Host metabolomic responses in recurrent P. vivax malaria Article Swipe
Michael N. Yakubu
,
Victor Irungu Mwangi
,
Rebeca Linhares Abreu Netto
,
Maria G. C. Alecrim
,
Jéssica R. S. Alves
,
Anne Cristine Gomes de Almeida
,
Gabriel F. Santos
,
Gesiane da Silva Lima
,
Lucas Machado
,
Héctor H. F. Koolen
,
Tiago Pereira Guimarães
,
Andréa Rodrigues Chaves
,
Boniek G. Vaz
,
Wuelton Marcelo Monteiro
,
Fábio Trindade Maranhão Costa
,
Marcus Lacerda
,
Luiz Gustavo Gardinassi
,
Gisely Cardoso de Melo
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-024-54231-5
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1038/s41598-024-54231-5
Malaria is the leading parasitic disease worldwide, with P. vivax being a major challenge for its control. Several studies have indicated metabolomics as a promising tool for combating the disease. The study evaluated plasma metabolomic profiles of patients with recurrent and non-recurrent P. vivax malaria in the Brazilian Amazon. Metabolites extracted from the plasma of P. vivax -infected patients were subjected to LC–MS analysis. Untargeted metabolomics was applied to investigate the metabolic profile of the plasma in the two groups. Overall, 51 recurrent and 59 non-recurrent patients were included in the study. Longitudinal metabolomic analysis revealed 52 and 37 significant metabolite features from the recurrent and non-recurrent participants, respectively. Recurrence was associated with disturbances in eicosanoid metabolism. Comparison between groups suggest alterations in vitamin B6 (pyridoxine) metabolism, tyrosine metabolism, 3-oxo-10-octadecatrienoate β-oxidation, and alkaloid biosynthesis II. Integrative network analysis revealed enrichment of other metabolic pathways for the recurrent phenotype, including the butanoate metabolism, aspartate and asparagine metabolism, and N-glycan biosynthesis. The metabolites and metabolic pathways predicted in our study suggest potential biomarkers of recurrence and provide insights into targets for antimalarial development against P. vivax .
Related Topics
Concepts
Metabolomics
Metabolite
Plasmodium vivax
Biology
Metabolic pathway
Metabolome
Metabolism
Malaria
Pyrimidine metabolism
Medicine
Biochemistry
Plasmodium falciparum
Immunology
Bioinformatics
Purine
Enzyme
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41598-024-54231-5
- https://www.nature.com/articles/s41598-024-54231-5.pdf
- OA Status
- gold
- Cited By
- 5
- References
- 74
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4393233020
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4393233020Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1038/s41598-024-54231-5Digital Object Identifier
- Title
-
Host metabolomic responses in recurrent P. vivax malariaWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2024Year of publication
- Publication date
-
2024-03-27Full publication date if available
- Authors
-
Michael N. Yakubu, Victor Irungu Mwangi, Rebeca Linhares Abreu Netto, Maria G. C. Alecrim, Jéssica R. S. Alves, Anne Cristine Gomes de Almeida, Gabriel F. Santos, Gesiane da Silva Lima, Lucas Machado, Héctor H. F. Koolen, Tiago Pereira Guimarães, Andréa Rodrigues Chaves, Boniek G. Vaz, Wuelton Marcelo Monteiro, Fábio Trindade Maranhão Costa, Marcus Lacerda, Luiz Gustavo Gardinassi, Gisely Cardoso de MeloList of authors in order
- Landing page
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https://doi.org/10.1038/s41598-024-54231-5Publisher landing page
- PDF URL
-
https://www.nature.com/articles/s41598-024-54231-5.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://www.nature.com/articles/s41598-024-54231-5.pdfDirect OA link when available
- Concepts
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Metabolomics, Metabolite, Plasmodium vivax, Biology, Metabolic pathway, Metabolome, Metabolism, Malaria, Pyrimidine metabolism, Medicine, Biochemistry, Plasmodium falciparum, Immunology, Bioinformatics, Purine, EnzymeTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
5Total citation count in OpenAlex
- Citations by year (recent)
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2025: 5Per-year citation counts (last 5 years)
- References (count)
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74Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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