Hypersensitivity Reactions to Iodinated Contrast Media: A Narrative Review of Current Evidence and Clinical Challenges Article Swipe
Francesca Losa
,
Giovanni Paoletti
,
Linda Borgonovo
,
Federica Buta
,
Stefania Merli
,
Serena Nannipieri
,
Marta Piantanida
,
Carlo Maria Rossi
,
Giada Sambugaro
,
Mona‐Rita Yacoub
,
Vincenzo Patella
,
Giorgio Walter Canonica
,
Enrico Heffler
,
Maria Teresa Costantino
·
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/healthcare13111308
YOU?
·
· 2025
· Open Access
·
· DOI: https://doi.org/10.3390/healthcare13111308
Background/Objectives: Hypersensitivity reactions (HSRs) to iodinated contrast media (ICM), both immediate and non-immediate, pose clinical challenges despite using low-osmolality agents. This review aims to summarize current diagnostic approaches, cross-reactivity patterns, and the debated role of premedication. Methods: A narrative review was conducted using PubMed (2014–2024), selecting studies on ICM-related HSRs, focusing on skin and in vitro testing, drug provocation tests (DPTs), cross-reactivity, and premedication. Results: Skin tests show limited sensitivity, especially for non-immediate reactions. Cross-reactivity among ICMs is common but unpredictable. DPTs are the diagnostic gold standard but lack standardized protocols. Premedication is frequently used, though its efficacy remains uncertain. Conclusions: The management of ICM hypersensitivity is limited by diagnostic gaps and insufficient evidence on premedication. Standardized protocols and prospective studies are needed to improve patient safety and guide clinical decisions.
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Concepts
Metadata
- Type
- review
- Language
- en
- Landing Page
- https://doi.org/10.3390/healthcare13111308
- https://www.mdpi.com/2227-9032/13/11/1308/pdf?version=1748617293
- OA Status
- gold
- References
- 62
- Related Works
- 10
- OpenAlex ID
- https://openalex.org/W4410969527
All OpenAlex metadata
Raw OpenAlex JSON
- OpenAlex ID
-
https://openalex.org/W4410969527Canonical identifier for this work in OpenAlex
- DOI
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https://doi.org/10.3390/healthcare13111308Digital Object Identifier
- Title
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Hypersensitivity Reactions to Iodinated Contrast Media: A Narrative Review of Current Evidence and Clinical ChallengesWork title
- Type
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reviewOpenAlex work type
- Language
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enPrimary language
- Publication year
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2025Year of publication
- Publication date
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2025-05-30Full publication date if available
- Authors
-
Francesca Losa, Giovanni Paoletti, Linda Borgonovo, Federica Buta, Stefania Merli, Serena Nannipieri, Marta Piantanida, Carlo Maria Rossi, Giada Sambugaro, Mona‐Rita Yacoub, Vincenzo Patella, Giorgio Walter Canonica, Enrico Heffler, Maria Teresa CostantinoList of authors in order
- Landing page
-
https://doi.org/10.3390/healthcare13111308Publisher landing page
- PDF URL
-
https://www.mdpi.com/2227-9032/13/11/1308/pdf?version=1748617293Direct link to full text PDF
- Open access
-
YesWhether a free full text is available
- OA status
-
goldOpen access status per OpenAlex
- OA URL
-
https://www.mdpi.com/2227-9032/13/11/1308/pdf?version=1748617293Direct OA link when available
- Concepts
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Premedication, Iodinated contrast media, Provocation test, Medicine, Narrative review, Gold standard (test), Iodinated contrast, Intensive care medicine, Hypersensitivity reaction, MEDLINE, Surgery, Internal medicine, Pathology, Alternative medicine, Computed tomography, Political science, LawTop concepts (fields/topics) attached by OpenAlex
- Cited by
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0Total citation count in OpenAlex
- References (count)
-
62Number of works referenced by this work
- Related works (count)
-
10Other works algorithmically related by OpenAlex
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| abstract_inverted_index.lack | 88 |
| abstract_inverted_index.pose | 13 |
| abstract_inverted_index.role | 33 |
| abstract_inverted_index.show | 67 |
| abstract_inverted_index.skin | 52 |
| abstract_inverted_index.HSRs, | 49 |
| abstract_inverted_index.among | 75 |
| abstract_inverted_index.guide | 128 |
| abstract_inverted_index.media | 7 |
| abstract_inverted_index.tests | 59, 66 |
| abstract_inverted_index.used, | 94 |
| abstract_inverted_index.using | 17, 42 |
| abstract_inverted_index.vitro | 55 |
| abstract_inverted_index.(HSRs) | 3 |
| abstract_inverted_index.(ICM), | 8 |
| abstract_inverted_index.PubMed | 43 |
| abstract_inverted_index.common | 78 |
| abstract_inverted_index.needed | 122 |
| abstract_inverted_index.review | 21, 39 |
| abstract_inverted_index.safety | 126 |
| abstract_inverted_index.though | 95 |
| abstract_inverted_index.(DPTs), | 60 |
| abstract_inverted_index.agents. | 19 |
| abstract_inverted_index.current | 25 |
| abstract_inverted_index.debated | 32 |
| abstract_inverted_index.despite | 16 |
| abstract_inverted_index.improve | 124 |
| abstract_inverted_index.limited | 68, 107 |
| abstract_inverted_index.patient | 125 |
| abstract_inverted_index.remains | 98 |
| abstract_inverted_index.studies | 46, 120 |
| abstract_inverted_index.Methods: | 36 |
| abstract_inverted_index.Results: | 64 |
| abstract_inverted_index.clinical | 14, 129 |
| abstract_inverted_index.contrast | 6 |
| abstract_inverted_index.efficacy | 97 |
| abstract_inverted_index.evidence | 113 |
| abstract_inverted_index.focusing | 50 |
| abstract_inverted_index.standard | 86 |
| abstract_inverted_index.testing, | 56 |
| abstract_inverted_index.conducted | 41 |
| abstract_inverted_index.immediate | 10 |
| abstract_inverted_index.iodinated | 5 |
| abstract_inverted_index.narrative | 38 |
| abstract_inverted_index.patterns, | 29 |
| abstract_inverted_index.protocols | 117 |
| abstract_inverted_index.reactions | 2 |
| abstract_inverted_index.selecting | 45 |
| abstract_inverted_index.summarize | 24 |
| abstract_inverted_index.challenges | 15 |
| abstract_inverted_index.decisions. | 130 |
| abstract_inverted_index.diagnostic | 26, 84, 109 |
| abstract_inverted_index.especially | 70 |
| abstract_inverted_index.frequently | 93 |
| abstract_inverted_index.management | 102 |
| abstract_inverted_index.protocols. | 90 |
| abstract_inverted_index.reactions. | 73 |
| abstract_inverted_index.uncertain. | 99 |
| abstract_inverted_index.ICM-related | 48 |
| abstract_inverted_index.approaches, | 27 |
| abstract_inverted_index.prospective | 119 |
| abstract_inverted_index.provocation | 58 |
| abstract_inverted_index.Conclusions: | 100 |
| abstract_inverted_index.Standardized | 116 |
| abstract_inverted_index.insufficient | 112 |
| abstract_inverted_index.sensitivity, | 69 |
| abstract_inverted_index.standardized | 89 |
| abstract_inverted_index.Premedication | 91 |
| abstract_inverted_index.non-immediate | 72 |
| abstract_inverted_index.(2014–2024), | 44 |
| abstract_inverted_index.low-osmolality | 18 |
| abstract_inverted_index.non-immediate, | 12 |
| abstract_inverted_index.premedication. | 35, 63, 115 |
| abstract_inverted_index.unpredictable. | 80 |
| abstract_inverted_index.Cross-reactivity | 74 |
| abstract_inverted_index.Hypersensitivity | 1 |
| abstract_inverted_index.cross-reactivity | 28 |
| abstract_inverted_index.hypersensitivity | 105 |
| abstract_inverted_index.cross-reactivity, | 61 |
| abstract_inverted_index.Background/Objectives: | 0 |
| cited_by_percentile_year | |
| countries_distinct_count | 1 |
| institutions_distinct_count | 14 |
| sustainable_development_goals[0].id | https://metadata.un.org/sdg/3 |
| sustainable_development_goals[0].score | 0.6499999761581421 |
| sustainable_development_goals[0].display_name | Good health and well-being |
| citation_normalized_percentile.value | 0.22936555 |
| citation_normalized_percentile.is_in_top_1_percent | False |
| citation_normalized_percentile.is_in_top_10_percent | False |