Human antigen R promotes lung fibroblast differentiation to myofibroblasts and increases extracellular matrix production Article Swipe
Fatmah Al‐Habeeb
,
Noof Aloufi
,
Hussein Traboulsi
,
Xingxing Liu
,
Parameswaran Nair
,
Christina K. Haston
,
Ilan Azuelos
,
Steven K. Huang
,
Eric S. White
,
Imed‐Eddine Gallouzi
,
Sergio Di Marco
,
David H. Eidelman
,
Carolyn J. Baglole
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1002/jcp.30380
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1002/jcp.30380
Idiopathic pulmonary fibrosis (IPF) is a disease of progressive scarring caused by excessive extracellular matrix (ECM) deposition and activation of α‐SMA‐expressing myofibroblasts. Human antigen R (HuR) is an RNA binding protein that promotes protein translation. Upon translocation from the nucleus to the cytoplasm, HuR functions to stabilize messenger RNA (mRNA) to increase protein levels. However, the role of HuR in promoting ECM production, myofibroblast differentiation, and lung fibrosis is unknown. Human lung fibroblasts (HLFs) treated with transforming growth factor β1 (TGF‐β1) showed a significant increase in translocation of HuR from the nucleus to the cytoplasm. TGF‐β‐treated HLFs that were transfected with HuR small interfering RNA had a significant reduction in α‐SMA protein as well as the ECM proteins COL1A1, COL3A, and FN1. HuR was also bound to mRNA for ACTA2, COL1A1, COL3A1 , and FN . HuR knockdown affected the mRNA stability of ACTA2 but not that of the ECM genes COL1A1, COL3A1 , or FN . In mouse models of pulmonary fibrosis, there was higher cytoplasmic HuR in lung structural cells compared to control mice. In human IPF lungs, there was also more cytoplasmic HuR. This study is the first to show that HuR in lung fibroblasts controls their differentiation to myofibroblasts and consequent ECM production. Further research on HuR could assist in establishing the basis for the development of new target therapy for fibrotic diseases, such as IPF.
Related Topics
Concepts
Myofibroblast
Extracellular matrix
Gene knockdown
Pulmonary fibrosis
RNA-binding protein
Idiopathic pulmonary fibrosis
Cytoplasm
Fibroblast
Messenger RNA
Cell biology
Biology
RNA splicing
Fibrosis
Transforming growth factor
Molecular biology
RNA
Cancer research
Lung
Pathology
Cell culture
Medicine
Gene
Internal medicine
Biochemistry
Genetics
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/jcp.30380
- OA Status
- green
- Cited By
- 24
- References
- 59
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W3153569053
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W3153569053Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1002/jcp.30380Digital Object Identifier
- Title
-
Human antigen R promotes lung fibroblast differentiation to myofibroblasts and increases extracellular matrix productionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-04-14Full publication date if available
- Authors
-
Fatmah Al‐Habeeb, Noof Aloufi, Hussein Traboulsi, Xingxing Liu, Parameswaran Nair, Christina K. Haston, Ilan Azuelos, Steven K. Huang, Eric S. White, Imed‐Eddine Gallouzi, Sergio Di Marco, David H. Eidelman, Carolyn J. BagloleList of authors in order
- Landing page
-
https://doi.org/10.1002/jcp.30380Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.ncbi.nlm.nih.gov/pmc/articles/8390431Direct OA link when available
- Concepts
-
Myofibroblast, Extracellular matrix, Gene knockdown, Pulmonary fibrosis, RNA-binding protein, Idiopathic pulmonary fibrosis, Cytoplasm, Fibroblast, Messenger RNA, Cell biology, Biology, RNA splicing, Fibrosis, Transforming growth factor, Molecular biology, RNA, Cancer research, Lung, Pathology, Cell culture, Medicine, Gene, Internal medicine, Biochemistry, GeneticsTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
24Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 3, 2024: 4, 2023: 6, 2022: 9, 2021: 2Per-year citation counts (last 5 years)
- References (count)
-
59Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W3153569053 |
|---|---|
| doi | https://doi.org/10.1002/jcp.30380 |
| ids.doi | https://doi.org/10.1002/jcp.30380 |
| ids.mag | 3153569053 |
| ids.pmid | https://pubmed.ncbi.nlm.nih.gov/33855709 |
| ids.openalex | https://openalex.org/W3153569053 |
| fwci | 3.71433807 |
| mesh[0].qualifier_ui | Q000235 |
| mesh[0].descriptor_ui | D000199 |
| mesh[0].is_major_topic | False |
| mesh[0].qualifier_name | genetics |
| mesh[0].descriptor_name | Actins |
| mesh[1].qualifier_ui | Q000378 |
| mesh[1].descriptor_ui | D000199 |
| mesh[1].is_major_topic | False |
| mesh[1].qualifier_name | metabolism |
| mesh[1].descriptor_name | Actins |
| mesh[2].qualifier_ui | |
| mesh[2].descriptor_ui | D000818 |
| mesh[2].is_major_topic | False |
| mesh[2].qualifier_name | |
| mesh[2].descriptor_name | Animals |
| mesh[3].qualifier_ui | Q000187 |
| mesh[3].descriptor_ui | D054338 |
| mesh[3].is_major_topic | True |
| mesh[3].qualifier_name | drug effects |
| mesh[3].descriptor_name | Cell Transdifferentiation |
| mesh[4].qualifier_ui | |
| mesh[4].descriptor_ui | D002478 |
| mesh[4].is_major_topic | False |
| mesh[4].qualifier_name | |
| mesh[4].descriptor_name | Cells, Cultured |
| mesh[5].qualifier_ui | |
| mesh[5].descriptor_ui | D004195 |
| mesh[5].is_major_topic | False |
| mesh[5].qualifier_name | |
| mesh[5].descriptor_name | Disease Models, Animal |
| mesh[6].qualifier_ui | Q000235 |
| mesh[6].descriptor_ui | D000067780 |
| mesh[6].is_major_topic | False |
| mesh[6].qualifier_name | genetics |
| mesh[6].descriptor_name | ELAV-Like Protein 1 |
| mesh[7].qualifier_ui | Q000378 |
| mesh[7].descriptor_ui | D000067780 |
| mesh[7].is_major_topic | False |
| mesh[7].qualifier_name | metabolism |
| mesh[7].descriptor_name | ELAV-Like Protein 1 |
| mesh[8].qualifier_ui | Q000187 |
| mesh[8].descriptor_ui | D005109 |
| mesh[8].is_major_topic | False |
| mesh[8].qualifier_name | drug effects |
| mesh[8].descriptor_name | Extracellular Matrix |
| mesh[9].qualifier_ui | Q000378 |
| mesh[9].descriptor_ui | D005109 |
| mesh[9].is_major_topic | False |
| mesh[9].qualifier_name | metabolism |
| mesh[9].descriptor_name | Extracellular Matrix |
| mesh[10].qualifier_ui | Q000473 |
| mesh[10].descriptor_ui | D005109 |
| mesh[10].is_major_topic | False |
| mesh[10].qualifier_name | pathology |
| mesh[10].descriptor_name | Extracellular Matrix |
| mesh[11].qualifier_ui | Q000235 |
| mesh[11].descriptor_ui | D016326 |
| mesh[11].is_major_topic | False |
| mesh[11].qualifier_name | genetics |
| mesh[11].descriptor_name | Extracellular Matrix Proteins |
| mesh[12].qualifier_ui | Q000378 |
| mesh[12].descriptor_ui | D016326 |
| mesh[12].is_major_topic | False |
| mesh[12].qualifier_name | metabolism |
| mesh[12].descriptor_name | Extracellular Matrix Proteins |
| mesh[13].qualifier_ui | Q000187 |
| mesh[13].descriptor_ui | D005347 |
| mesh[13].is_major_topic | False |
| mesh[13].qualifier_name | drug effects |
| mesh[13].descriptor_name | Fibroblasts |
| mesh[14].qualifier_ui | Q000378 |
| mesh[14].descriptor_ui | D005347 |
| mesh[14].is_major_topic | False |
| mesh[14].qualifier_name | metabolism |
| mesh[14].descriptor_name | Fibroblasts |
| mesh[15].qualifier_ui | Q000473 |
| mesh[15].descriptor_ui | D005347 |
| mesh[15].is_major_topic | False |
| mesh[15].qualifier_name | pathology |
| mesh[15].descriptor_name | Fibroblasts |
| mesh[16].qualifier_ui | |
| mesh[16].descriptor_ui | D005786 |
| mesh[16].is_major_topic | False |
| mesh[16].qualifier_name | |
| mesh[16].descriptor_name | Gene Expression Regulation |
| mesh[17].qualifier_ui | |
| mesh[17].descriptor_ui | D006801 |
| mesh[17].is_major_topic | False |
| mesh[17].qualifier_name | |
| mesh[17].descriptor_name | Humans |
| mesh[18].qualifier_ui | Q000235 |
| mesh[18].descriptor_ui | D054990 |
| mesh[18].is_major_topic | False |
| mesh[18].qualifier_name | genetics |
| mesh[18].descriptor_name | Idiopathic Pulmonary Fibrosis |
| mesh[19].qualifier_ui | Q000378 |
| mesh[19].descriptor_ui | D054990 |
| mesh[19].is_major_topic | False |
| mesh[19].qualifier_name | metabolism |
| mesh[19].descriptor_name | Idiopathic Pulmonary Fibrosis |
| mesh[20].qualifier_ui | Q000473 |
| mesh[20].descriptor_ui | D054990 |
| mesh[20].is_major_topic | False |
| mesh[20].qualifier_name | pathology |
| mesh[20].descriptor_name | Idiopathic Pulmonary Fibrosis |
| mesh[21].qualifier_ui | Q000187 |
| mesh[21].descriptor_ui | D008168 |
| mesh[21].is_major_topic | False |
| mesh[21].qualifier_name | drug effects |
| mesh[21].descriptor_name | Lung |
| mesh[22].qualifier_ui | Q000378 |
| mesh[22].descriptor_ui | D008168 |
| mesh[22].is_major_topic | False |
| mesh[22].qualifier_name | metabolism |
| mesh[22].descriptor_name | Lung |
| mesh[23].qualifier_ui | Q000473 |
| mesh[23].descriptor_ui | D008168 |
| mesh[23].is_major_topic | False |
| mesh[23].qualifier_name | pathology |
| mesh[23].descriptor_name | Lung |
| mesh[24].qualifier_ui | |
| mesh[24].descriptor_ui | D051379 |
| mesh[24].is_major_topic | False |
| mesh[24].qualifier_name | |
| mesh[24].descriptor_name | Mice |
| mesh[25].qualifier_ui | Q000378 |
| mesh[25].descriptor_ui | D058628 |
| mesh[25].is_major_topic | False |
| mesh[25].qualifier_name | metabolism |
| mesh[25].descriptor_name | Myofibroblasts |
| mesh[26].qualifier_ui | Q000473 |
| mesh[26].descriptor_ui | D058628 |
| mesh[26].is_major_topic | False |
| mesh[26].qualifier_name | pathology |
| mesh[26].descriptor_name | Myofibroblasts |
| mesh[27].qualifier_ui | Q000494 |
| mesh[27].descriptor_ui | D053773 |
| mesh[27].is_major_topic | False |
| mesh[27].qualifier_name | pharmacology |
| mesh[27].descriptor_name | Transforming Growth Factor beta1 |
| mesh[28].qualifier_ui | Q000235 |
| mesh[28].descriptor_ui | D000199 |
| mesh[28].is_major_topic | False |
| mesh[28].qualifier_name | genetics |
| mesh[28].descriptor_name | Actins |
| mesh[29].qualifier_ui | Q000378 |
| mesh[29].descriptor_ui | D000199 |
| mesh[29].is_major_topic | False |
| mesh[29].qualifier_name | metabolism |
| mesh[29].descriptor_name | Actins |
| mesh[30].qualifier_ui | |
| mesh[30].descriptor_ui | D000818 |
| mesh[30].is_major_topic | False |
| mesh[30].qualifier_name | |
| mesh[30].descriptor_name | Animals |
| mesh[31].qualifier_ui | Q000187 |
| mesh[31].descriptor_ui | D054338 |
| mesh[31].is_major_topic | True |
| mesh[31].qualifier_name | drug effects |
| mesh[31].descriptor_name | Cell Transdifferentiation |
| mesh[32].qualifier_ui | |
| mesh[32].descriptor_ui | D002478 |
| mesh[32].is_major_topic | False |
| mesh[32].qualifier_name | |
| mesh[32].descriptor_name | Cells, Cultured |
| mesh[33].qualifier_ui | |
| mesh[33].descriptor_ui | D004195 |
| mesh[33].is_major_topic | False |
| mesh[33].qualifier_name | |
| mesh[33].descriptor_name | Disease Models, Animal |
| mesh[34].qualifier_ui | Q000235 |
| mesh[34].descriptor_ui | D000067780 |
| mesh[34].is_major_topic | False |
| mesh[34].qualifier_name | genetics |
| mesh[34].descriptor_name | ELAV-Like Protein 1 |
| mesh[35].qualifier_ui | Q000378 |
| mesh[35].descriptor_ui | D000067780 |
| mesh[35].is_major_topic | False |
| mesh[35].qualifier_name | metabolism |
| mesh[35].descriptor_name | ELAV-Like Protein 1 |
| mesh[36].qualifier_ui | Q000187 |
| mesh[36].descriptor_ui | D005109 |
| mesh[36].is_major_topic | False |
| mesh[36].qualifier_name | drug effects |
| mesh[36].descriptor_name | Extracellular Matrix |
| mesh[37].qualifier_ui | Q000378 |
| mesh[37].descriptor_ui | D005109 |
| mesh[37].is_major_topic | False |
| mesh[37].qualifier_name | metabolism |
| mesh[37].descriptor_name | Extracellular Matrix |
| mesh[38].qualifier_ui | Q000473 |
| mesh[38].descriptor_ui | D005109 |
| mesh[38].is_major_topic | False |
| mesh[38].qualifier_name | pathology |
| mesh[38].descriptor_name | Extracellular Matrix |
| mesh[39].qualifier_ui | Q000235 |
| mesh[39].descriptor_ui | D016326 |
| mesh[39].is_major_topic | False |
| mesh[39].qualifier_name | genetics |
| mesh[39].descriptor_name | Extracellular Matrix Proteins |
| mesh[40].qualifier_ui | Q000378 |
| mesh[40].descriptor_ui | D016326 |
| mesh[40].is_major_topic | False |
| mesh[40].qualifier_name | metabolism |
| mesh[40].descriptor_name | Extracellular Matrix Proteins |
| mesh[41].qualifier_ui | Q000187 |
| mesh[41].descriptor_ui | D005347 |
| mesh[41].is_major_topic | False |
| mesh[41].qualifier_name | drug effects |
| mesh[41].descriptor_name | Fibroblasts |
| mesh[42].qualifier_ui | Q000378 |
| mesh[42].descriptor_ui | D005347 |
| mesh[42].is_major_topic | False |
| mesh[42].qualifier_name | metabolism |
| mesh[42].descriptor_name | Fibroblasts |
| mesh[43].qualifier_ui | Q000473 |
| mesh[43].descriptor_ui | D005347 |
| mesh[43].is_major_topic | False |
| mesh[43].qualifier_name | pathology |
| mesh[43].descriptor_name | Fibroblasts |
| mesh[44].qualifier_ui | |
| mesh[44].descriptor_ui | D005786 |
| mesh[44].is_major_topic | False |
| mesh[44].qualifier_name | |
| mesh[44].descriptor_name | Gene Expression Regulation |
| mesh[45].qualifier_ui | |
| mesh[45].descriptor_ui | D006801 |
| mesh[45].is_major_topic | False |
| mesh[45].qualifier_name | |
| mesh[45].descriptor_name | Humans |
| mesh[46].qualifier_ui | Q000235 |
| mesh[46].descriptor_ui | D054990 |
| mesh[46].is_major_topic | False |
| mesh[46].qualifier_name | genetics |
| mesh[46].descriptor_name | Idiopathic Pulmonary Fibrosis |
| mesh[47].qualifier_ui | Q000378 |
| mesh[47].descriptor_ui | D054990 |
| mesh[47].is_major_topic | False |
| mesh[47].qualifier_name | metabolism |
| mesh[47].descriptor_name | Idiopathic Pulmonary Fibrosis |
| mesh[48].qualifier_ui | Q000473 |
| mesh[48].descriptor_ui | D054990 |
| mesh[48].is_major_topic | False |
| mesh[48].qualifier_name | pathology |
| mesh[48].descriptor_name | Idiopathic Pulmonary Fibrosis |
| mesh[49].qualifier_ui | Q000187 |
| mesh[49].descriptor_ui | D008168 |
| mesh[49].is_major_topic | False |
| mesh[49].qualifier_name | drug effects |
| mesh[49].descriptor_name | Lung |
| type | article |
| title | Human antigen R promotes lung fibroblast differentiation to myofibroblasts and increases extracellular matrix production |
| biblio.issue | 10 |
| biblio.volume | 236 |
| biblio.last_page | 6851 |
| biblio.first_page | 6836 |
| grants[0].funder | https://openalex.org/F4320306257 |
| grants[0].award_id | BUILD |
| grants[0].funder_display_name | Boehringer Ingelheim |
| grants[1].funder | https://openalex.org/F4320319952 |
| grants[1].award_id | |
| grants[1].funder_display_name | Canada Foundation for Innovation |
| grants[2].funder | https://openalex.org/F4320321161 |
| grants[2].award_id | |
| grants[2].funder_display_name | Taibah University |
| grants[3].funder | https://openalex.org/F4320334593 |
| grants[3].award_id | RGPIN‐2020‐04462 |
| grants[3].funder_display_name | Natural Sciences and Engineering Research Council of Canada |
| grants[4].funder | https://openalex.org/F4320337338 |
| grants[4].award_id | HL127203 |
| grants[4].funder_display_name | National Heart, Lung, and Blood Institute |
| grants[5].funder | https://openalex.org/F4320338063 |
| grants[5].award_id | PJT‐168836 |
| grants[5].funder_display_name | Institute of Circulatory and Respiratory Health |
| grants[6].funder | https://openalex.org/F4320338067 |
| grants[6].award_id | PJT‐162273 |
| grants[6].funder_display_name | Institute of Infection and Immunity |
| topics[0].id | https://openalex.org/T10870 |
| topics[0].field.id | https://openalex.org/fields/27 |
| topics[0].field.display_name | Medicine |
| topics[0].score | 0.9998000264167786 |
| topics[0].domain.id | https://openalex.org/domains/4 |
| topics[0].domain.display_name | Health Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/2740 |
| topics[0].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[0].display_name | Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis |
| topics[1].id | https://openalex.org/T13759 |
| topics[1].field.id | https://openalex.org/fields/27 |
| topics[1].field.display_name | Medicine |
| topics[1].score | 0.9842000007629395 |
| topics[1].domain.id | https://openalex.org/domains/4 |
| topics[1].domain.display_name | Health Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/2740 |
| topics[1].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[1].display_name | Medical Imaging and Pathology Studies |
| topics[2].id | https://openalex.org/T10549 |
| topics[2].field.id | https://openalex.org/fields/27 |
| topics[2].field.display_name | Medicine |
| topics[2].score | 0.9532999992370605 |
| topics[2].domain.id | https://openalex.org/domains/4 |
| topics[2].domain.display_name | Health Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/2740 |
| topics[2].subfield.display_name | Pulmonary and Respiratory Medicine |
| topics[2].display_name | Neonatal Respiratory Health Research |
| funders[0].id | https://openalex.org/F4320306257 |
| funders[0].ror | https://ror.org/05kffp613 |
| funders[0].display_name | Boehringer Ingelheim |
| funders[1].id | https://openalex.org/F4320319952 |
| funders[1].ror | https://ror.org/000az4664 |
| funders[1].display_name | Canada Foundation for Innovation |
| funders[2].id | https://openalex.org/F4320321161 |
| funders[2].ror | https://ror.org/01xv1nn60 |
| funders[2].display_name | Taibah University |
| funders[3].id | https://openalex.org/F4320334593 |
| funders[3].ror | https://ror.org/01h531d29 |
| funders[3].display_name | Natural Sciences and Engineering Research Council of Canada |
| funders[4].id | https://openalex.org/F4320337338 |
| funders[4].ror | https://ror.org/012pb6c26 |
| funders[4].display_name | National Heart, Lung, and Blood Institute |
| funders[5].id | https://openalex.org/F4320338063 |
| funders[5].ror | https://ror.org/00bhv3b03 |
| funders[5].display_name | Institute of Circulatory and Respiratory Health |
| funders[6].id | https://openalex.org/F4320338067 |
| funders[6].ror | https://ror.org/05wdecy17 |
| funders[6].display_name | Institute of Infection and Immunity |
| is_xpac | False |
| apc_list.value | 4940 |
| apc_list.currency | USD |
| apc_list.value_usd | 4940 |
| apc_paid | |
| concepts[0].id | https://openalex.org/C207865475 |
| concepts[0].level | 3 |
| concepts[0].score | 0.7369396686553955 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q1467330 |
| concepts[0].display_name | Myofibroblast |
| concepts[1].id | https://openalex.org/C189165786 |
| concepts[1].level | 2 |
| concepts[1].score | 0.7259894609451294 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q193825 |
| concepts[1].display_name | Extracellular matrix |
| concepts[2].id | https://openalex.org/C173396325 |
| concepts[2].level | 3 |
| concepts[2].score | 0.6118022203445435 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q1501275 |
| concepts[2].display_name | Gene knockdown |
| concepts[3].id | https://openalex.org/C2781244666 |
| concepts[3].level | 3 |
| concepts[3].score | 0.5652865171432495 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q32446 |
| concepts[3].display_name | Pulmonary fibrosis |
| concepts[4].id | https://openalex.org/C41282012 |
| concepts[4].level | 4 |
| concepts[4].score | 0.5389659404754639 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q3928341 |
| concepts[4].display_name | RNA-binding protein |
| concepts[5].id | https://openalex.org/C2778341716 |
| concepts[5].level | 3 |
| concepts[5].score | 0.533094584941864 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q2290446 |
| concepts[5].display_name | Idiopathic pulmonary fibrosis |
| concepts[6].id | https://openalex.org/C190062978 |
| concepts[6].level | 2 |
| concepts[6].score | 0.5322715044021606 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q79899 |
| concepts[6].display_name | Cytoplasm |
| concepts[7].id | https://openalex.org/C2780381497 |
| concepts[7].level | 3 |
| concepts[7].score | 0.528602123260498 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q463418 |
| concepts[7].display_name | Fibroblast |
| concepts[8].id | https://openalex.org/C105580179 |
| concepts[8].level | 3 |
| concepts[8].score | 0.5120975971221924 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q188928 |
| concepts[8].display_name | Messenger RNA |
| concepts[9].id | https://openalex.org/C95444343 |
| concepts[9].level | 1 |
| concepts[9].score | 0.5085889101028442 |
| concepts[9].wikidata | https://www.wikidata.org/wiki/Q7141 |
| concepts[9].display_name | Cell biology |
| concepts[10].id | https://openalex.org/C86803240 |
| concepts[10].level | 0 |
| concepts[10].score | 0.4394959509372711 |
| concepts[10].wikidata | https://www.wikidata.org/wiki/Q420 |
| concepts[10].display_name | Biology |
| concepts[11].id | https://openalex.org/C54458228 |
| concepts[11].level | 4 |
| concepts[11].score | 0.4251742362976074 |
| concepts[11].wikidata | https://www.wikidata.org/wiki/Q237218 |
| concepts[11].display_name | RNA splicing |
| concepts[12].id | https://openalex.org/C2780559512 |
| concepts[12].level | 2 |
| concepts[12].score | 0.42374444007873535 |
| concepts[12].wikidata | https://www.wikidata.org/wiki/Q605709 |
| concepts[12].display_name | Fibrosis |
| concepts[13].id | https://openalex.org/C118131993 |
| concepts[13].level | 2 |
| concepts[13].score | 0.4188094735145569 |
| concepts[13].wikidata | https://www.wikidata.org/wiki/Q423671 |
| concepts[13].display_name | Transforming growth factor |
| concepts[14].id | https://openalex.org/C153911025 |
| concepts[14].level | 1 |
| concepts[14].score | 0.3967127799987793 |
| concepts[14].wikidata | https://www.wikidata.org/wiki/Q7202 |
| concepts[14].display_name | Molecular biology |
| concepts[15].id | https://openalex.org/C67705224 |
| concepts[15].level | 3 |
| concepts[15].score | 0.3578747510910034 |
| concepts[15].wikidata | https://www.wikidata.org/wiki/Q11053 |
| concepts[15].display_name | RNA |
| concepts[16].id | https://openalex.org/C502942594 |
| concepts[16].level | 1 |
| concepts[16].score | 0.3335842192173004 |
| concepts[16].wikidata | https://www.wikidata.org/wiki/Q3421914 |
| concepts[16].display_name | Cancer research |
| concepts[17].id | https://openalex.org/C2777714996 |
| concepts[17].level | 2 |
| concepts[17].score | 0.25032442808151245 |
| concepts[17].wikidata | https://www.wikidata.org/wiki/Q7886 |
| concepts[17].display_name | Lung |
| concepts[18].id | https://openalex.org/C142724271 |
| concepts[18].level | 1 |
| concepts[18].score | 0.23083969950675964 |
| concepts[18].wikidata | https://www.wikidata.org/wiki/Q7208 |
| concepts[18].display_name | Pathology |
| concepts[19].id | https://openalex.org/C81885089 |
| concepts[19].level | 2 |
| concepts[19].score | 0.21505454182624817 |
| concepts[19].wikidata | https://www.wikidata.org/wiki/Q189082 |
| concepts[19].display_name | Cell culture |
| concepts[20].id | https://openalex.org/C71924100 |
| concepts[20].level | 0 |
| concepts[20].score | 0.16577675938606262 |
| concepts[20].wikidata | https://www.wikidata.org/wiki/Q11190 |
| concepts[20].display_name | Medicine |
| concepts[21].id | https://openalex.org/C104317684 |
| concepts[21].level | 2 |
| concepts[21].score | 0.11573508381843567 |
| concepts[21].wikidata | https://www.wikidata.org/wiki/Q7187 |
| concepts[21].display_name | Gene |
| concepts[22].id | https://openalex.org/C126322002 |
| concepts[22].level | 1 |
| concepts[22].score | 0.09078231453895569 |
| concepts[22].wikidata | https://www.wikidata.org/wiki/Q11180 |
| concepts[22].display_name | Internal medicine |
| concepts[23].id | https://openalex.org/C55493867 |
| concepts[23].level | 1 |
| concepts[23].score | 0.05221450328826904 |
| concepts[23].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[23].display_name | Biochemistry |
| concepts[24].id | https://openalex.org/C54355233 |
| concepts[24].level | 1 |
| concepts[24].score | 0.0 |
| concepts[24].wikidata | https://www.wikidata.org/wiki/Q7162 |
| concepts[24].display_name | Genetics |
| keywords[0].id | https://openalex.org/keywords/myofibroblast |
| keywords[0].score | 0.7369396686553955 |
| keywords[0].display_name | Myofibroblast |
| keywords[1].id | https://openalex.org/keywords/extracellular-matrix |
| keywords[1].score | 0.7259894609451294 |
| keywords[1].display_name | Extracellular matrix |
| keywords[2].id | https://openalex.org/keywords/gene-knockdown |
| keywords[2].score | 0.6118022203445435 |
| keywords[2].display_name | Gene knockdown |
| keywords[3].id | https://openalex.org/keywords/pulmonary-fibrosis |
| keywords[3].score | 0.5652865171432495 |
| keywords[3].display_name | Pulmonary fibrosis |
| keywords[4].id | https://openalex.org/keywords/rna-binding-protein |
| keywords[4].score | 0.5389659404754639 |
| keywords[4].display_name | RNA-binding protein |
| keywords[5].id | https://openalex.org/keywords/idiopathic-pulmonary-fibrosis |
| keywords[5].score | 0.533094584941864 |
| keywords[5].display_name | Idiopathic pulmonary fibrosis |
| keywords[6].id | https://openalex.org/keywords/cytoplasm |
| keywords[6].score | 0.5322715044021606 |
| keywords[6].display_name | Cytoplasm |
| keywords[7].id | https://openalex.org/keywords/fibroblast |
| keywords[7].score | 0.528602123260498 |
| keywords[7].display_name | Fibroblast |
| keywords[8].id | https://openalex.org/keywords/messenger-rna |
| keywords[8].score | 0.5120975971221924 |
| keywords[8].display_name | Messenger RNA |
| keywords[9].id | https://openalex.org/keywords/cell-biology |
| keywords[9].score | 0.5085889101028442 |
| keywords[9].display_name | Cell biology |
| keywords[10].id | https://openalex.org/keywords/biology |
| keywords[10].score | 0.4394959509372711 |
| keywords[10].display_name | Biology |
| keywords[11].id | https://openalex.org/keywords/rna-splicing |
| keywords[11].score | 0.4251742362976074 |
| keywords[11].display_name | RNA splicing |
| keywords[12].id | https://openalex.org/keywords/fibrosis |
| keywords[12].score | 0.42374444007873535 |
| keywords[12].display_name | Fibrosis |
| keywords[13].id | https://openalex.org/keywords/transforming-growth-factor |
| keywords[13].score | 0.4188094735145569 |
| keywords[13].display_name | Transforming growth factor |
| keywords[14].id | https://openalex.org/keywords/molecular-biology |
| keywords[14].score | 0.3967127799987793 |
| keywords[14].display_name | Molecular biology |
| keywords[15].id | https://openalex.org/keywords/rna |
| keywords[15].score | 0.3578747510910034 |
| keywords[15].display_name | RNA |
| keywords[16].id | https://openalex.org/keywords/cancer-research |
| keywords[16].score | 0.3335842192173004 |
| keywords[16].display_name | Cancer research |
| keywords[17].id | https://openalex.org/keywords/lung |
| keywords[17].score | 0.25032442808151245 |
| keywords[17].display_name | Lung |
| keywords[18].id | https://openalex.org/keywords/pathology |
| keywords[18].score | 0.23083969950675964 |
| keywords[18].display_name | Pathology |
| keywords[19].id | https://openalex.org/keywords/cell-culture |
| keywords[19].score | 0.21505454182624817 |
| keywords[19].display_name | Cell culture |
| keywords[20].id | https://openalex.org/keywords/medicine |
| keywords[20].score | 0.16577675938606262 |
| keywords[20].display_name | Medicine |
| keywords[21].id | https://openalex.org/keywords/gene |
| keywords[21].score | 0.11573508381843567 |
| keywords[21].display_name | Gene |
| keywords[22].id | https://openalex.org/keywords/internal-medicine |
| keywords[22].score | 0.09078231453895569 |
| keywords[22].display_name | Internal medicine |
| keywords[23].id | https://openalex.org/keywords/biochemistry |
| keywords[23].score | 0.05221450328826904 |
| keywords[23].display_name | Biochemistry |
| language | en |
| locations[0].id | doi:10.1002/jcp.30380 |
| locations[0].is_oa | False |
| locations[0].source.id | https://openalex.org/S43643205 |
| locations[0].source.issn | 0021-9541, 1097-4652 |
| locations[0].source.type | journal |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | 0021-9541 |
| locations[0].source.is_core | True |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | Journal of Cellular Physiology |
| locations[0].source.host_organization | https://openalex.org/P4310320595 |
| locations[0].source.host_organization_name | Wiley |
| locations[0].source.host_organization_lineage | https://openalex.org/P4310320595 |
| locations[0].license | |
| locations[0].pdf_url | |
| locations[0].version | publishedVersion |
| locations[0].raw_type | journal-article |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | True |
| locations[0].raw_source_name | Journal of Cellular Physiology |
| locations[0].landing_page_url | https://doi.org/10.1002/jcp.30380 |
| locations[1].id | pmid:33855709 |
| locations[1].is_oa | False |
| locations[1].source.id | https://openalex.org/S4306525036 |
| locations[1].source.issn | |
| locations[1].source.type | repository |
| locations[1].source.is_oa | False |
| locations[1].source.issn_l | |
| locations[1].source.is_core | False |
| locations[1].source.is_in_doaj | False |
| locations[1].source.display_name | PubMed |
| locations[1].source.host_organization | https://openalex.org/I1299303238 |
| locations[1].source.host_organization_name | National Institutes of Health |
| locations[1].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[1].license | |
| locations[1].pdf_url | |
| locations[1].version | publishedVersion |
| locations[1].raw_type | |
| locations[1].license_id | |
| locations[1].is_accepted | True |
| locations[1].is_published | True |
| locations[1].raw_source_name | Journal of cellular physiology |
| locations[1].landing_page_url | https://pubmed.ncbi.nlm.nih.gov/33855709 |
| locations[2].id | pmh:oai:pubmedcentral.nih.gov:8390431 |
| locations[2].is_oa | True |
| locations[2].source.id | https://openalex.org/S2764455111 |
| locations[2].source.issn | |
| locations[2].source.type | repository |
| locations[2].source.is_oa | False |
| locations[2].source.issn_l | |
| locations[2].source.is_core | False |
| locations[2].source.is_in_doaj | False |
| locations[2].source.display_name | PubMed Central |
| locations[2].source.host_organization | https://openalex.org/I1299303238 |
| locations[2].source.host_organization_name | National Institutes of Health |
| locations[2].source.host_organization_lineage | https://openalex.org/I1299303238 |
| locations[2].license | |
| locations[2].pdf_url | |
| locations[2].version | submittedVersion |
| locations[2].raw_type | Text |
| locations[2].license_id | |
| locations[2].is_accepted | False |
| locations[2].is_published | False |
| locations[2].raw_source_name | J Cell Physiol |
| locations[2].landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8390431 |
| indexed_in | crossref, pubmed |
| authorships[0].author.id | https://openalex.org/A5076418377 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Fatmah Al‐Habeeb |
| authorships[0].countries | CA |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I2801766832 |
| authorships[0].affiliations[0].raw_affiliation_string | Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada |
| authorships[0].affiliations[1].institution_ids | https://openalex.org/I5023651 |
| authorships[0].affiliations[1].raw_affiliation_string | Department of Medicine, McGill University, Montreal, Quebec, Canada |
| authorships[0].institutions[0].id | https://openalex.org/I5023651 |
| authorships[0].institutions[0].ror | https://ror.org/01pxwe438 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I5023651 |
| authorships[0].institutions[0].country_code | CA |
| authorships[0].institutions[0].display_name | McGill University |
| authorships[0].institutions[1].id | https://openalex.org/I2801766832 |
| authorships[0].institutions[1].ror | https://ror.org/04cpxjv19 |
| authorships[0].institutions[1].type | healthcare |
| authorships[0].institutions[1].lineage | https://openalex.org/I2801766832 |
| authorships[0].institutions[1].country_code | CA |
| authorships[0].institutions[1].display_name | McGill University Health Centre |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Fatmah Al‐Habeeb |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Department of Medicine, McGill University, Montreal, Quebec, Canada, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada |
| authorships[1].author.id | https://openalex.org/A5041676911 |
| authorships[1].author.orcid | |
| authorships[1].author.display_name | Noof Aloufi |
| authorships[1].countries | CA |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I5023651 |
| authorships[1].affiliations[0].raw_affiliation_string | Departments of Pathology, McGill University, Montreal, Quebec, Canada |
| authorships[1].affiliations[1].institution_ids | https://openalex.org/I2801766832 |
| authorships[1].affiliations[1].raw_affiliation_string | Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada |
| authorships[1].institutions[0].id | https://openalex.org/I5023651 |
| authorships[1].institutions[0].ror | https://ror.org/01pxwe438 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I5023651 |
| authorships[1].institutions[0].country_code | CA |
| authorships[1].institutions[0].display_name | McGill University |
| authorships[1].institutions[1].id | https://openalex.org/I2801766832 |
| authorships[1].institutions[1].ror | https://ror.org/04cpxjv19 |
| authorships[1].institutions[1].type | healthcare |
| authorships[1].institutions[1].lineage | https://openalex.org/I2801766832 |
| authorships[1].institutions[1].country_code | CA |
| authorships[1].institutions[1].display_name | McGill University Health Centre |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Noof Aloufi |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Departments of Pathology, McGill University, Montreal, Quebec, Canada, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada |
| authorships[2].author.id | https://openalex.org/A5110478896 |
| authorships[2].author.orcid | |
| authorships[2].author.display_name | Hussein Traboulsi |
| authorships[2].countries | CA |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I5023651 |
| authorships[2].affiliations[0].raw_affiliation_string | Department of Medicine, McGill University, Montreal, Quebec, Canada |
| authorships[2].affiliations[1].institution_ids | https://openalex.org/I2801766832 |
| authorships[2].affiliations[1].raw_affiliation_string | Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada |
| authorships[2].institutions[0].id | https://openalex.org/I5023651 |
| authorships[2].institutions[0].ror | https://ror.org/01pxwe438 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I5023651 |
| authorships[2].institutions[0].country_code | CA |
| authorships[2].institutions[0].display_name | McGill University |
| authorships[2].institutions[1].id | https://openalex.org/I2801766832 |
| authorships[2].institutions[1].ror | https://ror.org/04cpxjv19 |
| authorships[2].institutions[1].type | healthcare |
| authorships[2].institutions[1].lineage | https://openalex.org/I2801766832 |
| authorships[2].institutions[1].country_code | CA |
| authorships[2].institutions[1].display_name | McGill University Health Centre |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Hussein Traboulsi |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Department of Medicine, McGill University, Montreal, Quebec, Canada, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada |
| authorships[3].author.id | https://openalex.org/A5110376211 |
| authorships[3].author.orcid | https://orcid.org/0009-0005-4012-503X |
| authorships[3].author.display_name | Xingxing Liu |
| authorships[3].countries | CA |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I2801766832 |
| authorships[3].affiliations[0].raw_affiliation_string | Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada |
| authorships[3].institutions[0].id | https://openalex.org/I2801766832 |
| authorships[3].institutions[0].ror | https://ror.org/04cpxjv19 |
| authorships[3].institutions[0].type | healthcare |
| authorships[3].institutions[0].lineage | https://openalex.org/I2801766832 |
| authorships[3].institutions[0].country_code | CA |
| authorships[3].institutions[0].display_name | McGill University Health Centre |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Xingxing Liu |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada |
| authorships[4].author.id | https://openalex.org/A5058199788 |
| authorships[4].author.orcid | https://orcid.org/0000-0002-1041-9492 |
| authorships[4].author.display_name | Parameswaran Nair |
| authorships[4].countries | CA |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I59293822, https://openalex.org/I98251732 |
| authorships[4].affiliations[0].raw_affiliation_string | Department of Medicine, McMaster University & St Joseph's Healthcare, Hamilton, Ontario, Canada |
| authorships[4].institutions[0].id | https://openalex.org/I98251732 |
| authorships[4].institutions[0].ror | https://ror.org/02fa3aq29 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I98251732 |
| authorships[4].institutions[0].country_code | CA |
| authorships[4].institutions[0].display_name | McMaster University |
| authorships[4].institutions[1].id | https://openalex.org/I59293822 |
| authorships[4].institutions[1].ror | https://ror.org/009z39p97 |
| authorships[4].institutions[1].type | healthcare |
| authorships[4].institutions[1].lineage | https://openalex.org/I59293822 |
| authorships[4].institutions[1].country_code | CA |
| authorships[4].institutions[1].display_name | St. Joseph’s Healthcare Hamilton |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Parameswaran Nair |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Department of Medicine, McMaster University & St Joseph's Healthcare, Hamilton, Ontario, Canada |
| authorships[5].author.id | https://openalex.org/A5002016551 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Christina K. Haston |
| authorships[5].countries | CA |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I141945490 |
| authorships[5].affiliations[0].raw_affiliation_string | Department of Computer Science, Mathematics, Physics and Statistics, University of British Columbia, British Columbia, Canada |
| authorships[5].institutions[0].id | https://openalex.org/I141945490 |
| authorships[5].institutions[0].ror | https://ror.org/03rmrcq20 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I141945490, https://openalex.org/I4210128534, https://openalex.org/I4210135497, https://openalex.org/I4387154919 |
| authorships[5].institutions[0].country_code | CA |
| authorships[5].institutions[0].display_name | University of British Columbia |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Christina Haston |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Department of Computer Science, Mathematics, Physics and Statistics, University of British Columbia, British Columbia, Canada |
| authorships[6].author.id | https://openalex.org/A5073420918 |
| authorships[6].author.orcid | https://orcid.org/0000-0002-7399-5649 |
| authorships[6].author.display_name | Ilan Azuelos |
| authorships[6].countries | CA |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I5023651 |
| authorships[6].affiliations[0].raw_affiliation_string | Department of Medicine, McGill University, Montreal, Quebec, Canada |
| authorships[6].affiliations[1].institution_ids | https://openalex.org/I2801766832 |
| authorships[6].affiliations[1].raw_affiliation_string | Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada |
| authorships[6].institutions[0].id | https://openalex.org/I5023651 |
| authorships[6].institutions[0].ror | https://ror.org/01pxwe438 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I5023651 |
| authorships[6].institutions[0].country_code | CA |
| authorships[6].institutions[0].display_name | McGill University |
| authorships[6].institutions[1].id | https://openalex.org/I2801766832 |
| authorships[6].institutions[1].ror | https://ror.org/04cpxjv19 |
| authorships[6].institutions[1].type | healthcare |
| authorships[6].institutions[1].lineage | https://openalex.org/I2801766832 |
| authorships[6].institutions[1].country_code | CA |
| authorships[6].institutions[1].display_name | McGill University Health Centre |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Ilan Azuelos |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Department of Medicine, McGill University, Montreal, Quebec, Canada, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada |
| authorships[7].author.id | https://openalex.org/A5088538395 |
| authorships[7].author.orcid | https://orcid.org/0000-0002-2090-6331 |
| authorships[7].author.display_name | Steven K. Huang |
| authorships[7].countries | US |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I27837315 |
| authorships[7].affiliations[0].raw_affiliation_string | Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA |
| authorships[7].institutions[0].id | https://openalex.org/I27837315 |
| authorships[7].institutions[0].ror | https://ror.org/00jmfr291 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I27837315 |
| authorships[7].institutions[0].country_code | US |
| authorships[7].institutions[0].display_name | University of Michigan |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Steven K. Huang |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA |
| authorships[8].author.id | https://openalex.org/A5055183282 |
| authorships[8].author.orcid | https://orcid.org/0000-0003-4060-8443 |
| authorships[8].author.display_name | Eric S. White |
| authorships[8].countries | US |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I27837315 |
| authorships[8].affiliations[0].raw_affiliation_string | Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA |
| authorships[8].institutions[0].id | https://openalex.org/I27837315 |
| authorships[8].institutions[0].ror | https://ror.org/00jmfr291 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I27837315 |
| authorships[8].institutions[0].country_code | US |
| authorships[8].institutions[0].display_name | University of Michigan |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Eric S. White |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA |
| authorships[9].author.id | https://openalex.org/A5004154228 |
| authorships[9].author.orcid | https://orcid.org/0000-0003-4758-4835 |
| authorships[9].author.display_name | Imed‐Eddine Gallouzi |
| authorships[9].countries | CA |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I5023651 |
| authorships[9].affiliations[0].raw_affiliation_string | Department of Biochemistry, McGill University, Montreal, Quebec, Canada |
| authorships[9].affiliations[1].institution_ids | https://openalex.org/I2801766832 |
| authorships[9].affiliations[1].raw_affiliation_string | Faculty of Medicine, Goodman Cancer Centre, McGill University, Montreal, Quebec, Canada |
| authorships[9].institutions[0].id | https://openalex.org/I5023651 |
| authorships[9].institutions[0].ror | https://ror.org/01pxwe438 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I5023651 |
| authorships[9].institutions[0].country_code | CA |
| authorships[9].institutions[0].display_name | McGill University |
| authorships[9].institutions[1].id | https://openalex.org/I2801766832 |
| authorships[9].institutions[1].ror | https://ror.org/04cpxjv19 |
| authorships[9].institutions[1].type | healthcare |
| authorships[9].institutions[1].lineage | https://openalex.org/I2801766832 |
| authorships[9].institutions[1].country_code | CA |
| authorships[9].institutions[1].display_name | McGill University Health Centre |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Imed E. Gallouzi |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Department of Biochemistry, McGill University, Montreal, Quebec, Canada, Faculty of Medicine, Goodman Cancer Centre, McGill University, Montreal, Quebec, Canada |
| authorships[10].author.id | https://openalex.org/A5071885510 |
| authorships[10].author.orcid | https://orcid.org/0000-0002-4039-0600 |
| authorships[10].author.display_name | Sergio Di Marco |
| authorships[10].countries | CA |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I2801766832 |
| authorships[10].affiliations[0].raw_affiliation_string | Faculty of Medicine, Goodman Cancer Centre, McGill University, Montreal, Quebec, Canada |
| authorships[10].affiliations[1].institution_ids | https://openalex.org/I5023651 |
| authorships[10].affiliations[1].raw_affiliation_string | Department of Biochemistry, McGill University, Montreal, Quebec, Canada |
| authorships[10].institutions[0].id | https://openalex.org/I5023651 |
| authorships[10].institutions[0].ror | https://ror.org/01pxwe438 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I5023651 |
| authorships[10].institutions[0].country_code | CA |
| authorships[10].institutions[0].display_name | McGill University |
| authorships[10].institutions[1].id | https://openalex.org/I2801766832 |
| authorships[10].institutions[1].ror | https://ror.org/04cpxjv19 |
| authorships[10].institutions[1].type | healthcare |
| authorships[10].institutions[1].lineage | https://openalex.org/I2801766832 |
| authorships[10].institutions[1].country_code | CA |
| authorships[10].institutions[1].display_name | McGill University Health Centre |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Sergio Di Marco |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Department of Biochemistry, McGill University, Montreal, Quebec, Canada, Faculty of Medicine, Goodman Cancer Centre, McGill University, Montreal, Quebec, Canada |
| authorships[11].author.id | https://openalex.org/A5010779267 |
| authorships[11].author.orcid | https://orcid.org/0000-0001-9780-7764 |
| authorships[11].author.display_name | David H. Eidelman |
| authorships[11].countries | CA |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I5023651 |
| authorships[11].affiliations[0].raw_affiliation_string | Department of Medicine, McGill University, Montreal, Quebec, Canada |
| authorships[11].institutions[0].id | https://openalex.org/I5023651 |
| authorships[11].institutions[0].ror | https://ror.org/01pxwe438 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I5023651 |
| authorships[11].institutions[0].country_code | CA |
| authorships[11].institutions[0].display_name | McGill University |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | David H. Eidelman |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Department of Medicine, McGill University, Montreal, Quebec, Canada |
| authorships[12].author.id | https://openalex.org/A5088963997 |
| authorships[12].author.orcid | https://orcid.org/0000-0002-3107-0437 |
| authorships[12].author.display_name | Carolyn J. Baglole |
| authorships[12].countries | CA |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I5023651 |
| authorships[12].affiliations[0].raw_affiliation_string | Department of Pharmacology & Therapeutics, McGill University, Montreal, Quebec, Canada |
| authorships[12].affiliations[1].institution_ids | https://openalex.org/I2801766832 |
| authorships[12].affiliations[1].raw_affiliation_string | Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada |
| authorships[12].affiliations[2].institution_ids | https://openalex.org/I5023651 |
| authorships[12].affiliations[2].raw_affiliation_string | Department of Medicine, McGill University, Montreal, Quebec, Canada |
| authorships[12].affiliations[3].institution_ids | https://openalex.org/I5023651 |
| authorships[12].affiliations[3].raw_affiliation_string | Departments of Pathology, McGill University, Montreal, Quebec, Canada |
| authorships[12].institutions[0].id | https://openalex.org/I5023651 |
| authorships[12].institutions[0].ror | https://ror.org/01pxwe438 |
| authorships[12].institutions[0].type | education |
| authorships[12].institutions[0].lineage | https://openalex.org/I5023651 |
| authorships[12].institutions[0].country_code | CA |
| authorships[12].institutions[0].display_name | McGill University |
| authorships[12].institutions[1].id | https://openalex.org/I2801766832 |
| authorships[12].institutions[1].ror | https://ror.org/04cpxjv19 |
| authorships[12].institutions[1].type | healthcare |
| authorships[12].institutions[1].lineage | https://openalex.org/I2801766832 |
| authorships[12].institutions[1].country_code | CA |
| authorships[12].institutions[1].display_name | McGill University Health Centre |
| authorships[12].author_position | last |
| authorships[12].raw_author_name | Carolyn J. Baglole |
| authorships[12].is_corresponding | True |
| authorships[12].raw_affiliation_strings | Department of Medicine, McGill University, Montreal, Quebec, Canada, Department of Pharmacology & Therapeutics, McGill University, Montreal, Quebec, Canada, Departments of Pathology, McGill University, Montreal, Quebec, Canada, Translational Research in Respiratory Diseases Program, Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada |
| has_content.pdf | False |
| has_content.grobid_xml | False |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8390431 |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Human antigen R promotes lung fibroblast differentiation to myofibroblasts and increases extracellular matrix production |
| has_fulltext | False |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10870 |
| primary_topic.field.id | https://openalex.org/fields/27 |
| primary_topic.field.display_name | Medicine |
| primary_topic.score | 0.9998000264167786 |
| primary_topic.domain.id | https://openalex.org/domains/4 |
| primary_topic.domain.display_name | Health Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/2740 |
| primary_topic.subfield.display_name | Pulmonary and Respiratory Medicine |
| primary_topic.display_name | Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis |
| related_works | https://openalex.org/W4379535685, https://openalex.org/W2063581984, https://openalex.org/W4367599807, https://openalex.org/W4318829784, https://openalex.org/W3084201698, https://openalex.org/W4309181476, https://openalex.org/W2743918347, https://openalex.org/W2024593827, https://openalex.org/W1976100904, https://openalex.org/W2944144358 |
| cited_by_count | 24 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 3 |
| counts_by_year[1].year | 2024 |
| counts_by_year[1].cited_by_count | 4 |
| counts_by_year[2].year | 2023 |
| counts_by_year[2].cited_by_count | 6 |
| counts_by_year[3].year | 2022 |
| counts_by_year[3].cited_by_count | 9 |
| counts_by_year[4].year | 2021 |
| counts_by_year[4].cited_by_count | 2 |
| locations_count | 3 |
| best_oa_location.id | pmh:oai:pubmedcentral.nih.gov:8390431 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S2764455111 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | PubMed Central |
| best_oa_location.source.host_organization | https://openalex.org/I1299303238 |
| best_oa_location.source.host_organization_name | National Institutes of Health |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I1299303238 |
| best_oa_location.license | |
| best_oa_location.pdf_url | |
| best_oa_location.version | submittedVersion |
| best_oa_location.raw_type | Text |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | False |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | J Cell Physiol |
| best_oa_location.landing_page_url | https://www.ncbi.nlm.nih.gov/pmc/articles/8390431 |
| primary_location.id | doi:10.1002/jcp.30380 |
| primary_location.is_oa | False |
| primary_location.source.id | https://openalex.org/S43643205 |
| primary_location.source.issn | 0021-9541, 1097-4652 |
| primary_location.source.type | journal |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | 0021-9541 |
| primary_location.source.is_core | True |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | Journal of Cellular Physiology |
| primary_location.source.host_organization | https://openalex.org/P4310320595 |
| primary_location.source.host_organization_name | Wiley |
| primary_location.source.host_organization_lineage | https://openalex.org/P4310320595 |
| primary_location.license | |
| primary_location.pdf_url | |
| primary_location.version | publishedVersion |
| primary_location.raw_type | journal-article |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | True |
| primary_location.raw_source_name | Journal of Cellular Physiology |
| primary_location.landing_page_url | https://doi.org/10.1002/jcp.30380 |
| publication_date | 2021-04-14 |
| publication_year | 2021 |
| referenced_works | https://openalex.org/W2121036590, https://openalex.org/W1822060589, https://openalex.org/W2058266230, https://openalex.org/W1970546936, https://openalex.org/W1996757076, https://openalex.org/W2889443263, https://openalex.org/W2157502876, https://openalex.org/W2010887974, https://openalex.org/W2128273168, https://openalex.org/W2802463506, https://openalex.org/W296319558, https://openalex.org/W2100379694, https://openalex.org/W2096307493, https://openalex.org/W2111685937, https://openalex.org/W2138584103, https://openalex.org/W2745356508, https://openalex.org/W2081946872, https://openalex.org/W2064492560, https://openalex.org/W2394621964, https://openalex.org/W2598250315, https://openalex.org/W2558011421, https://openalex.org/W2048085228, https://openalex.org/W1992938929, https://openalex.org/W2074478540, https://openalex.org/W1993841930, https://openalex.org/W2063025076, https://openalex.org/W2108090987, https://openalex.org/W2140735560, https://openalex.org/W2146726056, https://openalex.org/W2894655408, https://openalex.org/W2550753066, https://openalex.org/W1970120381, https://openalex.org/W2338221602, https://openalex.org/W2013426785, https://openalex.org/W2967561146, https://openalex.org/W2059646461, https://openalex.org/W2090009109, https://openalex.org/W2123399984, https://openalex.org/W2105777529, https://openalex.org/W2098530232, https://openalex.org/W1970902896, https://openalex.org/W1938547050, https://openalex.org/W2075847458, https://openalex.org/W2099540110, https://openalex.org/W2072622898, https://openalex.org/W2131477746, https://openalex.org/W2060928333, https://openalex.org/W1989847489, https://openalex.org/W2085300152, https://openalex.org/W2058694411, https://openalex.org/W1975181737, https://openalex.org/W1972167901, https://openalex.org/W1975221809, https://openalex.org/W2050489269, https://openalex.org/W2100649307, https://openalex.org/W2014972731, https://openalex.org/W2150969530, https://openalex.org/W2145619015, https://openalex.org/W1992237229 |
| referenced_works_count | 59 |
| abstract_inverted_index., | 133, 154 |
| abstract_inverted_index.. | 136, 157 |
| abstract_inverted_index.R | 25 |
| abstract_inverted_index.a | 6, 83, 107 |
| abstract_inverted_index.FN | 135, 156 |
| abstract_inverted_index.In | 158, 177 |
| abstract_inverted_index.an | 28 |
| abstract_inverted_index.as | 113, 115, 229 |
| abstract_inverted_index.by | 12 |
| abstract_inverted_index.in | 60, 86, 110, 169, 196, 214 |
| abstract_inverted_index.is | 5, 27, 69, 189 |
| abstract_inverted_index.of | 8, 20, 58, 88, 143, 148, 161, 221 |
| abstract_inverted_index.on | 210 |
| abstract_inverted_index.or | 155 |
| abstract_inverted_index.to | 41, 46, 51, 93, 127, 174, 192, 202 |
| abstract_inverted_index.ECM | 62, 117, 150, 206 |
| abstract_inverted_index.HuR | 44, 59, 89, 102, 123, 137, 168, 195, 211 |
| abstract_inverted_index.IPF | 179 |
| abstract_inverted_index.RNA | 29, 49, 105 |
| abstract_inverted_index.and | 18, 66, 121, 134, 204 |
| abstract_inverted_index.but | 145 |
| abstract_inverted_index.for | 129, 218, 225 |
| abstract_inverted_index.had | 106 |
| abstract_inverted_index.new | 222 |
| abstract_inverted_index.not | 146 |
| abstract_inverted_index.the | 39, 42, 56, 91, 94, 116, 140, 149, 190, 216, 219 |
| abstract_inverted_index.was | 124, 165, 182 |
| abstract_inverted_index.β1 | 80 |
| abstract_inverted_index.FN1. | 122 |
| abstract_inverted_index.HLFs | 97 |
| abstract_inverted_index.HuR. | 186 |
| abstract_inverted_index.IPF. | 230 |
| abstract_inverted_index.This | 187 |
| abstract_inverted_index.Upon | 36 |
| abstract_inverted_index.also | 125, 183 |
| abstract_inverted_index.from | 38, 90 |
| abstract_inverted_index.lung | 67, 72, 170, 197 |
| abstract_inverted_index.mRNA | 128, 141 |
| abstract_inverted_index.more | 184 |
| abstract_inverted_index.role | 57 |
| abstract_inverted_index.show | 193 |
| abstract_inverted_index.such | 228 |
| abstract_inverted_index.that | 32, 98, 147, 194 |
| abstract_inverted_index.well | 114 |
| abstract_inverted_index.were | 99 |
| abstract_inverted_index.with | 76, 101 |
| abstract_inverted_index.(ECM) | 16 |
| abstract_inverted_index.(HuR) | 26 |
| abstract_inverted_index.(IPF) | 4 |
| abstract_inverted_index.ACTA2 | 144 |
| abstract_inverted_index.Human | 23, 71 |
| abstract_inverted_index.basis | 217 |
| abstract_inverted_index.bound | 126 |
| abstract_inverted_index.cells | 172 |
| abstract_inverted_index.could | 212 |
| abstract_inverted_index.first | 191 |
| abstract_inverted_index.genes | 151 |
| abstract_inverted_index.human | 178 |
| abstract_inverted_index.mice. | 176 |
| abstract_inverted_index.mouse | 159 |
| abstract_inverted_index.small | 103 |
| abstract_inverted_index.study | 188 |
| abstract_inverted_index.their | 200 |
| abstract_inverted_index.there | 164, 181 |
| abstract_inverted_index.(HLFs) | 74 |
| abstract_inverted_index.(mRNA) | 50 |
| abstract_inverted_index.ACTA2, | 130 |
| abstract_inverted_index.COL3A, | 120 |
| abstract_inverted_index.COL3A1 | 132, 153 |
| abstract_inverted_index.assist | 213 |
| abstract_inverted_index.caused | 11 |
| abstract_inverted_index.factor | 79 |
| abstract_inverted_index.growth | 78 |
| abstract_inverted_index.higher | 166 |
| abstract_inverted_index.lungs, | 180 |
| abstract_inverted_index.matrix | 15 |
| abstract_inverted_index.models | 160 |
| abstract_inverted_index.showed | 82 |
| abstract_inverted_index.target | 223 |
| abstract_inverted_index.COL1A1, | 119, 131, 152 |
| abstract_inverted_index.Further | 208 |
| abstract_inverted_index.antigen | 24 |
| abstract_inverted_index.binding | 30 |
| abstract_inverted_index.control | 175 |
| abstract_inverted_index.disease | 7 |
| abstract_inverted_index.levels. | 54 |
| abstract_inverted_index.nucleus | 40, 92 |
| abstract_inverted_index.protein | 31, 34, 53, 112 |
| abstract_inverted_index.therapy | 224 |
| abstract_inverted_index.treated | 75 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.However, | 55 |
| abstract_inverted_index.affected | 139 |
| abstract_inverted_index.compared | 173 |
| abstract_inverted_index.controls | 199 |
| abstract_inverted_index.fibrosis | 3, 68 |
| abstract_inverted_index.fibrotic | 226 |
| abstract_inverted_index.increase | 52, 85 |
| abstract_inverted_index.promotes | 33 |
| abstract_inverted_index.proteins | 118 |
| abstract_inverted_index.research | 209 |
| abstract_inverted_index.scarring | 10 |
| abstract_inverted_index.unknown. | 70 |
| abstract_inverted_index.α‐SMA | 111 |
| abstract_inverted_index.diseases, | 227 |
| abstract_inverted_index.excessive | 13 |
| abstract_inverted_index.fibrosis, | 163 |
| abstract_inverted_index.functions | 45 |
| abstract_inverted_index.knockdown | 138 |
| abstract_inverted_index.messenger | 48 |
| abstract_inverted_index.promoting | 61 |
| abstract_inverted_index.pulmonary | 2, 162 |
| abstract_inverted_index.reduction | 109 |
| abstract_inverted_index.stability | 142 |
| abstract_inverted_index.stabilize | 47 |
| abstract_inverted_index.Idiopathic | 1 |
| abstract_inverted_index.activation | 19 |
| abstract_inverted_index.consequent | 205 |
| abstract_inverted_index.cytoplasm, | 43 |
| abstract_inverted_index.cytoplasm. | 95 |
| abstract_inverted_index.deposition | 17 |
| abstract_inverted_index.structural | 171 |
| abstract_inverted_index.(TGF‐β1) | 81 |
| abstract_inverted_index.cytoplasmic | 167, 185 |
| abstract_inverted_index.development | 220 |
| abstract_inverted_index.fibroblasts | 73, 198 |
| abstract_inverted_index.interfering | 104 |
| abstract_inverted_index.production, | 63 |
| abstract_inverted_index.production. | 207 |
| abstract_inverted_index.progressive | 9 |
| abstract_inverted_index.significant | 84, 108 |
| abstract_inverted_index.transfected | 100 |
| abstract_inverted_index.establishing | 215 |
| abstract_inverted_index.transforming | 77 |
| abstract_inverted_index.translation. | 35 |
| abstract_inverted_index.extracellular | 14 |
| abstract_inverted_index.myofibroblast | 64 |
| abstract_inverted_index.translocation | 37, 87 |
| abstract_inverted_index.myofibroblasts | 203 |
| abstract_inverted_index.differentiation | 201 |
| abstract_inverted_index.myofibroblasts. | 22 |
| abstract_inverted_index.differentiation, | 65 |
| abstract_inverted_index.TGF‐β‐treated | 96 |
| abstract_inverted_index.α‐SMA‐expressing | 21 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 93 |
| corresponding_author_ids | https://openalex.org/A5088963997 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 13 |
| corresponding_institution_ids | https://openalex.org/I2801766832, https://openalex.org/I5023651 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.550000011920929 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.92525838 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |