Human genetic ancestry, Mycobacterium tuberculosis diversity and tuberculosis disease severity in Dar es Salaam, Tanzania Article Swipe
Michaela Zwyer
,
Zhi Ming Xu
,
Amanda Ross
,
Jerry Hella
,
Mohamed Sasamalo
,
Maxime Rotival
,
Hellen Hiza
,
Liliana K. Rutaihwa
,
Sònia Borrell
,
Klaus Reither
,
Jacques Fellay
,
Damien Portevin
,
Lluis Quintana-Murci
,
Sébastien Gagneux
,
Daniela Brites
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7554/elife.103533
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.7554/elife.103533
Infectious diseases have affected humanity for millennia and are among the strongest selective forces. Tuberculosis (TB) is an ancient disease, caused by the human-adapted members of the Mycobacterium tuberculosis complex (MTBC). The outcome of TB infection and disease is highly variable, and co-evolution between human populations and MTBC strains may account for some of this variability. Particular human genetic ancestries have been associated with higher susceptibility to TB, but socio-demographic aspects of the disease can confound such associations. Here, we studied 1,000 TB patients from Dar es Salaam, Tanzania, together with their respective MTBC isolates, by combining human and bacterial genomics with clinical data. We found that the genetic background of the TB patient population was strongly influenced by migrationsof Bantu-speaking populations from West Africa, which is in contrast to the corresponding MTBC genotypes that were mainly introduced from outside Africa. These findings suggest a recent evolutionary history of co-existence between the human and MTBC populations in Dar es Salaam. We detected no evidence of an effect of human genetic ancestry, or MTBC phylogenetic diversity alone, nor their interaction, on TB disease severity. There was also no evidence of an association between human variation genome-wide and TB disease severity.Treatment-seeking, social and environmental factors are likely to be the main determinants of disease severity at the point of care in this patient population.
Related Topics
Concepts
Tuberculosis
Tanzania
Mycobacterium tuberculosis complex
Disease
Mycobacterium tuberculosis
Genetic diversity
Population
Genotype
Biology
Medicine
Virology
Genetics
Environmental health
Geography
Pathology
Gene
Environmental planning
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.7554/elife.103533
- OA Status
- gold
- References
- 110
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4406097474
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4406097474Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.7554/elife.103533Digital Object Identifier
- Title
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Human genetic ancestry, Mycobacterium tuberculosis diversity and tuberculosis disease severity in Dar es Salaam, TanzaniaWork title
- Type
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preprintOpenAlex work type
- Language
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enPrimary language
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2025Year of publication
- Publication date
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2025-01-06Full publication date if available
- Authors
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Michaela Zwyer, Zhi Ming Xu, Amanda Ross, Jerry Hella, Mohamed Sasamalo, Maxime Rotival, Hellen Hiza, Liliana K. Rutaihwa, Sònia Borrell, Klaus Reither, Jacques Fellay, Damien Portevin, Lluis Quintana-Murci, Sébastien Gagneux, Daniela BritesList of authors in order
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https://doi.org/10.7554/elife.103533Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.7554/elife.103533Direct OA link when available
- Concepts
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Tuberculosis, Tanzania, Mycobacterium tuberculosis complex, Disease, Mycobacterium tuberculosis, Genetic diversity, Population, Genotype, Biology, Medicine, Virology, Genetics, Environmental health, Geography, Pathology, Gene, Environmental planningTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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