Abstract Objective To summarize applications of natural language processing (NLP) in model informed drug development (MIDD) and identify potential areas of improvement. Materials and Methods Publications found on PubMed and Google Scholar, websites and GitHub repositories for NLP libraries and models. Publications describing applications of NLP in MIDD were reviewed. The applications were stratified into 3 stages: drug discovery, clinical trials, and pharmacovigilance. Key NLP functionalities used for these applic…