Human Nervous System‐Based Biohybrid Robot‐On‐A‐Chip with Sensing Function for Toxicity Screening Article Swipe
Minkyu Shin
,
Joungpyo Lim
,
Seewoo Kim
,
Sangeun Lee
,
Wei Su
,
Jinho Yoon
,
Jeong‐Woo Choi
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/advs.202501452
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.1002/advs.202501452
Biohybrid robots and biohybrid robot‐on‐a‐chip have been developed for drug screening and toxicity screening the complementing animal experiments. A sensing system is needed to evaluate the response to external stimulation, but until now, only the human motor system‐based biohybrid robot‐on‐a‐chip with neuromuscular system has been developed without a sensing system. A human nervous system‐based biohybrid robot‐on‐a‐chip with eye function as a sensing system in addition to brain/motor neuron/muscle functions is proposed for the first time. Eye assembloid is fabricated by a combination of thalamic organoid covered with Au nanomesh and four retinal organoids. By a combination of eye assembloid, cerebral organoid, motor neuron spheroid, and muscle bundle on polymer substrate, a human nervous system‐based biohybrid robot‐on‐a‐chip is made. When blue light is used to cause retinal damage or a hydroxychloroquine (HCQ), a retinal toxic chemical, is applied to the eye assembloid, they caused a decrease in muscle bundle contraction. These results indicated that electrophysiological signals generated by the eye assembloid are transmitted to the muscle bundle through cerebral organoid and motor neuron spheroids, and thus the proposed system can perform the toxicity screening. Human nervous system‐based biohybrid robot‐on‐a‐chip can be applied to drug screening of neurodegenerative diseases and toxicity screening for the complement of animal experiments in the future.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1002/advs.202501452
- https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.202501452
- OA Status
- gold
- Cited By
- 2
- References
- 45
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4412011334
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4412011334Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.1002/advs.202501452Digital Object Identifier
- Title
-
Human Nervous System‐Based Biohybrid Robot‐On‐A‐Chip with Sensing Function for Toxicity ScreeningWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2025Year of publication
- Publication date
-
2025-07-02Full publication date if available
- Authors
-
Minkyu Shin, Joungpyo Lim, Seewoo Kim, Sangeun Lee, Wei Su, Jinho Yoon, Jeong‐Woo ChoiList of authors in order
- Landing page
-
https://doi.org/10.1002/advs.202501452Publisher landing page
- PDF URL
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.202501452Direct link to full text PDF
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YesWhether a free full text is available
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goldOpen access status per OpenAlex
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https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/advs.202501452Direct OA link when available
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Nervous system, Organ-on-a-chip, Computer science, Neuroscience, Biomedical engineering, Nanotechnology, Materials science, Medicine, Biology, MicrofluidicsTop concepts (fields/topics) attached by OpenAlex
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2Total citation count in OpenAlex
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2025: 2Per-year citation counts (last 5 years)
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45Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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