Human group II 14 kDa phospholipase A2 activates human platelets Article Swipe
János Polgár
,
Ruth M. Kramer
,
Suzane L. Um
,
Joseph A. Jakubowski
,
Kenneth J. Clemetson
·
YOU?
·
· 1997
· Open Access
·
· DOI: https://doi.org/10.1042/bj3270259
YOU?
·
· 1997
· Open Access
·
· DOI: https://doi.org/10.1042/bj3270259
Recombinant human group II phospholipase A2 (sPLA2) added to human platelets in the low μg/ml range induced platelet activation, as demonstrated by measurement of platelet aggregation, thromboxane A2 generation and influx of intracellular free Ca2+ concentration and by detection of time-dependent tyrosine phosphorylation of platelet proteins. The presence of Ca2+ at low millimolar concentrations is a prerequisite for the activation of platelets by sPLA2. Mg2+ cannot replace Ca2+. Mg2+, given in addition to the necessary Ca2+, inhibits sPLA2-induced platelet activation. Pre-exposure to sPLA2 completely blocked the aggregating effect of a second dose of sPLA2. Albumin or indomethacin inhibited sPLA2-induced aggregation, similarly to the inhibition of arachidonic acid-induced aggregation. Platelets pre-treated with heparitinase or phosphatidylinositol-specific phospholipase C lost their ability to aggregate in response to sPLA2, although they still responded to other agonists. This suggests that a glycophosphatidylinositol-anchored platelet-membrane heparan sulphate proteoglycan is the binding site for sPLA2 on platelets. Previous reports have stated that sPLA2 is unable to activate platelets. The inhibitory effect of albumin and Mg2+, frequently used in aggregation studies, and the fact that isolated platelets lose their responsiveness to sPLA2 relatively quickly, may explain why the platelet-activating effects of sPLA2 have not been reported earlier.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1042/bj3270259
- https://portlandpress.com/biochemj/article-pdf/327/1/259/624536/bj3270259.pdf
- OA Status
- bronze
- Cited By
- 15
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2417946977
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W2417946977Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1042/bj3270259Digital Object Identifier
- Title
-
Human group II 14 kDa phospholipase A2 activates human plateletsWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
1997Year of publication
- Publication date
-
1997-10-01Full publication date if available
- Authors
-
János Polgár, Ruth M. Kramer, Suzane L. Um, Joseph A. Jakubowski, Kenneth J. ClemetsonList of authors in order
- Landing page
-
https://doi.org/10.1042/bj3270259Publisher landing page
- PDF URL
-
https://portlandpress.com/biochemj/article-pdf/327/1/259/624536/bj3270259.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
bronzeOpen access status per OpenAlex
- OA URL
-
https://portlandpress.com/biochemj/article-pdf/327/1/259/624536/bj3270259.pdfDirect OA link when available
- Concepts
-
Platelet, Chemistry, Phospholipase A2, Phospholipase C, Biochemistry, Arachidonic acid, Platelet activation, Phospholipase, Phosphatidylinositol, Albumin, Tyrosine phosphorylation, Biophysics, Phosphorylation, Enzyme, Biology, ImmunologyTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
15Total citation count in OpenAlex
- Citations by year (recent)
-
2020: 1, 2015: 1, 2012: 1Per-year citation counts (last 5 years)
- References (count)
-
56Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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