How TRPC Channels Modulate Hippocampal Function Article Swipe
Roberta Gualdani
,
Philippe Gailly
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/ijms21113915
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3390/ijms21113915
Transient receptor potential canonical (TRPC) proteins constitute a group of receptor-operated calcium-permeable nonselective cationic membrane channels of the TRP superfamily. They are largely expressed in the hippocampus and are able to modulate neuronal functions. Accordingly, they have been involved in different hippocampal functions such as learning processes and different types of memories, as well as hippocampal dysfunctions such as seizures. This review covers the mechanisms of activation of these channels, how these channels can modulate neuronal excitability, in particular the after-burst hyperpolarization, and in the persistent activity, how they control synaptic plasticity including pre- and postsynaptic processes and how they can interfere with cell survival and neurogenesis.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms21113915
- https://www.mdpi.com/1422-0067/21/11/3915/pdf?version=1591186222
- OA Status
- gold
- Cited By
- 20
- References
- 182
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3031477637
All OpenAlex metadata
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https://openalex.org/W3031477637Canonical identifier for this work in OpenAlex
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https://doi.org/10.3390/ijms21113915Digital Object Identifier
- Title
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How TRPC Channels Modulate Hippocampal FunctionWork title
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reviewOpenAlex work type
- Language
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enPrimary language
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2020Year of publication
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2020-05-30Full publication date if available
- Authors
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Roberta Gualdani, Philippe GaillyList of authors in order
- Landing page
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https://doi.org/10.3390/ijms21113915Publisher landing page
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https://www.mdpi.com/1422-0067/21/11/3915/pdf?version=1591186222Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.mdpi.com/1422-0067/21/11/3915/pdf?version=1591186222Direct OA link when available
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TRPC, Transient receptor potential channel, Neuroscience, Hippocampal formation, Postsynaptic potential, Neurogenesis, Biology, Bursting, Chemistry, Receptor, BiochemistryTop concepts (fields/topics) attached by OpenAlex
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20Total citation count in OpenAlex
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2025: 5, 2024: 6, 2023: 1, 2022: 3, 2021: 5Per-year citation counts (last 5 years)
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182Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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