Human centromere repositioning activates transcription and opens chromatin fibre structure Article Swipe
Catherine Naughton
,
Covadonga Huidobro
,
Claudia Rita Catacchio
,
Adam Buckle
,
Graeme R. Grimes
,
Ryu‐Suke Nozawa
,
Stefania Purgato
,
Mariano Rocchi
,
Nick Gilbert
·
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1038/s41467-022-33426-2
YOU?
·
· 2022
· Open Access
·
· DOI: https://doi.org/10.1038/s41467-022-33426-2
Human centromeres appear as constrictions on mitotic chromosomes and form a platform for kinetochore assembly in mitosis. Biophysical experiments led to a suggestion that repetitive DNA at centromeric regions form a compact scaffold necessary for function, but this was revised when neocentromeres were discovered on non-repetitive DNA. To test whether centromeres have a special chromatin structure we have analysed the architecture of a neocentromere. Centromere repositioning is accompanied by RNA polymerase II recruitment and active transcription to form a decompacted, negatively supercoiled domain enriched in ‘open’ chromatin fibres. In contrast, centromerisation causes a spreading of repressive epigenetic marks to surrounding regions, delimited by H3K27me3 polycomb boundaries and divergent genes. This flanking domain is transcriptionally silent and partially remodelled to form ‘compact’ chromatin, similar to satellite-containing DNA sequences, and exhibits genomic instability. We suggest transcription disrupts chromatin to provide a foundation for kinetochore formation whilst compact pericentromeric heterochromatin generates mechanical rigidity.
Related Topics
Concepts
Chromatin
Centromere
Biology
Kinetochore
Mitosis
Cell biology
Transcription (linguistics)
RNA polymerase II
Genetics
CTCF
Heterochromatin
DNA
Chromosome
Transcription factor
Gene
Gene expression
Promoter
Enhancer
Linguistics
Philosophy
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1038/s41467-022-33426-2
- https://www.nature.com/articles/s41467-022-33426-2.pdf
- OA Status
- gold
- Cited By
- 30
- References
- 87
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4297183124
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4297183124Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1038/s41467-022-33426-2Digital Object Identifier
- Title
-
Human centromere repositioning activates transcription and opens chromatin fibre structureWork title
- Type
-
articleOpenAlex work type
- Language
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enPrimary language
- Publication year
-
2022Year of publication
- Publication date
-
2022-09-24Full publication date if available
- Authors
-
Catherine Naughton, Covadonga Huidobro, Claudia Rita Catacchio, Adam Buckle, Graeme R. Grimes, Ryu‐Suke Nozawa, Stefania Purgato, Mariano Rocchi, Nick GilbertList of authors in order
- Landing page
-
https://doi.org/10.1038/s41467-022-33426-2Publisher landing page
- PDF URL
-
https://www.nature.com/articles/s41467-022-33426-2.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
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https://www.nature.com/articles/s41467-022-33426-2.pdfDirect OA link when available
- Concepts
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Chromatin, Centromere, Biology, Kinetochore, Mitosis, Cell biology, Transcription (linguistics), RNA polymerase II, Genetics, CTCF, Heterochromatin, DNA, Chromosome, Transcription factor, Gene, Gene expression, Promoter, Enhancer, Linguistics, PhilosophyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
30Total citation count in OpenAlex
- Citations by year (recent)
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2025: 15, 2024: 5, 2023: 9, 2022: 1Per-year citation counts (last 5 years)
- References (count)
-
87Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.Human | 1 |
| abstract_inverted_index.marks | 98 |
| abstract_inverted_index.active | 75 |
| abstract_inverted_index.appear | 3 |
| abstract_inverted_index.causes | 92 |
| abstract_inverted_index.domain | 83, 112 |
| abstract_inverted_index.genes. | 109 |
| abstract_inverted_index.silent | 115 |
| abstract_inverted_index.whilst | 144 |
| abstract_inverted_index.compact | 32, 145 |
| abstract_inverted_index.fibres. | 88 |
| abstract_inverted_index.genomic | 130 |
| abstract_inverted_index.mitotic | 7 |
| abstract_inverted_index.provide | 138 |
| abstract_inverted_index.regions | 29 |
| abstract_inverted_index.revised | 40 |
| abstract_inverted_index.similar | 123 |
| abstract_inverted_index.special | 54 |
| abstract_inverted_index.suggest | 133 |
| abstract_inverted_index.whether | 50 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.H3K27me3 | 104 |
| abstract_inverted_index.analysed | 59 |
| abstract_inverted_index.assembly | 15 |
| abstract_inverted_index.disrupts | 135 |
| abstract_inverted_index.enriched | 84 |
| abstract_inverted_index.exhibits | 129 |
| abstract_inverted_index.flanking | 111 |
| abstract_inverted_index.mitosis. | 17 |
| abstract_inverted_index.platform | 12 |
| abstract_inverted_index.polycomb | 105 |
| abstract_inverted_index.regions, | 101 |
| abstract_inverted_index.scaffold | 33 |
| abstract_inverted_index.chromatin | 55, 87, 136 |
| abstract_inverted_index.contrast, | 90 |
| abstract_inverted_index.delimited | 102 |
| abstract_inverted_index.divergent | 108 |
| abstract_inverted_index.formation | 143 |
| abstract_inverted_index.function, | 36 |
| abstract_inverted_index.generates | 148 |
| abstract_inverted_index.necessary | 34 |
| abstract_inverted_index.partially | 117 |
| abstract_inverted_index.rigidity. | 150 |
| abstract_inverted_index.spreading | 94 |
| abstract_inverted_index.structure | 56 |
| abstract_inverted_index.Centromere | 65 |
| abstract_inverted_index.boundaries | 106 |
| abstract_inverted_index.chromatin, | 122 |
| abstract_inverted_index.discovered | 44 |
| abstract_inverted_index.epigenetic | 97 |
| abstract_inverted_index.foundation | 140 |
| abstract_inverted_index.mechanical | 149 |
| abstract_inverted_index.negatively | 81 |
| abstract_inverted_index.polymerase | 71 |
| abstract_inverted_index.remodelled | 118 |
| abstract_inverted_index.repetitive | 25 |
| abstract_inverted_index.repressive | 96 |
| abstract_inverted_index.sequences, | 127 |
| abstract_inverted_index.suggestion | 23 |
| abstract_inverted_index.‘open’ | 86 |
| abstract_inverted_index.Biophysical | 18 |
| abstract_inverted_index.accompanied | 68 |
| abstract_inverted_index.centromeres | 2, 51 |
| abstract_inverted_index.centromeric | 28 |
| abstract_inverted_index.chromosomes | 8 |
| abstract_inverted_index.experiments | 19 |
| abstract_inverted_index.kinetochore | 14, 142 |
| abstract_inverted_index.recruitment | 73 |
| abstract_inverted_index.supercoiled | 82 |
| abstract_inverted_index.surrounding | 100 |
| abstract_inverted_index.architecture | 61 |
| abstract_inverted_index.decompacted, | 80 |
| abstract_inverted_index.instability. | 131 |
| abstract_inverted_index.constrictions | 5 |
| abstract_inverted_index.repositioning | 66 |
| abstract_inverted_index.transcription | 76, 134 |
| abstract_inverted_index.‘compact’ | 121 |
| abstract_inverted_index.neocentromere. | 64 |
| abstract_inverted_index.neocentromeres | 42 |
| abstract_inverted_index.non-repetitive | 46 |
| abstract_inverted_index.heterochromatin | 147 |
| abstract_inverted_index.pericentromeric | 146 |
| abstract_inverted_index.centromerisation | 91 |
| abstract_inverted_index.transcriptionally | 114 |
| abstract_inverted_index.satellite-containing | 125 |
| cited_by_percentile_year.max | 100 |
| cited_by_percentile_year.min | 89 |
| countries_distinct_count | 2 |
| institutions_distinct_count | 9 |
| citation_normalized_percentile.value | 0.96464439 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | True |