hPSC-Derived Astrocytes at the Forefront of Translational Applications in Neurological Disorders Article Swipe
Vukasin M. Jovanovic
,
Kendall T. Mesch
,
Carlos A. Tristan
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/cells13110903
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.3390/cells13110903
Astrocytes, the most abundant glial cell type in the brain, play crucial roles in maintaining homeostasis within the central nervous system (CNS). Impairment or abnormalities of typical astrocyte functions in the CNS serve as a causative or contributing factor in numerous neurodevelopmental, neurodegenerative, and neuropsychiatric disorders. Currently, disease-modeling and drug-screening approaches, primarily focused on human astrocytes, rely on human pluripotent stem cell (hPSC)-derived astrocytes. However, it is important to acknowledge that these hPSC-derived astrocytes exhibit notable differences across studies and when compared to their in vivo counterparts. These differences may potentially compromise translational outcomes if not carefully accounted for. This review aims to explore state-of-the-art in vitro models of human astrocyte development, focusing on the developmental processes, functional maturity, and technical aspects of various hPSC-derived astrocyte differentiation protocols. Additionally, it summarizes their successful application in modeling neurological disorders. The discussion extends to recent advancements in the large-scale production of human astrocytes and their application in developing high-throughput assays conducive to therapeutic drug discovery.
Related Topics
Concepts
Neuroscience
Astrocyte
Induced pluripotent stem cell
Biology
Translational research
Drug discovery
Disease
Central nervous system
Embryonic stem cell
Medicine
Bioinformatics
Pathology
Biochemistry
Gene
Biotechnology
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/cells13110903
- https://www.mdpi.com/2073-4409/13/11/903/pdf?version=1716539743
- OA Status
- gold
- Cited By
- 1
- References
- 130
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4398777992
All OpenAlex metadata
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- OpenAlex ID
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https://openalex.org/W4398777992Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/cells13110903Digital Object Identifier
- Title
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hPSC-Derived Astrocytes at the Forefront of Translational Applications in Neurological DisordersWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2024Year of publication
- Publication date
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2024-05-24Full publication date if available
- Authors
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Vukasin M. Jovanovic, Kendall T. Mesch, Carlos A. TristanList of authors in order
- Landing page
-
https://doi.org/10.3390/cells13110903Publisher landing page
- PDF URL
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https://www.mdpi.com/2073-4409/13/11/903/pdf?version=1716539743Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://www.mdpi.com/2073-4409/13/11/903/pdf?version=1716539743Direct OA link when available
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Neuroscience, Astrocyte, Induced pluripotent stem cell, Biology, Translational research, Drug discovery, Disease, Central nervous system, Embryonic stem cell, Medicine, Bioinformatics, Pathology, Biochemistry, Gene, BiotechnologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
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1Total citation count in OpenAlex
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2025: 1Per-year citation counts (last 5 years)
- References (count)
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130Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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