HLA Class I-Mediated HIV-1 Control in Vietnamese Infected with HIV-1 Subtype A/E Article Swipe
Takayuki Chikata
,
Giang Van Tran
,
Hayato Murakoshi
,
Tomohiro Akahoshi
,
Qi Ying
,
Vivek Naranbhai
,
Nozomi Kuse
,
Yoshiko Tamura
,
Madoka Koyanagi
,
Sachiko Sakai
,
Dung Hoai Thi Nguyen
,
Dung Thi Nguyen
,
Ha Nguyen
,
Trung Vu Nguyen
,
Shinichi Oka
,
Maureen P. Martin
,
Mary Carrington
,
Keiko Sakai
,
Kinh Van Nguyen
,
Masafumi Takiguchi
·
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1128/jvi.01749-17
YOU?
·
· 2017
· Open Access
·
· DOI: https://doi.org/10.1128/jvi.01749-17
HIV-1-specific cytotoxic T cells (CTLs) play an important role in the control of HIV-1 subtype B or C infection. However, the role of CTLs in HIV-1 subtype A/E infection still remains unclear. Here we investigated the association of HLA class I alleles with clinical outcomes in treatment-naive Vietnamese infected with subtype A/E virus. We found that HLA-C*12:02 was significantly associated with lower plasma viral loads (pVL) and higher CD4 counts and that the HLA-A*29:01-B*07:05-C*15:05 haplotype was significantly associated with higher pVL and lower CD4 counts than those for individuals without these respective genotypes. Nine Pol and three Nef mutations were associated with at least one HLA allele in the HLA-A*29:01-B*07:05-C*15:05 haplotype, with a strong negative correlation between the number of HLA-associated Pol mutations and CD4 count as well as a positive correlation with pVL for individuals with these HLA alleles. The results suggest that the accumulation of mutations selected by CTLs restricted by these HLA alleles affects HIV control. IMPORTANCE Most previous studies on HLA association with disease progression after HIV-1 infection have been performed on cohorts infected with HIV-1 subtypes B and C, whereas few such population-based studies have been reported for cohorts infected with the Asian subtype A/E virus. In this study, we analyzed the association of HLA class I alleles with clinical outcomes for 536 HIV-1 subtype A/E-infected Vietnamese individuals. We found that HLA-C*12:02 is protective, while the HLA haplotype HLA-A*29:01-B*07:05-C*15:05 is deleterious. The individuals with HIV-1 mutations associated with at least one of the HLA alleles in the deleterious HLA haplotype had higher plasma viral loads and lower CD4 counts than those of individuals without the mutations, suggesting that viral adaptation and escape from HLA-mediated immune control occurred. The present study identifies a protective allele and a deleterious haplotype for HIV-1 subtype A/E infection which are different from those identified for cohorts infected with HIV-1 subtypes B and C.
Related Topics
Concepts
Biology
Allele
Human leukocyte antigen
Haplotype
Immunology
Genotype
Virology
HLA-B Antigens
Population
Viral load
HLA-C
Cytotoxic T cell
Virus
Genetics
Antigen
Gene
Medicine
Environmental health
In vitro
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1128/jvi.01749-17
- https://jvi.asm.org/content/jvi/92/5/e01749-17.full.pdf
- OA Status
- bronze
- Cited By
- 19
- References
- 28
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2773359593
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2773359593Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1128/jvi.01749-17Digital Object Identifier
- Title
-
HLA Class I-Mediated HIV-1 Control in Vietnamese Infected with HIV-1 Subtype A/EWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2017Year of publication
- Publication date
-
2017-12-13Full publication date if available
- Authors
-
Takayuki Chikata, Giang Van Tran, Hayato Murakoshi, Tomohiro Akahoshi, Qi Ying, Vivek Naranbhai, Nozomi Kuse, Yoshiko Tamura, Madoka Koyanagi, Sachiko Sakai, Dung Hoai Thi Nguyen, Dung Thi Nguyen, Ha Nguyen, Trung Vu Nguyen, Shinichi Oka, Maureen P. Martin, Mary Carrington, Keiko Sakai, Kinh Van Nguyen, Masafumi TakiguchiList of authors in order
- Landing page
-
https://doi.org/10.1128/jvi.01749-17Publisher landing page
- PDF URL
-
https://jvi.asm.org/content/jvi/92/5/e01749-17.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://jvi.asm.org/content/jvi/92/5/e01749-17.full.pdfDirect OA link when available
- Concepts
-
Biology, Allele, Human leukocyte antigen, Haplotype, Immunology, Genotype, Virology, HLA-B Antigens, Population, Viral load, HLA-C, Cytotoxic T cell, Virus, Genetics, Antigen, Gene, Medicine, Environmental health, In vitroTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
19Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 1, 2022: 4, 2021: 1, 2020: 5Per-year citation counts (last 5 years)
- References (count)
-
28Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.plasma | 63, 258 |
| abstract_inverted_index.strong | 114 |
| abstract_inverted_index.study, | 204 |
| abstract_inverted_index.virus. | 53, 201 |
| abstract_inverted_index.affects | 157 |
| abstract_inverted_index.alleles | 42, 156, 213, 250 |
| abstract_inverted_index.between | 117 |
| abstract_inverted_index.cohorts | 177, 194, 306 |
| abstract_inverted_index.control | 12, 281 |
| abstract_inverted_index.disease | 168 |
| abstract_inverted_index.present | 284 |
| abstract_inverted_index.remains | 31 |
| abstract_inverted_index.results | 142 |
| abstract_inverted_index.studies | 163, 189 |
| abstract_inverted_index.subtype | 15, 27, 51, 199, 220, 296 |
| abstract_inverted_index.suggest | 143 |
| abstract_inverted_index.whereas | 185 |
| abstract_inverted_index.without | 90, 269 |
| abstract_inverted_index.ABSTRACT | 0 |
| abstract_inverted_index.However, | 20 |
| abstract_inverted_index.alleles. | 140 |
| abstract_inverted_index.analyzed | 206 |
| abstract_inverted_index.clinical | 44, 215 |
| abstract_inverted_index.control. | 159 |
| abstract_inverted_index.infected | 49, 178, 195, 307 |
| abstract_inverted_index.negative | 115 |
| abstract_inverted_index.outcomes | 45, 216 |
| abstract_inverted_index.positive | 131 |
| abstract_inverted_index.previous | 162 |
| abstract_inverted_index.reported | 192 |
| abstract_inverted_index.selected | 149 |
| abstract_inverted_index.subtypes | 181, 310 |
| abstract_inverted_index.unclear. | 32 |
| abstract_inverted_index.cytotoxic | 2 |
| abstract_inverted_index.different | 301 |
| abstract_inverted_index.haplotype | 75, 233, 255, 293 |
| abstract_inverted_index.important | 8 |
| abstract_inverted_index.infection | 29, 172, 298 |
| abstract_inverted_index.mutations | 99, 123, 148, 241 |
| abstract_inverted_index.occurred. | 282 |
| abstract_inverted_index.performed | 175 |
| abstract_inverted_index.IMPORTANCE | 160 |
| abstract_inverted_index.Vietnamese | 48, 222 |
| abstract_inverted_index.adaptation | 275 |
| abstract_inverted_index.associated | 60, 78, 101, 242 |
| abstract_inverted_index.genotypes. | 93 |
| abstract_inverted_index.haplotype, | 111 |
| abstract_inverted_index.identified | 304 |
| abstract_inverted_index.identifies | 286 |
| abstract_inverted_index.infection. | 19 |
| abstract_inverted_index.mutations, | 271 |
| abstract_inverted_index.protective | 288 |
| abstract_inverted_index.respective | 92 |
| abstract_inverted_index.restricted | 152 |
| abstract_inverted_index.suggesting | 272 |
| abstract_inverted_index.HLA-C*12:02 | 57, 227 |
| abstract_inverted_index.association | 37, 166, 208 |
| abstract_inverted_index.correlation | 116, 132 |
| abstract_inverted_index.deleterious | 253, 292 |
| abstract_inverted_index.individuals | 89, 136, 238, 268 |
| abstract_inverted_index.progression | 169 |
| abstract_inverted_index.protective, | 229 |
| abstract_inverted_index.A/E-infected | 221 |
| abstract_inverted_index.HLA-mediated | 279 |
| abstract_inverted_index.accumulation | 146 |
| abstract_inverted_index.deleterious. | 236 |
| abstract_inverted_index.individuals. | 223 |
| abstract_inverted_index.investigated | 35 |
| abstract_inverted_index.significantly | 59, 77 |
| abstract_inverted_index.HIV-1-specific | 1 |
| abstract_inverted_index.HLA-associated | 121 |
| abstract_inverted_index.treatment-naive | 47 |
| abstract_inverted_index.population-based | 188 |
| abstract_inverted_index.HLA-A*29:01-B*07:05-C*15:05 | 74, 110, 234 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 4 |
| institutions_distinct_count | 20 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8199999928474426 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.8244637 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |