How We Treat ANCA-Associated Vasculitis: A Focus on the Maintenance Therapy Article Swipe

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Dario Roccatello , Roberta Fenoglio , Emanuele De Simone , Savino Sciascia ·

YOU? · · 2025 · Open Access · · DOI: https://doi.org/10.3390/jcm14010208

Recent progress has notably improved outcomes for patients with anti-neutrophil cytoplasmic antibody-associated vasculitis (AAV), namely granulomatosis with polyangiitis and microscopic polyangiitis. Since 2021, several international scientific societies have recommended rituximab (RTX) as the preferred primary treatment for maintaining remission in AAV patients. Decisions regarding retreatment with RTX are based on individual patient risk factors for disease flare-ups and the potential consequences of such flares. In reviewing available evidence and reporting our experiences at G. Bosco Hub Hospital in Turin, Italy, we explore various trials focusing on the maintenance therapy in AAV and discuss areas of unmet need.

Related Topics

Medicine

Rituximab

Granulomatosis With Polyangiitis

Vasculitis

Disease

Anti-Neutrophil Cytoplasmic Antibody

Immunology

Internal Medicine

Chemotherapy

Concepts

Medicine Rituximab Microscopic polyangiitis Granulomatosis with polyangiitis Vasculitis Maintenance therapy Intensive care medicine ANCA-Associated Vasculitis Disease Anti-neutrophil cytoplasmic antibody Immunology Internal medicine Antibody Chemotherapy

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Type: review
Language: en
Landing Page: https://doi.org/10.3390/jcm14010208
PDF: https://www.mdpi.com/2077-0383/14/1/208/pdf?version=1735805575
OA Status: gold
Cited By: 1
References: 55
Related Works: 10
OpenAlex ID: https://openalex.org/W4405994604

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OpenAlex ID: https://openalex.org/W4405994604

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DOI: https://doi.org/10.3390/jcm14010208

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Title: How We Treat ANCA-Associated Vasculitis: A Focus on the Maintenance Therapy

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Type: review

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Language: en

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Publication year: 2025

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Publication date: 2025-01-02

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Authors: Dario Roccatello, Roberta Fenoglio, Emanuele De Simone, Savino Sciascia

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Landing page: https://doi.org/10.3390/jcm14010208

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PDF URL: https://www.mdpi.com/2077-0383/14/1/208/pdf?version=1735805575

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Concepts: Medicine, Rituximab, Microscopic polyangiitis, Granulomatosis with polyangiitis, Vasculitis, Maintenance therapy, Intensive care medicine, ANCA-Associated Vasculitis, Disease, Anti-neutrophil cytoplasmic antibody, Immunology, Internal medicine, Antibody, Chemotherapy

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Cited by: 1

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