Human rhinoviruses enter and induce proliferation of B lymphocytes Article Swipe

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Biology Flow cytometry Rhinovirus Molecular biology Peripheral blood mononuclear cell Virology Immunofluorescence Virus Viral replication Immune system CD19 Antibody In vitro Immunology Biochemistry

Alar Aab , Oliver F. Wirz , Willem van de Veen , Stefan Söllner , Barbara Stanić , Beate Rückert , Julia Aniscenko , Michael R. Edwards , Sebastian L. Johnston , Nikolaos G. Papadopoulos , Ana Rebane , Cezmi A. Akdiş , Mübeccel Akdiş ·

YOU? · · 2016 · Open Access · · DOI: https://doi.org/10.1111/all.12931 · OA: W2386280368

Our results demonstrate for the first time that HRVs enter and form viral replication centers in B lymphocytes and induce the proliferation of B cells. Newly formed virions have the capacity to infect other cells (HeLa). These findings indicate that the regulation of human rhinovirus-induced B-cell responses could be a novel approach to develop therapeutics to treat the virus-induced exacerbation of asthma.