Huangbai liniment and berberine promoted wound healing in high-fat diet/Streptozotocin-induced diabetic rats Article Swipe
Jingjing Zhang
,
Rui Zhou
,
Lijuan Deng
,
Guangzhao Cao
,
Yi Zhang
,
He Xu
,
Jingyi Hou
,
Shang Ju
,
Hongjun Yang
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.biopha.2022.112948
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1016/j.biopha.2022.112948
Diabetic ulcer is a challenging complication of diabetes mellitus but current treatments cannot achieve satisfactory results. In this study, the effect of Huangbai liniment (HB) and berberine on the wound healing in high fat diet/streptozotocin injection induced diabetic rats was investigated by RNA-seq technology. HB topical treatment promoted wound healing in the diabetic patients and diabetic rats, and it affected multiple processes, of which IL-17 signalling pathway was of importance. Inhibiting IL-17a by its inhibitor or antibody remarkably facilitated wound healing and HB significantly repressed the high IL-17 expression and its downstream targets, including Cxcl1, Ccl2, Mmp3, Mmp9, G-CSF, IL1B and IL6, in diabetic wounds, promoted T-AOC, SOD activity and GSH levels; decreased the levels of nitrotyrosine and 8-OHdG; enhanced angiogenesis-related CD31, PDGF-BB and ANG1 expression; inhibited cleaved caspase-3 levels and promoted TIMP1 and TGFB1. Moreover, berberine (a major component in HB) repressed the IL-17 signalling pathway, and promoted wound healing in diabetes mellitus. This study highlights the strategy of targeting IL-17a in diabetic wounds, deepens the understanding of wound healing in diabetes mellitus in a dynamic way and reveals the characteristics of HB and berberine in promoting wound healing of type 2 diabetes mellitus.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1016/j.biopha.2022.112948
- OA Status
- gold
- Cited By
- 36
- References
- 40
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4224145605
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4224145605Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1016/j.biopha.2022.112948Digital Object Identifier
- Title
-
Huangbai liniment and berberine promoted wound healing in high-fat diet/Streptozotocin-induced diabetic ratsWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-04-13Full publication date if available
- Authors
-
Jingjing Zhang, Rui Zhou, Lijuan Deng, Guangzhao Cao, Yi Zhang, He Xu, Jingyi Hou, Shang Ju, Hongjun YangList of authors in order
- Landing page
-
https://doi.org/10.1016/j.biopha.2022.112948Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://doi.org/10.1016/j.biopha.2022.112948Direct OA link when available
- Concepts
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Berberine, Wound healing, Diabetes mellitus, Medicine, Streptozotocin, Pharmacology, Angiogenesis, Glibenclamide, MMP3, MMP9, Internal medicine, Endocrinology, Downregulation and upregulation, Chemistry, Surgery, Biochemistry, Gene expression, GeneTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
36Total citation count in OpenAlex
- Citations by year (recent)
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2025: 13, 2024: 15, 2023: 6, 2022: 2Per-year citation counts (last 5 years)
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40Number of works referenced by this work
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10Other works algorithmically related by OpenAlex
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