HLA-DR expression in neonates after cardiac surgery under cardiopulmonary bypass: a pilot study Article Swipe
Alexis Chenouard
,
Cécile Braudeau
,
Nicolas Cottron
,
Pierre Bourgoin
,
Nina Salabert
,
Antoine Roquilly
,
Régis Josien
,
Nicolas Joram
,
Karim Asehnoune
·
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1186/s40635-017-0166-x
YOU?
·
· 2018
· Open Access
·
· DOI: https://doi.org/10.1186/s40635-017-0166-x
Monocyte HLA-DR expression has been reported as a marker of immunosuppression and a predictor of sepsis development. However, to date, there is no report on monocyte HLA-DR monitoring exclusively in neonates (< 28 days of life) who underwent cardiac surgery under cardiopulmonary bypass (CPB), which have a high risk of nosocomial infection. In this pilot study, we studied nine neonates with a diagnosis of congenital heart disease requiring surgery under CPB. There was a significant reduction in monocyte HLA-DR expression for the first two postoperative days, as compared to preoperatively (p = 0.004). Moreover, neonates who displayed an episode of NI had a dramatically lower HLA-DR expression at day 4, as compared to neonates without NI (4257 AB/c [2220-5895] vs 14,947 AB/c [9858-16,960]; p = 0.04). Our preliminary results could indicate that HLA-DR expression may be a useful biomarker of immunosuppression-induced secondary infection after CPB in neonates.
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- Type
- letter
- Language
- en
- Landing Page
- https://doi.org/10.1186/s40635-017-0166-x
- https://icm-experimental.springeropen.com/track/pdf/10.1186/s40635-017-0166-x
- OA Status
- gold
- Cited By
- 17
- References
- 17
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2784200500
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Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2784200500Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1186/s40635-017-0166-xDigital Object Identifier
- Title
-
HLA-DR expression in neonates after cardiac surgery under cardiopulmonary bypass: a pilot studyWork title
- Type
-
letterOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2018Year of publication
- Publication date
-
2018-01-11Full publication date if available
- Authors
-
Alexis Chenouard, Cécile Braudeau, Nicolas Cottron, Pierre Bourgoin, Nina Salabert, Antoine Roquilly, Régis Josien, Nicolas Joram, Karim AsehnouneList of authors in order
- Landing page
-
https://doi.org/10.1186/s40635-017-0166-xPublisher landing page
- PDF URL
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https://icm-experimental.springeropen.com/track/pdf/10.1186/s40635-017-0166-xDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://icm-experimental.springeropen.com/track/pdf/10.1186/s40635-017-0166-xDirect OA link when available
- Concepts
-
Medicine, Cardiopulmonary bypass, Immunosuppression, Monocyte, Sepsis, Cardiac surgery, Human leukocyte antigen, Biomarker, Heart disease, Internal medicine, Immunology, Anesthesia, Antigen, Chemistry, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
17Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 2, 2023: 1, 2022: 1, 2020: 3Per-year citation counts (last 5 years)
- References (count)
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17Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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