HMGB1: a double-edged sword and therapeutic target in the female reproductive system Article Swipe
Yu Ren
,
Damin Zhu
,
Xingxing Han
,
Qiqi Zhang
,
Beili Chen
,
Ping Zhou
,
Zhaolian Wei
,
Zhiguo Zhang
,
Yunxia Cao
,
Huijuan Zou
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2023.1238785
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.3389/fimmu.2023.1238785
HMGB1 that belongs to the High Mobility Group-box superfamily, is a nonhistone chromatin associated transcription factor. It is present in the nucleus of eukaryotes and can be actively secreted or passively released by kinds of cells. HMGB1 is important for maintaining DNA structure by binding to DNA and histones, protecting it from damage. It also regulates the interaction between histones and DNA, affecting chromatin packaging, and can influence gene expression by promoting nucleosome sliding. And as a DAMP, HMGB1 binding to RAGE and TLRs activates NF-κB, which triggers the expression of downstream genes like IL-18, IL-1β, and TNF-α. HMGB1 is known to be involved in numerous physiological and pathological processes. Recent studies have demonstrated the significance of HMGB1 as DAMPs in the female reproductive system. These findings have shed light on the potential role of HMGB1 in the pathogenesis of diseases in female reproductive system and the possibilities of HMGB1-targeted therapies for treating them. Such therapies can help reduce inflammation and metabolic dysfunction and alleviate the symptoms of reproductive system diseases. Overall, the identification of HMGB1 as a key player in disease of the female reproductive system represents a significant breakthrough in our understanding of these conditions and presents exciting opportunities for the development of novel therapies.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3389/fimmu.2023.1238785
- OA Status
- gold
- Cited By
- 15
- References
- 195
- Related Works
- 10
- OpenAlex ID
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All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4385996404Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fimmu.2023.1238785Digital Object Identifier
- Title
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HMGB1: a double-edged sword and therapeutic target in the female reproductive systemWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2023Year of publication
- Publication date
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2023-08-18Full publication date if available
- Authors
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Yu Ren, Damin Zhu, Xingxing Han, Qiqi Zhang, Beili Chen, Ping Zhou, Zhaolian Wei, Zhiguo Zhang, Yunxia Cao, Huijuan ZouList of authors in order
- Landing page
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https://doi.org/10.3389/fimmu.2023.1238785Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3389/fimmu.2023.1238785Direct OA link when available
- Concepts
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HMGB1, Chromatin, Histone, Biology, Cell biology, Transcription factor, Nucleosome, Rage (emotion), DNA repair, Inflammation, DNA, Gene, Immunology, Bioinformatics, Genetics, NeuroscienceTop concepts (fields/topics) attached by OpenAlex
- Cited by
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15Total citation count in OpenAlex
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2025: 11, 2024: 3, 2023: 1Per-year citation counts (last 5 years)
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10Other works algorithmically related by OpenAlex
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