Hydrogen Sulfide Coordinates Glucose Metabolism Switch through Destabilizing Tetrameric Pyruvate Kinase M2 Article Swipe
Rong‐Hsuan Wang
,
Pin‐Ru Chen
,
Yueting Chen
,
Yi‐Chang Chen
,
Yu-Hsin Chu
,
Chia-Chen Chien
,
Po-Chen Chien
,
S. K. Lo
,
Zhongliang Wang
,
Min-Chen Tsou
,
Ssu-Yu Chen
,
Guang-Shen Chiu
,
Wen‐Ling Chen
,
Yi‐Hsuan Wu
,
Lily Wang
,
Wen‐Ching Wang
,
Shu‐Yi Lin
,
Hsing‐Jien Kung
,
Lu‐Hai Wang
,
Hui‐Chun Cheng
,
Kai‐Ti Lin
·
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.09.02.555034
YOU?
·
· 2023
· Open Access
·
· DOI: https://doi.org/10.1101/2023.09.02.555034
Cancer cells reprogram their glucose metabolic pathway from oxidative phosphorylation toward aerobic glycolysis. Pyruvate kinase M2 (PKM2), which converts phosphoenolpyruvate (PEP) to pyruvate, is considered the rate-limiting enzyme involved in cancer glucose metabolism. By reducing PKM2 enzyme activity, cancer cells attain a greater fraction of glycolytic metabolites for macromolecule synthesis needed for rapid proliferation. Here we demonstrate that hydrogen sulfide (H 2 S) destabilizes PKM2 tetramer into dimer/monomer, leading to reduced PKM2 enzyme activity and an increase in the activation of nuclear transcriptional genes mediated by dimeric PKM2. Proteomic profiling of endogenous PKM2 reveals the occurrence of sulfhydration at cysteines, notably at cysteine 326. Blocking PKM2 sulfhydration at cysteine 326 through amino acid mutation stabilizes PKM2 tetramer and crystal structure further indicating that the tetramer organization of PKM2 C326S is different from the currently known T or R states, revealing PKM2 C326S as a newly identified form. The presence of a PKM2 C326S mutant in cancer cells effectively rewires glucose metabolism to mitochondrial respiration, resulting in the significant inhibition of tumor growth. Collectively, PKM2 sulfhydration by H 2 S serves as a glucose metabolic rewiring mechanism in promoting tumorigenesis, and inhibition of PKM2 sulfhydration may be applied as a new therapeutic approach targeting cancer metabolism. One-Sentence Summary H 2 S rewires glucose metabolism by destabilizing PKM2 tetramerization majorly through sulfhydration at cysteine 326 Highlights H 2 S enhances PKM2 dissociation from tetramer to dimer to facilitate dimeric PKM2 nuclear translocation. H 2 S modifies PKM2 sulfhydration, notably at cysteine 326. The crystal structure reveals PKM2 C326S as a unique tetramer conformation. Blockage of PKM2 sulfhydration at C326 rewires cancer glucose metabolism and significantly inhibits tumor growth.
Related Topics
Concepts
Metadata
- Type
- preprint
- Language
- en
- Landing Page
- https://doi.org/10.1101/2023.09.02.555034
- https://www.biorxiv.org/content/biorxiv/early/2023/09/03/2023.09.02.555034.full.pdf
- OA Status
- green
- Cited By
- 2
- References
- 56
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4386409618
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4386409618Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1101/2023.09.02.555034Digital Object Identifier
- Title
-
Hydrogen Sulfide Coordinates Glucose Metabolism Switch through Destabilizing Tetrameric Pyruvate Kinase M2Work title
- Type
-
preprintOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2023Year of publication
- Publication date
-
2023-09-03Full publication date if available
- Authors
-
Rong‐Hsuan Wang, Pin‐Ru Chen, Yueting Chen, Yi‐Chang Chen, Yu-Hsin Chu, Chia-Chen Chien, Po-Chen Chien, S. K. Lo, Zhongliang Wang, Min-Chen Tsou, Ssu-Yu Chen, Guang-Shen Chiu, Wen‐Ling Chen, Yi‐Hsuan Wu, Lily Wang, Wen‐Ching Wang, Shu‐Yi Lin, Hsing‐Jien Kung, Lu‐Hai Wang, Hui‐Chun Cheng, Kai‐Ti LinList of authors in order
- Landing page
-
https://doi.org/10.1101/2023.09.02.555034Publisher landing page
- PDF URL
-
https://www.biorxiv.org/content/biorxiv/early/2023/09/03/2023.09.02.555034.full.pdfDirect link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
-
https://www.biorxiv.org/content/biorxiv/early/2023/09/03/2023.09.02.555034.full.pdfDirect OA link when available
- Concepts
-
PKM2, Tetramer, Pyruvate kinase, Chemistry, Biochemistry, Glycolysis, Cysteine, Metabolism, EnzymeTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
2Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 2Per-year citation counts (last 5 years)
- References (count)
-
56Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
Full payload
| id | https://openalex.org/W4386409618 |
|---|---|
| doi | https://doi.org/10.1101/2023.09.02.555034 |
| ids.doi | https://doi.org/10.1101/2023.09.02.555034 |
| ids.openalex | https://openalex.org/W4386409618 |
| fwci | 0.44517014 |
| type | preprint |
| title | Hydrogen Sulfide Coordinates Glucose Metabolism Switch through Destabilizing Tetrameric Pyruvate Kinase M2 |
| biblio.issue | |
| biblio.volume | |
| biblio.last_page | |
| biblio.first_page | |
| topics[0].id | https://openalex.org/T10631 |
| topics[0].field.id | https://openalex.org/fields/13 |
| topics[0].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[0].score | 0.9998999834060669 |
| topics[0].domain.id | https://openalex.org/domains/1 |
| topics[0].domain.display_name | Life Sciences |
| topics[0].subfield.id | https://openalex.org/subfields/1306 |
| topics[0].subfield.display_name | Cancer Research |
| topics[0].display_name | Cancer, Hypoxia, and Metabolism |
| topics[1].id | https://openalex.org/T12770 |
| topics[1].field.id | https://openalex.org/fields/13 |
| topics[1].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[1].score | 0.9998000264167786 |
| topics[1].domain.id | https://openalex.org/domains/1 |
| topics[1].domain.display_name | Life Sciences |
| topics[1].subfield.id | https://openalex.org/subfields/1303 |
| topics[1].subfield.display_name | Biochemistry |
| topics[1].display_name | Amino Acid Enzymes and Metabolism |
| topics[2].id | https://openalex.org/T10269 |
| topics[2].field.id | https://openalex.org/fields/13 |
| topics[2].field.display_name | Biochemistry, Genetics and Molecular Biology |
| topics[2].score | 0.9986000061035156 |
| topics[2].domain.id | https://openalex.org/domains/1 |
| topics[2].domain.display_name | Life Sciences |
| topics[2].subfield.id | https://openalex.org/subfields/1312 |
| topics[2].subfield.display_name | Molecular Biology |
| topics[2].display_name | Epigenetics and DNA Methylation |
| is_xpac | False |
| apc_list | |
| apc_paid | |
| concepts[0].id | https://openalex.org/C10730799 |
| concepts[0].level | 5 |
| concepts[0].score | 0.8638827800750732 |
| concepts[0].wikidata | https://www.wikidata.org/wiki/Q18030568 |
| concepts[0].display_name | PKM2 |
| concepts[1].id | https://openalex.org/C2778886173 |
| concepts[1].level | 3 |
| concepts[1].score | 0.6043742895126343 |
| concepts[1].wikidata | https://www.wikidata.org/wiki/Q53832 |
| concepts[1].display_name | Tetramer |
| concepts[2].id | https://openalex.org/C2780854706 |
| concepts[2].level | 4 |
| concepts[2].score | 0.600146472454071 |
| concepts[2].wikidata | https://www.wikidata.org/wiki/Q900970 |
| concepts[2].display_name | Pyruvate kinase |
| concepts[3].id | https://openalex.org/C185592680 |
| concepts[3].level | 0 |
| concepts[3].score | 0.5853106379508972 |
| concepts[3].wikidata | https://www.wikidata.org/wiki/Q2329 |
| concepts[3].display_name | Chemistry |
| concepts[4].id | https://openalex.org/C55493867 |
| concepts[4].level | 1 |
| concepts[4].score | 0.5799020528793335 |
| concepts[4].wikidata | https://www.wikidata.org/wiki/Q7094 |
| concepts[4].display_name | Biochemistry |
| concepts[5].id | https://openalex.org/C20251656 |
| concepts[5].level | 3 |
| concepts[5].score | 0.5249738097190857 |
| concepts[5].wikidata | https://www.wikidata.org/wiki/Q162643 |
| concepts[5].display_name | Glycolysis |
| concepts[6].id | https://openalex.org/C2779201268 |
| concepts[6].level | 3 |
| concepts[6].score | 0.4880937337875366 |
| concepts[6].wikidata | https://www.wikidata.org/wiki/Q186474 |
| concepts[6].display_name | Cysteine |
| concepts[7].id | https://openalex.org/C62231903 |
| concepts[7].level | 2 |
| concepts[7].score | 0.41522371768951416 |
| concepts[7].wikidata | https://www.wikidata.org/wiki/Q1057 |
| concepts[7].display_name | Metabolism |
| concepts[8].id | https://openalex.org/C181199279 |
| concepts[8].level | 2 |
| concepts[8].score | 0.27099859714508057 |
| concepts[8].wikidata | https://www.wikidata.org/wiki/Q8047 |
| concepts[8].display_name | Enzyme |
| keywords[0].id | https://openalex.org/keywords/pkm2 |
| keywords[0].score | 0.8638827800750732 |
| keywords[0].display_name | PKM2 |
| keywords[1].id | https://openalex.org/keywords/tetramer |
| keywords[1].score | 0.6043742895126343 |
| keywords[1].display_name | Tetramer |
| keywords[2].id | https://openalex.org/keywords/pyruvate-kinase |
| keywords[2].score | 0.600146472454071 |
| keywords[2].display_name | Pyruvate kinase |
| keywords[3].id | https://openalex.org/keywords/chemistry |
| keywords[3].score | 0.5853106379508972 |
| keywords[3].display_name | Chemistry |
| keywords[4].id | https://openalex.org/keywords/biochemistry |
| keywords[4].score | 0.5799020528793335 |
| keywords[4].display_name | Biochemistry |
| keywords[5].id | https://openalex.org/keywords/glycolysis |
| keywords[5].score | 0.5249738097190857 |
| keywords[5].display_name | Glycolysis |
| keywords[6].id | https://openalex.org/keywords/cysteine |
| keywords[6].score | 0.4880937337875366 |
| keywords[6].display_name | Cysteine |
| keywords[7].id | https://openalex.org/keywords/metabolism |
| keywords[7].score | 0.41522371768951416 |
| keywords[7].display_name | Metabolism |
| keywords[8].id | https://openalex.org/keywords/enzyme |
| keywords[8].score | 0.27099859714508057 |
| keywords[8].display_name | Enzyme |
| language | en |
| locations[0].id | doi:10.1101/2023.09.02.555034 |
| locations[0].is_oa | True |
| locations[0].source.id | https://openalex.org/S4306402567 |
| locations[0].source.issn | |
| locations[0].source.type | repository |
| locations[0].source.is_oa | False |
| locations[0].source.issn_l | |
| locations[0].source.is_core | False |
| locations[0].source.is_in_doaj | False |
| locations[0].source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| locations[0].source.host_organization | https://openalex.org/I2750212522 |
| locations[0].source.host_organization_name | Cold Spring Harbor Laboratory |
| locations[0].source.host_organization_lineage | https://openalex.org/I2750212522 |
| locations[0].license | |
| locations[0].pdf_url | https://www.biorxiv.org/content/biorxiv/early/2023/09/03/2023.09.02.555034.full.pdf |
| locations[0].version | acceptedVersion |
| locations[0].raw_type | posted-content |
| locations[0].license_id | |
| locations[0].is_accepted | True |
| locations[0].is_published | False |
| locations[0].raw_source_name | |
| locations[0].landing_page_url | https://doi.org/10.1101/2023.09.02.555034 |
| indexed_in | crossref |
| authorships[0].author.id | https://openalex.org/A5058791166 |
| authorships[0].author.orcid | |
| authorships[0].author.display_name | Rong‐Hsuan Wang |
| authorships[0].countries | TW |
| authorships[0].affiliations[0].institution_ids | https://openalex.org/I25846049 |
| authorships[0].affiliations[0].raw_affiliation_string | Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[0].institutions[0].id | https://openalex.org/I25846049 |
| authorships[0].institutions[0].ror | https://ror.org/00zdnkx70 |
| authorships[0].institutions[0].type | education |
| authorships[0].institutions[0].lineage | https://openalex.org/I25846049 |
| authorships[0].institutions[0].country_code | TW |
| authorships[0].institutions[0].display_name | National Tsing Hua University |
| authorships[0].author_position | first |
| authorships[0].raw_author_name | Rong-Hsuan Wang |
| authorships[0].is_corresponding | False |
| authorships[0].raw_affiliation_strings | Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[1].author.id | https://openalex.org/A5062604020 |
| authorships[1].author.orcid | https://orcid.org/0009-0001-8653-2651 |
| authorships[1].author.display_name | Pin‐Ru Chen |
| authorships[1].countries | TW |
| authorships[1].affiliations[0].institution_ids | https://openalex.org/I25846049 |
| authorships[1].affiliations[0].raw_affiliation_string | Institute of Bioinformatics and Structural Biology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[1].institutions[0].id | https://openalex.org/I25846049 |
| authorships[1].institutions[0].ror | https://ror.org/00zdnkx70 |
| authorships[1].institutions[0].type | education |
| authorships[1].institutions[0].lineage | https://openalex.org/I25846049 |
| authorships[1].institutions[0].country_code | TW |
| authorships[1].institutions[0].display_name | National Tsing Hua University |
| authorships[1].author_position | middle |
| authorships[1].raw_author_name | Pin-Ru Chen |
| authorships[1].is_corresponding | False |
| authorships[1].raw_affiliation_strings | Institute of Bioinformatics and Structural Biology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[2].author.id | https://openalex.org/A5003982996 |
| authorships[2].author.orcid | https://orcid.org/0000-0002-2759-9784 |
| authorships[2].author.display_name | Yueting Chen |
| authorships[2].countries | TW |
| authorships[2].affiliations[0].institution_ids | https://openalex.org/I25846049 |
| authorships[2].affiliations[0].raw_affiliation_string | Institute of Bioinformatics and Structural Biology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[2].institutions[0].id | https://openalex.org/I25846049 |
| authorships[2].institutions[0].ror | https://ror.org/00zdnkx70 |
| authorships[2].institutions[0].type | education |
| authorships[2].institutions[0].lineage | https://openalex.org/I25846049 |
| authorships[2].institutions[0].country_code | TW |
| authorships[2].institutions[0].display_name | National Tsing Hua University |
| authorships[2].author_position | middle |
| authorships[2].raw_author_name | Yue-Ting Chen |
| authorships[2].is_corresponding | False |
| authorships[2].raw_affiliation_strings | Institute of Bioinformatics and Structural Biology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[3].author.id | https://openalex.org/A5101438452 |
| authorships[3].author.orcid | https://orcid.org/0000-0003-0936-7004 |
| authorships[3].author.display_name | Yi‐Chang Chen |
| authorships[3].countries | TW |
| authorships[3].affiliations[0].institution_ids | https://openalex.org/I25846049 |
| authorships[3].affiliations[0].raw_affiliation_string | Institute of Bioinformatics and Structural Biology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[3].institutions[0].id | https://openalex.org/I25846049 |
| authorships[3].institutions[0].ror | https://ror.org/00zdnkx70 |
| authorships[3].institutions[0].type | education |
| authorships[3].institutions[0].lineage | https://openalex.org/I25846049 |
| authorships[3].institutions[0].country_code | TW |
| authorships[3].institutions[0].display_name | National Tsing Hua University |
| authorships[3].author_position | middle |
| authorships[3].raw_author_name | Yi-Chang Chen |
| authorships[3].is_corresponding | False |
| authorships[3].raw_affiliation_strings | Institute of Bioinformatics and Structural Biology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[4].author.id | https://openalex.org/A5089187146 |
| authorships[4].author.orcid | |
| authorships[4].author.display_name | Yu-Hsin Chu |
| authorships[4].countries | TW |
| authorships[4].affiliations[0].institution_ids | https://openalex.org/I25846049 |
| authorships[4].affiliations[0].raw_affiliation_string | Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[4].institutions[0].id | https://openalex.org/I25846049 |
| authorships[4].institutions[0].ror | https://ror.org/00zdnkx70 |
| authorships[4].institutions[0].type | education |
| authorships[4].institutions[0].lineage | https://openalex.org/I25846049 |
| authorships[4].institutions[0].country_code | TW |
| authorships[4].institutions[0].display_name | National Tsing Hua University |
| authorships[4].author_position | middle |
| authorships[4].raw_author_name | Yu-Hsin Chu |
| authorships[4].is_corresponding | False |
| authorships[4].raw_affiliation_strings | Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[5].author.id | https://openalex.org/A5102633844 |
| authorships[5].author.orcid | |
| authorships[5].author.display_name | Chia-Chen Chien |
| authorships[5].countries | TW |
| authorships[5].affiliations[0].institution_ids | https://openalex.org/I25846049 |
| authorships[5].affiliations[0].raw_affiliation_string | Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[5].institutions[0].id | https://openalex.org/I25846049 |
| authorships[5].institutions[0].ror | https://ror.org/00zdnkx70 |
| authorships[5].institutions[0].type | education |
| authorships[5].institutions[0].lineage | https://openalex.org/I25846049 |
| authorships[5].institutions[0].country_code | TW |
| authorships[5].institutions[0].display_name | National Tsing Hua University |
| authorships[5].author_position | middle |
| authorships[5].raw_author_name | Chia-Chen Chien |
| authorships[5].is_corresponding | False |
| authorships[5].raw_affiliation_strings | Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[6].author.id | https://openalex.org/A5041497912 |
| authorships[6].author.orcid | |
| authorships[6].author.display_name | Po-Chen Chien |
| authorships[6].countries | TW |
| authorships[6].affiliations[0].institution_ids | https://openalex.org/I25846049 |
| authorships[6].affiliations[0].raw_affiliation_string | Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[6].institutions[0].id | https://openalex.org/I25846049 |
| authorships[6].institutions[0].ror | https://ror.org/00zdnkx70 |
| authorships[6].institutions[0].type | education |
| authorships[6].institutions[0].lineage | https://openalex.org/I25846049 |
| authorships[6].institutions[0].country_code | TW |
| authorships[6].institutions[0].display_name | National Tsing Hua University |
| authorships[6].author_position | middle |
| authorships[6].raw_author_name | Po-Chen Chien |
| authorships[6].is_corresponding | False |
| authorships[6].raw_affiliation_strings | Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[7].author.id | https://openalex.org/A5103328528 |
| authorships[7].author.orcid | |
| authorships[7].author.display_name | S. K. Lo |
| authorships[7].countries | TW |
| authorships[7].affiliations[0].institution_ids | https://openalex.org/I25846049 |
| authorships[7].affiliations[0].raw_affiliation_string | Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[7].institutions[0].id | https://openalex.org/I25846049 |
| authorships[7].institutions[0].ror | https://ror.org/00zdnkx70 |
| authorships[7].institutions[0].type | education |
| authorships[7].institutions[0].lineage | https://openalex.org/I25846049 |
| authorships[7].institutions[0].country_code | TW |
| authorships[7].institutions[0].display_name | National Tsing Hua University |
| authorships[7].author_position | middle |
| authorships[7].raw_author_name | Shao-Yun Lo |
| authorships[7].is_corresponding | False |
| authorships[7].raw_affiliation_strings | Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[8].author.id | https://openalex.org/A5100664122 |
| authorships[8].author.orcid | https://orcid.org/0000-0001-9388-149X |
| authorships[8].author.display_name | Zhongliang Wang |
| authorships[8].countries | TW |
| authorships[8].affiliations[0].institution_ids | https://openalex.org/I25846049 |
| authorships[8].affiliations[0].raw_affiliation_string | Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[8].institutions[0].id | https://openalex.org/I25846049 |
| authorships[8].institutions[0].ror | https://ror.org/00zdnkx70 |
| authorships[8].institutions[0].type | education |
| authorships[8].institutions[0].lineage | https://openalex.org/I25846049 |
| authorships[8].institutions[0].country_code | TW |
| authorships[8].institutions[0].display_name | National Tsing Hua University |
| authorships[8].author_position | middle |
| authorships[8].raw_author_name | Zhong-Liang Wang |
| authorships[8].is_corresponding | False |
| authorships[8].raw_affiliation_strings | Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[9].author.id | https://openalex.org/A5109772285 |
| authorships[9].author.orcid | |
| authorships[9].author.display_name | Min-Chen Tsou |
| authorships[9].countries | TW |
| authorships[9].affiliations[0].institution_ids | https://openalex.org/I25846049 |
| authorships[9].affiliations[0].raw_affiliation_string | Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[9].institutions[0].id | https://openalex.org/I25846049 |
| authorships[9].institutions[0].ror | https://ror.org/00zdnkx70 |
| authorships[9].institutions[0].type | education |
| authorships[9].institutions[0].lineage | https://openalex.org/I25846049 |
| authorships[9].institutions[0].country_code | TW |
| authorships[9].institutions[0].display_name | National Tsing Hua University |
| authorships[9].author_position | middle |
| authorships[9].raw_author_name | Min-Chen Tsou |
| authorships[9].is_corresponding | False |
| authorships[9].raw_affiliation_strings | Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[10].author.id | https://openalex.org/A5042248038 |
| authorships[10].author.orcid | |
| authorships[10].author.display_name | Ssu-Yu Chen |
| authorships[10].countries | TW |
| authorships[10].affiliations[0].institution_ids | https://openalex.org/I25846049 |
| authorships[10].affiliations[0].raw_affiliation_string | Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[10].institutions[0].id | https://openalex.org/I25846049 |
| authorships[10].institutions[0].ror | https://ror.org/00zdnkx70 |
| authorships[10].institutions[0].type | education |
| authorships[10].institutions[0].lineage | https://openalex.org/I25846049 |
| authorships[10].institutions[0].country_code | TW |
| authorships[10].institutions[0].display_name | National Tsing Hua University |
| authorships[10].author_position | middle |
| authorships[10].raw_author_name | Ssu-Yu Chen |
| authorships[10].is_corresponding | False |
| authorships[10].raw_affiliation_strings | Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[11].author.id | https://openalex.org/A5104164495 |
| authorships[11].author.orcid | |
| authorships[11].author.display_name | Guang-Shen Chiu |
| authorships[11].countries | TW |
| authorships[11].affiliations[0].institution_ids | https://openalex.org/I25846049 |
| authorships[11].affiliations[0].raw_affiliation_string | Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[11].institutions[0].id | https://openalex.org/I25846049 |
| authorships[11].institutions[0].ror | https://ror.org/00zdnkx70 |
| authorships[11].institutions[0].type | education |
| authorships[11].institutions[0].lineage | https://openalex.org/I25846049 |
| authorships[11].institutions[0].country_code | TW |
| authorships[11].institutions[0].display_name | National Tsing Hua University |
| authorships[11].author_position | middle |
| authorships[11].raw_author_name | Guang-Shen Chiu |
| authorships[11].is_corresponding | False |
| authorships[11].raw_affiliation_strings | Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[12].author.id | https://openalex.org/A5005866572 |
| authorships[12].author.orcid | https://orcid.org/0000-0001-5143-0543 |
| authorships[12].author.display_name | Wen‐Ling Chen |
| authorships[12].countries | TW |
| authorships[12].affiliations[0].institution_ids | https://openalex.org/I165441096 |
| authorships[12].affiliations[0].raw_affiliation_string | Institute of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan |
| authorships[12].institutions[0].id | https://openalex.org/I165441096 |
| authorships[12].institutions[0].ror | https://ror.org/02r6fpx29 |
| authorships[12].institutions[0].type | nonprofit |
| authorships[12].institutions[0].lineage | https://openalex.org/I165441096 |
| authorships[12].institutions[0].country_code | TW |
| authorships[12].institutions[0].display_name | National Health Research Institutes |
| authorships[12].author_position | middle |
| authorships[12].raw_author_name | Wen-Ling Chen |
| authorships[12].is_corresponding | False |
| authorships[12].raw_affiliation_strings | Institute of Molecular and Genomic Medicine, National Health Research Institutes, Taiwan |
| authorships[13].author.id | https://openalex.org/A5106482293 |
| authorships[13].author.orcid | https://orcid.org/0000-0003-0178-2713 |
| authorships[13].author.display_name | Yi‐Hsuan Wu |
| authorships[13].countries | TW |
| authorships[13].affiliations[0].institution_ids | https://openalex.org/I25846049 |
| authorships[13].affiliations[0].raw_affiliation_string | Institute of Molecular and Cellular Biology, National Tsing Hua University, Taiwan |
| authorships[13].institutions[0].id | https://openalex.org/I25846049 |
| authorships[13].institutions[0].ror | https://ror.org/00zdnkx70 |
| authorships[13].institutions[0].type | education |
| authorships[13].institutions[0].lineage | https://openalex.org/I25846049 |
| authorships[13].institutions[0].country_code | TW |
| authorships[13].institutions[0].display_name | National Tsing Hua University |
| authorships[13].author_position | middle |
| authorships[13].raw_author_name | Yi-Hsuan Wu |
| authorships[13].is_corresponding | False |
| authorships[13].raw_affiliation_strings | Institute of Molecular and Cellular Biology, National Tsing Hua University, Taiwan |
| authorships[14].author.id | https://openalex.org/A5020503630 |
| authorships[14].author.orcid | https://orcid.org/0000-0003-0659-0139 |
| authorships[14].author.display_name | Lily Wang |
| authorships[14].countries | TW |
| authorships[14].affiliations[0].institution_ids | https://openalex.org/I25846049 |
| authorships[14].affiliations[0].raw_affiliation_string | School of Medicine, National Tsing Hua University |
| authorships[14].affiliations[1].institution_ids | https://openalex.org/I25846049 |
| authorships[14].affiliations[1].raw_affiliation_string | Institute of Molecular and Cellular Biology, National Tsing Hua University, Taiwan |
| authorships[14].affiliations[2].institution_ids | https://openalex.org/I25846049 |
| authorships[14].affiliations[2].raw_affiliation_string | Department of Medical Science, National Tsing Hua University, Taiwan |
| authorships[14].institutions[0].id | https://openalex.org/I25846049 |
| authorships[14].institutions[0].ror | https://ror.org/00zdnkx70 |
| authorships[14].institutions[0].type | education |
| authorships[14].institutions[0].lineage | https://openalex.org/I25846049 |
| authorships[14].institutions[0].country_code | TW |
| authorships[14].institutions[0].display_name | National Tsing Hua University |
| authorships[14].author_position | middle |
| authorships[14].raw_author_name | Lily Hui-Ching Wang |
| authorships[14].is_corresponding | False |
| authorships[14].raw_affiliation_strings | Department of Medical Science, National Tsing Hua University, Taiwan, Institute of Molecular and Cellular Biology, National Tsing Hua University, Taiwan, School of Medicine, National Tsing Hua University |
| authorships[15].author.id | https://openalex.org/A5057178901 |
| authorships[15].author.orcid | https://orcid.org/0000-0002-7422-3667 |
| authorships[15].author.display_name | Wen‐Ching Wang |
| authorships[15].countries | TW |
| authorships[15].affiliations[0].institution_ids | https://openalex.org/I25846049 |
| authorships[15].affiliations[0].raw_affiliation_string | Department of Life Science, National Tsing Hua University, Taiwan |
| authorships[15].affiliations[1].institution_ids | https://openalex.org/I25846049 |
| authorships[15].affiliations[1].raw_affiliation_string | Institute of Molecular and Cellular Biology, National Tsing Hua University, Taiwan |
| authorships[15].institutions[0].id | https://openalex.org/I25846049 |
| authorships[15].institutions[0].ror | https://ror.org/00zdnkx70 |
| authorships[15].institutions[0].type | education |
| authorships[15].institutions[0].lineage | https://openalex.org/I25846049 |
| authorships[15].institutions[0].country_code | TW |
| authorships[15].institutions[0].display_name | National Tsing Hua University |
| authorships[15].author_position | middle |
| authorships[15].raw_author_name | Wen-Ching Wang |
| authorships[15].is_corresponding | False |
| authorships[15].raw_affiliation_strings | Department of Life Science, National Tsing Hua University, Taiwan, Institute of Molecular and Cellular Biology, National Tsing Hua University, Taiwan |
| authorships[16].author.id | https://openalex.org/A5050618169 |
| authorships[16].author.orcid | https://orcid.org/0000-0002-6871-6617 |
| authorships[16].author.display_name | Shu‐Yi Lin |
| authorships[16].countries | TW |
| authorships[16].affiliations[0].institution_ids | https://openalex.org/I165441096 |
| authorships[16].affiliations[0].raw_affiliation_string | Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Taiwan |
| authorships[16].institutions[0].id | https://openalex.org/I165441096 |
| authorships[16].institutions[0].ror | https://ror.org/02r6fpx29 |
| authorships[16].institutions[0].type | nonprofit |
| authorships[16].institutions[0].lineage | https://openalex.org/I165441096 |
| authorships[16].institutions[0].country_code | TW |
| authorships[16].institutions[0].display_name | National Health Research Institutes |
| authorships[16].author_position | middle |
| authorships[16].raw_author_name | Shu-Yi Lin |
| authorships[16].is_corresponding | False |
| authorships[16].raw_affiliation_strings | Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Taiwan |
| authorships[17].author.id | https://openalex.org/A5105975577 |
| authorships[17].author.orcid | https://orcid.org/0000-0002-9903-5830 |
| authorships[17].author.display_name | Hsing‐Jien Kung |
| authorships[17].countries | TW |
| authorships[17].affiliations[0].institution_ids | https://openalex.org/I47519274 |
| authorships[17].affiliations[0].raw_affiliation_string | School of Medical Laboratory Science and Biotechnology, Taipei Medical University |
| authorships[17].institutions[0].id | https://openalex.org/I47519274 |
| authorships[17].institutions[0].ror | https://ror.org/05031qk94 |
| authorships[17].institutions[0].type | education |
| authorships[17].institutions[0].lineage | https://openalex.org/I47519274 |
| authorships[17].institutions[0].country_code | TW |
| authorships[17].institutions[0].display_name | Taipei Medical University |
| authorships[17].author_position | middle |
| authorships[17].raw_author_name | Hsing-Jien Kung |
| authorships[17].is_corresponding | False |
| authorships[17].raw_affiliation_strings | School of Medical Laboratory Science and Biotechnology, Taipei Medical University |
| authorships[18].author.id | https://openalex.org/A5020997600 |
| authorships[18].author.orcid | https://orcid.org/0000-0003-0050-8560 |
| authorships[18].author.display_name | Lu‐Hai Wang |
| authorships[18].countries | TW |
| authorships[18].affiliations[0].institution_ids | https://openalex.org/I184693016 |
| authorships[18].affiliations[0].raw_affiliation_string | Chiese Medicine Research Center, and Institute of Integrated Medicine, China Medical University, Taiwan |
| authorships[18].institutions[0].id | https://openalex.org/I184693016 |
| authorships[18].institutions[0].ror | https://ror.org/00v408z34 |
| authorships[18].institutions[0].type | education |
| authorships[18].institutions[0].lineage | https://openalex.org/I184693016 |
| authorships[18].institutions[0].country_code | TW |
| authorships[18].institutions[0].display_name | China Medical University |
| authorships[18].author_position | middle |
| authorships[18].raw_author_name | Lu-Hai Wang |
| authorships[18].is_corresponding | True |
| authorships[18].raw_affiliation_strings | Chiese Medicine Research Center, and Institute of Integrated Medicine, China Medical University, Taiwan |
| authorships[19].author.id | https://openalex.org/A5046255159 |
| authorships[19].author.orcid | https://orcid.org/0000-0003-3591-8906 |
| authorships[19].author.display_name | Hui‐Chun Cheng |
| authorships[19].countries | TW |
| authorships[19].affiliations[0].institution_ids | https://openalex.org/I25846049 |
| authorships[19].affiliations[0].raw_affiliation_string | Department of Life Science, National Tsing Hua University, Taiwan |
| authorships[19].affiliations[1].institution_ids | https://openalex.org/I25846049 |
| authorships[19].affiliations[1].raw_affiliation_string | Institute of Bioinformatics and Structural Biology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[19].institutions[0].id | https://openalex.org/I25846049 |
| authorships[19].institutions[0].ror | https://ror.org/00zdnkx70 |
| authorships[19].institutions[0].type | education |
| authorships[19].institutions[0].lineage | https://openalex.org/I25846049 |
| authorships[19].institutions[0].country_code | TW |
| authorships[19].institutions[0].display_name | National Tsing Hua University |
| authorships[19].author_position | middle |
| authorships[19].raw_author_name | Hui-Chun Cheng |
| authorships[19].is_corresponding | True |
| authorships[19].raw_affiliation_strings | Department of Life Science, National Tsing Hua University, Taiwan, Institute of Bioinformatics and Structural Biology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[20].author.id | https://openalex.org/A5045306079 |
| authorships[20].author.orcid | https://orcid.org/0000-0001-8656-5755 |
| authorships[20].author.display_name | Kai‐Ti Lin |
| authorships[20].countries | TW |
| authorships[20].affiliations[0].institution_ids | https://openalex.org/I25846049 |
| authorships[20].affiliations[0].raw_affiliation_string | Department of Medical Science, National Tsing Hua University, Taiwan |
| authorships[20].affiliations[1].institution_ids | https://openalex.org/I25846049 |
| authorships[20].affiliations[1].raw_affiliation_string | Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| authorships[20].institutions[0].id | https://openalex.org/I25846049 |
| authorships[20].institutions[0].ror | https://ror.org/00zdnkx70 |
| authorships[20].institutions[0].type | education |
| authorships[20].institutions[0].lineage | https://openalex.org/I25846049 |
| authorships[20].institutions[0].country_code | TW |
| authorships[20].institutions[0].display_name | National Tsing Hua University |
| authorships[20].author_position | last |
| authorships[20].raw_author_name | Kai-Ti Lin |
| authorships[20].is_corresponding | True |
| authorships[20].raw_affiliation_strings | Department of Medical Science, National Tsing Hua University, Taiwan, Institute of Biotechnology, College of Life Science, National Tsing Hua University, Taiwan |
| has_content.pdf | True |
| has_content.grobid_xml | True |
| is_paratext | False |
| open_access.is_oa | True |
| open_access.oa_url | https://www.biorxiv.org/content/biorxiv/early/2023/09/03/2023.09.02.555034.full.pdf |
| open_access.oa_status | green |
| open_access.any_repository_has_fulltext | False |
| created_date | 2025-10-10T00:00:00 |
| display_name | Hydrogen Sulfide Coordinates Glucose Metabolism Switch through Destabilizing Tetrameric Pyruvate Kinase M2 |
| has_fulltext | True |
| is_retracted | False |
| updated_date | 2025-11-06T03:46:38.306776 |
| primary_topic.id | https://openalex.org/T10631 |
| primary_topic.field.id | https://openalex.org/fields/13 |
| primary_topic.field.display_name | Biochemistry, Genetics and Molecular Biology |
| primary_topic.score | 0.9998999834060669 |
| primary_topic.domain.id | https://openalex.org/domains/1 |
| primary_topic.domain.display_name | Life Sciences |
| primary_topic.subfield.id | https://openalex.org/subfields/1306 |
| primary_topic.subfield.display_name | Cancer Research |
| primary_topic.display_name | Cancer, Hypoxia, and Metabolism |
| related_works | https://openalex.org/W2017788809, https://openalex.org/W2047697966, https://openalex.org/W1969404194, https://openalex.org/W3010320114, https://openalex.org/W2091672398, https://openalex.org/W2910483590, https://openalex.org/W2928601850, https://openalex.org/W2321193133, https://openalex.org/W4390685640, https://openalex.org/W3149454508 |
| cited_by_count | 2 |
| counts_by_year[0].year | 2025 |
| counts_by_year[0].cited_by_count | 2 |
| locations_count | 1 |
| best_oa_location.id | doi:10.1101/2023.09.02.555034 |
| best_oa_location.is_oa | True |
| best_oa_location.source.id | https://openalex.org/S4306402567 |
| best_oa_location.source.issn | |
| best_oa_location.source.type | repository |
| best_oa_location.source.is_oa | False |
| best_oa_location.source.issn_l | |
| best_oa_location.source.is_core | False |
| best_oa_location.source.is_in_doaj | False |
| best_oa_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| best_oa_location.source.host_organization | https://openalex.org/I2750212522 |
| best_oa_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| best_oa_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| best_oa_location.license | |
| best_oa_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2023/09/03/2023.09.02.555034.full.pdf |
| best_oa_location.version | acceptedVersion |
| best_oa_location.raw_type | posted-content |
| best_oa_location.license_id | |
| best_oa_location.is_accepted | True |
| best_oa_location.is_published | False |
| best_oa_location.raw_source_name | |
| best_oa_location.landing_page_url | https://doi.org/10.1101/2023.09.02.555034 |
| primary_location.id | doi:10.1101/2023.09.02.555034 |
| primary_location.is_oa | True |
| primary_location.source.id | https://openalex.org/S4306402567 |
| primary_location.source.issn | |
| primary_location.source.type | repository |
| primary_location.source.is_oa | False |
| primary_location.source.issn_l | |
| primary_location.source.is_core | False |
| primary_location.source.is_in_doaj | False |
| primary_location.source.display_name | bioRxiv (Cold Spring Harbor Laboratory) |
| primary_location.source.host_organization | https://openalex.org/I2750212522 |
| primary_location.source.host_organization_name | Cold Spring Harbor Laboratory |
| primary_location.source.host_organization_lineage | https://openalex.org/I2750212522 |
| primary_location.license | |
| primary_location.pdf_url | https://www.biorxiv.org/content/biorxiv/early/2023/09/03/2023.09.02.555034.full.pdf |
| primary_location.version | acceptedVersion |
| primary_location.raw_type | posted-content |
| primary_location.license_id | |
| primary_location.is_accepted | True |
| primary_location.is_published | False |
| primary_location.raw_source_name | |
| primary_location.landing_page_url | https://doi.org/10.1101/2023.09.02.555034 |
| publication_date | 2023-09-03 |
| publication_year | 2023 |
| referenced_works | https://openalex.org/W2028897202, https://openalex.org/W2102322990, https://openalex.org/W2234115940, https://openalex.org/W2038009564, https://openalex.org/W2467152122, https://openalex.org/W2161471210, https://openalex.org/W2029255902, https://openalex.org/W2955340545, https://openalex.org/W1969836970, https://openalex.org/W2089551665, https://openalex.org/W2125836344, https://openalex.org/W2062851356, https://openalex.org/W2774243559, https://openalex.org/W2766710101, https://openalex.org/W2919189760, https://openalex.org/W2028606217, https://openalex.org/W2043239658, https://openalex.org/W2131577505, https://openalex.org/W2054064167, https://openalex.org/W2033461907, https://openalex.org/W2122438668, https://openalex.org/W3175180381, https://openalex.org/W2143912446, https://openalex.org/W2112056314, https://openalex.org/W2036033897, https://openalex.org/W2027598957, https://openalex.org/W3107397986, https://openalex.org/W2016535776, https://openalex.org/W2988309021, https://openalex.org/W2325288941, https://openalex.org/W2125731933, https://openalex.org/W2120404934, https://openalex.org/W2039558597, https://openalex.org/W2908554896, https://openalex.org/W2134847995, https://openalex.org/W1996562397, https://openalex.org/W2116437342, https://openalex.org/W2059991546, https://openalex.org/W2152466192, https://openalex.org/W1965341570, https://openalex.org/W2017496419, https://openalex.org/W29902740, https://openalex.org/W2048938594, https://openalex.org/W2062214822, https://openalex.org/W3196666147, https://openalex.org/W2795321138, https://openalex.org/W807920197, https://openalex.org/W2097975403, https://openalex.org/W2792937385, https://openalex.org/W2099540110, https://openalex.org/W2072540192, https://openalex.org/W1539796472, https://openalex.org/W2109184569, https://openalex.org/W2180229411, https://openalex.org/W2154197653, https://openalex.org/W2144081223 |
| referenced_works_count | 56 |
| abstract_inverted_index.2 | 62, 178, 209, 226, 242 |
| abstract_inverted_index.H | 177, 208, 225, 241 |
| abstract_inverted_index.R | 138 |
| abstract_inverted_index.S | 179, 210, 227, 243 |
| abstract_inverted_index.T | 136 |
| abstract_inverted_index.a | 42, 144, 151, 182, 199, 258 |
| abstract_inverted_index.(H | 61 |
| abstract_inverted_index.By | 34 |
| abstract_inverted_index.M2 | 16 |
| abstract_inverted_index.S) | 63 |
| abstract_inverted_index.an | 76 |
| abstract_inverted_index.as | 143, 181, 198, 257 |
| abstract_inverted_index.at | 99, 102, 108, 221, 248, 266 |
| abstract_inverted_index.be | 196 |
| abstract_inverted_index.by | 86, 176, 214 |
| abstract_inverted_index.in | 30, 78, 155, 166, 187 |
| abstract_inverted_index.is | 24, 130 |
| abstract_inverted_index.of | 45, 81, 91, 97, 127, 150, 170, 192, 263 |
| abstract_inverted_index.or | 137 |
| abstract_inverted_index.to | 22, 70, 162, 233, 235 |
| abstract_inverted_index.we | 56 |
| abstract_inverted_index.326 | 110, 223 |
| abstract_inverted_index.The | 148, 251 |
| abstract_inverted_index.and | 75, 118, 190, 272 |
| abstract_inverted_index.for | 48, 52 |
| abstract_inverted_index.may | 195 |
| abstract_inverted_index.new | 200 |
| abstract_inverted_index.the | 26, 79, 95, 124, 133, 167 |
| abstract_inverted_index.326. | 104, 250 |
| abstract_inverted_index.C326 | 267 |
| abstract_inverted_index.Here | 55 |
| abstract_inverted_index.PKM2 | 36, 65, 72, 93, 106, 116, 128, 141, 152, 174, 193, 216, 229, 238, 245, 255, 264 |
| abstract_inverted_index.acid | 113 |
| abstract_inverted_index.from | 8, 132, 231 |
| abstract_inverted_index.into | 67 |
| abstract_inverted_index.that | 58, 123 |
| abstract_inverted_index.(PEP) | 21 |
| abstract_inverted_index.C326S | 129, 142, 153, 256 |
| abstract_inverted_index.PKM2. | 88 |
| abstract_inverted_index.amino | 112 |
| abstract_inverted_index.cells | 2, 40, 157 |
| abstract_inverted_index.dimer | 234 |
| abstract_inverted_index.form. | 147 |
| abstract_inverted_index.genes | 84 |
| abstract_inverted_index.known | 135 |
| abstract_inverted_index.newly | 145 |
| abstract_inverted_index.rapid | 53 |
| abstract_inverted_index.their | 4 |
| abstract_inverted_index.tumor | 171, 275 |
| abstract_inverted_index.which | 18 |
| abstract_inverted_index.Cancer | 1 |
| abstract_inverted_index.attain | 41 |
| abstract_inverted_index.cancer | 31, 39, 156, 204, 269 |
| abstract_inverted_index.enzyme | 28, 37, 73 |
| abstract_inverted_index.kinase | 15 |
| abstract_inverted_index.mutant | 154 |
| abstract_inverted_index.needed | 51 |
| abstract_inverted_index.serves | 180 |
| abstract_inverted_index.toward | 11 |
| abstract_inverted_index.unique | 259 |
| abstract_inverted_index.(PKM2), | 17 |
| abstract_inverted_index.Summary | 207 |
| abstract_inverted_index.aerobic | 12 |
| abstract_inverted_index.applied | 197 |
| abstract_inverted_index.crystal | 119, 252 |
| abstract_inverted_index.dimeric | 87, 237 |
| abstract_inverted_index.further | 121 |
| abstract_inverted_index.glucose | 5, 32, 160, 183, 212, 270 |
| abstract_inverted_index.greater | 43 |
| abstract_inverted_index.growth. | 172, 276 |
| abstract_inverted_index.leading | 69 |
| abstract_inverted_index.majorly | 218 |
| abstract_inverted_index.notably | 101, 247 |
| abstract_inverted_index.nuclear | 82, 239 |
| abstract_inverted_index.pathway | 7 |
| abstract_inverted_index.reduced | 71 |
| abstract_inverted_index.reveals | 94, 254 |
| abstract_inverted_index.rewires | 159, 211, 268 |
| abstract_inverted_index.states, | 139 |
| abstract_inverted_index.sulfide | 60 |
| abstract_inverted_index.through | 111, 219 |
| abstract_inverted_index.Abstract | 0 |
| abstract_inverted_index.Blockage | 262 |
| abstract_inverted_index.Blocking | 105 |
| abstract_inverted_index.Pyruvate | 14 |
| abstract_inverted_index.activity | 74 |
| abstract_inverted_index.approach | 202 |
| abstract_inverted_index.converts | 19 |
| abstract_inverted_index.cysteine | 103, 109, 222, 249 |
| abstract_inverted_index.enhances | 228 |
| abstract_inverted_index.fraction | 44 |
| abstract_inverted_index.hydrogen | 59 |
| abstract_inverted_index.increase | 77 |
| abstract_inverted_index.inhibits | 274 |
| abstract_inverted_index.involved | 29 |
| abstract_inverted_index.mediated | 85 |
| abstract_inverted_index.modifies | 244 |
| abstract_inverted_index.mutation | 114 |
| abstract_inverted_index.presence | 149 |
| abstract_inverted_index.reducing | 35 |
| abstract_inverted_index.rewiring | 185 |
| abstract_inverted_index.tetramer | 66, 117, 125, 232, 260 |
| abstract_inverted_index.Proteomic | 89 |
| abstract_inverted_index.activity, | 38 |
| abstract_inverted_index.currently | 134 |
| abstract_inverted_index.different | 131 |
| abstract_inverted_index.mechanism | 186 |
| abstract_inverted_index.metabolic | 6, 184 |
| abstract_inverted_index.oxidative | 9 |
| abstract_inverted_index.profiling | 90 |
| abstract_inverted_index.promoting | 188 |
| abstract_inverted_index.pyruvate, | 23 |
| abstract_inverted_index.reprogram | 3 |
| abstract_inverted_index.resulting | 165 |
| abstract_inverted_index.revealing | 140 |
| abstract_inverted_index.structure | 120, 253 |
| abstract_inverted_index.synthesis | 50 |
| abstract_inverted_index.targeting | 203 |
| abstract_inverted_index.Highlights | 224 |
| abstract_inverted_index.activation | 80 |
| abstract_inverted_index.considered | 25 |
| abstract_inverted_index.cysteines, | 100 |
| abstract_inverted_index.endogenous | 92 |
| abstract_inverted_index.facilitate | 236 |
| abstract_inverted_index.glycolytic | 46 |
| abstract_inverted_index.identified | 146 |
| abstract_inverted_index.indicating | 122 |
| abstract_inverted_index.inhibition | 169, 191 |
| abstract_inverted_index.metabolism | 161, 213, 271 |
| abstract_inverted_index.occurrence | 96 |
| abstract_inverted_index.stabilizes | 115 |
| abstract_inverted_index.demonstrate | 57 |
| abstract_inverted_index.effectively | 158 |
| abstract_inverted_index.glycolysis. | 13 |
| abstract_inverted_index.metabolism. | 33, 205 |
| abstract_inverted_index.metabolites | 47 |
| abstract_inverted_index.significant | 168 |
| abstract_inverted_index.therapeutic | 201 |
| abstract_inverted_index.One-Sentence | 206 |
| abstract_inverted_index.destabilizes | 64 |
| abstract_inverted_index.dissociation | 230 |
| abstract_inverted_index.organization | 126 |
| abstract_inverted_index.respiration, | 164 |
| abstract_inverted_index.Collectively, | 173 |
| abstract_inverted_index.conformation. | 261 |
| abstract_inverted_index.destabilizing | 215 |
| abstract_inverted_index.macromolecule | 49 |
| abstract_inverted_index.mitochondrial | 163 |
| abstract_inverted_index.rate-limiting | 27 |
| abstract_inverted_index.significantly | 273 |
| abstract_inverted_index.sulfhydration | 98, 107, 175, 194, 220, 265 |
| abstract_inverted_index.dimer/monomer, | 68 |
| abstract_inverted_index.proliferation. | 54 |
| abstract_inverted_index.sulfhydration, | 246 |
| abstract_inverted_index.translocation. | 240 |
| abstract_inverted_index.tumorigenesis, | 189 |
| abstract_inverted_index.phosphorylation | 10 |
| abstract_inverted_index.tetramerization | 217 |
| abstract_inverted_index.transcriptional | 83 |
| abstract_inverted_index.phosphoenolpyruvate | 20 |
| cited_by_percentile_year.max | 97 |
| cited_by_percentile_year.min | 95 |
| corresponding_author_ids | https://openalex.org/A5045306079, https://openalex.org/A5046255159, https://openalex.org/A5020997600 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 21 |
| corresponding_institution_ids | https://openalex.org/I184693016, https://openalex.org/I25846049 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.41999998688697815 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.74986149 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |