Hsa_circ_0001859 promotes NSCLC progression through the miRNA-101-3p/MMP1 axis Article Swipe
Jianxin Tan
,
Fan Zhou
,
Rongguo Lu
,
Shugao Ye
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2025.1568367
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3389/fonc.2025.1568367
Background Non-small cell lung cancer (NSCLC) is a prevalent form of lung cancer characterized by a significant incidence and mortality rate in China. Most patients are diagnosed at an advanced stage. Circ_0001859 served as an exon circular RNA, but its specific role in NSCLC remained extensively unexplored. Methods Quantitative Real-Time-Polymerase Chain Reaction (qRT-PCR) and western blotting were utilized to detect messenger RNA (mRNA) and protein expression levels in NSCLC tissues and cells. Cell proliferation was assessed by Cell Counting Kit-8 (CCK-8) and colony formation assays. Cell migration and invasion were evaluated by transwell assay. Mechanistically, the mechanisms and target binding relationship between circ_0001859, miR-101-3p and MMP1 were assessed through the luciferase reporter and RNA immunoprecipitation (RIP) assays. In vivo xenograft model was established to examine the impact of circ_0001859. Results Circ_0001859 was significantly overexpressed in NSCLC tissues and cells. Functional studies demonstrated that silencing circ_0001859 significantly impeded the malignant phenotype of NSCLC cells. Bioinformatics analysis and rescue experiments disclosed that circ_0001859 functioned as a sponge for miR-101-3p, modulating MMP1 expression and thereby controlling NSCLC development and metastasis. The role of circ_0001859/miR-101-3p/MMP1 axis was validated in xenograft tumor models in vivo . Conclusions Our research findings demonstrated that circ_0001859 engaged in regulating NSCLC growth and metastasis via the miR-101-3p/MMP1 pathway. These studies presented the first investigation into the precise function and putative regulatory mechanism of circ_0001859 in NSCLC, providing valuable insights towards prognostic indicators and therapeutic targets for malignant tumors.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fonc.2025.1568367
- https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1568367/pdf
- OA Status
- gold
- References
- 51
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4411916615
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4411916615Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3389/fonc.2025.1568367Digital Object Identifier
- Title
-
Hsa_circ_0001859 promotes NSCLC progression through the miRNA-101-3p/MMP1 axisWork title
- Type
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articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-07-01Full publication date if available
- Authors
-
Jianxin Tan, Fan Zhou, Rongguo Lu, Shugao YeList of authors in order
- Landing page
-
https://doi.org/10.3389/fonc.2025.1568367Publisher landing page
- PDF URL
-
https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1568367/pdfDirect link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1568367/pdfDirect OA link when available
- Concepts
-
MMP1, Gene silencing, microRNA, Cancer research, Metastasis, Lung cancer, Cell growth, Messenger RNA, In vivo, Biology, Small hairpin RNA, Molecular biology, RNA, Medicine, Cancer, Oncology, Gene expression, Internal medicine, Gene, Biotechnology, Genetics, BiochemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
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51Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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