HOW DO THEY ADD UP? THE INTERACTION BETWEEN THE PLACEBO AND TREATMENT EFFECT : A SYSTEMATIC REVIEW. Article Swipe
Rémy Boussageon
,
Jeremy Howick
,
Raphael Baron
,
Florian Naudet
,
Bruno Falissard
,
Ghina Harika‐Germaneau
,
Issa Wassouf
,
François Gueyffier
,
Némat Jaafari
,
Clara Blanchard
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.22541/au.163320737.74598661/v1
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.22541/au.163320737.74598661/v1
Aim: The placebo effect and the specific effect are often thought to add up (additive model). Whether this is true or whether there is an interaction between the two, can modify the external validity of a trial. This assumption of additivity was tested by Kleijnen et al. in 1994 but the data produced since then has not been synthetized. In this review, we aimed to systematically review the literature to determine whether additivity held. Methods: We searched Medline and Psychinfo up to 10/01/2019. Studies using the balanced placebo design (BPD), testing two different strengths of placebos, were included. The presence of interaction was evaluated by comparing each group in BPD with analysis of variance or covariance. Results: 30 studies were included and the overall risk of bias was high: four found evidence of additivity and 16 studies found evidence of interaction (seven had evidence of positive additivity). Conclusion: Evidence of additivity between placebo and specific features of treatments was rare in our sample. For ailments that are placebo-responsive, pragmatic trials should be preferred to increase their external validity.
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Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.22541/au.163320737.74598661/v1
- https://www.authorea.com/doi/pdf/10.22541/au.163320737.74598661/v1
- OA Status
- gold
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4240307436
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4240307436Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.22541/au.163320737.74598661/v1Digital Object Identifier
- Title
-
HOW DO THEY ADD UP? THE INTERACTION BETWEEN THE PLACEBO AND TREATMENT EFFECT : A SYSTEMATIC REVIEW.Work title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-10-02Full publication date if available
- Authors
-
Rémy Boussageon, Jeremy Howick, Raphael Baron, Florian Naudet, Bruno Falissard, Ghina Harika‐Germaneau, Issa Wassouf, François Gueyffier, Némat Jaafari, Clara BlanchardList of authors in order
- Landing page
-
https://doi.org/10.22541/au.163320737.74598661/v1Publisher landing page
- PDF URL
-
https://www.authorea.com/doi/pdf/10.22541/au.163320737.74598661/v1Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.authorea.com/doi/pdf/10.22541/au.163320737.74598661/v1Direct OA link when available
- Concepts
-
Placebo, Meta-analysis, Additive function, Placebo response, Analysis of covariance, Clinical psychology, Medicine, Treatment effect, Psychology, Internal medicine, Statistics, Alternative medicine, Mathematics, Mathematical analysis, Traditional medicine, PathologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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