Human 3β‐hydroxysteroid dehydrogenase type 1 in human breast cancer: clinical significance and prognostic associations Article Swipe
Toru Hanamura
,
Tokiko Ito
,
Toshiharu Kanai
,
Kazuma Maeno
,
Yasuyo Shimojo
,
Takeshi Uehara
,
Takashi Suzuki
,
Shinichi Hayashi
,
Kenichi Ito
·
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1002/cam4.708
YOU?
·
· 2016
· Open Access
·
· DOI: https://doi.org/10.1002/cam4.708
Active sex steroids including estrogens and androgens are locally produced from circulating inactive steroids by various steroid‐metabolizing enzymes, and play pivotal roles in the progression of hormone‐dependent breast cancers. Human 3 β ‐hydroxysteroid dehydrogenase type 1 (3 β ‐ HSD type 1) is a critical enzyme in the formation of all classes of active steroid hormones, and is also involved in the inactivation of potent androgen dihydrotestosterone ( DHT ). Therefore, this enzyme is suggested to modulate active sex steroid production or inactivation, with a role in hormone‐dependent breast cancer. The purpose of this study was to investigate the clinical significance of 3 β ‐ HSD type 1 in human breast cancer. Using immunohistochemistry ( IHC ), we evaluated 3 β ‐ HSD type 1 expression in 161 human breast cancers and analyzed correlations of 3 β ‐ HSD type 1 expression with various clinicopathological factors. Of 161 breast cancer cases, 3 β ‐ HSD type 1 expression in cancer cells was detected in 119 cases (73.9%), and was positively correlated with estrogen receptor (ER)‐positivity but not HER ‐2 status. In ER ‐positive cases ( n = 130), 3 β ‐ HSD type 1 expression was inversely correlated with invasive tumor size ( P = 0.0009), presence of invasive region ( P = 0.0107), and lymphatic involvement ( P = 0.0004). 3 β ‐ HSD type 1 expression was significantly associated with decreased risk of recurrence or improved prognosis by both univariate ( P = 0.0003 and P = 0.009, respectively) and multivariate ( P = 0.027 and P = 0.023, respectively) analyses. Our findings indicate that this enzyme is a prognostic factor in hormone‐dependent breast cancer.
Related Topics
Concepts
Breast cancer
Internal medicine
Endocrinology
Dihydrotestosterone
Immunohistochemistry
Hormone
Cancer
Estrogen receptor
Androgen
Estrogen
Testosterone (patch)
Androgen receptor
Steroid hormone
Biology
Cancer research
Medicine
Prostate cancer
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/cam4.708
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.708
- OA Status
- gold
- Cited By
- 10
- References
- 48
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2346819844
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2346819844Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/cam4.708Digital Object Identifier
- Title
-
Human 3β‐hydroxysteroid dehydrogenase type 1 in human breast cancer: clinical significance and prognostic associationsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2016Year of publication
- Publication date
-
2016-05-03Full publication date if available
- Authors
-
Toru Hanamura, Tokiko Ito, Toshiharu Kanai, Kazuma Maeno, Yasuyo Shimojo, Takeshi Uehara, Takashi Suzuki, Shinichi Hayashi, Kenichi ItoList of authors in order
- Landing page
-
https://doi.org/10.1002/cam4.708Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.708Direct link to full text PDF
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/cam4.708Direct OA link when available
- Concepts
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Breast cancer, Internal medicine, Endocrinology, Dihydrotestosterone, Immunohistochemistry, Hormone, Cancer, Estrogen receptor, Androgen, Estrogen, Testosterone (patch), Androgen receptor, Steroid hormone, Biology, Cancer research, Medicine, Prostate cancerTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
10Total citation count in OpenAlex
- Citations by year (recent)
-
2022: 3, 2021: 1, 2020: 2, 2019: 2, 2017: 2Per-year citation counts (last 5 years)
- References (count)
-
48Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.that | 267 |
| abstract_inverted_index.this | 72, 94, 268 |
| abstract_inverted_index.type | 35, 41, 107, 124, 140, 156, 193, 226 |
| abstract_inverted_index.with | 84, 143, 172, 199, 232 |
| abstract_inverted_index.‐2 | 179 |
| abstract_inverted_index.0.027 | 257 |
| abstract_inverted_index.130), | 188 |
| abstract_inverted_index.Human | 30 |
| abstract_inverted_index.Using | 113 |
| abstract_inverted_index.cases | 166, 184 |
| abstract_inverted_index.cells | 161 |
| abstract_inverted_index.human | 110, 129 |
| abstract_inverted_index.roles | 22 |
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| abstract_inverted_index.tumor | 201 |
| abstract_inverted_index.0.0003 | 246 |
| abstract_inverted_index.0.009, | 250 |
| abstract_inverted_index.0.023, | 261 |
| abstract_inverted_index.Active | 1 |
| abstract_inverted_index.active | 54, 78 |
| abstract_inverted_index.breast | 28, 89, 111, 130, 149, 276 |
| abstract_inverted_index.cancer | 150, 160 |
| abstract_inverted_index.cases, | 151 |
| abstract_inverted_index.enzyme | 46, 73, 269 |
| abstract_inverted_index.factor | 273 |
| abstract_inverted_index.potent | 65 |
| abstract_inverted_index.region | 210 |
| abstract_inverted_index.cancer. | 90, 112, 277 |
| abstract_inverted_index.cancers | 131 |
| abstract_inverted_index.classes | 52 |
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| abstract_inverted_index.pivotal | 21 |
| abstract_inverted_index.purpose | 92 |
| abstract_inverted_index.status. | 180 |
| abstract_inverted_index.steroid | 55, 80 |
| abstract_inverted_index.various | 16, 144 |
| abstract_inverted_index.(73.9%), | 167 |
| abstract_inverted_index.0.0004). | 221 |
| abstract_inverted_index.0.0009), | 206 |
| abstract_inverted_index.0.0107), | 214 |
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| abstract_inverted_index.cancers. | 29 |
| abstract_inverted_index.clinical | 100 |
| abstract_inverted_index.critical | 45 |
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| abstract_inverted_index.estrogen | 173 |
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| abstract_inverted_index.findings | 265 |
| abstract_inverted_index.improved | 238 |
| abstract_inverted_index.inactive | 13 |
| abstract_inverted_index.indicate | 266 |
| abstract_inverted_index.invasive | 200, 209 |
| abstract_inverted_index.involved | 60 |
| abstract_inverted_index.modulate | 77 |
| abstract_inverted_index.presence | 207 |
| abstract_inverted_index.produced | 10 |
| abstract_inverted_index.receptor | 174 |
| abstract_inverted_index.steroids | 3, 14 |
| abstract_inverted_index.analyses. | 263 |
| abstract_inverted_index.androgens | 7 |
| abstract_inverted_index.decreased | 233 |
| abstract_inverted_index.estrogens | 5 |
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| abstract_inverted_index.hormones, | 56 |
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| abstract_inverted_index.inversely | 197 |
| abstract_inverted_index.lymphatic | 216 |
| abstract_inverted_index.prognosis | 239 |
| abstract_inverted_index.suggested | 75 |
| abstract_inverted_index.Therefore, | 71 |
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| abstract_inverted_index.correlated | 171, 198 |
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| abstract_inverted_index.positively | 170 |
| abstract_inverted_index.production | 81 |
| abstract_inverted_index.prognostic | 272 |
| abstract_inverted_index.recurrence | 236 |
| abstract_inverted_index.univariate | 242 |
| abstract_inverted_index.circulating | 12 |
| abstract_inverted_index.investigate | 98 |
| abstract_inverted_index.involvement | 217 |
| abstract_inverted_index.progression | 25 |
| abstract_inverted_index.‐positive | 183 |
| abstract_inverted_index.correlations | 134 |
| abstract_inverted_index.inactivation | 63 |
| abstract_inverted_index.multivariate | 253 |
| abstract_inverted_index.significance | 101 |
| abstract_inverted_index.dehydrogenase | 34 |
| abstract_inverted_index.inactivation, | 83 |
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| abstract_inverted_index.significantly | 230 |
| abstract_inverted_index.(ER)‐positivity | 175 |
| abstract_inverted_index.‐hydroxysteroid | 33 |
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| abstract_inverted_index.dihydrotestosterone | 67 |
| abstract_inverted_index.hormone‐dependent | 27, 88, 275 |
| abstract_inverted_index.immunohistochemistry | 114 |
| abstract_inverted_index.steroid‐metabolizing | 17 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5070119292 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 9 |
| corresponding_institution_ids | https://openalex.org/I137975476 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.8500000238418579 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.83988003 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |