Hydroxydiorygmone A, a New Guaiane-Sesquiterpene from the Cultured Lichen Mycobiont of Diorygma sp Article Swipe
Ngoc‐Hong Nguyen
,
Thuc‐Huy Duong
,
Gia‐Huy Duong
,
Huy Truong Nguyen
,
Thi‐Hoai‐Thu Nguyen
,
Nguyen-Hong-Nhi Phan
,
Thi‐Phi‐Giao Vo
,
Thi‐Minh‐Dinh Tran
,
Thi-Phuong Nguyen
·
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1177/1934578x241297992
YOU?
·
· 2024
· Open Access
·
· DOI: https://doi.org/10.1177/1934578x241297992
Objective: Cultured mycobiont of the Vietnamese crustose-lichen Diorygma sp. has been chemically investigated. Biological activities including cytotoxicity against HepG2 cell line, α-glucosidase inhibition, and nitric oxide inhibitory activity were evaluated. Methods: Extensive spectroscopic methods (NMR and ECD) and HRESI mass data were employed for structural elucidation. These isolates were evaluated for their cytotoxicity against HepG2 cell line, α-glucosidase inhibition, and inhibitory activity toward nitric oxide production in LPS-stimulated RAW 264.7 cells. Results: Four compounds (1–4), including a new guaiane-sesquiterpene, hydroxydiorygmone A (1), along with three known analogues, diorygmones A and B (2 and 3) and pruinosone (4), were isolated and characterized. Compound 1 showed moderate α-glucosidase inhibition with an IC 50 value of 160 ± 2.2 µM and significant inhibitory activity toward nitric oxide production in LPS-stimulated RAW 264.7 cells with an IC 50 value of 8.11 ± 0.21 µM. Others were inactive in α-glucosidase inhibitory and nitric oxide inhibitory tests. Conclusion: A new guaiane-sesquiterpene, hydroxydiorygmone A (1) was isolated and showed moderate α-glucosidase inhibition with an IC 50 value of 160 ± 2.2 µM and significant inhibitory activity toward nitric oxide production in LPS-stimulated RAW 264.7 cells with an IC 50 value of 8.11 ± 0.21 µM.
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Metadata
- Type
- article
- Language
- en
- Landing Page
- https://doi.org/10.1177/1934578x241297992
- OA Status
- gold
- References
- 19
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4404289909
All OpenAlex metadata
Raw OpenAlex JSON
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https://openalex.org/W4404289909Canonical identifier for this work in OpenAlex
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https://doi.org/10.1177/1934578x241297992Digital Object Identifier
- Title
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Hydroxydiorygmone A, a New Guaiane-Sesquiterpene from the Cultured Lichen Mycobiont of Diorygma spWork title
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articleOpenAlex work type
- Language
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enPrimary language
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2024Year of publication
- Publication date
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2024-11-01Full publication date if available
- Authors
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Ngoc‐Hong Nguyen, Thuc‐Huy Duong, Gia‐Huy Duong, Huy Truong Nguyen, Thi‐Hoai‐Thu Nguyen, Nguyen-Hong-Nhi Phan, Thi‐Phi‐Giao Vo, Thi‐Minh‐Dinh Tran, Thi-Phuong NguyenList of authors in order
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https://doi.org/10.1177/1934578x241297992Publisher landing page
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YesWhether a free full text is available
- OA status
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goldOpen access status per OpenAlex
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https://doi.org/10.1177/1934578x241297992Direct OA link when available
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Lichen, Sesquiterpene, Chemistry, Botany, Terpene, Traditional medicine, Stereochemistry, Biology, MedicineTop concepts (fields/topics) attached by OpenAlex
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0Total citation count in OpenAlex
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10Other works algorithmically related by OpenAlex
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