Hydrogen Sulfide Targets the Cys320/Cys529 Motif in Kv4.2 to Inhibit the Ito Potassium Channels in Cardiomyocytes and Regularizes Fatal Arrhythmia in Myocardial Infarction Article Swipe
Shan‐Feng Ma
,
Yan Luo
,
Ying-Jiong Ding
,
Ying Chen
,
Shi-Xin Pu
,
Hang‐Jing Wu
,
Zhongfeng Wang
,
Bei‐Bei Tao
,
Wenwei Wang
,
Yi‐Chun Zhu
·
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1089/ars.2014.6094
YOU?
·
· 2015
· Open Access
·
· DOI: https://doi.org/10.1089/ars.2014.6094
H2S targets the Cys320/Cys529 motif in Kv4.2 to regulate the Ito potassium channels. H2S also shows a potent regularizing effect against fatal arrhythmia in a rat model of myocardial infarction. The study provides the first piece of evidence for the role of H2S in regulating Ito potassium channels and also the specific motif in an ion channel labile for H2S regulation.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1089/ars.2014.6094
- OA Status
- green
- Cited By
- 26
- References
- 46
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W2045544614
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
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https://openalex.org/W2045544614Canonical identifier for this work in OpenAlex
- DOI
-
https://doi.org/10.1089/ars.2014.6094Digital Object Identifier
- Title
-
Hydrogen Sulfide Targets the Cys320/Cys529 Motif in Kv4.2 to Inhibit the Ito Potassium Channels in Cardiomyocytes and Regularizes Fatal Arrhythmia in Myocardial InfarctionWork title
- Type
-
articleOpenAlex work type
- Language
-
enPrimary language
- Publication year
-
2015Year of publication
- Publication date
-
2015-03-10Full publication date if available
- Authors
-
Shan‐Feng Ma, Yan Luo, Ying-Jiong Ding, Ying Chen, Shi-Xin Pu, Hang‐Jing Wu, Zhongfeng Wang, Bei‐Bei Tao, Wenwei Wang, Yi‐Chun ZhuList of authors in order
- Landing page
-
https://doi.org/10.1089/ars.2014.6094Publisher landing page
- Open access
-
YesWhether a free full text is available
- OA status
-
greenOpen access status per OpenAlex
- OA URL
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https://doi.org/10.1089/ars.2014.6094Direct OA link when available
- Concepts
-
Potassium channel, Cysteine, Ion channel, Myocardial infarction, Hydrogen sulfide, Chemistry, Myocyte, Inhibitory postsynaptic potential, Biophysics, Internal medicine, Cardiology, Medicine, Receptor, Biochemistry, Biology, Sulfur, Enzyme, Organic chemistryTop concepts (fields/topics) attached by OpenAlex
- Cited by
-
26Total citation count in OpenAlex
- Citations by year (recent)
-
2025: 1, 2024: 3, 2023: 2, 2022: 5, 2021: 3Per-year citation counts (last 5 years)
- References (count)
-
46Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.H2S | 0, 13, 42, 59 |
| abstract_inverted_index.Ito | 10, 45 |
| abstract_inverted_index.The | 30 |
| abstract_inverted_index.and | 48 |
| abstract_inverted_index.for | 38, 58 |
| abstract_inverted_index.ion | 55 |
| abstract_inverted_index.rat | 25 |
| abstract_inverted_index.the | 2, 9, 33, 39, 50 |
| abstract_inverted_index.also | 14, 49 |
| abstract_inverted_index.role | 40 |
| abstract_inverted_index.Kv4.2 | 6 |
| abstract_inverted_index.fatal | 21 |
| abstract_inverted_index.first | 34 |
| abstract_inverted_index.model | 26 |
| abstract_inverted_index.motif | 4, 52 |
| abstract_inverted_index.piece | 35 |
| abstract_inverted_index.shows | 15 |
| abstract_inverted_index.study | 31 |
| abstract_inverted_index.effect | 19 |
| abstract_inverted_index.labile | 57 |
| abstract_inverted_index.potent | 17 |
| abstract_inverted_index.against | 20 |
| abstract_inverted_index.channel | 56 |
| abstract_inverted_index.targets | 1 |
| abstract_inverted_index.channels | 47 |
| abstract_inverted_index.evidence | 37 |
| abstract_inverted_index.provides | 32 |
| abstract_inverted_index.regulate | 8 |
| abstract_inverted_index.specific | 51 |
| abstract_inverted_index.channels. | 12 |
| abstract_inverted_index.potassium | 11, 46 |
| abstract_inverted_index.arrhythmia | 22 |
| abstract_inverted_index.myocardial | 28 |
| abstract_inverted_index.regulating | 44 |
| abstract_inverted_index.infarction. | 29 |
| abstract_inverted_index.regulation. | 60 |
| abstract_inverted_index.regularizing | 18 |
| abstract_inverted_index.Cys320/Cys529 | 3 |
| cited_by_percentile_year.max | 98 |
| cited_by_percentile_year.min | 89 |
| corresponding_author_ids | https://openalex.org/A5076130185 |
| countries_distinct_count | 1 |
| institutions_distinct_count | 10 |
| corresponding_institution_ids | https://openalex.org/I133868755 |
| citation_normalized_percentile.value | 0.82043302 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |