing page
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https://doi.org/10.20944/preprints202308.2148.v1Publisher landing page
- PDF URL
-
https://www.preprints.org/manuscript/202308.2148/v1/downloadDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://www.preprints.org/manuscript/202308.2148/v1/downloadDirect OA link when available
- Concepts
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Medicine, Interquartile range, Odds ratio, Confidence interval, Drug resistance, HIV drug resistance, Randomized controlled trial, Viral load, Internal medicine, Logistic regression, Pediatrics, Clinical endpoint, Antiretroviral therapy, Human immunodeficiency virus (HIV), Immunology, Microbiology, BiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
- Citations by year (recent)
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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22Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.associate | 143 |
| abstract_inverted_index.committee | 67 |
| abstract_inverted_index.control). | 139 |
| abstract_inverted_index.determine | 226 |
| abstract_inverted_index.genotypic | 55 |
| abstract_inverted_index.included. | 34 |
| abstract_inverted_index.including | 156 |
| abstract_inverted_index.increased | 200 |
| abstract_inverted_index.mutations | 80, 142 |
| abstract_inverted_index.prevalent | 208 |
| abstract_inverted_index.treatment | 12, 75 |
| abstract_inverted_index.Increasing | 0 |
| abstract_inverted_index.associated | 89, 198, 218 |
| abstract_inverted_index.clinically | 91 |
| abstract_inverted_index.confidence | 177 |
| abstract_inverted_index.enrollment | 190 |
| abstract_inverted_index.facilities | 28 |
| abstract_inverted_index.mutations, | 155 |
| abstract_inverted_index.randomized | 37 |
| abstract_inverted_index.regression | 84 |
| abstract_inverted_index.resistance | 3, 57, 221 |
| abstract_inverted_index.concerning. | 15 |
| abstract_inverted_index.prioritized | 231 |
| abstract_inverted_index.resistance. | 162 |
| abstract_inverted_index.significant | 92 |
| abstract_inverted_index.copies/ml)). | 64 |
| abstract_inverted_index.intervention | 43, 136 |
| abstract_inverted_index.participants | 148 |
| abstract_inverted_index.(> | 62 |
| abstract_inverted_index.(interquartile | 106 |
| abstract_inverted_index.(point-of-care | 44 |
| abstract_inverted_index.antiretroviral | 11 |
| abstract_inverted_index.recommendations. | 76 |
| abstract_inverted_index.multidisciplinary | 66 |
| abstract_inverted_index.(standard-of-care) | 41 |
| cited_by_percentile_year.max | 95 |
| cited_by_percentile_year.min | 91 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 20 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8700000047683716 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.53806288 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |