Human Brown Adipose Tissue Estimated With Magnetic Resonance Imaging Undergoes Changes in Composition After Cold Exposure: An in vivo MRI Study in Healthy Volunteers Article Swipe
Gustavo Abreu-Vieira
,
Aashley S. D. Sardjoe Mishre
,
Jedrzej Burakiewicz
,
Laura G.M. Janssen
,
Kimberly J. Nahon
,
Jari A. van der Eijk
,
T. Riem
,
Mariëtte R. Boon
,
Oleh Dzyubachyk
,
Andrew Webb
,
Patrick C.N. Rensen
,
Hermien E. Kan
·
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2019.00898
YOU?
·
· 2020
· Open Access
·
· DOI: https://doi.org/10.3389/fendo.2019.00898
Aim: Magnetic resonance imaging (MRI) is increasingly being used to evaluate brown adipose tissue (BAT) function. Reports on the extent and direction of cold-induced changes in MRI fat fraction and estimated BAT volume vary between studies. Here, we aimed to explore the effect of different fat fraction threshold ranges on outcomes measured by MRI. Moreover, we aimed to investigate the effect of cold exposure on estimated BAT mass and energy content. Methods: The effects of cold exposure at different fat fraction thresholding levels were analyzed in the supraclavicular adipose depot of nine adult males. MRI data were reconstructed, co-registered and analyzed in two ways. First, we analyzed cold-induced changes in fat fraction, T2* relaxation time, volume, mass, and energy of the entire supraclavicular adipose depot at different fat fraction threshold levels. As a control, we assessed fat fraction differences of deltoid subcutaneous adipose tissue (SAT). Second, a local analysis was performed to study changes in fat fraction and T2* on a voxel-level. Thermoneutral and post-cooling data were compared using paired-sample t-tests (p < 0.05). Results: Global analysis unveiled that the largest cold-induced change in fat fraction occurred within a thermoneutral fat fraction range of 30-100% (-3.5 ± 1.9%), without changing the estimated BAT volume. However, the largest cold-induced changes in estimated BAT volume were observed when applying a thermoneutral fat fraction range of 70-100% (-3.8 ± 2.6%). No changes were observed for the deltoid SAT fat fractions. Tissue energy content was reduced from 126 ± 33 to 121 ± 30 kcal, when using a 30-100% fat fraction range, and also depended on different fat fraction thresholds. Voxel-wise analysis showed that while cold exposure changed the fat fraction across nearly all thermoneutral fat fractions, decreases were most pronounced at high thermoneutral fat fractions. Conclusion: Cold-induced changes in fat fraction occurred over the entire range of thermoneutral fat fractions, and were especially found in lipid-rich regions of the supraclavicular adipose depot. Due to the variability in response between lipid-rich and lipid-poor regions, care should be taken when applying fat fraction thresholds for MRI BAT analysis.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.3389/fendo.2019.00898
- https://www.frontiersin.org/articles/10.3389/fendo.2019.00898/pdf
- OA Status
- gold
- Cited By
- 21
- References
- 73
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2998854345
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- OpenAlex ID
-
https://openalex.org/W2998854345Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.3389/fendo.2019.00898Digital Object Identifier
- Title
-
Human Brown Adipose Tissue Estimated With Magnetic Resonance Imaging Undergoes Changes in Composition After Cold Exposure: An in vivo MRI Study in Healthy VolunteersWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2020Year of publication
- Publication date
-
2020-01-09Full publication date if available
- Authors
-
Gustavo Abreu-Vieira, Aashley S. D. Sardjoe Mishre, Jedrzej Burakiewicz, Laura G.M. Janssen, Kimberly J. Nahon, Jari A. van der Eijk, T. Riem, Mariëtte R. Boon, Oleh Dzyubachyk, Andrew Webb, Patrick C.N. Rensen, Hermien E. KanList of authors in order
- Landing page
-
https://doi.org/10.3389/fendo.2019.00898Publisher landing page
- PDF URL
-
https://www.frontiersin.org/articles/10.3389/fendo.2019.00898/pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.frontiersin.org/articles/10.3389/fendo.2019.00898/pdfDirect OA link when available
- Concepts
-
Adipose tissue, Brown adipose tissue, Magnetic resonance imaging, Stromal vascular fraction, Medicine, Chemistry, Nuclear medicine, Anatomy, Endocrinology, RadiologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
21Total citation count in OpenAlex
- Citations by year (recent)
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2025: 2, 2024: 2, 2023: 2, 2022: 7, 2021: 4Per-year citation counts (last 5 years)
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73Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.largest | 180, 206 |
| abstract_inverted_index.levels. | 130 |
| abstract_inverted_index.reduced | 241 |
| abstract_inverted_index.regions | 313 |
| abstract_inverted_index.volume, | 115 |
| abstract_inverted_index.volume. | 203 |
| abstract_inverted_index.without | 198 |
| abstract_inverted_index.However, | 204 |
| abstract_inverted_index.Magnetic | 1 |
| abstract_inverted_index.analysis | 148, 176, 267 |
| abstract_inverted_index.analyzed | 84, 100, 106 |
| abstract_inverted_index.applying | 216, 335 |
| abstract_inverted_index.assessed | 135 |
| abstract_inverted_index.changing | 199 |
| abstract_inverted_index.compared | 167 |
| abstract_inverted_index.content. | 70 |
| abstract_inverted_index.control, | 133 |
| abstract_inverted_index.depended | 260 |
| abstract_inverted_index.evaluate | 10 |
| abstract_inverted_index.exposure | 63, 76, 272 |
| abstract_inverted_index.fraction | 28, 46, 80, 128, 137, 156, 185, 191, 220, 256, 264, 276, 297, 337 |
| abstract_inverted_index.measured | 51 |
| abstract_inverted_index.observed | 214, 230 |
| abstract_inverted_index.occurred | 186, 298 |
| abstract_inverted_index.outcomes | 50 |
| abstract_inverted_index.regions, | 329 |
| abstract_inverted_index.response | 324 |
| abstract_inverted_index.studies. | 35 |
| abstract_inverted_index.unveiled | 177 |
| abstract_inverted_index.(<i>p</i> | 171 |
| abstract_inverted_index.Moreover, | 54 |
| abstract_inverted_index.analysis. | 342 |
| abstract_inverted_index.decreases | 283 |
| abstract_inverted_index.different | 44, 78, 126, 262 |
| abstract_inverted_index.direction | 21 |
| abstract_inverted_index.estimated | 30, 65, 201, 210 |
| abstract_inverted_index.fraction, | 111 |
| abstract_inverted_index.function. | 15 |
| abstract_inverted_index.performed | 150 |
| abstract_inverted_index.resonance | 2 |
| abstract_inverted_index.threshold | 47, 129 |
| abstract_inverted_index.Voxel-wise | 266 |
| abstract_inverted_index.especially | 309 |
| abstract_inverted_index.fractions, | 282, 306 |
| abstract_inverted_index.fractions. | 236, 291 |
| abstract_inverted_index.lipid-poor | 328 |
| abstract_inverted_index.lipid-rich | 312, 326 |
| abstract_inverted_index.pronounced | 286 |
| abstract_inverted_index.relaxation | 113 |
| abstract_inverted_index.thresholds | 338 |
| abstract_inverted_index.<b>Aim:</b> | 0 |
| abstract_inverted_index.differences | 138 |
| abstract_inverted_index.investigate | 58 |
| abstract_inverted_index.thresholds. | 265 |
| abstract_inverted_index.variability | 322 |
| abstract_inverted_index.Cold-induced | 293 |
| abstract_inverted_index.cold-induced | 23, 107, 181, 207 |
| abstract_inverted_index.increasingly | 6 |
| abstract_inverted_index.post-cooling | 164 |
| abstract_inverted_index.subcutaneous | 141 |
| abstract_inverted_index.thresholding | 81 |
| abstract_inverted_index.voxel-level. | 161 |
| abstract_inverted_index.Thermoneutral | 162 |
| abstract_inverted_index.co-registered | 98 |
| abstract_inverted_index.paired-sample | 169 |
| abstract_inverted_index.thermoneutral | 189, 218, 280, 289, 304 |
| abstract_inverted_index.<i>t</i>-tests | 170 |
| abstract_inverted_index.reconstructed, | 97 |
| abstract_inverted_index.<b>Methods:</b> | 71 |
| abstract_inverted_index.<b>Results:</b> | 174 |
| abstract_inverted_index.supraclavicular | 87, 122, 316 |
| abstract_inverted_index.<b>Conclusion:</b> | 292 |
| cited_by_percentile_year.max | 99 |
| cited_by_percentile_year.min | 94 |
| corresponding_author_ids | https://openalex.org/A5033804414 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 12 |
| corresponding_institution_ids | https://openalex.org/I2800006345 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/7 |
| sustainable_development_goals[0].score | 0.6399999856948853 |
| sustainable_development_goals[0].display_name | Affordable and clean energy |
| citation_normalized_percentile.value | 0.87287166 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |