Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers: population-based follow-up of a cluster-randomised trial Article Swipe
Matti Lehtinen
,
Camilla Lagheden
,
Tapio Luostarinen
,
Tiina Eriksson
,
Dan Apter
,
Anne Bly
,
Penelope Gray
,
Katja Harjula
,
Kaisa Heikkilä
,
Mari Hokkanen
,
Heidi Karttunen
,
Marjo Kuortti
,
Pekka Nieminen
,
Mervi Nummela
,
Jorma Paavonen
,
Johanna Palmroth
,
Tiina Petäjä
,
Eero Pukkala
,
Anna Söderlund‐Strand
,
Ulla Veivo
,
Joakim Dillner
·
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1136/bmjopen-2021-050669
YOU?
·
· 2021
· Open Access
·
· DOI: https://doi.org/10.1136/bmjopen-2021-050669
Background Human papillomavirus (HPV) vaccination protects against HPV, a necessary risk factor for cervical cancer. We now report results from population-based follow-up of randomised cohorts that vaccination provides HPV-type-specific protection against invasive cancer. Methods Individually and/or cluster randomised cohorts of HPV-vaccinated and non-vaccinated women were enrolled in 2002–2005. HPV vaccine cohorts comprised originally 16–17 year-old HPV 16/18-vaccinated PATRICIA ( NCT00122681 ) and 012 trial ( NCT00169494 ) participants (2465) and HPV6/11/16/18-vaccinated FUTURE II ( NCT00092534 ) participants (866). Altogether, 3341 vaccines were followed by the Finnish Cancer Registry in the same way as 16 526 non-HPV-vaccinated controls. The control cohort stemmed from 15 665 originally 18–19 years-old women enrolled in 2003 (6499) or 2005 (9166) and 861 placebo recipients of the FUTURE II trial. The follow-up started 6 months after the clinical trials in 2007 and 2009 and ended in 2019. It was age aligned for the cohorts. Findings During a follow-up time of up to 11 years, we identified 17 HPV-positive invasive cancer cases (14 cervical cancers, 1 vaginal cancer, 1 vulvar cancer and 1 tongue cancer) in the non-HPV-vaccinated cohorts and no cases in the HPV-vaccinated cohorts. HPV typing of diagnostic tumour blocks found HPV16 in nine cervical cancer cases, HPV18, HPV33 and HPV52 each in two cases and HPV45 in one cervical cancer case. The vaginal, vulvar and tongue cancer cases were, respectively, positive for HPV16, HPV52/66 and HPV213. Intention-to-treat vaccine efficacy against all HPV-positive cancers was 100% (95% CI 2 to 100, p<0.05). Interpretation Vaccination is effective against invasive HPV-positive cancer. Trial registration number NCT00122681 , Post-results; NCT00169494 , Post-results; NCT00092534 , Post-results.
Related Topics
Concepts
Medicine
Human papillomavirus
Epidemiology
Cluster (spacecraft)
Population
Clinical trial
Internal medicine
Oncology
Cervical cancer
Randomized controlled trial
HPV vaccines
Human papilloma virus
Cancer
HPV infection
Environmental health
Computer science
Programming language
Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1136/bmjopen-2021-050669
- https://bmjopen.bmj.com/content/bmjopen/11/12/e050669.full.pdf
- OA Status
- gold
- Cited By
- 38
- References
- 24
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4206471801
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W4206471801Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1136/bmjopen-2021-050669Digital Object Identifier
- Title
-
Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers: population-based follow-up of a cluster-randomised trialWork title
- Type
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articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2021Year of publication
- Publication date
-
2021-12-01Full publication date if available
- Authors
-
Matti Lehtinen, Camilla Lagheden, Tapio Luostarinen, Tiina Eriksson, Dan Apter, Anne Bly, Penelope Gray, Katja Harjula, Kaisa Heikkilä, Mari Hokkanen, Heidi Karttunen, Marjo Kuortti, Pekka Nieminen, Mervi Nummela, Jorma Paavonen, Johanna Palmroth, Tiina Petäjä, Eero Pukkala, Anna Söderlund‐Strand, Ulla Veivo, Joakim DillnerList of authors in order
- Landing page
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https://doi.org/10.1136/bmjopen-2021-050669Publisher landing page
- PDF URL
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https://bmjopen.bmj.com/content/bmjopen/11/12/e050669.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
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https://bmjopen.bmj.com/content/bmjopen/11/12/e050669.full.pdfDirect OA link when available
- Concepts
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Medicine, Human papillomavirus, Epidemiology, Cluster (spacecraft), Population, Clinical trial, Internal medicine, Oncology, Cervical cancer, Randomized controlled trial, HPV vaccines, Human papilloma virus, Cancer, HPV infection, Environmental health, Computer science, Programming languageTop concepts (fields/topics) attached by OpenAlex
- Cited by
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38Total citation count in OpenAlex
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2025: 9, 2024: 12, 2023: 8, 2022: 9Per-year citation counts (last 5 years)
- References (count)
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24Number of works referenced by this work
- Related works (count)
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10Other works algorithmically related by OpenAlex
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