Human Antimicrobial Peptides as Therapeutics for Viral Infections Article Swipe
Aslaa Ahmed
,
Gavriella Siman-Tov
,
Grant Hall
,
Nishank Bhalla
,
Aarthi Narayanan
·
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3390/v11080704
YOU?
·
· 2019
· Open Access
·
· DOI: https://doi.org/10.3390/v11080704
Successful in vivo infection following pathogen entry requires the evasion and subversion of multiple immunological barriers. Antimicrobial peptides (AMPs) are one of the first immune pathways upregulated during infection by multiple pathogens, in multiple organs in vivo. In humans, there are many classes of AMPs exhibiting broad antimicrobial activities, with defensins and the human cathelicidin LL-37 being the best studied examples. Whereas historically the efficacy and therapeutic potential of AMPs against bacterial infection has been the primary focus of research, recent studies have begun to elucidate the antiviral properties of AMPs as well as their role in regulation of inflammation and chemoattraction. AMPs as therapeutic tools seem especially promising against emerging infectious viral pathogens for which no approved vaccines or treatments are currently available, such as dengue virus (DENV) and Zika virus (ZIKV). In this review, we summarize recent studies elucidating the efficacy and diverse mechanisms of action of various classes of AMPs against multiple viral pathogens, as well as the potential use of human AMPs in novel antiviral therapeutic strategies.
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Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/v11080704
- OA Status
- gold
- Cited By
- 217
- References
- 169
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2965044151
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W2965044151Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/v11080704Digital Object Identifier
- Title
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Human Antimicrobial Peptides as Therapeutics for Viral InfectionsWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2019Year of publication
- Publication date
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2019-08-01Full publication date if available
- Authors
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Aslaa Ahmed, Gavriella Siman-Tov, Grant Hall, Nishank Bhalla, Aarthi NarayananList of authors in order
- Landing page
-
https://doi.org/10.3390/v11080704Publisher landing page
- Open access
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YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://doi.org/10.3390/v11080704Direct OA link when available
- Concepts
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Antimicrobial peptides, Cathelicidin, Antimicrobial, Biology, Dengue virus, Dengue fever, Antiviral drug, Immune system, Human pathogen, Innate immune system, Immunology, Virology, Microbiology, Virus, Bacteria, GeneticsTop concepts (fields/topics) attached by OpenAlex
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-
217Total citation count in OpenAlex
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2025: 23, 2024: 27, 2023: 20, 2022: 44, 2021: 59Per-year citation counts (last 5 years)
- References (count)
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169Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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