HSF1Base: A Comprehensive Database of HSF1 (Heat Shock Factor 1) Target Genes Article Swipe
Dániel Kovács
,
Tímea Sigmond
,
Bernadette Hotzi
,
Balázs Bohár
,
Dávid Fazekas
,
Veronika Deák
,
Tibor Vellai
,
János Barna
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3390/ijms20225815
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3390/ijms20225815
HSF1 (heat shock factor 1) is an evolutionarily conserved master transcriptional regulator of the heat shock response (HSR) in eukaryotic cells. In response to high temperatures, HSF1 upregulates genes encoding molecular chaperones, also called heat shock proteins, which assist the refolding or degradation of damaged intracellular proteins. Accumulating evidence reveals however that HSF1 participates in several other physiological and pathological processes such as differentiation, immune response, and multidrug resistance, as well as in ageing, neurodegenerative demise, and cancer. To address how HSF1 controls these processes one should systematically analyze its target genes. Here we present a novel database called HSF1Base (hsf1base.org) that contains a nearly comprehensive list of HSF1 target genes identified so far. The list was obtained by manually curating publications on individual HSF1 targets and analyzing relevant high throughput transcriptomic and chromatin immunoprecipitation data derived from the literature and the Yeastract database. To support the biological relevance of HSF1 targets identified by high throughput methods, we performed an enrichment analysis of (potential) HSF1 targets across different tissues/cell types and organisms. We found that general HSF1 functions (targets are expressed in all tissues/cell types) are mostly related to cellular proteostasis. Furthermore, HSF1 targets that are conserved across various animal taxa operate mostly in cellular stress pathways (e.g., autophagy), chromatin remodeling, ribosome biogenesis, and ageing. Together, these data highlight diverse roles for HSF1, expanding far beyond the HSR.
Related Topics
Concepts
HSF1
Proteostasis
Biology
Heat shock
Heat shock factor
Ribosome biogenesis
Chromatin immunoprecipitation
Transcriptome
Genetics
Gene
Cell biology
Heat shock protein
Computational biology
Gene expression
Promoter
Hsp70
Ribosome
RNA
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3390/ijms20225815
- https://www.mdpi.com/1422-0067/20/22/5815/pdf?version=1574249998
- OA Status
- gold
- Cited By
- 86
- References
- 91
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2990611031
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2990611031Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3390/ijms20225815Digital Object Identifier
- Title
-
HSF1Base: A Comprehensive Database of HSF1 (Heat Shock Factor 1) Target GenesWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2019Year of publication
- Publication date
-
2019-11-19Full publication date if available
- Authors
-
Dániel Kovács, Tímea Sigmond, Bernadette Hotzi, Balázs Bohár, Dávid Fazekas, Veronika Deák, Tibor Vellai, János BarnaList of authors in order
- Landing page
-
https://doi.org/10.3390/ijms20225815Publisher landing page
- PDF URL
-
https://www.mdpi.com/1422-0067/20/22/5815/pdf?version=1574249998Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/1422-0067/20/22/5815/pdf?version=1574249998Direct OA link when available
- Concepts
-
HSF1, Proteostasis, Biology, Heat shock, Heat shock factor, Ribosome biogenesis, Chromatin immunoprecipitation, Transcriptome, Genetics, Gene, Cell biology, Heat shock protein, Computational biology, Gene expression, Promoter, Hsp70, Ribosome, RNATop concepts (fields/topics) attached by OpenAlex
- Cited by
-
86Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 11, 2024: 13, 2023: 11, 2022: 23, 2021: 19Per-year citation counts (last 5 years)
- References (count)
-
91Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.from | 137 |
| abstract_inverted_index.heat | 14, 34 |
| abstract_inverted_index.high | 24, 129, 154 |
| abstract_inverted_index.list | 106, 115 |
| abstract_inverted_index.such | 61 |
| abstract_inverted_index.taxa | 200 |
| abstract_inverted_index.that | 51, 101, 174, 194 |
| abstract_inverted_index.well | 70 |
| abstract_inverted_index.(HSR) | 17 |
| abstract_inverted_index.(heat | 1 |
| abstract_inverted_index.HSF1, | 222 |
| abstract_inverted_index.found | 173 |
| abstract_inverted_index.genes | 28, 110 |
| abstract_inverted_index.novel | 96 |
| abstract_inverted_index.other | 56 |
| abstract_inverted_index.roles | 220 |
| abstract_inverted_index.shock | 2, 15, 35 |
| abstract_inverted_index.these | 83, 216 |
| abstract_inverted_index.types | 169 |
| abstract_inverted_index.which | 37 |
| abstract_inverted_index.(e.g., | 207 |
| abstract_inverted_index.across | 166, 197 |
| abstract_inverted_index.animal | 199 |
| abstract_inverted_index.assist | 38 |
| abstract_inverted_index.beyond | 225 |
| abstract_inverted_index.called | 33, 98 |
| abstract_inverted_index.cells. | 20 |
| abstract_inverted_index.factor | 3 |
| abstract_inverted_index.genes. | 91 |
| abstract_inverted_index.immune | 64 |
| abstract_inverted_index.master | 9 |
| abstract_inverted_index.mostly | 186, 202 |
| abstract_inverted_index.nearly | 104 |
| abstract_inverted_index.should | 86 |
| abstract_inverted_index.stress | 205 |
| abstract_inverted_index.target | 90, 109 |
| abstract_inverted_index.types) | 184 |
| abstract_inverted_index.address | 79 |
| abstract_inverted_index.ageing, | 73 |
| abstract_inverted_index.ageing. | 214 |
| abstract_inverted_index.analyze | 88 |
| abstract_inverted_index.cancer. | 77 |
| abstract_inverted_index.damaged | 44 |
| abstract_inverted_index.demise, | 75 |
| abstract_inverted_index.derived | 136 |
| abstract_inverted_index.diverse | 219 |
| abstract_inverted_index.general | 175 |
| abstract_inverted_index.however | 50 |
| abstract_inverted_index.operate | 201 |
| abstract_inverted_index.present | 94 |
| abstract_inverted_index.related | 187 |
| abstract_inverted_index.reveals | 49 |
| abstract_inverted_index.several | 55 |
| abstract_inverted_index.support | 145 |
| abstract_inverted_index.targets | 125, 151, 165, 193 |
| abstract_inverted_index.various | 198 |
| abstract_inverted_index.(targets | 178 |
| abstract_inverted_index.HSF1Base | 99 |
| abstract_inverted_index.analysis | 161 |
| abstract_inverted_index.cellular | 189, 204 |
| abstract_inverted_index.contains | 102 |
| abstract_inverted_index.controls | 82 |
| abstract_inverted_index.curating | 120 |
| abstract_inverted_index.database | 97 |
| abstract_inverted_index.encoding | 29 |
| abstract_inverted_index.evidence | 48 |
| abstract_inverted_index.manually | 119 |
| abstract_inverted_index.methods, | 156 |
| abstract_inverted_index.obtained | 117 |
| abstract_inverted_index.pathways | 206 |
| abstract_inverted_index.relevant | 128 |
| abstract_inverted_index.response | 16, 22 |
| abstract_inverted_index.ribosome | 211 |
| abstract_inverted_index.Together, | 215 |
| abstract_inverted_index.Yeastract | 142 |
| abstract_inverted_index.analyzing | 127 |
| abstract_inverted_index.chromatin | 133, 209 |
| abstract_inverted_index.conserved | 8, 196 |
| abstract_inverted_index.database. | 143 |
| abstract_inverted_index.different | 167 |
| abstract_inverted_index.expanding | 223 |
| abstract_inverted_index.expressed | 180 |
| abstract_inverted_index.functions | 177 |
| abstract_inverted_index.highlight | 218 |
| abstract_inverted_index.molecular | 30 |
| abstract_inverted_index.multidrug | 67 |
| abstract_inverted_index.performed | 158 |
| abstract_inverted_index.processes | 60, 84 |
| abstract_inverted_index.proteins, | 36 |
| abstract_inverted_index.proteins. | 46 |
| abstract_inverted_index.refolding | 40 |
| abstract_inverted_index.regulator | 11 |
| abstract_inverted_index.relevance | 148 |
| abstract_inverted_index.response, | 65 |
| abstract_inverted_index.biological | 147 |
| abstract_inverted_index.enrichment | 160 |
| abstract_inverted_index.eukaryotic | 19 |
| abstract_inverted_index.identified | 111, 152 |
| abstract_inverted_index.individual | 123 |
| abstract_inverted_index.literature | 139 |
| abstract_inverted_index.organisms. | 171 |
| abstract_inverted_index.throughput | 130, 155 |
| abstract_inverted_index.(potential) | 163 |
| abstract_inverted_index.autophagy), | 208 |
| abstract_inverted_index.biogenesis, | 212 |
| abstract_inverted_index.chaperones, | 31 |
| abstract_inverted_index.degradation | 42 |
| abstract_inverted_index.remodeling, | 210 |
| abstract_inverted_index.resistance, | 68 |
| abstract_inverted_index.upregulates | 27 |
| abstract_inverted_index.Accumulating | 47 |
| abstract_inverted_index.Furthermore, | 191 |
| abstract_inverted_index.participates | 53 |
| abstract_inverted_index.pathological | 59 |
| abstract_inverted_index.publications | 121 |
| abstract_inverted_index.tissues/cell | 168, 183 |
| abstract_inverted_index.comprehensive | 105 |
| abstract_inverted_index.intracellular | 45 |
| abstract_inverted_index.physiological | 57 |
| abstract_inverted_index.proteostasis. | 190 |
| abstract_inverted_index.temperatures, | 25 |
| abstract_inverted_index.(hsf1base.org) | 100 |
| abstract_inverted_index.evolutionarily | 7 |
| abstract_inverted_index.systematically | 87 |
| abstract_inverted_index.transcriptomic | 131 |
| abstract_inverted_index.transcriptional | 10 |
| abstract_inverted_index.differentiation, | 63 |
| abstract_inverted_index.neurodegenerative | 74 |
| abstract_inverted_index.immunoprecipitation | 134 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 99 |
| corresponding_author_ids | https://openalex.org/A5059648584, https://openalex.org/A5029503476 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 8 |
| corresponding_institution_ids | https://openalex.org/I106118109 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.47999998927116394 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.95703562 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |